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Drug-nutrient interactions最新文献

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Effect of gold on selenium and glutathione peroxidase activities in rat tissues. 金对大鼠组织中硒及谷胱甘肽过氧化物酶活性的影响。
Drug-nutrient interactions Pub Date : 1985-01-01
M A Baker, C J Dillard, A L Tappel
{"title":"Effect of gold on selenium and glutathione peroxidase activities in rat tissues.","authors":"M A Baker,&nbsp;C J Dillard,&nbsp;A L Tappel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Gold (Au) thioglucose, used to treat inflammatory diseases such as rheumatoid arthritis, inhibits the selenium (Se)-dependent glutathione peroxidase. The present study examines the ability of Au to act either as a Se antagonist or as a GSH peroxidase inhibitor in vivo. The effects of gold thioglucose loading on Se distribution, and on Se-dependent GSH peroxidase and GSH S-transferase, were examined in rats fed three dietary levels of Se (0, 0.2, and 2.0 ppm), and with or without adjuvant-induced inflammation. Kidney, liver, spleen, testes, and erythrocytes were selected for study based upon their high Se content and their ability to concentrate Au. Au loading increased kidney, liver, and spleen Se concentrations, and this effect was dependent upon dietary Se levels. Rats fed Se-supplemented diets had higher levels of Au in kidney, liver, and spleens than did rats fed a Se-deficient diet. Au loading decreased GSH peroxidase activity in kidney, liver, and erythrocytes. The decrease in GSH peroxidase in kidney and liver, and the increase in Se concentration in these tissues, suggest that Au-Se complexes may have limited the biosynthesis of the enzyme. Au affects Se distribution, and Se concentrates Au in tissues with a high lysosomal content.</p>","PeriodicalId":11372,"journal":{"name":"Drug-nutrient interactions","volume":"3 3","pages":"141-52"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15141688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug metabolism and actions in the aged. 老年人的药物代谢及作用。
Drug-nutrient interactions Pub Date : 1985-01-01
S Garattini
{"title":"Drug metabolism and actions in the aged.","authors":"S Garattini","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11372,"journal":{"name":"Drug-nutrient interactions","volume":"4 1-2","pages":"87-97"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14003901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrient effects on drug metabolism and action in the elderly. 营养素对老年人药物代谢和作用的影响。
Drug-nutrient interactions Pub Date : 1985-01-01
P Welling
{"title":"Nutrient effects on drug metabolism and action in the elderly.","authors":"P Welling","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11372,"journal":{"name":"Drug-nutrient interactions","volume":"4 1-2","pages":"173-207"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15024655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case history of myopathic carnitine deficiency benefited by glucocorticoids and L-carnitine supplementation. 一例肌病性肉毒碱缺乏症通过糖皮质激素和左旋肉碱补充获益。
Drug-nutrient interactions Pub Date : 1985-01-01
L J Howard, A H Beckerman
{"title":"A case history of myopathic carnitine deficiency benefited by glucocorticoids and L-carnitine supplementation.","authors":"L J Howard,&nbsp;A H Beckerman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>While the term \"drug-nutrient interactions\" tends to conjure up a concept of an adverse combination, such as anticonvulsants impairing folate metabolism or alcohol blocking active thiamine absorption, there are situations in which a drug and nutrient can act in a complementary manner, to correct a metabolic defect. This case history illustrates such a positive interaction of glucocorticoids and L-carnitine supplements improving muscle function in a patient with myopathic carnitine deficiency.</p>","PeriodicalId":11372,"journal":{"name":"Drug-nutrient interactions","volume":"3 4","pages":"191-6"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15176626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics of dixyrazine: low bioavailability, improved by food intake. 二嗪的药代动力学:低生物利用度，通过食物摄入改善。
Drug-nutrient interactions Pub Date : 1985-01-01
H Liedholm, A Lidén, L Kroon, A Melander, E Wåhlin-Boll
{"title":"Pharmacokinetics of dixyrazine: low bioavailability, improved by food intake.","authors":"H Liedholm,&nbsp;A Lidén,&nbsp;L Kroon,&nbsp;A Melander,&nbsp;E Wåhlin-Boll","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The single-dose kinetics of the psychotropic phenothiazine dixyrazine was assessed in eight young healthy volunteers given the drug at three occasions: 10 mg intravenously, 25 mg orally in the fasting state, and 25 mg orally together with a standardized breakfast of 1,840 kJ. The plasma concentrations of dixyrazine were measured by high-pressure liquid chromatography. Like some other lipophilic weakly basic drugs, dixyrazine showed a rapid disappearance from plasma, having an elimination half-life of 3.4 h, a clearance of about 1,200 ml/min, and an apparent volume of distribution of 5.9 l/kg. Dixyrazine was found to have a very low and interindividually varying bioavailability; in the fasting state, dixyrazine bioavailability was only 1% in one subject, 3-6% in five others, and 11 and 24% in the remaining two subjects. The mean fasting bioavailability was 7.4%. After intake with breakfast, the mean bioavailability was increased to 12.4% (p less than 0.01), with a range of 2-29%. Probably, the low oral bioavailability is due to extensive presystemic (hepatic) degradation, and the food effect to a reduction of this process.</p>","PeriodicalId":11372,"journal":{"name":"Drug-nutrient interactions","volume":"3 2","pages":"87-92"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15099934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetic profile of antipyrine in young rhesus monkeys (Macaca mulatta) with protein energy malnutrition. 安替比林在蛋白质能量营养不良的年轻恒河猴体内的药代动力学特征。
Drug-nutrient interactions Pub Date : 1985-01-01
B Sharma, S Mehta, C K Nain, V S Mathur
{"title":"Pharmacokinetic profile of antipyrine in young rhesus monkeys (Macaca mulatta) with protein energy malnutrition.","authors":"B Sharma,&nbsp;S Mehta,&nbsp;C K Nain,&nbsp;V S Mathur","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An experimental model of protein energy malnutrition was produced in five young rhesus monkeys and the pharmacokinetics of antipyrine were studied at three points, initially, during protein energy malnutrition and following nutritional rehabilitation. In a separate group of animals, the estimation of hepatic enzyme aminopyrine N-demethylase was performed. There was a significant decrease in the elimination kinetics, the half life was increased, and the clearance rate was decreased in the malnourished animals, which correlated with a corresponding decrease in aminopyrine N-demethylase activity.</p>","PeriodicalId":11372,"journal":{"name":"Drug-nutrient interactions","volume":"3 2","pages":"93-8"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15037284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrients/non-nutrients and drug metabolism. 营养素/非营养素和药物代谢。
Drug-nutrient interactions Pub Date : 1985-01-01
K Krishnaswamy
{"title":"Nutrients/non-nutrients and drug metabolism.","authors":"K Krishnaswamy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11372,"journal":{"name":"Drug-nutrient interactions","volume":"4 1-2","pages":"235-47"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15024657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrient needs and nutritional status in relation to aging. 与衰老有关的营养需要和营养状况。
Drug-nutrient interactions Pub Date : 1985-01-01
H N Munro
{"title":"Nutrient needs and nutritional status in relation to aging.","authors":"H N Munro","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11372,"journal":{"name":"Drug-nutrient interactions","volume":"4 1-2","pages":"55-74"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15024658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypocholesterolemic agents: a comparison of the relative effectiveness of cholestyramine and pectin in rats. 降胆固醇剂:大鼠胆胺和果胶相对有效性的比较。
Drug-nutrient interactions Pub Date : 1985-01-01
M M Baig, C W Burgin, J J Cerda
{"title":"Hypocholesterolemic agents: a comparison of the relative effectiveness of cholestyramine and pectin in rats.","authors":"M M Baig,&nbsp;C W Burgin,&nbsp;J J Cerda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Studies were carried out to evaluate the comparative effectiveness of cholestyramine and pectin as hypocholesterolemic agents. Circulating levels of serum cholesterol and lipoprotein-associated cholesterol were measured in rats fed high cholesterol diet supplemented with either cholestyramine or pectin. When compared with controls, a significant decrease in the level of total cholesterol was observed in rats fed either cholestyramine or pectin (p less than 0.001, 43% reduction in cholesterol, and p less than 0.04, 25% reduction in cholesterol, respectively) and this was due exclusively to the lowering of low density lipoprotein. Further statistical evaluation of data revealed no significant difference between the cholesterol levels of rats fed either cholestyramine or pectin (p greater than 0.07). The data acquired in this study suggest that both cholestyramine and pectin are comparable and effective hypocholesterolemic agents and the observed hypocholesterolemic effect of these agents is mediated through lowering of cholesterol associated with the low density lipoprotein.</p>","PeriodicalId":11372,"journal":{"name":"Drug-nutrient interactions","volume":"3 2","pages":"109-13"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15099933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of soy flour and N-nitrosobis (2-oxopropyl) amine on the pancreas of the hamster. 大豆粉和 N-亚硝基双（2-氧代丙基）胺对仓鼠胰腺的影响
Drug-nutrient interactions Pub Date : 1985-01-01
A Hasdai, I E Liener
{"title":"The effects of soy flour and N-nitrosobis (2-oxopropyl) amine on the pancreas of the hamster.","authors":"A Hasdai, I E Liener","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Syrian golden hamsters fed diets of raw or heated soy flour for 16 months had an incidence (4%) of pancreatic neoplasms in both groups. Animals injected with N-nitrosobis (2-oxopropyl) amine (BOP) and fed heated soy flour for 15 months developed a high incidence (88%) of microscopic benign and malignant neoplasms, primarily of ductal origin. This was in marked contrast to a similar group of BOP-injected animals which had been fed raw soy flour and in which the incidence of pancreatic neoplasms was less than 10%.</p>","PeriodicalId":11372,"journal":{"name":"Drug-nutrient interactions","volume":"3 3","pages":"173-9"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15153413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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