ecancermedicalscience最新文献

{"title":"Building research capacity among health care professionals in LMICs: experiences from the 9th Tata Annual Biostatistics and Research Methods Course, 2025.","authors":"Soumitra Shankar Datta, Jigeesha Ghosh, Dishari Choudhury, Suvro Sankha Datta, Prateek Jain, Sakshi Adhia, Indranil Mallick, Sanjit Agrawal, Sanjay Garg, Shouriyo Ghosh, Arijit Nag, Arnab Mukherjee, Soumita Ghose, Sayantani Das, Rima Mukherjee, Sujit Sarkhel, Pattatheyil Arun","doi":"10.3332/ecancer.2026.2077","DOIUrl":"10.3332/ecancer.2026.2077","url":null,"abstract":"<p><p>Modern medicine, especially oncology in low- and middle-income countries (LMICs), requires clinicians to remain updated in a rapidly evolving field of medicine in the face of a high clinical load. Clinicians need to be able to critically evaluate published evidence and make informed decisions about the individual patients they treat. A clinical culture that encourages clinicians to question and think critically would produce high-quality research from parts of the world that have highest disease burden but lowest contribution to published research. A two-day research methods course was conducted jointly by the Tata Medical Center, Kolkata and the West Bengal Chapter of the Indian Psychiatric Society on 22nd-23rd August 2025. We report on our experience of organising this course and the lessons learned from interacting with the audience in an LMIC setting. Live anonymous participant responses were captured using Mentimeter software during the training, and written anonymous feedback were provided by majority of attendees. The three main barriers to conducting research that our participants reported were: 'lack of training in research', 'difficulties in writing a research paper' and the 'researcher's personal circumstances'. The participants in our course comprised both men and women clinicians, mostly in their early careers and this group of learners appreciated hands-on training on literature search, reference management and working with the SPSS statistical software to conduct standard statistical tests. To achieve this, institutions and individuals need to foster a conducive environment for research, inspiring those who will be responsible for the future health care delivery.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"20 ","pages":"2077"},"PeriodicalIF":1.5,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13068371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Society of Paediatric Surgical Oncology (IPSO) Minimally Invasive Surgery (MIS) Guidelines.","authors":"Israel Fernandez-Pineda, Simone de Campos Vieira Abib, Tristan Boam, Diego Aspiazu Salinas, Samer Michael, Justin Ted Gerstle, Steven Warmann, Jorg Fuchs, Alyssa Stetson, Gloria Gonzalez, Greg Tiao, Timothy B Lautz, Rodrigo Chaves Ribeiro, Roshni Dasgupta, Jaime Shalkow-Klincovstein, Cristian Puerta, Andrew M Davidoff, Marianna Cornet, Julien Grosman, Aurore Pire, Sabine Sarnacki, Thomas Blanc, Abdelhafeez H Abdelhafeez","doi":"10.3332/ecancer.2026.2076","DOIUrl":"10.3332/ecancer.2026.2076","url":null,"abstract":"<p><p>Paediatric oncology surgeons play a crucial role in diagnosing, staging, and treating malignant solid tumors. In recent years, many solid tumour protocols have advocated for a more tailored surgical approach to both the primary tumour site and metastatic disease. The integration of Minimally Invasive Surgery (MIS) into paediatric oncology practice has gained popularity over the past few decades. While the benefits of MIS are well established in non-oncologic surgery, its role in paediatric solid tumours is still evolving and, in many cases, lacks high-quality evidence. These IPSO-MIS guidelines guidelines aim to provide practical surgical recommendations for diverse clinical scenarios, addressing the needs of both High-Income Countries (HICs) and Low- and Middle-Income Countries (LMICs). The contributing authors represent both settings, ensuring a comprehensive and inclusive perspective. We hope that these guidelines will contribute to improving outcomes for children with cancer worldwide. Israel Fernandez-Pineda, IPSO Education Committee Chair Abdelhafeez H Abdelhafeez, IPSO Education Committee Member.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"20 ","pages":"2076"},"PeriodicalIF":1.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 19th St. Gallen international breast cancer conference 'primary therapy of patients with early breast cancer. Evidence, controversies, consensus': key moments and breakthroughs.","authors":"Consuelo Morigi","doi":"10.3332/ecancer.2026.2075","DOIUrl":"10.3332/ecancer.2026.2075","url":null,"abstract":"<p><p>The 19th St. Gallen International Breast Cancer Conference took place at the Austria Centre in Vienna from March 12th to 15th, 2025. The event achieved remarkable success, drawing over 3,100 participants from all over the world. This accomplishment is attributable to the high calibre of scientific lectures presented by leading global experts in breast cancer (BC) treatment, the opportunity for the audience to interact with panellists through questions, the interesting and varied scope of submitted posters, the debates that punctuated the many sessions, and notably, the renowned St. Gallen Consensus Session. This year's Opening Ceremony held particular significance. In commemoration of the Swiss physician and oncologist Hansjoerg Senn, who passed away in 2023, the Hansjoerg Senn Memorial Lecture was instituted to honour his profound contributions to the treatment and care of patients, particularly those affected by BC. The Memorial Lecture serves as a platform to recognise and celebrate individuals who have significantly advanced BC research. The recipient is presented with the St. Gallen Breast Cancer Award and invited to deliver an address at the opening ceremony of the St. Gallen International Breast Cancer Conference. This year, this prestigious award was presented to Prof. Armando E. Giuliano, who delivered an insightful lecture entitled 'My Personal Experience: Changing Surgery for BC.' In it, drawing from his impressive surgical career during which he changed the standard of care-exemplified by the sentinel lymph node procedure and the Z0011 study-he spoke about how change, though difficult, is both necessary and inevitable, emphasising that no one is too young or too old to change.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"20 ","pages":"2075"},"PeriodicalIF":1.5,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incidence, clinicopathological characteristics and the survival outcomes among young breast cancer patients in Alexandria, Egypt.","authors":"Abeid Omar, Omar Shebl, Abdelaziz Belal, Azza Darwish","doi":"10.3332/ecancer.2026.2074","DOIUrl":"10.3332/ecancer.2026.2074","url":null,"abstract":"<p><p>Breast cancer (BC) is predominantly considered a postmenopausal disorder in Western countries, with only 6% being in women below 40. In contrast, developing low- and middle-income countries (LMIC) see a much higher incidence of BC in premenopausal women due to genetic and demographic factors-reaching as much as 25%. The lack of well-established data on the features and prevalence of BC in premenopausal females in LMIC calls for a wholesome assessment of its features. Our retrospective study was conducted at two major oncology centers in Alexandria, Egypt. We included patients aged 18-40 years diagnosed from January 2008 to December 2017. We included non-metastatic patients and extracted data from files and charts. We assessed patients for clinicopathological characteristics, treatments and survival outcomes. Statistical analysis was performed using SPSS Version 2.0, and survival was assessed by Kaplan-Meir curves. Results were considered statistically significant at a <i>p</i>-value <0.05. After a median follow-up of 41 months, more than one-third of patients experienced relapse, with more cases of distant recurrence (73%) than locoregional recurrence (27%). The median disease-free survival (DFS) was 78 months, and the 5-year overall survival was 92%, both of which were independently predicted by tumour size and nodal status for DFS only. Our cohort had comparable features compared to prior studies conducted in Europe and the States. We also found some similarities to Kenya regarding BC in the young, where one study done in Kijabe, Kenya, showed a median presentation age of 38.2 years and a DFS of 75 months.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"20 ","pages":"2074"},"PeriodicalIF":1.5,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical setting of initial cholecystectomy influences prognosis in incidentally detected gallbladder carcinoma.","authors":"Ajay Kumar Yadav, Anshuman Pandey, Rahul Singh, Hareesh Shanthappa Nellikoppad, Bhanu Pratap Singh","doi":"10.3332/ecancer.2026.2073","DOIUrl":"10.3332/ecancer.2026.2073","url":null,"abstract":"<p><strong>Background: </strong>Gallbladder cancer (GBC) is a common biliary malignancy in India, with many cases diagnosed incidentally as gallbladder carcinoma (IGBC) after cholecystectomy for presumed benign disease. IGBC often has a better prognosis due to earlier stage detection. However, limited access to high-quality imaging, especially in peripheral centres, contributes to missed preoperative diagnoses. Routine histopathological examination has improved detection rates. This study aims to compare survival outcomes and identify prognostic factors in IGBC patients treated at peripheral versus tertiary care centres.</p><p><strong>Methods: </strong>This retrospective study reviewed medical records of patients diagnosed with IGBC following cholecystectomy for presumed benign disease between 2015 and 2022 at a North Indian tertiary hospital. Patients were grouped based on initial surgery site (tertiary versus peripheral centres). Management followed National Comprehensive Cancer Network guidelines, with T1a patients advised follow-up and T1b or higher undergoing radical resection. Data on clinical, pathological and treatment parameters were analysed. Survival outcomes were assessed using Kaplan-Meier and Cox regression methods.</p><p><strong>Results: </strong>Of 39 IGBC patients reviewed, 30 were included in the final analysis. No significant differences were observed between tertiary and peripheral groups in demographics, symptoms or pathology. However, patients from peripheral centres had longer delays between surgeries and higher rates of metastasis. Overall survival was significantly better in the tertiary group (3- and 5-year OS: 88.2% and 72.8%) compared to the peripheral group (53.6% and 26.9%, <i>p</i> = 0.01). Multivariate analysis did not identify significant independent prognostic factors.</p><p><strong>Conclusion: </strong>Patients undergoing cholecystectomy at peripheral centres for presumed benign disease and later diagnosed with IGBC have poorer survival, primarily due to delayed diagnosis, limited resources and late referral. In contrast, timely referral, standardised evaluation and specialised care at tertiary centres significantly improve survival outcomes.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"20 ","pages":"2073"},"PeriodicalIF":1.5,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global cancer crisis: a review of growing burden, deepening inequality and initiatives for prevention and early detection.","authors":"Charles M Balch, Ning Liao, Dennis S C Lam, Jeffrey N Weitzel, Rui-Hua Xu, Gerhardt Attard, Paul A Bunn, Alexander M M Eggermont, Jie He, Yuko Kitagawa, Soon Thye Lim, Eduardo Cazap, Bernard Esquivel, Xianqun Fan, Louis W C Chow, Edward S F Liu, Hector Martinez Said, John E Niederhuber, Isabel T Rubio, Ashraf Saad Zaghloul, Oscar G Arrieta, Riccardo A Audisio, Geerard L Beets, Felipe J F Coimbra, Jorge E Gallardo, Judy E Garber, Alessandro Gronchi, Volker Heinemann, Allison W Kurian, Miriam Mutebi, Masaki Mori, Funmi I Olopade, Piotr Rutkowski, Mansoor Saleh, William M Sanchez, Raymond Sawaya, John F Thompson, Gerald Tumusiime, Carlos S Vallejos, David C Whiteman, YiLong Wu, King-David T Yawe, Nayef Awad Al Zahrani, Odysseas Zoras, Banu K Arun, Carol J Fabian, Jeffrey E Gershenwald, William J Gradishar, Jin He, V Suzanne Kimberg, Ronald M K Lam, Victor H F Lee, Domenica Lorusso, Tony S K Mok, N D Perrier, Hope S Rugo, Cornelia Ulrich, Chandrakanth Are, J Vignat, I Soerjomataram","doi":"10.3332/ecancer.2026.2071","DOIUrl":"10.3332/ecancer.2026.2071","url":null,"abstract":"<p><p>Cancer constitutes one of the most urgent global health crises, with over 20 million new cases diagnosed annually worldwide, claiming 10 million lives. This devastating burden disproportionately affects vulnerable populations: 75% of cancer deaths occur in low- and middle-income countries despite these regions having lower reported incidence rates. Lung cancer leads the global toll, representing 12% of all cases but 19% of deaths, followed by breast cancer (12% of cases) and colorectal cancer (9.6%). A stark geographical inequity defines the cancer landscape-while wealthy regions such as North America, Northern Europe and Australia report the highest incidence rates, Africa and Latin America suffer the highest mortality rates. This disparity will intensify dramatically: cancer deaths in low-income countries are projected to surge 155% compared to just 56% in high-income nations by 2050. The financial devastation compounds this crisis, with 56% of patients worldwide facing catastrophic health expenditures extending beyond medical costs to include lost income and reduced productivity. Economic burden varies starkly by wealth: 75% of patients in low-income countries experience financial catastrophe versus 58% in middle-income countries and 26% in high-income nations. However, cancer prevention offers unprecedented opportunities to transform this crisis through interventions we already possess. From largely preventable infectious cancers like stomach and cervical malignancies, to lifestyle-driven epidemics including lung and colorectal cancers, to complex multifactorial diseases like breast cancer. Evidence-based prevention strategies can dramatically reduce suffering while generating massive healthcare savings. Emerging genetic technologies amplify this potential: universal genetic testing and pharmacogenomics now enable identification of high-risk individuals before disease develops, allowing targeted prevention while optimising treatments based on individual genetic profiles. Cancer prevention represents not merely a health opportunity but an economic imperative. The primary barrier is no longer scientific understanding but systematic implementation. Governments, policymakers, insurance companies and the public urgently need clearer evidence and education demonstrating proven successes to motivate decisive action toward creating healthier populations and reducing cancer burdens worldwide.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"20 ","pages":"2071"},"PeriodicalIF":1.5,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psycho-emotional impact on oncology staff in Abidjan (Côte d'Ivoire): a cross-sectional study.","authors":"Pétiori G Laurence Touré, Stéphane Ipou, Ismael Kamara, Brahim Samuel Traoré, Bitty Adde Odo, Dion Aristide Gonce, Malan N'Guessan Prosper Mebiala, Gnonsian Estelle Gahie, Etobo Innocent Ahounou, Aka Rita, Kouamé Konan Yvon Kouassi, Moctar Touré, Innocent Adoubi, Gustave Koffi, Jean Marie Yeo Tenena, Roger Charles Joseph Delafosse","doi":"10.3332/ecancer.2026.2072","DOIUrl":"10.3332/ecancer.2026.2072","url":null,"abstract":"<p><strong>Background: </strong>The mental health of oncology staff is often impacted by the suffering of patients, in the face of which they frequently feel powerless. The objective of this study was to examine the psycho-emotional experiences of medical and paramedical staff in the oncology and onco-hematology departments of the Treichville and Yopougon University Hospitals.</p><p><strong>Methods: </strong>We conducted a prospective, descriptive, bicentric study from January 2021 to May 2022 involving 73 healthcare workers recruited through exhaustive sampling. The Hamilton Anxiety Rating Scale was used to assess anxiety among the participants.</p><p><strong>Results: </strong>Our results revealed that nearly three-quarters of the study participants (73%) had between 1 and 5 years of professional experience and were mostly physicians (72%) or nurses (25%). Symptoms of psychological trauma were observed, particularly avoidance behaviours (46%) and traumatic re-experiencing (46%). A consistently sad mood was reported by 71% of the caregivers. Frequent psychosomatic complaints such as headaches (42%) and epigastric pain (35%) were also noted. Severe anxiety was found in 29% of participants. A shift in personal values was observed, including an increase in religious practices, which rose from 19% to 30%. Finally, 72% of caregivers expressed a desire for psycho-oncological support.</p><p><strong>Conclusion: </strong>Healthcare personnel in onco-hematology, who care for seriously ill patients often nearing the end of life, are regularly affected on a psycho-emotional level, highlighting the need to establish dedicated psycho-emotional support for this workforce.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"20 ","pages":"2072"},"PeriodicalIF":1.5,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NaPPOCON 2025: translating evidence into meaningful clinical practice in paediatric psycho-oncology-reflections from the First National Paediatric Psycho-Oncology Conference, 1-2 August 2025, Bangalore, India.","authors":"Lakshmi R Varma, Krishna Gayathri Alakkal Rajesh, Sunil Bhat, Rhea Daruvala","doi":"10.3332/ecancer.2026.2068","DOIUrl":"10.3332/ecancer.2026.2068","url":null,"abstract":"<p><p>The National Paediatric Psycho Oncology Conference 2025 was the first such conference to be conducted in India with an exclusive focus on paediatric psycho-oncology. The conference brought together a multidisciplinary faculty coupled with participants from various specialities, including paediatric oncologists, surgical oncologists, radiation oncologists, nutritionists, nurses, psychologists, psychiatrists, social workers and trained psycho oncologists. This 2-day programme began with a hands-on skill-building workshop, followed by a day full of evidence-based, clinically applicable and research-rooted topics and discussions specific to various aspects of paediatric psycho-oncology. The added objective of focusing on applicability in low- and middle-income settings, while keeping cultural relevance in mindaided in making the discussions specific to the Indian context.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"20 ","pages":"2068"},"PeriodicalIF":1.5,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating social networks in cancer care: a phenomenological exploration of patient experiences.","authors":"Yousef Roosta, Hero Khezri, Vahid Hoseinpour, Mohamad Jebraeily, Amirhossein Rayegani, Saeed Razavi-Dizaji","doi":"10.3332/ecancer.2026.2069","DOIUrl":"10.3332/ecancer.2026.2069","url":null,"abstract":"<p><strong>Background: </strong>Social networks (SNs) are increasingly shaping the landscape of cancer care by providing online platforms for information exchange, emotional support and patient engagement. However, the nuanced experiences of patients using these platforms, along with the associated risks and expectations, remain underexplored. This qualitative study aimed to investigate cancer patients' perspectives on the role of SNs throughout their care journey.</p><p><strong>Methods: </strong>A phenomenological design was employed in 2024, involving 20 cancer patients who were active users of SNs. Participants were purposively selected from hospitals affiliated with Urmia University of Medical Sciences, Iran. Data were collected through semi-structured interviews focusing on three main areas: perceived opportunities, challenges and expectations. Thematic analysis was conducted following Braun and Clarke's six-phase framework.</p><p><strong>Results: </strong>Findings are presented within three main categories derived from the interview guide: opportunities, challenges and expectations. Thematic analysis revealed several key subthemes under each category. Opportunities included enhanced cancer awareness, improved communication with healthcare providers, emotional support and self-care promotion. Challenges encompassed misinformation, privacy breaches, emotional distress, social isolation and commercial exploitation. Expectations included greater provider engagement as well as improved access to reliable treatment information and social support.</p><p><strong>Conclusion: </strong>Findings highlight that while SNs offer meaningful benefits in cancer care, they also pose substantial risks. To maximise their utility and minimise harm, these platforms must prioritise content accuracy, user privacy and clinical collaboration. To be effective in health contexts, SNs should specifically address health-related issues.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"20 ","pages":"2069"},"PeriodicalIF":1.5,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locally advanced breast cancer is the number of dissected nodes after neoadjuvant chemotherapy important?","authors":"Josepmilly Del Valle Peña Colmenares, Wladimir José Villegas Rodríguez, Osama Bahsas Zaky, Carlos Eduardo Martínez, Douglas José Angulo Herrera","doi":"10.3332/ecancer.2026.2070","DOIUrl":"10.3332/ecancer.2026.2070","url":null,"abstract":"<p><strong>Objective: </strong>To assess whether the number of lymph nodes (LN) in breast cancer (BC) patients undergoing axillary dissection (AD) after neoadjuvant chemotherapy affects disease-free survival (DFS) and overall survival (OS).</p><p><strong>Methods: </strong>Descriptive, retrospective, longitudinal cut-off study (2011-2020).</p><p><strong>Results: </strong>391 patients, 176 patients in the <10 LNs group and 215 ≥10 dissected LGs. The mean number of dissected nodes was 6.2 and 13.8 in the < or ≥ 10 LN groups, respectively. The <10 LN group had a higher proportion of stage IIIB (<i>p</i> = 0.012) and ypN0 (<i>p</i> = 0.001) patients and higher frequency in the phenotypes: luminal A 23.5%, TN 24.1% and HER 2 18.7% when compared with patients with ≥10 LN. Patients with ≥10 LN retrieved had a higher mean OS compared to the group of patients <10 LN with no statistical association (<i>p</i> = 0.184) (hazard ratio = 1.91 95% CI: 0.73-4.98) and a survival probability at 120 months (both groups) of 96.2%. There was also no statistical difference in the DFS when comparing the two groups of patients, indicating that the number of nodes removed is not associated with a differential risk of relapse, with a survival probability at 120 months of 63.3%.</p><p><strong>Conclusion: </strong>The results of the study indicate that the number of nodes removed during AD does not affect survival (OS and EFS) in patients with neoadjuvant (ypN0/ypN+) BC. Axillary staging remains a key factor in the management of BC; therefore, an individualised approach considering the response to triple negative breast cancer and tumour burden in therapeutic decision making is recommended.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"20 ","pages":"2070"},"PeriodicalIF":1.5,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}