Drug Research最新文献_第10页

A Comprehensive Review of Capsaicin and Its Role in Cancer Prevention and Treatment. 辣椒素及其在癌症预防和治疗中作用的全面回顾。

IF 2.2

Drug Research Pub Date : 2024-06-01 Epub Date: 2024-05-10 DOI: 10.1055/a-2309-5581

Govardhan Katta Radhakrishna, Damodar Nayak Ammunje, Selvaraj Kunjiappan, Kaveena Ravi, Shangavi Vellingiri, Sameera Hammigi Ramesh, Shannon D Almeida, Golla Sireesha, Soundarya Ramesh, Saud Al-Qahtani, Kumarappan Chidamabaram, Panneerselvam Theivendren, Parasuraman Pavadai

{"title":"A Comprehensive Review of Capsaicin and Its Role in Cancer Prevention and Treatment.","authors":"Govardhan Katta Radhakrishna, Damodar Nayak Ammunje, Selvaraj Kunjiappan, Kaveena Ravi, Shangavi Vellingiri, Sameera Hammigi Ramesh, Shannon D Almeida, Golla Sireesha, Soundarya Ramesh, Saud Al-Qahtani, Kumarappan Chidamabaram, Panneerselvam Theivendren, Parasuraman Pavadai","doi":"10.1055/a-2309-5581","DOIUrl":"10.1055/a-2309-5581","url":null,"abstract":"This study examines the fundamental chemical mechanisms responsible for capsaicin's advantageous impact on cancer, specifically investigating its influence on several biological processes such as inflammation in cancer metastasis, apoptosis, angiogenesis, and cellular proliferation. This entity's connections with other signaling pathways, including PI3K/AKT, NF-B, and TRPV channels, which have been linked to tumor growth, are thoroughly examined in this work. This study presents a thorough analysis of preclinical studies and clinical trials investigating the efficacy of capsaicin in treating many forms of cancer, such as breast, prostate, colorectal, pancreatic, and others. Through tests conducted in both live organisms and laboratory settings, it has been determined that capsaicin has the ability to inhibit tumor growth and induce apoptosis in cancer cells. (in vitro and in vivo). Researchers have also looked at the results of combining capsaicin with chemotherapy medications in traditional treatment. The efficacy and bioavailability of capsaicin as a viable medicinal drug are being studied, along with ways to improve its clinical value. The present investigation carefully assesses the challenges and potential options for maximizing the therapeutic benefits of capsaicin, including customized drug delivery and personalized therapeutic strategies. In finalization, this comprehensive investigation brings together the evidence currently obtainable on the anticancer properties of capsaicin, underscoring its potential as an autonomous treatment option in the struggle against cancer. Capsaicin is a compound of significant relevance for continuing research and clinical exploration in the field of cancer treatment due to its diverse mechanisms of action and ability for boosting prevailing therapy approaches.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"195-207"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic anxiolytic efficacy exploring the combined effects of diazepam and zinc chloride in wistar albino rats. 探索地西泮和氯化锌对白腊大鼠的协同抗焦虑作用。

IF 2.2

Drug Research Pub Date : 2024-06-01 Epub Date: 2024-05-10 DOI: 10.1055/a-2308-9192

Vishwani V Naik, Vedita Hegde Desai, Sam Noronha

引用次数: 0

Sweeteners in Orodispersible Films: How Much is too Much? 可发散薄膜中的甜味剂：多少才算多？

IF 2.2

Drug Research Pub Date : 2024-04-01 Epub Date: 2024-03-20 DOI: 10.1055/a-2266-2522

Ognjenka Rahić, Sabina Behrem, Amina Tucak-Smajić, Jasmina Hadžiabdić, Belma Imamović, Lamija Hindija, Merima Šahinović, Edina Vranić

{"title":"Sweeteners in Orodispersible Films: How Much is too Much?","authors":"Ognjenka Rahić, Sabina Behrem, Amina Tucak-Smajić, Jasmina Hadžiabdić, Belma Imamović, Lamija Hindija, Merima Šahinović, Edina Vranić","doi":"10.1055/a-2266-2522","DOIUrl":"10.1055/a-2266-2522","url":null,"abstract":"Four natural sweeteners (sucrose, xylitol, fructose, and isomalt) were selected to examine the influence of their qualities and amounts on the characteristics of orodispersible films. Sodium carboxymethylcellulose (2% w/w) was utilized as the film-forming polymer and 1% w/w glycerol as a plasticizer. Films were produced through the solvent casting method, rendering them suitable for convenient application in community or hospital pharmacy settings. The physicochemical and optical properties of the films were analyzed, and Fourier-transform infrared analysis was carried out. All films exhibited acceptable disintegration time, uniformity of mass, thickness, and optical characteristics, with significant dependence (p<0.05) on both sweetener type and quantity. Disintegration time varied based on the employed method, as well as the characteristics and amount of sweetener. Additionally, all films maintained pH values within the oral cavity range, suggesting no potential irritancy upon administration. Fourier-transform infrared analysis confirmed the formation of the film and demonstrated compatibility between its components.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"180-186"},"PeriodicalIF":2.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspectives About Ascorbic Acid to Treat Inflammatory Bowel Diseases. 关于抗坏血酸治疗炎症性肠病的观点。

IF 2.2

Drug Research Pub Date : 2024-04-01 Epub Date: 2024-03-11 DOI: 10.1055/a-2263-1388

Ian Richard Lucena Andriolo, Larissa Venzon, Luisa Mota da Silva

{"title":"Perspectives About Ascorbic Acid to Treat Inflammatory Bowel Diseases.","authors":"Ian Richard Lucena Andriolo, Larissa Venzon, Luisa Mota da Silva","doi":"10.1055/a-2263-1388","DOIUrl":"10.1055/a-2263-1388","url":null,"abstract":"It is known that reactive oxygen species cause abnormal immune responses in the gut during inflammatory bowel diseases (IBD). Therefore, oxidative stress has been theorized as an agent of IBD development and antioxidant compounds such as vitamin C (L-ascorbic acid) have been studied as a new tool to treat IBD. Therefore, the potential of vitamin C to treat IBD was reviewed here as a critical discussion about this field and guide future research. Indeed, some preclinical studies have shown the beneficial effects of vitamin C in models of ulcerative colitis in mice and clinical and experimental findings have shown that deficiency in this vitamin is associated with the development of IBD and its worsening. The main mechanisms that may be involved in the activity of ascorbic acid in IBD include its well-established role as an antioxidant, but also others diversified actions. However, some experimental studies employed high doses of vitamin C and most of them did not perform dose-response curves and neither determined the minimum effective dose nor the ED50. Allometric extrapolations were also not made. Also, clinical studies on the subject are still in their infancy. Therefore, it is suggested that the research agenda in this matter covers experimental studies that assess the effective, safe, and translational doses, as well as the appropriate administration route and its action mechanism. After that, robust clinical trials to increase knowledge about the role of ascorbic acid deficiency in IBD patients and the effects of their supplementation in these patients can be encouraged.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"149-155"},"PeriodicalIF":2.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preclinical Targeting of the PGRMC1-CK2 Axis with Silmitasertib: A Potential Strategy for Lung Adenocarcinoma Therapy. 临床前使用 Silmitasertib 靶向 PGRMC1-CK2 轴：肺腺癌治疗的潜在策略。

IF 2.1

Drug Research Pub Date : 2024-04-01 Epub Date: 2024-03-20 DOI: 10.1055/a-2273-2389

S Solaipriya, M Anbalagan, V Sivaramakrishnan

{"title":"Preclinical Targeting of the PGRMC1-CK2 Axis with Silmitasertib: A Potential Strategy for Lung Adenocarcinoma Therapy.","authors":"S Solaipriya, M Anbalagan, V Sivaramakrishnan","doi":"10.1055/a-2273-2389","DOIUrl":"10.1055/a-2273-2389","url":null,"abstract":"Progesterone receptor membrane component 1 (PGRMC1) is a pleiotropic protein over-expressed in lung adenocarcinoma (LUAD). The precise molecular mechanisms underlying the signature motif of Casein kinase (CK2) presence in PGRMC1 and their role in LUAD remain unclear. X-ray crystallographic structure for CK2 and PGRMC1 from the PubChem database was obtained and subjected to protein-protein interaction (PPI) analysis to identify their interactions. In addition, the CK2 inhibitor - Silmitasertib was also utilised to understand the interaction between PGRMC1-CK2. The PPI complex (PGRMC1-CK2) and the PPI-ligand interaction analysis and their Molecular Dynamics (MD) studies revealed the stability of their interactions and critical amino acid contacts within the 5Ǻ vicinity of the CK2 signature motif \"T/S-x-x-E/D\". Moreover, in-vitro colony formation assay, migration assay, and gene expression analysis using quantitative Real-time PCR revealed that Silmitasertib (IC50-2.5 μM) was highly influential in suppressing the PGRMC1-CK2 expression axis. In conclusion, our study infers that PGRMC1-CK-2 axis inhibition could be a potential therapeutic option to limit the promotion and progression of lung cancer.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"187-190"},"PeriodicalIF":2.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Diclofenac-induced Renal Damage in Normotensive and Hypertensive Rats: A Comparative Analysis. 双氯芬酸诱导的正常血压大鼠和高血压大鼠肾损伤的特征：比较分析

IF 2.2

Drug Research Pub Date : 2024-04-01 Epub Date: 2024-03-19 DOI: 10.1055/a-2277-8458

Thaise Boeing, Alana Bittencourt F Lima, Maria Eduarda Busana, Luísa Nathália Bolda Mariano, Luisa Mota da Silva, Rita de Cássia Vilhena da Silva, Priscila de Souza

{"title":"Characterization of Diclofenac-induced Renal Damage in Normotensive and Hypertensive Rats: A Comparative Analysis.","authors":"Thaise Boeing, Alana Bittencourt F Lima, Maria Eduarda Busana, Luísa Nathália Bolda Mariano, Luisa Mota da Silva, Rita de Cássia Vilhena da Silva, Priscila de Souza","doi":"10.1055/a-2277-8458","DOIUrl":"10.1055/a-2277-8458","url":null,"abstract":"Background: Diclofenac is the non-steroidal anti-inflammatory drug (NSAID) mostly prescribed worldwide, but it is highly associated with hypertension and acute kidney injury. Despite that, little information is available about the renal effects of diclofenac in hypertensive individuals, which led us to carry out this comparative study between the renal effects of this NSAID in normotensive (NTR) and spontaneously hypertensive rats (SHR).Methods: Male Wistar NTR and SHR were orally treated with vehicle (V: 10 mL/kg) or diclofenac sodium (D: 100 mg/kg) once a day for 3 days. Urine volume, electrolytes excretion (Na+, K+, Cl-, and Ca2+), urea, creatinine, pH, and osmolarity were evaluated. Furthermore, blood samples and renal tissue were collected to perform biochemical and histological analysis.Results: Diclofenac increased the renal corpuscle and bowman's space in the SHR, while no microscopic changes were observed in the renal tissue of NTR. Regarding the urinary parameters, diclofenac reduced urine volume, pH, osmolarity, and all electrolytes excretion, followed by decreased urea and creatinine levels in both lineages. Moreover, it also induced hyponatremia, hypokalemia, and hypocalcemia in SHR, while reduced glutathione-S-transferase activity, lipid hydroperoxides, and nitrite levels in renal tissue.Conclusions: The data presented herein demonstrated that diclofenac induces renal damage and impaired renal function in both NTR and SHR, but those effects are exacerbated in SHR, as seen by the histological changes and electrolytes balance disturbance, therefore, reinforcing that diclofenac may increase the risks of cardiovascular events in hypertensive patients.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"171-179"},"PeriodicalIF":2.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potential of Diosgenin in Amelioration of Carbon Tetrachloride-Induced Murine Liver Injury. 薯蓣皂苷在改善四氯化碳诱发的小鼠肝损伤中的治疗潜力

IF 2.2

Drug Research Pub Date : 2024-04-01 Epub Date: 2024-03-08 DOI: 10.1055/a-2263-1329

Mohamad-Hasan Ghosian-Moghaddam, Parvaneh Mohseni-Moghaddam, Mehrdad Roghani

{"title":"Therapeutic Potential of Diosgenin in Amelioration of Carbon Tetrachloride-Induced Murine Liver Injury.","authors":"Mohamad-Hasan Ghosian-Moghaddam, Parvaneh Mohseni-Moghaddam, Mehrdad Roghani","doi":"10.1055/a-2263-1329","DOIUrl":"10.1055/a-2263-1329","url":null,"abstract":"Diosgenin is a sapogenin with antidiabetic, antioxidant, and anti-inflammatory properties. The current study investigated whether diosgenin could ameliorate carbon tetrachloride (CCL4)-induced liver injury. To cause liver injury, CCL4 was injected intraperitoneally twice a week for 8 weeks. Daily oral administration of diosgenin at doses of 20, 40, and 80 mg/kg was started one day before CCL4 injection and continued for 8 weeks. Finally, serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and also albumin were assessed. Catalase and superoxide dismutase (SOD) activities in addition to glutathione (GSH) and malondialdehyde (MDA) levels were also quantified in the liver homogenate and routine histological evaluation was also conducted. Elevated serum levels of liver enzymes and decreased serum level of albumin caused by CCL4 were significantly restored following diosgenin administration at doses of 40 and 80 mg/kg. Long-term administration of CCL4 increased inflammatory and apoptotic factors such as IL-1β, caspase 3, TNF-α, and IL-6 and decreased SOD and catalase activities as well as GSH level in liver homogenates; while MDA level was increased. Treatment with diosgenin increased SOD and catalase activities and GSH levels in the liver of injured animals. In addition, liver MDA, IL-1β, caspase 3, TNF-α, and IL-6 level or activity decreased by diosgenin treatment. Additionally, diosgenin aptly prevented aberrant liver histological changes. According to obtained results, diosgenin can dose-dependently diminish CCl4-induced liver functional deficits and histological changes in a dose-dependent manner, possibly due to its antioxidant and anti-inflammation properties, and its beneficial effect is comparable to known hepatoprotective agent silymarin.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"156-163"},"PeriodicalIF":2.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140065057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Observational Study on Cosmetics Use-related Adverse Effects: Cosmetovigilance Need of the Day. 化妆品使用相关不良反应的观察研究：当今化妆品警戒的需要。

IF 2.2

Drug Research Pub Date : 2024-04-01 Epub Date: 2024-03-11 DOI: 10.1055/a-2251-6655

Geetika Mehta, Daksh Raj Tyagi, Monika Sachdeva, Rashmi Tripathi, Himanshu Tyagi

{"title":"An Observational Study on Cosmetics Use-related Adverse Effects: Cosmetovigilance Need of the Day.","authors":"Geetika Mehta, Daksh Raj Tyagi, Monika Sachdeva, Rashmi Tripathi, Himanshu Tyagi","doi":"10.1055/a-2251-6655","DOIUrl":"10.1055/a-2251-6655","url":null,"abstract":"Introduction: The pursuit of aesthetic attractiveness and increased awareness have contributed significantly to the growth of the cosmetic industry. However, it is crucial to recognize that even the minimal use of cosmetics may have harmful consequences for both the overall well-being and the broader community, an issue that has yet to be adequately recognized or addressed.Objective: This study is aimed at providing insights into the usage pattern of consumer behavior regarding skin care products and to assess the prevalence and determinants of cosmetic-related adverse events among the general populace.Materials and methods: A community-based cross-sectional study was carried out for four months in a satellite city of the National Capital Region (NCR) of India. The data from 435 respondents was collected using a self-administered questionnaire and analyzed using frequencies and percentages.Results: Among 435 participants, 32.9% experienced one or more adverse effects owing to the use of skincare products; the prevalence was higher in females (36.3%). Hair loss, allergies, and dry skin were the most frequently reported adverse effects. The majority of the adverse reactions were reported with soap (21%), followed by shampoo (17%). The gender-wise difference between adverse effects of skin care products was found to be statistically significant.Conclusion: To improve the system's efficiency, a comprehensive review of the current regulatory protocols for cosmetics is crucial. Additionally, it is essential to widely disseminate information on Cosmetovigilance and promote the reporting of any adverse effects of cosmetics within the community; this is the demand of the present time.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"164-170"},"PeriodicalIF":2.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the Potential of mRNA as Biomarker to Revolutionize Diagnosis of Colorectal Cancer. 了解 mRNA 作为生物标记物的潜力，彻底改变结直肠癌诊断。

IF 2.2

Drug Research Pub Date : 2024-03-01 Epub Date: 2024-02-13 DOI: 10.1055/a-2244-6572

Rina Das, Dinesh Kumar Mehta, Nidhi Gupta

{"title":"Understanding the Potential of mRNA as Biomarker to Revolutionize Diagnosis of Colorectal Cancer.","authors":"Rina Das, Dinesh Kumar Mehta, Nidhi Gupta","doi":"10.1055/a-2244-6572","DOIUrl":"10.1055/a-2244-6572","url":null,"abstract":"MicroRNA as potential biomarker for early diagnosis, differentiating various stages, interpreting the success of postoperative curative surgery and predicting early relapse of Colorectal cancer.In the realm of medical research, the quest to find effective biomarkers for various diseases has always been a top priority. Colorectal cancer (CRC), one of the leading causes of cancer-related deaths worldwide, is no exception. The emergence of microRNA (mRNA) as a potential biomarker for CRC has sparked immense interest among scientists and clinicians alike. mRNA, a molecule responsible for translating genetic information into functional proteins, presents a promising avenue for early detection and personalized treatment of this deadly disease. By analyzing the specific patterns and levels of mRNA expression in CRC cells, researchers have the ability to identify signatures that can aid in accurate diagnosis, predict patient prognosis, and even guide targeted therapies. This breakthrough in molecular biology not only enhances our understanding of CRC but also holds the potential to revolutionize the field of cancer diagnostics and treatment. In this article, we will delve deeper into the potential of mRNA as a biomarker for CRC, exploring its benefits and challenges in the field of cancer research.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"102-112"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status. 格列吡嗪临床前和临床现状百科全书。

IF 2.2

Drug Research Pub Date : 2024-03-01 Epub Date: 2024-02-26 DOI: 10.1055/a-2237-8566

Saad Mohammed, Tarique Mahmood, Arshiya Shamim, Farogh Ahsan, Mohammad Shariq, Saba Parveen, Rufaida Waseem, Aditya Singh

{"title":"Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status.","authors":"Saad Mohammed, Tarique Mahmood, Arshiya Shamim, Farogh Ahsan, Mohammad Shariq, Saba Parveen, Rufaida Waseem, Aditya Singh","doi":"10.1055/a-2237-8566","DOIUrl":"10.1055/a-2237-8566","url":null,"abstract":"Glipizide is an oral glucose-lowering medication that is beneficial for the treatment of type 2 diabetes. This study compiles exhaustively all accessible information on glipizide, from preclinical to clinical studies. Glipizide may be used in concert with TRAIL to treat cancer cells; in vitro studies have shown that it suppresses angiogenesis and vasculogenesis while shielding cells from glycation-induced damage. Anticonvulsant effects and modifications in the pharmacokinetics of other medications, such as Divalproex Sodium, were seen in glipizide in vivo experiments. Propranolol amplifies glipizide's hypoglycemic effect briefly in normal animals but consistently enhances it in diabetic ones. In the treatment of cancer and neurodegenerative poly(Q) illnesses, glipizide has demonstrated to offer potential therapeutic advantages. It is ineffective in preventing DENA-induced liver cancer and may cause DNA damage over time. The way glipizide interacts with genetic variants may increase the risk of hypoglycemia. Combining Syzygium cumini and ARBE to glipizide may enhance glycemic and lipid control in type 2 diabetes. Individuals with coronary artery disease who take glipizide or glyburide have an increased risk of death. The risk of muscular responses and acute pancreatitis is minimal when glipizide and dulaglutide are combined. In conclusion, glipizide has shown promising therapeutic efficacy across a variety of disorders.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"123-132"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0