Drug-nutrient interactions最新文献_第9页

Some thoughts on nutrition and aging. 关于营养和衰老的一些想法。

Drug-nutrient interactions Pub Date : 1985-01-01

H H Sandstead

引用次数: 0

Effects of hypercholesterolemia on beta adrenoceptors in the rabbit heart. 高胆固醇血症对兔心脏β肾上腺素受体的影响。

Drug-nutrient interactions Pub Date : 1985-01-01

C M Mokler, M T Abdel-Aziz, E Heric

引用次数: 0

A discussion of ethanol-nutrient interactions in the elderly. 老年人酒精-营养素相互作用的讨论。

Drug-nutrient interactions Pub Date : 1985-01-01

R M Russell

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Nutrient and non-nutrient effects on drug metabolism. 营养和非营养对药物代谢的影响。

Drug-nutrient interactions Pub Date : 1985-01-01

J N Hathcock

引用次数: 0

Effects of cigarette smoke and dietary vitamin E levels on selected lung and hepatic biotransformation enzymes in mice. 香烟烟雾和膳食维生素 E 水平对小鼠肺部和肝部某些生物转化酶的影响。

Drug-nutrient interactions Pub Date : 1985-01-01

M J Graziano, C Gairola, H W Dorough

{"title":"Effects of cigarette smoke and dietary vitamin E levels on selected lung and hepatic biotransformation enzymes in mice.","authors":"M J Graziano, C Gairola, H W Dorough","doi":"","DOIUrl":"","url":null,"abstract":"Young male C57BL mice were exposed nose-only to cigarette smoke 20 min/day for 8 weeks while maintained on diets containing 0, 5, and 100 ppm of vitamin E. Smoking had no effect on hepatic aryl hydrocarbon hydroxylase (AHH), UDP-glucuronyltransferase, glutathione S-transferase, parathion desulfurase, or parathion esterase activity. Lung AHH activity was increased in all smoke-exposed mice, although the increase was significantly less in animals maintained on the vitamin E-free diet. All mice on the vitamin E-free diet showed reduced lung AHH activity and increased hepatic lipid peroxidation. No other biotransformations tested were significantly altered by varying vitamin E concentrations alone or in combination with cigarette smoke. For all vitamin E diets, both the smoke-exposed and sham-treated mice gained significantly less weight than the control animals. This effect was attributed to stress induced by restraint of the animals within the smoking apparatus. The results of these experiments show that both cigarette smoke and vitamin E-deficient diets may affect xenobiotic metabolism but that the combination does not appear to alter markedly their individual effects or to induce ones not previously observed.","PeriodicalId":11372,"journal":{"name":"Drug-nutrient interactions","volume":"3 4","pages":"213-22"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15176630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of raw soy flour, feeding regime, and azaserine on rat pancreas. 生黄豆粉、喂养方式和氮杂环庚烷对大鼠胰腺的影响

Drug-nutrient interactions Pub Date : 1985-01-01

Z Nitsan, A Hasdai, I E Liener

引用次数: 0

Differential effects of dietary selenium on hepatic and renal glutathione metabolism in the rat. 膳食硒对大鼠肝脏和肾脏谷胱甘肽代谢的差异影响。

Drug-nutrient interactions Pub Date : 1985-01-01

M H Davies, B A Merrick, D F Birt, R C Schnell

{"title":"Differential effects of dietary selenium on hepatic and renal glutathione metabolism in the rat.","authors":"M H Davies, B A Merrick, D F Birt, R C Schnell","doi":"","DOIUrl":"","url":null,"abstract":"Studies were undertaken to determine whether or not dietary selenium (Se), as sodium selenite, at suboptimal (unsupplemented torula yeast diets, 0.02 ppm Se) or supplemented up to dietary excess, but nontoxic, levels (5.0 ppm Se) could selectively modify hepatic and renal reduced glutathione (GSH) levels and the enzymes involved in GSH metabolism. Male rats were provided torula yeast semipurified diets containing approximately 0.02 ppm Se in the basal diet and supplements of 0.1, 2.0, or 5.0 ppm Se for 3 or 6 weeks. Hepatic GSH increased in a nonlinear manner, with increasing dietary Se at both time points. Renal GSH was not similarly influenced. Neither hepatic nor renal gamma-glutamylcysteine synthetase or gamma-glutamyl transpeptidase activities are altered by supplements of Se. This suggests that synthetic and degradation enzyme activities are not influenced by Se. The capacity for the maintenance of GSH in the reduced state by glutathione reductase activity increased with increasing levels of dietary Se in the liver but not in the kidney. In both tissues greater Se supplements yielded greater tissue burdens of Se. These results suggest that GSH metabolism in hepatic and renal systems is differentially mediated, and the basis for these differences could be influenced by the relative levels in glutathione metabolizing enzymes.","PeriodicalId":11372,"journal":{"name":"Drug-nutrient interactions","volume":"3 4","pages":"229-38"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15176632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A discussion of drug metabolism and actions in the aged. 老年人药物代谢及作用的探讨。

Drug-nutrient interactions Pub Date : 1985-01-01

A Grahnen

引用次数: 0

A discussion of nutrient effects on drug metabolism and action in the elderly. 营养物质对老年人药物代谢和作用的影响。

Drug-nutrient interactions Pub Date : 1985-01-01

W B Abrams

引用次数: 0

Discussion of biomarkers of aging. 衰老生物标志物的讨论。

Drug-nutrient interactions Pub Date : 1985-01-01

R B McGandy

引用次数: 0