Hypocholesterolemic agents: a comparison of the relative effectiveness of cholestyramine and pectin in rats.

Drug-nutrient interactions Pub Date : 1985-01-01
M M Baig, C W Burgin, J J Cerda
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Abstract

Studies were carried out to evaluate the comparative effectiveness of cholestyramine and pectin as hypocholesterolemic agents. Circulating levels of serum cholesterol and lipoprotein-associated cholesterol were measured in rats fed high cholesterol diet supplemented with either cholestyramine or pectin. When compared with controls, a significant decrease in the level of total cholesterol was observed in rats fed either cholestyramine or pectin (p less than 0.001, 43% reduction in cholesterol, and p less than 0.04, 25% reduction in cholesterol, respectively) and this was due exclusively to the lowering of low density lipoprotein. Further statistical evaluation of data revealed no significant difference between the cholesterol levels of rats fed either cholestyramine or pectin (p greater than 0.07). The data acquired in this study suggest that both cholestyramine and pectin are comparable and effective hypocholesterolemic agents and the observed hypocholesterolemic effect of these agents is mediated through lowering of cholesterol associated with the low density lipoprotein.

降胆固醇剂:大鼠胆胺和果胶相对有效性的比较。
进行了研究,以评估胆固醇胺和果胶作为降胆固醇药物的相对有效性。研究人员测量了在高胆固醇饮食中添加胆固醇胺或果胶的大鼠的血清胆固醇和脂蛋白相关胆固醇的循环水平。与对照组相比,观察到喂食胆胺或果胶的大鼠总胆固醇水平显著下降(p < 0.001,胆固醇降低43%,p < 0.04,胆固醇降低25%),这完全是由于低密度脂蛋白的降低。进一步的统计评估数据显示,饲喂胆胺和果胶的大鼠胆固醇水平无显著差异(p > 0.07)。本研究获得的数据表明,胆固醇胺和果胶都是相当有效的降胆固醇药物,观察到这些药物的降胆固醇作用是通过降低与低密度脂蛋白相关的胆固醇来介导的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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