Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity最新文献

{"title":"Effects of time-restricted feeding (TRF)-model of intermittent fasting on adipose organ: a narrative review.","authors":"Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi","doi":"10.1007/s40519-024-01709-w","DOIUrl":"10.1007/s40519-024-01709-w","url":null,"abstract":"<p><p>Time-restricted feeding (TRF), an intermittent fasting approach involving a shortened eating window within 24 h, has gained popularity as a weight management approach. This review addresses how TRF may favor fat redistribution and the function of the adipose organ. TRF trials (mainly 16:8 model, with a duration of 5-48 weeks) reported a significant weight loss (1.2-10.2%, ~ 1.4-9.4 kg), with a considerable decrease in total fat mass (1.6-21%, ~ 0.5-7 kg) and visceral adipose compartment (VAC, 11-27%) in overweight and obese subjects. Experimental TRF in normal-fed and obesogenic-diet-fed mice and rats (with a fasting duration ranging between 9 and 21 h within 1-17 weeks) reported a significant reduction in body weight (~ 7-40%), total fat mass (~ 17-71%), and intrahepatic fat (~ 25-72%). TRF also improves VAC and subcutaneous adipose compartment (SAC) function by decreasing adipocyte size, macrophage infiltration, M1-macrophage polarity, and downregulating inflammatory genes. In conclusion, beyond its effect on body weight loss, total fat mass, and intrahepatic fat accumulation, TRF favors adipose organ fat redistribution in overweight and obese subjects by decreasing VAC and improving the function of VAC and SAC.</p>","PeriodicalId":11391,"journal":{"name":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","volume":"29 1","pages":"77"},"PeriodicalIF":2.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of weight-adjusted waist index (WWI) and a body shape index (ABSI) with serum neurofilament light chain levels in a national study of U.S. adults.","authors":"Zixuan Yan, Qingxin Gu, Hong Yin, Mingliang Yi, Xiao Wang, Ruirui Sun, Fanrong Liang, Dingjun Cai, Wenchuan Qi","doi":"10.1007/s40519-024-01706-z","DOIUrl":"10.1007/s40519-024-01706-z","url":null,"abstract":"<p><strong>Objective: </strong>This study explored how the weight-adjusted waist index (WWI) and a body shape index (ABSI) are related to serum neurofilament light chain (sNfL) levels among U.S. adults. We aimed to evaluate sNfL, which plays key roles in neuronal injury in neurological diseases, given its understudied connection to obesity.</p><p><strong>Methods: </strong>We used cross-sectional data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) of people with complete information on the weight-adjusted waist index (WWI), a body shape index (ABSI), and serum neurofilament light chain (sNfL). Multiple linear regression analysis allowed us to investigate the separate connections among the WWI, ABSI, and sNfL. Moreover, interaction testing and subgroup analysis were performed to improve the general validity of our results. To assess any nonlinear correlations, we also performed threshold effect analysis and smoothed curve fitting.</p><p><strong>Results: </strong>WWI and ABSI were positively linked with sNfL (WWI: β = 0.05, 95% CI 0.01-0.09; ABSI: β = 1.65, 95% CI 3.53-13.72). There was no clear reliance on this association according to subgroup analysis and interaction tests. Smoothed curve fitting and saturation effects also demonstrated nonlinear associations between WWI and ABSI and sNfL, with inflection points of 10.38 and 0.38, respectively.</p><p><strong>Conclusion: </strong>In the adult American population, while the WWI and ABSI are linearly positively correlated with serum neurofilament light protein (sNfL), the effect size is greater for the ABSI. This correlation provides fresh evidence connecting obesity to neurological conditions, deepening our comprehension of the extensive health impacts associated with obesity. Level of Evidence Level I, experimental studies.</p>","PeriodicalId":11391,"journal":{"name":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","volume":"29 1","pages":"76"},"PeriodicalIF":2.9,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal evolution of physical activity type and eating and weight concerns among adolescents.","authors":"Giulio D'Anna, Lorenzo Lucherini Angeletti, Lara Allegrini, Arianna Ida Altomare, Daniela Betti, Alessandra De Martino, Giulia Minotti, Chiara Muscarella, Federica Benvenuti, Valdo Ricca, Francesco Rotella","doi":"10.1007/s40519-024-01696-y","DOIUrl":"10.1007/s40519-024-01696-y","url":null,"abstract":"<p><strong>Purpose: </strong>To provide a prospective 2 year follow-up of a previously enrolled adolescent high school sample, regarding body image and eating concerns, and patterns of sports type and physical activity.</p><p><strong>Methods: </strong>Sports type, weekly time devoted to it, and psychopathological self-reports (Eating Disorders Examination Questionnaire 6.0, Body Uneasiness Test, and Muscle Dysmorphia Disorder Inventory) were evaluated longitudinally in a general population sample enrolled in a previous study, testing prospective variations in an observational setting.</p><p><strong>Results: </strong>At follow-up, girls expressed increased dietary restraint and body uneasiness as compared to baseline, whereas boys expressed increased body uneasiness-and specifically in the avoidance, depersonalisation and compulsive self-monitoring dimensions. Among both sexes, a significant shift towards individual activities or lack of activity was observed after 2 years, with a reduction in team sports involvement. Among girls, time devoted to exercise significantly decreased at follow-up.</p><p><strong>Conclusions: </strong>The present findings indirectly confirm an increased vulnerability to dietary, bodily and appearance-based concerns among adolescents. The role of different patterns of physical activity and exercise time may interact bidirectionally with these problematic areas, considering that previous studies point out increased concerns among inactive subjects, and among those who choose individual activities.</p><p><strong>Level of evidence: </strong>Level IV-longitudinal observational study.</p>","PeriodicalId":11391,"journal":{"name":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","volume":"29 1","pages":"75"},"PeriodicalIF":2.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of dietary vs. non-dietary approaches in obesity and disordered eating behaviors: a narrative review of the literature.","authors":"Chiara Breda, Adriana Chiarelli, Giulia Quarantelli, Maria Vittoria Conti, Nagaia Madini, Hellas Cena","doi":"10.1007/s40519-024-01702-3","DOIUrl":"10.1007/s40519-024-01702-3","url":null,"abstract":"<p><strong>Purpose: </strong>This narrative review aims to conduct a comparative analysis of dietary and non-dietary approaches in the management of weight and disordered eating behaviors (DEBs) in adults with obesity.</p><p><strong>Methods: </strong>Studies were identified from Medline (PubMed), including only English-language manuscripts published from 1998 to 2024. To be included in the review the studies had to be RCTs that compared the effect of dietary and non-dietary approaches on weight loss and DEBs in adults with obesity not being treated with pharmacological treatments.</p><p><strong>Results: </strong>Seven randomized controlled trials (RCTs) reported in 8 manuscripts published between 1998 and 2024 met the inclusion criteria. The sample size ranged from a minimum of 16 subjects to a maximum of 219. All studies involved adult subjects, mainly women, with first-, second-, or third-degree obesity and most subjects had cognitive restriction and/or uncontrolled eating. Dietary approaches were characterized by moderate caloric restriction (CR) and restriction of fat intake. In contrast, non-dietary approaches focused on mindful eating (ME), intuitive eating (IE) and weight neutral (WN) approaches. Of the 7 RCTs included, 5 reported greater weight loss in the diet group compared to the non-diet group; however, only one of these sustained the result at follow-up. In contrast, 4 studies demonstrated greater improvements in DEBs in the non-diet group.</p><p><strong>Conclusion: </strong>CR is essential for weight loss in individuals with obesity, but long-term weight management also hinges on their relationship with food. The psychological improvements reported in non-dietary versus dietary approaches should not be overlooked and can be a starting point for the development of multidisciplinary interventions involving synergistic actions between diet, exercise, and practices to improve DEBs with the goal of reducing the obesity epidemic. Level of evidence Level I, at least one properly designed randomized controlled trials; systematic reviews and meta-analyses; experimental studies.</p>","PeriodicalId":11391,"journal":{"name":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","volume":"29 1","pages":"74"},"PeriodicalIF":2.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the ORTO-R in an adult population: the Turkish version, reliability, and validity study.","authors":"Seda Kaya, Esma Asil, Funda Pınar Çakıroğlu, Sümeyye Sertdemir, Yaren Can, Emine Muradoğlu","doi":"10.1007/s40519-024-01705-0","DOIUrl":"10.1007/s40519-024-01705-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine the psychometric properties of a Turkish version of the ORTO-R scale by testing its factorial structure, reliability, and validity in a large adult population.</p><p><strong>Methods: </strong>This cross-sectional study was conducted between November 2022 and February 2023. Through an online questionnaire, 1077 participants were recruited. Confirmatory factor analysis (CFA) was used to examine the construct validity of the questionnaires. The internal consistency of the ORTO-R scale was evaluated with Cronbach's alpha, Omega and test-retest coefficients. For the convergent and divergent validity of the scale, Pearson correlation analysis was performed on the scores of the Eating Attitude Test-26, the Generalized Anxiety Disorder-7 and the Life Satisfaction Scale.</p><p><strong>Results: </strong>The two-factor model fit the data well. Analyses confirmed that the two-factor model of the ORTO-R had acceptable or good fit indices (χ 2/df = 2.126; GFI = 0.997; CFI = 0.992; AGFI = 0.992; TLI = 0.985; RMSEA = 0.032; SRMR = 0.029). According to the reliability coefficients, the orthorexia nervosa and method subscales were found to be reliable. The correlations supported the convergent and divergent validity of the scale.</p><p><strong>Conclusions: </strong>The results demonstrate that the Turkish version of the ORTO-R is a valid and reliable instrument for assessing orthorexic behaviors in a theoretically meaningful way.</p><p><strong>Level of evidence: </strong>Level V, descriptive study.</p>","PeriodicalId":11391,"journal":{"name":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","volume":"29 1","pages":"73"},"PeriodicalIF":2.9,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dutch Body Shape Questionnaire among patients with binge-eating disorder: psychometrics and norms of the full version (BSQ34) and the short version (BSQ8C).","authors":"Bernou Melisse, Liselotte de Mooij, Margo de Jonge, Daniela Schlochtermeier, Edwin de Beurs","doi":"10.1007/s40519-024-01699-9","DOIUrl":"10.1007/s40519-024-01699-9","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined the psychometric properties and provided normative data of the Dutch Body Shape Questionnaire (BSQ34) and its shortened BSQ8C among patients with binge-eating disorder.</p><p><strong>Methods: </strong>The two versions of the BSQ were administered to patients with binge-eating disorder (N = 155) enrolled for treatment, and to a community sample (N = 333). The translation and back-translation of the BSQ were performed by translators with and without eating-disorder expertise. Internal consistency, concurrent validity, test-retest reliability, incremental validity, and sensitivity to change were determined. A receiver-operating-characteristic curve-analysis was used to establish criterion-related validity, for which the Eating Disorder Examination-Shape concern subscale, was used. Uni-dimensionality of the instrument was investigated with confirmatory factor analysis. Norms (population-based T-scores and clinical percentile-scores) were determined.</p><p><strong>Results: </strong>The psychometric properties of the BSQs were satisfactory. The BSQ34 discriminated well in body-shape dissatisfaction between patients with binge-eating disorder and the community sample (area-under-the-curve value = 0.91-0.98) and had a unidimensional factor structure. Comparing structural invariance between both samples revealed that scaler invariance was not supported, indicating that items may be interpreted differently by patients with binge-eating disorder and subjects from the community. Analyses were repeated for the BSQ8C, which yielded similar results.</p><p><strong>Conclusion: </strong>The results indicated that both versions of the BSQ appeared suitable to screen for body-shape dissatisfaction among patients with binge-eating disorder. The BSQ34 supplies valuable information on the various types of concerns respondents have, which are critical to consider in clinical settings; the BSQ8C is recommended as a short screening tool.</p><p><strong>Level of evidence: </strong>Level III: Evidence obtained from well-designed cohort or case-control analytic studies.</p>","PeriodicalId":11391,"journal":{"name":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","volume":"29 1","pages":"72"},"PeriodicalIF":2.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Intrinsic and extrinsic motivations as moderators of the association between exercise frequency and exercise behavior.","authors":"Cody Staples, Madeline Palermo, Diana Rancourt","doi":"10.1007/s40519-024-01701-4","DOIUrl":"10.1007/s40519-024-01701-4","url":null,"abstract":"","PeriodicalId":11391,"journal":{"name":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","volume":"29 1","pages":"71"},"PeriodicalIF":2.9,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcultural adaptation and validation of the Eating Self-Efficacy Brief Scale (ESEBS): the Brazilian version.","authors":"Ana Maria Pandolfo Feoli, Tainá Lopes da Silva, Janete de Souza Urbanetto, Monica D'Amico, Silvia Cerolini, Caterina Lombardo","doi":"10.1007/s40519-024-01703-2","DOIUrl":"10.1007/s40519-024-01703-2","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop and validate the Brief Eating Self-Efficacy Scale (ESEBS-BR) in Brazilian Portuguese, addressing the lack of tools to assess eating self-efficacy beliefs in Portuguese-speaking populations.</p><p><strong>Method: </strong>The study sought to cross-culturally adapt the scale, evaluate its internal structure, validate its reliability and validity, and explore potential associations between eating self-efficacy and eating behaviors. The cross-cultural adaptation process involved translation and back-translation, expert committees, and pre-testing. Scale validation was conducted with 228 participants, including reliability analyses, confirmatory factor analysis, and correlations with established measures of eating behavior.</p><p><strong>Results: </strong>The ESEBS-BR, maintaining all 8 original items, demonstrated high reliability, with a two-factor structure model confirmed by confirmatory factor analysis. Significant correlations were found between ESEBS-BR scores and measures of binge eating and eating behaviors, validating its criterion validity.</p><p><strong>Conclusions: </strong>The development and validation of the ESEBS-BR represent a significant contribution to the assessment of eating self-efficacy in the Brazilian population. The scale proved to be sensitive, reliable, and valid, offering an important tool for research and clinical interventions related to eating behavior.</p><p><strong>Level of evidence: </strong>V, descriptive cross-sectional study.</p>","PeriodicalId":11391,"journal":{"name":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","volume":"29 1","pages":"70"},"PeriodicalIF":2.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risk of kidney dysfunction in metabolically healthy/unhealthy population with normal weight or overweight/obesity: a systematic review and meta-analysis.","authors":"Majid Valizadeh, Amirhossein Ramezani Ahmadi, Faeze Abbaspour, Ali Valizadeh, Ahad Hasan Syed Hasani, Seyed Mohammadmisagh Moteshakereh, Mohammad Nikoohemmat, Behnaz Abiri","doi":"10.1007/s40519-024-01697-x","DOIUrl":"10.1007/s40519-024-01697-x","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a major global health concern with increasing prevalence and associated complications. Obesity and obesity-related metabolic disorders have been linked to chronic kidney disease (CKD), although the evidence is still inconsistent. To investigate the relationship between different obesity phenotypes and the risk of CKD, we conducted a systematic review and meta-analysis.</p><p><strong>Method: </strong>We conducted a comprehensive search of databases for all relevant studies up to February 2024, without imposing a specific start date, for observational studies assessing the relationship between obesity phenotypes and incident kidney dysfunction. We used fixed and random effects models for the meta-analysis, subgroup analyses were carried out to explore heterogeneity, and Egger's and Begg's tests were used to assess publication bias.</p><p><strong>Result: </strong>This meta-analysis included 13 eligible observational studies with 492,829 participants. Pooling the studies regardless of the effect measure showed that individuals with metabolically unhealthy normal weight (MUNW) (ES = 1.58, 95% CI = 1.43-1.76), metabolically healthy obese (MHO) (ES = 1.20, 95% CI = 1.06-1.34), and metabolically unhealthy obese (MUO) (ES = 1.90, 95% CI = 1.63-2.20) phenotypes had a significantly increased risk for kidney dysfunction (KD) events. On the other hand, MUOW individuals did not significantly correlate with risk of CKD (ES = 1.63, 95% CI = 0.97-2.23) compared to the MHNW phenotype.</p><p><strong>Conclusion: </strong>Healthy overweight and obese individuals had higher risk for the incident KD events; refuting the notion that metabolically healthy overweight and obese phenotypes are benign conditions.</p><p><strong>Level of evidence: </strong>III Evidence obtained from well-designed cohort or cross-sectional studies.</p>","PeriodicalId":11391,"journal":{"name":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","volume":"29 1","pages":"69"},"PeriodicalIF":2.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Optimising healthcare transition of adolescents and young adults to adult care: a perspective statement of the Italian Society of Obesity.","authors":"Anita Morandi, Giuseppina Rosaria Umano, Andrea Vania, Valeria Guglielmi, Giovanna Muscogiuri, Claudio Maffeis, Luca Busetto, Silvio Buscemi, Valentino Cherubini, Rocco Barazzoni, Melania Manco","doi":"10.1007/s40519-024-01700-5","DOIUrl":"10.1007/s40519-024-01700-5","url":null,"abstract":"","PeriodicalId":11391,"journal":{"name":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","volume":"29 1","pages":"68"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}