Drug Research最新文献_第3页

Linalool: Therapeutic Indication And Their Multifaceted Biomedical Applications. 芳樟醇：治疗适应症及其多方面的生物医学应用。

IF 1.7

Drug Research Pub Date : 2024-07-01 Epub Date: 2024-07-05 DOI: 10.1055/a-2321-9571

Shiva Singh, Anuradha Mishra

引用次数: 0

Exploring the Anticonvulsant Properties of a Celecoxib-Phospholipid Conjugate: Synthesis, Activation, and Evaluation of Cytotoxicity. 探索塞来昔布-磷脂共轭物的抗惊厥特性：合成、激活和细胞毒性评估。

IF 1.7

Drug Research Pub Date : 2024-07-01 Epub Date: 2024-07-05 DOI: 10.1055/a-2331-7114

Puthusserikkunnu B Anjali, Natarajan Jawahar, Mandadhi R Praharsh Kumar, Selvaraj Jubie, Subramanian Selvamuthukumar

{"title":"Exploring the Anticonvulsant Properties of a Celecoxib-Phospholipid Conjugate: Synthesis, Activation, and Evaluation of Cytotoxicity.","authors":"Puthusserikkunnu B Anjali, Natarajan Jawahar, Mandadhi R Praharsh Kumar, Selvaraj Jubie, Subramanian Selvamuthukumar","doi":"10.1055/a-2331-7114","DOIUrl":"https://doi.org/10.1055/a-2331-7114","url":null,"abstract":"Background: Epilepsy poses a significant global health challenge, particularly in regions with limited financial resources hindering access to treatment. Recent research highlights neuroinflammation, particularly involving cyclooxygenase-2 (COX-2) pathways, as a promising avenue for epilepsy management.Methods: This study aimed to develop a Cyclooxygenase-2 inhibitor with potential anticonvulsant properties. A promising drug candidate was identified and chemically linked with phospholipids through docking analyses. The activation of this prodrug was assessed using phospholipase A2 (PLA2)-mediated hydrolysis studies. The conjugate's confirmation and cytotoxicity were evaluated using Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), and Sulphoramide B (SRB) assays.Results: Docking studies revealed that the Celecoxib-Phospholipid conjugate exhibited a superior affinity for PLA2 compared to other drug-phospholipid conjugates. FT-IR spectroscopy confirmed the successful synthesis of the conjugate, while DSC analysis confirmed its purity and formation. PLA2-mediated hydrolysis experiments demonstrated selective activation of the prodrug depending on PLA2 concentration. SRB experiments indicated dose-dependent cytotoxic effects of Celecoxib, phospholipid non-toxicity, and efficient celecoxib-phospholipid conjugation.Conclusion: This study successfully developed a Celecoxib-phospholipid conjugate with potential anticonvulsant properties. The prodrug's specific activation and cytotoxicity profile makes it a promising therapeutic candidate. Further investigation into underlying mechanisms and in vivo studies is necessary to assess its translational potential fully.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":"74 6","pages":"296-301"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.7

Drug Research Pub Date : 2024-07-01 Epub Date: 2024-07-05 DOI: 10.1055/a-2332-3253

Fatemah Abedipour, Hossein Hadavand Mirzaei, Hossein Ansari, Neda Ehsanzadeh, Amin Rashki, Mohammad Mahdi Vahedi, Asma Rashki

{"title":"Remdesivir-Related Cardiac Adverse Effects in COVID-19 Patients: A Case-Control Study.","authors":"Fatemah Abedipour, Hossein Hadavand Mirzaei, Hossein Ansari, Neda Ehsanzadeh, Amin Rashki, Mohammad Mahdi Vahedi, Asma Rashki","doi":"10.1055/a-2332-3253","DOIUrl":"https://doi.org/10.1055/a-2332-3253","url":null,"abstract":"Background: There have been reports of serious side effects of Remdesivir, including cardiovascular complications. The present study aimed to determine the adverse cardiovascular effects of Remdesivir and the factors affecting them in COVID-19 patients.Methods: The patients were classified into two groups: those receiving Remdesivir without cardiac complications and those receiving Remdesivir with cardiovascular complications. After reviewing the patient's medical records, the relationship of some factors with the incidence of adverse cardiovascular effects was measured.Results: Chi-square test showed that the distribution of complications in men was significantly higher than in women (P=0.001). The independent t-test revealed that the mean age in the group with complications was significantly higher than the group without complications (P=0.013). Fisher's exact test demonstrated a significant relationship between smoking and cardiovascular complications (P=0.05). According to the Mann-Whitney test, a significant difference was found in the mean changes of Bilirubin (P=0.02) and ALKP (P=0.01) before and after treatment in the groups with and without heart complications.Conclusion: Our findings indicated that most of the COVID-19 patients suffered from sinus bradycardia, and the distribution of complications was more pronounced in men than in women. The mean age in the group with complications was higher than the group without complications. Smoking was found to be associated with the occurrence of cardiovascular complications and the mean changes of Bilirubin and ALKP before and after treatment were significantly different in the groups with and without cardiovascular complications.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":"74 6","pages":"290-295"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bedaquiline: An Insight Into its Clinical Use in Multidrug-Resistant Pulmonary Tuberculosis. 贝达喹啉贝达喹啉：耐多药肺结核临床应用透视。

IF 1.7

Drug Research Pub Date : 2024-07-01 Epub Date: 2024-07-05 DOI: 10.1055/a-2331-7061

Asad Ahmad, Juber Akhtar, Mohammad Ahmad, Mohammad Irfan Khan, Rufaida Wasim, Anas Islam, Aditya Singh

{"title":"Bedaquiline: An Insight Into its Clinical Use in Multidrug-Resistant Pulmonary Tuberculosis.","authors":"Asad Ahmad, Juber Akhtar, Mohammad Ahmad, Mohammad Irfan Khan, Rufaida Wasim, Anas Islam, Aditya Singh","doi":"10.1055/a-2331-7061","DOIUrl":"https://doi.org/10.1055/a-2331-7061","url":null,"abstract":"Every year, the World Health Organization reports 500,000 new cases of drug-resistant tuberculosis (TB), which poses a serious global danger. The increased number of XDR-TB and MDR-TB cases reported worldwide necessitates the use of new therapeutic approaches. The main issues with the antitubercular medications now in use for the treatment of multidrug-resistant tuberculosis are their poor side effect profile, reduced efficacy, and antimicrobial resistance. One possible remedy for these problems is bedaquiline. The need for better treatment strategies is highlighted by the strong minimum inhibitory concentrations that bedaquiline (BDQ), a novel anti-TB medicine, exhibits against both drug-resistant and drug-susceptible TB. Bedaquiline may be able to help with these problems. Bedaquiline is a medication that is first in its class and has a distinct and particular mode of action. Bedaquiline is an ATP synthase inhibitor that is specifically directed against Mycobacterium tuberculosis and some nontuberculous mycobacteria. It is metabolized by CYP3A4. Bedaquiline preclinical investigations revealed intralesional drug biodistribution. The precise intralesional and multi-compartment pharmacokinetics of bedaquiline were obtained using PET bioimaging and high-resolution autoradiography investigations. Reduced CFU counts were observed in another investigation after a 12-week course of therapy. Meta-analyses and systematic reviews of phase II trials on bedaquiline's efficacy in treating drug-resistant tuberculosis in patients reported higher rates of cure, better culture conversion, and lower death rates when taken in conjunction with a background regimen. Here is a thorough medication profile for bedaquiline to aid medical professionals in treating individuals with tuberculosis.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":"74 6","pages":"269-279"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potential of Pentoxifylline in Paraquat-Induced Pulmonary Toxicity: Role of the Phosphodiesterase Enzymes. 五氧去氧肾上腺素对百草枯诱导的肺毒性的治疗潜力：磷酸二酯酶的作用。

IF 2.2

Drug Research Pub Date : 2024-06-01 Epub Date: 2024-06-03 DOI: 10.1055/a-2314-1137

Farshad Ghasemi, Mobina Mohammadi, Fatemeh Ghaffari, Ali Hosseini-Sharifabad, Navid Omidifar, Amir Nili-Ahmadabadi

{"title":"Therapeutic Potential of Pentoxifylline in Paraquat-Induced Pulmonary Toxicity: Role of the Phosphodiesterase Enzymes.","authors":"Farshad Ghasemi, Mobina Mohammadi, Fatemeh Ghaffari, Ali Hosseini-Sharifabad, Navid Omidifar, Amir Nili-Ahmadabadi","doi":"10.1055/a-2314-1137","DOIUrl":"https://doi.org/10.1055/a-2314-1137","url":null,"abstract":"Pentoxifylline (PTX), a non-selective phosphodiesterase inhibitor, has demonstrated protective effects against lung injury in animal models. Given the significance of pulmonary toxicity resulting from paraquat (PQ) exposure, the present investigation was designed to explore the impact of PTX on PQ-induced pulmonary oxidative impairment in male mice.Following preliminary studies, thirty-six mice were divided into six groups. Group 1 received normal saline, group 2 received a single dose of PQ (20 mg/kg; i.p.), and group 3 received PTX (100 mg/kg/day; i.p.). Additionally, treatment groups 4-6 were received various doses of PTX (25, 50, and 100 mg/kg/day; respectively) one hour after a single dose of PQ. After 72 hours, the animals were sacrificed, and lung tissue was collected.PQ administration caused a significant decrease in hematocrit and an increase in blood potassium levels. Moreover, a notable increase was found in the lipid peroxidation (LPO), nitric oxide (NO), and myeloperoxidase (MPO) levels, along with a notable decrease in total thiol (TTM) and total antioxidant capacity (TAC) contents, catalase (CAT) and superoxide dismutase (SOD) enzymes activity in lung tissue. PTX demonstrated the ability to improve hematocrit levels; enhance SOD activity and TTM content; and decrease MPO activity, LPO and NO levels in PQ-induced pulmonary toxicity. Furthermore, these findings were well-correlated with the observed lung histopathological changes.In conclusion, our results suggest that the high dose of PTX may ameliorate lung injury by improving the oxidant/antioxidant balance in animals exposed to PQ.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":"74 5","pages":"241-249"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Review of Capsaicin and Its Role in Cancer Prevention and Treatment. 辣椒素及其在癌症预防和治疗中作用的全面回顾。

IF 2.2

Drug Research Pub Date : 2024-06-01 Epub Date: 2024-05-10 DOI: 10.1055/a-2309-5581

Govardhan Katta Radhakrishna, Damodar Nayak Ammunje, Selvaraj Kunjiappan, Kaveena Ravi, Shangavi Vellingiri, Sameera Hammigi Ramesh, Shannon D Almeida, Golla Sireesha, Soundarya Ramesh, Saud Al-Qahtani, Kumarappan Chidamabaram, Panneerselvam Theivendren, Parasuraman Pavadai

{"title":"A Comprehensive Review of Capsaicin and Its Role in Cancer Prevention and Treatment.","authors":"Govardhan Katta Radhakrishna, Damodar Nayak Ammunje, Selvaraj Kunjiappan, Kaveena Ravi, Shangavi Vellingiri, Sameera Hammigi Ramesh, Shannon D Almeida, Golla Sireesha, Soundarya Ramesh, Saud Al-Qahtani, Kumarappan Chidamabaram, Panneerselvam Theivendren, Parasuraman Pavadai","doi":"10.1055/a-2309-5581","DOIUrl":"10.1055/a-2309-5581","url":null,"abstract":"This study examines the fundamental chemical mechanisms responsible for capsaicin's advantageous impact on cancer, specifically investigating its influence on several biological processes such as inflammation in cancer metastasis, apoptosis, angiogenesis, and cellular proliferation. This entity's connections with other signaling pathways, including PI3K/AKT, NF-B, and TRPV channels, which have been linked to tumor growth, are thoroughly examined in this work. This study presents a thorough analysis of preclinical studies and clinical trials investigating the efficacy of capsaicin in treating many forms of cancer, such as breast, prostate, colorectal, pancreatic, and others. Through tests conducted in both live organisms and laboratory settings, it has been determined that capsaicin has the ability to inhibit tumor growth and induce apoptosis in cancer cells. (in vitro and in vivo). Researchers have also looked at the results of combining capsaicin with chemotherapy medications in traditional treatment. The efficacy and bioavailability of capsaicin as a viable medicinal drug are being studied, along with ways to improve its clinical value. The present investigation carefully assesses the challenges and potential options for maximizing the therapeutic benefits of capsaicin, including customized drug delivery and personalized therapeutic strategies. In finalization, this comprehensive investigation brings together the evidence currently obtainable on the anticancer properties of capsaicin, underscoring its potential as an autonomous treatment option in the struggle against cancer. Capsaicin is a compound of significant relevance for continuing research and clinical exploration in the field of cancer treatment due to its diverse mechanisms of action and ability for boosting prevailing therapy approaches.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"195-207"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence in Drug Identification and Validation: A Scoping Review. 人工智能在药物鉴定和验证中的应用：范围综述。

IF 2.2

Drug Research Pub Date : 2024-06-01 Epub Date: 2024-06-03 DOI: 10.1055/a-2306-8311

Mukhtar Lawal Abubakar, Neha Kapoor, Asha Sharma, Lokesh Gambhir, Nakuleshwar Dutt Jasuja, Gaurav Sharma

{"title":"Artificial Intelligence in Drug Identification and Validation: A Scoping Review.","authors":"Mukhtar Lawal Abubakar, Neha Kapoor, Asha Sharma, Lokesh Gambhir, Nakuleshwar Dutt Jasuja, Gaurav Sharma","doi":"10.1055/a-2306-8311","DOIUrl":"https://doi.org/10.1055/a-2306-8311","url":null,"abstract":"The end-to-end process in the discovery of drugs involves therapeutic candidate identification, validation of identified targets, identification of hit compound series, lead identification and optimization, characterization, and formulation and development. The process is lengthy, expensive, tedious, and inefficient, with a large attrition rate for novel drug discovery. Today, the pharmaceutical industry is focused on improving the drug discovery process. Finding and selecting acceptable drug candidates effectively can significantly impact the price and profitability of new medications. Aside from the cost, there is a need to reduce the end-to-end process time, limiting the number of experiments at various stages. To achieve this, artificial intelligence (AI) has been utilized at various stages of drug discovery. The present study aims to identify the recent work that has developed AI-based models at various stages of drug discovery, identify the stages that need more concern, present the taxonomy of AI methods in drug discovery, and provide research opportunities. From January 2016 to September 1, 2023, the study identified all publications that were cited in the electronic databases including Scopus, NCBI PubMed, MEDLINE, Anthropology Plus, Embase, APA PsycInfo, SOCIndex, and CINAHL. Utilising a standardized form, data were extracted, and presented possible research prospects based on the analysis of the extracted data.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":"74 5","pages":"208-219"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of Substituted 2-oxoquinolinylthiazolidin-4-one Analogues as Potential EGFRK Inhibitors in Lung Cancer Treatment. 发现取代的 2-oxoquinolinylthiazolidin-4-one 类似物作为肺癌治疗中潜在的表皮生长因子受体 K 抑制剂。

IF 2.2

Drug Research Pub Date : 2024-06-01 Epub Date: 2024-06-03 DOI: 10.1055/a-2305-2789

Soniya Naik, Vasu Soumya, Shivlingrao N Mamledesai, M Manickavasagam, Prafulla Choudhari, Sanket Rathod

{"title":"Discovery of Substituted 2-oxoquinolinylthiazolidin-4-one Analogues as Potential EGFRK Inhibitors in Lung Cancer Treatment.","authors":"Soniya Naik, Vasu Soumya, Shivlingrao N Mamledesai, M Manickavasagam, Prafulla Choudhari, Sanket Rathod","doi":"10.1055/a-2305-2789","DOIUrl":"10.1055/a-2305-2789","url":null,"abstract":"Purpose: Cancer is the second leading cause of death globally and is responsible for an estimated 9.6 million deaths in 2018. Globally, about 1 in 6 deaths is due to cancer and the chemotherapeutic drugs available have high toxicity and have reported side effects hence, there is a need for the synthesis of novel drugs in the treatment of cancer.Methods: The current research work dealt with the synthesis of a series of 3-(3-acetyl-2-oxoquinolin-1-(2H)-yl-2-(substitutedphenyl)thiazolidin-4-one (Va-j) derivatives and evaluation of their in-vitro anticancer activity. All the synthesized compounds were satisfactorily characterized by IR and NMR data. Compounds were further evaluated for their in-vitro anticancer activity against A-549 (lung cancer) cell lines. The in-vitro anticancer activity was based upon the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assay method.Results: The synthesized compounds exhibited satisfactory anticancer properties against the A-549 cell line. The compound (VH): showed the highest potency amongst the tested derivatives against the A-549 cell line with IC50 values of 100 µg/ml respectively and was also found to be more potent than Imatinib (150 µg/ml) which was used as a standard drug. Molecular docking studies of the titled compounds (Va-j) were carried out using AutoDock Vina/PyRx software. The synthesized compounds exhibited well-conserved hydrogen bonds with one or more amino acid residues in the active pocket of the EGFRK tyrosine kinase domain (PDB 1m17).Conclusion: Among all the synthesized analogues, the binding affinity of the compound (Vh) was found to be higher than other synthesized derivatives and a molecular dynamics simulation study explored the stability of the docked complex system.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":"74 5","pages":"227-240"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic anxiolytic efficacy exploring the combined effects of diazepam and zinc chloride in wistar albino rats. 探索地西泮和氯化锌对白腊大鼠的协同抗焦虑作用。

IF 2.2

Drug Research Pub Date : 2024-06-01 Epub Date: 2024-05-10 DOI: 10.1055/a-2308-9192

Vishwani V Naik, Vedita Hegde Desai, Sam Noronha

引用次数: 0

Sweeteners in Orodispersible Films: How Much is too Much? 可发散薄膜中的甜味剂：多少才算多？

IF 2.2

Drug Research Pub Date : 2024-04-01 Epub Date: 2024-03-20 DOI: 10.1055/a-2266-2522

Ognjenka Rahić, Sabina Behrem, Amina Tucak-Smajić, Jasmina Hadžiabdić, Belma Imamović, Lamija Hindija, Merima Šahinović, Edina Vranić

{"title":"Sweeteners in Orodispersible Films: How Much is too Much?","authors":"Ognjenka Rahić, Sabina Behrem, Amina Tucak-Smajić, Jasmina Hadžiabdić, Belma Imamović, Lamija Hindija, Merima Šahinović, Edina Vranić","doi":"10.1055/a-2266-2522","DOIUrl":"10.1055/a-2266-2522","url":null,"abstract":"Four natural sweeteners (sucrose, xylitol, fructose, and isomalt) were selected to examine the influence of their qualities and amounts on the characteristics of orodispersible films. Sodium carboxymethylcellulose (2% w/w) was utilized as the film-forming polymer and 1% w/w glycerol as a plasticizer. Films were produced through the solvent casting method, rendering them suitable for convenient application in community or hospital pharmacy settings. The physicochemical and optical properties of the films were analyzed, and Fourier-transform infrared analysis was carried out. All films exhibited acceptable disintegration time, uniformity of mass, thickness, and optical characteristics, with significant dependence (p<0.05) on both sweetener type and quantity. Disintegration time varied based on the employed method, as well as the characteristics and amount of sweetener. Additionally, all films maintained pH values within the oral cavity range, suggesting no potential irritancy upon administration. Fourier-transform infrared analysis confirmed the formation of the film and demonstrated compatibility between its components.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"180-186"},"PeriodicalIF":2.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0