Endoscopic Ultrasound最新文献

{"title":"A novel lumen-apposing metal stent for EUS-guided drainage of pancreatic fluid collections: A multicenter prospective study.","authors":"Huiyun Zhu, Yuting Liu, Kaixuan Wang, Danqi Zhao, Xun Li, Xiaoping Zou, Xiaofeng Zhang, Youxiang Chen, Ning Zhong, Jianying Bai, Liang Zhong, Peng Li, Bin Xiao, Wei Chen, Enqiang Linghu, Zhaoshen Li, Ningli Chai, Yiqi Du, Zhendong Jin","doi":"10.1097/eus.0000000000000162","DOIUrl":"10.1097/eus.0000000000000162","url":null,"abstract":"<p><strong>Background and objectives: </strong>Various lumen-apposing metal stents (LAMSs) were used for pancreatic fluid collection (PFC) drainage for many years. The structural design of LAMS needs to be improved to reduce the occurrence of adverse events. This trial assessed the efficacy and safety of a novel modified LAMS for the drainage of PFCs.</p><p><strong>Methods: </strong>This open-label, multicenter, prospective trial was done at 11 tertiary care hospitals. This study enrolled patients (18-75 years old) with confirmed diagnosis of PFC with cyst diameter no less than 6 cm. Novel LAMS (Micro-Tech Co, Ltd, Nanjing, China) was used. The primary end point was the 1-month postoperative drainage success rate. The secondary end points were technical success rate and adverse events. This study is registered with Chictr.org.cn, ChiCTR2000039955.</p><p><strong>Results: </strong>Between December 9, 2020, and December 27, 2021, 100 patients with PFC were assessed for eligibility, and 94 patients met the criteria and agreed to participate in the trial. The median size of PFC cyst was 11.23 ± 3.84 cm. The drainage success rate was 90.48% (95% CI, 83.6%-97.3%) and achieved the prespecified target value of 75% (<i>P</i> < 0.0001). In subgroup analysis, the clinical success rates of pancreatic pseudocyst (PPC) and walled-off necrosis (WON) were 95.45% and 85%, respectively (<i>P</i> = 0.143). The overall technical success rate was 98.94%. Postoperative early adverse events occurred in 57 (60.64%) of 94 patients, and late adverse events were encountered in 16 (17.02%) of 94 patients. The overall rate of serious adverse event (bleeding-related death) was 2.13% (2/94). Patients with WON had a significantly higher rate of early adverse events compared to those with PPC (77.78% <i>vs</i>. 44.90%, <i>P</i> = 0.001).</p><p><strong>Conclusions: </strong>The novel LAMS used in this trial was technically feasible, efficient, and safe for the treatment of PFCs. Comparable with WON, the usage of LAMS in PPC achieved a high drainage success rate and acceptable adverse events.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"15 2","pages":"126-133"},"PeriodicalIF":4.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of EUS-guided tissue acquisition in suspected autoimmune pancreatitis: A 15-year single-center retrospective study.","authors":"Wei Du, Yuyan Zhou, Haojie Huang, Deyu Zhang, Yilin Ren, Yingyue Sheng, Xinyue Wang, Yue Liu, Dongling Wan, Xiaorong Tian, Wanshun Li, Jiayu Li, Mengruo Jiang, Jiaheng Xu, Zhenghui Yang, Yu Bai, Yuzheng Xue, Zhendong Jin","doi":"10.1097/eus.0000000000000158","DOIUrl":"10.1097/eus.0000000000000158","url":null,"abstract":"<p><strong>Background and objectives: </strong>Autoimmune pancreatitis is a distinct type of pancreatitis mediated by autoimmune processes. Imaging studies frequently reveal diffuse or focal pancreatic enlargement, as well as irregular narrowing of the pancreatic duct. The clinical manifestations of this condition often overlap with those of other malignant conditions, such as pancreatic cancer, which can result in a high rate of misdiagnosis. EUS-guided fine-needle aspiration biopsy is a novel approach for the pathological diagnosis of AIP, enabling pancreatic tissue sampling. However, there remains a paucity of research on the efficacy of EUS-guided tissue sampling in the diagnosis of suspected AIP. The objective of this study is to assess the diagnostic value of EUS-guided tissue acquisition (including EUS-FNA and EUS-FNB) in patients with suspected AIP.</p><p><strong>Method: </strong>Patients suspected of AIP who underwent EUS-guided tissue acquisition (EUS-TA) at Changhai Hospital between 2010 and 2025.</p><p><strong>Results: </strong>This study included 148 patients with suspected AIP. Ultimately, 131 were diagnosed with AIP, 9 with pancreatic malignancy, and 8 with other pancreatic diseases. Among the 131 patients diagnosed with AIP, EUS-TA achieved a success rate of 88.66% for obtaining histopathological evidence in type 1 AIP, 76.47% in type 2 AIP, and 85.5% overall for AIP. The ROC curve indicates that EUS-TA demonstrates good diagnostic value for patients suspected of having AIP (AUC = 0.839, 95% CI: 0.729-0.95). Compared with EUS-FNB, EUS-FNA showed significantly lower sensitivity (78.57% <i>vs.</i> 90.67%, <i>P</i> = 0.029), specificity (75% <i>vs.</i> 88.89%, <i>P</i> = 0.017), negative predictive value (33.33% <i>vs.</i> 53.3%, <i>P</i> = 0.007), and accuracy (78.13% <i>vs.</i> 90.48%, <i>P</i> = 0.034).</p><p><strong>Conclusion: </strong>EUS-guided tissue acquisition demonstrates good diagnostic value for patients suspected of AIP, with EUS-FNB showing higher diagnostic value for AIP than EUS-FNA. EUS-FNB is the preferred diagnostic method for patients suspected of AIP.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"15 2","pages":"134-142"},"PeriodicalIF":4.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of one-step EUS-guided hepaticogastrostomy using an 8F stent introducer featuring an ultra-tapered metal tip and a preloaded partially covered metal stent (with video).","authors":"Gunn Huh, Yoonchan Lee, Ho Seung Lee, Sung Hyun Cho, John J Vargo, Steven A Edmundowicz, Sunguk Jang, Do Hyun Park","doi":"10.1097/eus.0000000000000173","DOIUrl":"10.1097/eus.0000000000000173","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study evaluated the clinical outcomes of a newly refined 8F stent introducer featuring an ultra-tapered metal tip and a preloaded, partially covered, self-expandable metal stent (PCSEMS) for one-step stent deployment during EUS-guided hepaticogastrostomy (EUS-HGS).</p><p><strong>Methods: </strong>A retrospective review of 34 patients who underwent EUS-HGS using the refined PCSEMS between February 2024 and February 2025 was conducted using a prospectively collected database. An expert and a novice endoscopist performed procedures. The primary outcome was technical success. Secondary outcomes included one-step deployment rate, adverse events, clinical success, recurrent biliary obstruction (RBO), and predictors of one-step stent deployment.</p><p><strong>Results: </strong>The technical success rate was 100%, with 88.2% of deployments being one-step. Adverse events occurred in 14.7%. Clinical success was 94.1%. RBO occurred in 12 patients (37.5%), with a median time to RBO of 115 days (95% confidence interval, 91 to not reached). Endoscopic reintervention was successful in 91.7% (11/12). Outcomes were comparable between the expert and novice, except for procedure time. A narrow needle-scope angle (≤138°) was associated with successful one-step deployment (86.7% <i>vs.</i> 25.0%, <i>P</i> = 0.027). On multivariable analysis, a needle-scope angle ≤138° was the only independent predictor (odds ratio 26.2; 95% confidence interval, 1.50-457.4; <i>P</i> = 0.025) for one-step stent deployment.</p><p><strong>Conclusion: </strong>The refined dedicated 8F stent introducer, featuring an ultra-tapered metal tip and preloaded with a PCSEMS for one-step EUS-HGS, achieved excellent technical and clinical success with an acceptable safety profile, although larger prospective studies are warranted.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"15 2","pages":"143-152"},"PeriodicalIF":4.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of postprocedural adverse events between same-day and separate-day combined EUS-guided fine-needle aspiration/biopsy and endoscopic retrograde cholangiopancreatography in patients with pancreatic mass and biliary obstruction: A retrospective cohort study.","authors":"Hong-Yuan Zou, Zheng-Dong Li, Jia-Hui Zhu, Zhen-Dong Jin, Zhuan Liao, Zhao-Shen Li, Yang-Yang Qian, Lei Wang","doi":"10.1097/eus.0000000000000174","DOIUrl":"10.1097/eus.0000000000000174","url":null,"abstract":"<p><strong>Background and objective: </strong>The optimal timing between endoscopic retrograde cholangiopancreatography (ERCP) and EUS-guided fine-needle aspiration/biopsy (EUS-FNA/B) remains undefined. This study compared The optimal timing between endoscopic retrograde cholangiopancreatography (ERCP) and EUS-guided fine-needle aspiration/biopsy (EUS-FNA/B) remains undefined. This study compared the safety and efficacy of same-day <i>versus</i> separate-day procedures.the safety and efficacy of same-day versus separate-day procedures.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 362 patients with pancreatic mass and biliary obstruction who underwent EUS-FNA/B and ERCP during one hospitalization period at Changhai Hospital between January 2017 and February 2024. Outcomes included adverse events, technical success of biliary stenting, and diagnostic yield of EUS-FNA/B. Logistic regression identified risk factors for adverse events.</p><p><strong>Results: </strong>Patients were stratified into same-day (group A, <i>n</i> = 60) and separate-day (group B, <i>n</i> = 302) groups. No perforations occurred in either group. Rates of pancreatitis (10.0% <i>vs.</i> 9.3%), infection (10.0% <i>vs.</i> 8.3%), and bleeding (1.7% <i>vs.</i> 3.7%) were comparable (all <i>P</i> > 0.05). Technical success of biliary stenting (96.7% <i>vs.</i> 96.7%) and diagnostic yield of EUS-FNA/B (80.0% <i>vs.</i> 84.8%) showed no intergroup differences. Notably, same-day procedures significantly shortened median hospital stay (6 [4-8.75] days <i>vs.</i> 7 [6-10] days, <i>P</i> = 0.002). Multivariable analysis identified advancing age (odds ratio [OR]: 0.957; 95% confidence interval [CI], 0.924-0.991; <i>P</i> = 0.014) and larger mass short-axis diameter (OR: 0.918; 95% CI, 0.868-0.971; <i>P</i> = 0.003) as independent protective factors against pancreatitis, while overweight status (body mass index > 23.9 kg/m²) increased pancreatitis risk (OR: 3.491; 95% CI, 1.574-7.744; <i>P</i> = 0.002). Precut sphincterotomy was independently associated with bleeding risk (OR: 1.607; 95% CI, 1.230-20.242; <i>P</i> = 0.024). Crucially, the same-day procedure was not linked to increased adverse events.</p><p><strong>Conclusion: </strong>Same-day ERCP and EUS-FNA/B is safe and feasible, does not increase adverse events, and reduces hospital stay.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"15 1","pages":"71-78"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and comparison of 3 preoperative drainage methods for acute cholecystitis.","authors":"Keiichi Suzuki, Takero Koike, Naoto Yoshitake, Hirofumi Naito, Eri Naito, Tomoki Ohashi, Daisuke Udagawa, Yuka Koseki, Kenshi Omagari, Takeo Hashimoto","doi":"10.1097/eus.0000000000000164","DOIUrl":"10.1097/eus.0000000000000164","url":null,"abstract":"<p><strong>Background and objectives: </strong>In some cases of acute cholecystitis, preoperative drainage may be necessary, depending on the patient's condition. We compared the results of 3 preoperative drainage methods, endoscopic transpapillary gallbladder drainage (ETGBD), EUS-guided biliary drainage (EUS-GBD), and percutaneous transhepatic gallbladder drainage (PTGBD), to determine the optimal drainage method.</p><p><strong>Methods: </strong>ETGBD was performed in 138 patients, EUS-GBD in 17, and PTGBD in 45.</p><p><strong>Results: </strong>The technical success rate of ETGBD was 87.0%, 94.1% for EUS-GBD, and 100% for PTGBD. ETGBD was associated with a significantly shorter time to white blood cell normalization (<i>P</i> = 0.02) and oral intake initiation (<i>P</i> < 0.01) compared with PTGBD and a shorter time to temporary discharge (<i>P</i> < 0.01) compared with EUS-GBD and PTGBD. A total of 114 patients underwent elective laparoscopic cholecystectomy (Lap-C). The waiting period before surgery was significantly shorter in the ETGBD group (<i>P</i> = 0.03) compared with the other 2 groups. There were no differences in operative time and blood loss between the 3 groups, but there were 4 cases (11.1%) of open conversion in the PTGBD group, which was a significantly higher number than that in the ETGBD group (<i>P</i> = 0.02). Among the 3 groups, the adverse events rate was highest in the PTGBD group, at 9 cases (25%), and the postoperative hospital stay was shortest in the ETGBD group, at 4 days.</p><p><strong>Conclusion: </strong>Preoperative drainage as a bridging therapy for elective Lap-C should be performed in cases of acute cholecystitis, with ETGBD as the first choice and EUS-GBD as the second in cases of ETGBD failure.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"15 1","pages":"31-38"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of diagnostic and therapeutic EUS procedures in live course <i>versus</i> routine service between 2015 and 2021: A propensity score analysis.","authors":"Tiffany Y Chua, Anthony Y B Teoh, Shannon M Chan, Terry C F Yip, Ting Ting Chan, James Y W Lau, Philip W Y Chiu, Raymond S Y Tang","doi":"10.1097/eus.0000000000000172","DOIUrl":"10.1097/eus.0000000000000172","url":null,"abstract":"<p><strong>Background and objectives: </strong>Live courses are important sources of endoscopy education. While diagnostic and therapeutic EUS procedures have been increasingly performed in live courses recently, data on outcomes of EUS in live courses remain scarce. This study aims to compare outcomes of EUS procedures in live courses <i>versus</i> routine clinical service.</p><p><strong>Methods: </strong>All diagnostic and therapeutic EUS cases performed in workshops at Prince of Wales Hospital at The Chinese University of Hong Kong from 2015 to 2021 were considered for inclusion. Therapeutic EUS cases were divided into 5 subtypes: rendezvous, access (biliary, pancreatic, and enteric), endohepatology, lesion ablation or injection, and drainage (cystogastrostomy and gallbladder drainage). Propensity score matching of procedure subtype, procedure date, and age-adjusted Charlson Comorbidity Index was performed to match live course and routine service cases on a 1:1 basis for comparison.</p><p><strong>Results: </strong>After propensity score matching, 108 live courses and 108 routine service cases were included in the analysis. Access procedures were the most common therapeutic EUS subtype performed, followed by lesion injection/ablation and drainage procedures. Rates of benign and malignant indications for procedure were comparable in both cohorts. Technical success was 100% in diagnostic EUS in both groups. There was no significant difference in technical success in therapeutic EUS (96.7% <i>vs.</i> 100%, <i>P</i> = 0.496). Intraprocedure and postprocedure adverse events were also comparable in both groups. There were no 30-day procedure-related mortalities.</p><p><strong>Conclusion: </strong>In this study, diagnostic and therapeutic EUS performed during live courses yield similar technical success and safety outcomes compared with cases performed routinely.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"15 1","pages":"57-61"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transesophageal EUS of mediastinal and pulmonary lesions: An Italian survey from i-EUS Working Group.","authors":"Giacomo Emanuele Maria Rizzo, Cecilia Binda, Aurelio Mauro, Chiara Coluccio, Stefano Mazza, Dario Ligresti, Gabriele Rancatore, Andrea Anderloni, Carlo Fabbri, Ilaria Tarantino","doi":"10.1097/eus.0000000000000165","DOIUrl":"10.1097/eus.0000000000000165","url":null,"abstract":"<p><strong>Background and objectives: </strong>Pulmonary and mediastinal masses are diagnostic challenges for digestive endosonographers, and patients with these conditions are usually managed in thoracic or pulmonology units. EUS with tissue acquisition can result in adequate samples for histological examination and molecular analysis. Its spread among digestive endosonographers is limited; thus, we aimed to investigate the current management practices among the EUS Italian centers for those patients with mediastinal or pulmonary lesions to identify the principal areas of disagreement and help guide future research towards useful standardization.</p><p><strong>Methods: </strong>A 44‑question survey was sent during a temporal trend of 3 months to the endosonographers in Italian centers performing EUS. The survey includes questions with either a single answer choice or with multiple options exploring different aspects of the EUS done for the evaluation of thoracic lesions. The questions were grouped into specific sections: expertise of the center, periprocedural management, procedural aspects, and future perspectives.</p><p><strong>Results: </strong>Thirty-nine centers completed the survey, 27 (69.2%) from the north of Italy. Only 2 centers among the responders did not perform any mediastinal EUS (5.13%). The majority of centers (22, 59.5%) performed between 0 and 30 mediastinal EUS yearly, and only 3 centers did more than 100 mediastinal EUS per year. Responders were mainly gastroenterologists (34, 87.2%) <i>versus</i> surgeons (5, 12.8%). Only 5 centers performed mediastinal EUS in a shared room with bronchoscopy and endobronchial ultrasound (13.5%). The procedure was considered simple for 20 (54.1%) responders, complex for 5 (13.5%), and needed to be performed in a tertiary thoracic center for 12 (32.4%). Franseen and Fork tips were the most used tips (67.6% and 27%, respectively), and the most common needle diameter was 22 gauge (86.5%). Fifteen centers (40.5%) preferred deep sedation with an anesthesiologist without endotracheal intubation. The main growing indications appear to be local EUS-guided treatments (tumors or collections).</p><p><strong>Conclusions: </strong>This is the first survey assessing an evaluation on mediastinal/pulmonary EUS, which is well represented in Italy. Nonetheless, centers largely have low volumes of these procedures. Our results show heterogeneity in the management of patients affected with mediastinal/pulmonary lesions needing tissue acquisition. More studies also involving pulmonologists, thoracic surgeons, and oncologists are needed to increase data and understanding regarding this procedure.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"15 1","pages":"13-21"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and a prediction model for false-negative diagnosis in repeat EUS-FNA/B of pancreatic solid lesions following initially nondiagnostic or inconclusive findings.","authors":"Jia-Yi Ma, Wen Jiang, Bin Cheng, Si Xiong, Ning Zhong, Jun Gao, Guo-Bao Wang, Hong-Bo Shan, Jian-Qiang Liu, Ke Chen, Bai-Wen Li, Kui Peng, Jing Shan, Ming Zhao, Xiao-Yan Wang, Zhen-Dong Jin, Kai-Xuan Wang","doi":"10.1097/eus.0000000000000171","DOIUrl":"10.1097/eus.0000000000000171","url":null,"abstract":"<p><strong>Background and objectives: </strong>Repeated EUS-guided fine-needle aspiration/biopsy (rEUS-FNA/B) is recommended in solid pancreatic lesions (SPLs) with inconclusive initial results. However, even rEUS-FNA/B cannot completely eliminate false negatives in challenging cases. This study aims to identify risk factors of false-negative results in rEUS-FNA/B and develop a prediction model.</p><p><strong>Methods: </strong>Data of patients who had an initial inconclusive diagnosis and underwent rEUS-FNA/B for SPLs across 8 Chinese medical centers from January 2013 to June 2024 were retrospectively reviewed. Logistic regression was performed to identify the risk factors of false-negative results in rEUS-FNA/B. A clinical prediction model using a random forest algorithm was developed with leave-one-hospital-out cross-validation.</p><p><strong>Results: </strong>A total of 230 patients were enrolled in this study. Among them,159 patients (69.1%) were diagnosed with malignancies, while 71 patients (30.8%) had benign lesions. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of rEUS-FNA/B was 78.26%, 68.55%, 100%, 100%, and 58.68%. At multivariate analysis, lesion size 20-40 mm (odds ratio [OR] 0.26), lesion size ≥40 mm (OR 0.20), ≤2 needle passes (OR 3.1), and no liquid-based cytology (LBC) examination (OR 3.95) were found to be independently associated with false-negative results. A final random forest model with 4 features (lesion size, rEUS-FNA/B needle type, LBC, and smear cytology) showed moderate ability to distinguish false-negative results in both training (area under the receiver operating characteristic curve = 0.78) and validation sets (area under the receiver operating characteristic curve = 0.68).</p><p><strong>Conclusion: </strong>To minimize false-negative outcomes during rEUS-FNA/B, LBC is strongly recommended. Additionally, SPLs with a maximum diameter of ≤20 mm exhibit a higher probability for producing false-negative results during rEUS-FNA/B procedures.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"15 1","pages":"22-30"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolution of diagnostic EUS: Milestones, technologies, and global contributions.","authors":"Christoph Frank Dietrich, Manoop S Bhutani, Laurent Palazzo, Barbara Braden, Christian Jenssen, Masayuki Kitano, Kathleen Möller, Svein Ødegaard, Siyu Sun, Peter Vilmann, Yasunobu Yamashita, Pietro Fusaroli","doi":"10.1097/eus.0000000000000168","DOIUrl":"10.1097/eus.0000000000000168","url":null,"abstract":"<p><p>EUS has evolved remarkably from rigid, blind probes in the 1950s to sophisticated imaging and tissue acquisition techniques today. Although initially met with skepticism, EUS has become indispensable in diagnosing and staging gastrointestinal and pancreaticobiliary diseases. This article traces the historical milestones and technological innovations of diagnostic EUS, setting the stage for a subsequent review of therapeutic applications.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"15 1","pages":"1-12"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-step EUS-guided gastrojejunostomy for the treatment of a case of afferent loop syndrome (with video).","authors":"Guoyao Sun, Wanting Wang, Jiao Liu, Yong Sun, Zhuo Yang","doi":"10.1097/eus.0000000000000175","DOIUrl":"10.1097/eus.0000000000000175","url":null,"abstract":"","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"15 1","pages":"82-83"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}