Sec 系统：大肠杆菌中的蛋白质输出。

Q1 Medicine

EcoSal Plus Pub Date : 2017-11-01 DOI:10.1128/ecosalplus.ESP-0002-2017

Jennine M Crane, Linda L Randall

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引用次数: 0

摘要

在大肠杆菌中，外质或外膜中的蛋白质在获得稳定的折叠结构之前，会通过一般分泌系统（Sec）从细胞质中输出。这一动态过程涉及细胞质和膜蛋白（包括外周蛋白和整体蛋白）以及脂质之间错综复杂的相互作用。在体内，需要 ATP 水解和质子动力。在此，我们回顾了 Sec 系统从该领域创立之初到 2016 年初的发展历程，包括生化、遗传和结构数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The Sec System: Protein Export in Escherichia coli.

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The Sec System: Protein Export in Escherichia coli.

In Escherichia coli, proteins found in the periplasm or the outer membrane are exported from the cytoplasm by the general secretory, Sec, system before they acquire stably folded structure. This dynamic process involves intricate interactions among cytoplasmic and membrane proteins, both peripheral and integral, as well as lipids. In vivo, both ATP hydrolysis and proton motive force are required. Here, we review the Sec system from the inception of the field through early 2016, including biochemical, genetic, and structural data.

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来源期刊

EcoSal Plus Immunology and Microbiology-Microbiology

CiteScore

12.20

自引率

0.00%

发文量

期刊介绍： EcoSal Plus is the authoritative online review journal that publishes an ever-growing body of expert reviews covering virtually all aspects of E. coli, Salmonella, and other members of the family Enterobacteriaceae and their use as model microbes for biological explorations. This journal is intended primarily for the research community as a comprehensive and continuously updated archive of the entire corpus of knowledge about the enteric bacterial cell. Thoughtful reviews focus on physiology, metabolism, genetics, pathogenesis, ecology, genomics, systems biology, and history E. coli and its relatives. These provide the integrated background needed for most microbiology investigations and are essential reading for research scientists. Articles contain links to E. coli K12 genes on the EcoCyc database site and are available as downloadable PDF files. Images and tables are downloadable to PowerPoint files.