EcoSal Plus最新文献_第9页

Pili Assembled by the Chaperone/Usher Pathway in Escherichia coli and Salmonella. 大肠杆菌和沙门氏菌中通过伴侣/追随途径组装的纤毛。

EcoSal Plus Pub Date : 2018-03-01 DOI: 10.1128/ecosalplus.ESP-0007-2017

Glenn T Werneburg, David G Thanassi

引用次数: 0

Pathogenesis of Proteus mirabilis Infection. 奇异变形杆菌感染的发病机制。

EcoSal Plus Pub Date : 2018-02-01 DOI: 10.1128/ecosalplus.ESP-0009-2017

Chelsie E Armbruster, Harry L T Mobley, Melanie M Pearson

{"title":"Pathogenesis of Proteus mirabilis Infection.","authors":"Chelsie E Armbruster, Harry L T Mobley, Melanie M Pearson","doi":"10.1128/ecosalplus.ESP-0009-2017","DOIUrl":"10.1128/ecosalplus.ESP-0009-2017","url":null,"abstract":"Proteus mirabilis, a Gram-negative rod-shaped bacterium most noted for its swarming motility and urease activity, frequently causes catheter-associated urinary tract infections (CAUTIs) that are often polymicrobial. These infections may be accompanied by urolithiasis, the development of bladder or kidney stones due to alkalinization of urine from urease-catalyzed urea hydrolysis. Adherence of the bacterium to epithelial and catheter surfaces is mediated by 17 different fimbriae, most notably MR/P fimbriae. Repressors of motility are often encoded by these fimbrial operons. Motility is mediated by flagella encoded on a single contiguous 54-kb chromosomal sequence. On agar plates, P. mirabilis undergoes a morphological conversion to a filamentous swarmer cell expressing hundreds of flagella. When swarms from different strains meet, a line of demarcation, a \"Dienes line,\" develops due to the killing action of each strain's type VI secretion system. During infection, histological damage is caused by cytotoxins including hemolysin and a variety of proteases, some autotransported. The pathogenesis of infection, including assessment of individual genes or global screens for virulence or fitness factors has been assessed in murine models of ascending urinary tract infections or CAUTIs using both single-species and polymicrobial models. Global gene expression studies performed in culture and in the murine model have revealed the unique metabolism of this bacterium. Vaccines, using MR/P fimbria and its adhesin, MrpH, have been shown to be efficacious in the murine model. A comprehensive review of factors associated with urinary tract infection is presented, encompassing both historical perspectives and current advances.","PeriodicalId":11500,"journal":{"name":"EcoSal Plus","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880328/pdf/nihms925686.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35814536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Test article. 测试的文章。

EcoSal Plus Pub Date : 2018-01-01 DOI: 10.1128/vishal-article2

引用次数: 0

Test article3. 测试第三条。

EcoSal Plus Pub Date : 2018-01-01 DOI: 10.1128/vishal-article4

引用次数: 0

A Brief History of Shigella. 志贺氏菌简史。

EcoSal Plus Pub Date : 2018-01-01 DOI: 10.1128/ecosalplus.ESP-0006-2017

Keith A Lampel, Samuel B Formal, Anthony T Maurelli

{"title":"A Brief History of Shigella.","authors":"Keith A Lampel, Samuel B Formal, Anthony T Maurelli","doi":"10.1128/ecosalplus.ESP-0006-2017","DOIUrl":"https://doi.org/10.1128/ecosalplus.ESP-0006-2017","url":null,"abstract":"The history of Shigella, the causative agent of bacillary dysentery, is a long and fascinating one. This brief historical account starts with descriptions of the disease and its impact on human health from ancient time to the present. Our story of the bacterium starts just before the identification of the dysentery bacillus by Kiyoshi Shiga in 1898 and follows the scientific discoveries and principal scientists who contributed to the elucidation of Shigella pathogenesis in the first 100 years. Over the past century, Shigella has proved to be an outstanding model of an invasive bacterial pathogen and has served as a paradigm for the study of other bacterial pathogens. In addition to invasion of epithelial cells, some of those shared virulence traits include toxin production, multiple-antibiotic resistance, virulence genes encoded on plasmids and bacteriophages, global regulation of virulence genes, pathogenicity islands, intracellular motility, remodeling of host cytoskeleton, inflammation/polymorphonuclear leukocyte signaling, apoptosis induction/inhibition, and \"black holes\" and antivirulence genes. While there is still much to learn from studying Shigella pathogenesis, what we have learned so far has also contributed greatly to our broader understanding of bacterial pathogenesis.","PeriodicalId":11500,"journal":{"name":"EcoSal Plus","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1128/ecosalplus.ESP-0006-2017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35723467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

The Sec System: Protein Export in Escherichia coli. Sec 系统：大肠杆菌中的蛋白质输出。

EcoSal Plus Pub Date : 2017-11-01 DOI: 10.1128/ecosalplus.ESP-0002-2017

Jennine M Crane, Linda L Randall

引用次数: 0

Osmoregulated Periplasmic Glucans. Osmoregulated Periplasmic Glucans.

EcoSal Plus Pub Date : 2017-06-01 DOI: 10.1128/ecosalplus.ESP-0001-2017

Sébastien Bontemps-Gallo, Jean-Pierre Bohin, Jean-Marie Lacroix

引用次数: 0

Regulation of Escherichia coli Pathogenesis by Alternative Sigma Factor N. 替代西格玛因子 N 对大肠杆菌致病机理的调控

EcoSal Plus Pub Date : 2017-06-01 DOI: 10.1128/ecosalplus.ESP-0016-2016

James T Riordan, Avishek Mitra

{"title":"Regulation of Escherichia coli Pathogenesis by Alternative Sigma Factor N.","authors":"James T Riordan, Avishek Mitra","doi":"10.1128/ecosalplus.ESP-0016-2016","DOIUrl":"10.1128/ecosalplus.ESP-0016-2016","url":null,"abstract":"σN (also σ54) is an alternative sigma factor subunit of the RNA polymerase complex that regulates the expression of genes from many different ontological groups. It is broadly conserved in the Eubacteria with major roles in nitrogen metabolism, membrane biogenesis, and motility. σN is encoded as the first gene of a five-gene operon including rpoN (σN), ptsN, hpf, rapZ, and npr that has been genetically retained among species of Escherichia, Shigella, and Salmonella. In an increasing number of bacteria, σN has been implicated in the control of genes essential to pathogenic behavior, including those involved in adherence, secretion, immune subversion, biofilm formation, toxin production, and resistance to both antimicrobials and biological stressors. For most pathogens how this is achieved is unknown. In enterohemorrhagic Escherichia coli (EHEC) O157, Salmonella enterica, and Borrelia burgdorferi, regulation of virulence by σN requires another alternative sigma factor, σS, yet the model by which σN-σS virulence regulation is predicted to occur is varied in each of these pathogens. In this review, the importance of σN to bacterial pathogenesis is introduced, and common features of σN-dependent virulence regulation discussed. Emphasis is placed on the molecular mechanisms underlying σN virulence regulation in E. coli O157. This includes a review of the structure and function of regulatory pathways connecting σN to virulence expression, predicted input signals for pathway stimulation, and the role for cognate σN activators in initiation of gene systems determining pathogenic behavior.","PeriodicalId":11500,"journal":{"name":"EcoSal Plus","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35106722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Legacy of Genetic Analysis Advances Contemporary Research with Escherichia coli K-12 and Salmonella enterica serovar Typhimurium LT2. 遗传分析的遗产推动了对大肠杆菌 K-12 和伤寒沙门氏菌 LT2 的当代研究。

EcoSal Plus Pub Date : 2017-04-01 DOI: 10.1128/ecosalplus.ESP-0014-2016

Valley Stewart

引用次数: 0

Targeting and Insertion of Membrane Proteins. 膜蛋白的靶向和插入。

EcoSal Plus Pub Date : 2017-03-01 DOI: 10.1128/ecosalplus.ESP-0012-2016

Andreas Kuhn, Hans-Georg Koch, Ross E Dalbey

引用次数: 0