Drug Safety - Case Reports最新文献_第3页

Naloxone-Induced Non-Cardiogenic Pulmonary Edema: A Case Report. 纳洛酮诱导的非心源性肺水肿1例报告。

Drug Safety - Case Reports Pub Date : 2018-05-10 DOI: 10.1007/s40800-018-0088-x

Nasheena Jiwa, Himesh Sheth, Richard Silverman

{"title":"Naloxone-Induced Non-Cardiogenic Pulmonary Edema: A Case Report.","authors":"Nasheena Jiwa, Himesh Sheth, Richard Silverman","doi":"10.1007/s40800-018-0088-x","DOIUrl":"https://doi.org/10.1007/s40800-018-0088-x","url":null,"abstract":"A 22-year-old man was admitted for an elective right-shoulder open subacromial decompression and distal clavicle excision. He received a single intravenous dose of fentanyl 50 μg for anesthesia. His procedure was completed without intra-operative complications; however, he developed post-operative respiratory depression in the setting of narcotic administration. He was given naloxone 0.2 mg intravenously once to reverse this effect, which subsequently led to acute hypoxic respiratory failure secondary to pulmonary edema shortly after administration of naloxone. His oxygen saturation was noted to be 50% on room air, he was tachypneic with a respiratory rate of 22, and his heart rate ranged from 89 to 104 beats per minute. His blood pressure remained within normal limits at 128/62. His chest X-ray was notable for patchy bilateral perihilar infiltrates and the patient was intubated postoperatively. An EKG revealed normal sinus rhythm, and cardiac enzymes were negative. He was diagnosed with naloxone-induced non-cardiogenic pulmonary edema supported by the temporal relationship of the causal drug and no other identifiable cause of his clinical picture. He received furosemide and underwent diuresis while intubated, with subsequent improvement in his oxygen requirements. His vitals remained stable and he was extubated 6 h later. A Naranjo assessment score of 6 was obtained, indicating a probable relationship between the patient's symptoms and the suspect drug.","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":"5 1","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2018-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40800-018-0088-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36088401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Desmopressin-Induced Severe Hyponatremia with Central Pontine Myelinolysis: A Case Report. 去氨加压素诱发的严重低钠血症伴中央脑桥髓鞘溶解1例。

Drug Safety - Case Reports Pub Date : 2018-04-25 DOI: 10.1007/s40800-018-0084-1

Tanzib Hossain, Marya Ghazipura, Vineet Reddy, Pedro J Rivera, Vikramjit Mukherjee

{"title":"Desmopressin-Induced Severe Hyponatremia with Central Pontine Myelinolysis: A Case Report.","authors":"Tanzib Hossain, Marya Ghazipura, Vineet Reddy, Pedro J Rivera, Vikramjit Mukherjee","doi":"10.1007/s40800-018-0084-1","DOIUrl":"https://doi.org/10.1007/s40800-018-0084-1","url":null,"abstract":"Desmopressin, a synthetic vasopressin analog, is used to treat central diabetes insipidus, hemostatic disorders such as von Willebrand's disease, and nocturnal enuresis. We present the case of a 69-year-old man who developed severe hyponatremia during treatment with intranasal desmopressin at 10 µg twice daily for chronic polyuria and nocturia thought to be due to central diabetes insipidus. After 5 months of therapy, the patient noticed progressive fatigue, anorexia, dizziness, weakness, light-headedness, decreased concentration, and new-onset falls. At 6 months of therapy, the patient was brought to the emergency department for altered mental status and was found to be severely hyponatremic with a serum sodium level of 96 mmol/L, down from a value of 134 mmol/L at the initiation of therapy. The intranasal desmopressin was discontinued and the patient was admitted to the intensive care unit where the hyponatremia was slowly corrected over the next week to 132 mmol/L, never increasing by more than 8 mmol/L a day, with careful fluid management. This included infusion of over 11 L of 5% dextrose to account for a high urine output, which peaked at 7.4 L in 1 day. However, while the recommended rate for sodium correction was followed, the patient's magnetic resonance imaging of the brain obtained after discharge displayed evidence of central pontine myelinolysis. Despite this finding, the patient eventually returned to his baseline mental status with no permanent neurologic deficits.","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":"5 1","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2018-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40800-018-0084-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36044062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Severe Adverse Reactions Following Ketoconazole, Fluconazole, and Environmental Exposures: A Case Report. 酮康唑、氟康唑和环境暴露后的严重不良反应:1例报告。

Drug Safety - Case Reports Pub Date : 2018-04-18 DOI: 10.1007/s40800-018-0083-2

Allan Lieberman, Luke Curtis

{"title":"Severe Adverse Reactions Following Ketoconazole, Fluconazole, and Environmental Exposures: A Case Report.","authors":"Allan Lieberman, Luke Curtis","doi":"10.1007/s40800-018-0083-2","DOIUrl":"10.1007/s40800-018-0083-2","url":null,"abstract":"In this case report, we describe a 66-year-old man who developed multiple adverse reactions beginning at age 56 after exposure to several azole antifungal drugs including ketoconazole and fluconazole. He also had a history of more than 40 years exposure to chemicals including pesticides, wood preservatives, fertilizers, and welding chemicals. His reactions involved dehydration (requiring several liters of intravenous fluids in less than an hour to alleviate this condition), angioedema, nausea, tinnitus, hypotension, and difficulty breathing. His acute adverse reactions were triggered by a wide range of chemicals including gasoline, diesel fuel, pesticides, chlorine, topical isopropyl alcohol, and paper mill emissions. His acute reactions were also triggered by a wide range of foods such as bananas, apples, milk, white potatoes, and processed sweets. A number of mechanisms could be responsible for his increased sensitivity to chemicals following exposure to fluconazole/ketoconazole, including inhibition of P450 and other detoxification enzymes, acetaldehyde buildup, and neurogenic sensitization.","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":"5 1","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2018-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40800-018-0083-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36021912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Nephrotoxicity of Ciprofloxacin: Five Cases and a Review of the Literature. 环丙沙星肾毒性5例及文献复习。

Drug Safety - Case Reports Pub Date : 2018-04-18 DOI: 10.1007/s40800-018-0073-4

Meriam Hajji, Hela Jebali, Aymen Mrad, Yassine Blel, Nozha Brahmi, Rania Kheder, Soumaya Beji, Lilia Ben Fatma, Wided Smaoui, Madiha Krid, Fethi Ben Hmida, Lamia Rais, Mohammed Karim Zouaghi

{"title":"Nephrotoxicity of Ciprofloxacin: Five Cases and a Review of the Literature.","authors":"Meriam Hajji, Hela Jebali, Aymen Mrad, Yassine Blel, Nozha Brahmi, Rania Kheder, Soumaya Beji, Lilia Ben Fatma, Wided Smaoui, Madiha Krid, Fethi Ben Hmida, Lamia Rais, Mohammed Karim Zouaghi","doi":"10.1007/s40800-018-0073-4","DOIUrl":"https://doi.org/10.1007/s40800-018-0073-4","url":null,"abstract":"Fluoroquinolones are usually well tolerated with a minimum of serious adverse effects; renal toxicity is uncommon. Apart from the renal side effects of ciprofloxacin, we aimed to highlight the renal impact of a ciprofloxacin overdose, and thus conducted a prospective study in the Department of Nephrology at La Rabta Hospital between 2010 and 2015. The cohort database was continually updated until the inclusion of five patients who were subjected to an overdose and who were initially admitted to the medical intensive care unit and then transferred to our department for acute renal failure (ARF) due to ciprofloxacin ingestion requiring urgent hemodialysis. All patients developed ARF after 12-36 h of ingestion. Renal ultrasound was normal in all cases. Twenty-four-hour proteinuria was present but not significant in one case, while microscopic hematuria was present in one case. Treatment consisted of supportive therapy and extrarenal purification by conventional intermittent hemodialysis. Four patients recovered normal renal function within 3 weeks and the remaining patient eventually had chronic kidney failure.","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":"5 1","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2018-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40800-018-0073-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Drug Safety - Case Reports Pub Date : 2018-04-09 DOI: 10.1007/s40800-018-0080-5

Ang Xu, David Hyman, Lee Bach Lu

{"title":"Cefazolin-Related Acute Interstitial Nephritis with Associated Nephrotic-Range Proteinuria: A Case Report.","authors":"Ang Xu, David Hyman, Lee Bach Lu","doi":"10.1007/s40800-018-0080-5","DOIUrl":"https://doi.org/10.1007/s40800-018-0080-5","url":null,"abstract":"A 67-year-old male with history of well controlled type 2 diabetes mellitus and hypertension developed acute interstitial nephritis (AIN) with nephrotic-range proteinuria during treatment with cefazolin for methicillin-sensitive Staphylococcus aureus and Group B Streptococcus (GBS) bacteremia. The patient received intravenous cefazolin 2 g every 8 h for 4 weeks prior to presentation to the emergency department with abdominal distension, nausea, and vomiting. Investigations revealed a serum ascites albumin gradient of 1.0 with total protein of 1.8 g/dL suggestive of nephrotic syndrome, which was confirmed with a spot urine protein/creatinine ratio that estimated 7.95 g of protein per day. Serum creatinine was elevated compared with baseline. Urine studies showed sterile pyuria with 3+ protein and eosinophiluria. The patient was diagnosed with AIN with nephrotic-range proteinuria associated with cefazolin use. Cefazolin was discontinued and, within a couple of days, the patient's creatinine stabilized. He was discharged with prednisone 60 mg once a day for 10 days with a taper over 2 weeks for his AIN. The patient's creatinine and proteinuria slowly decreased over the next couple of weeks, however, did not recover to baseline. A Naranjo assessment score of 6 was obtained, indicating a probable relationship between the patient's AIN with nephrotic-range proteinuria and his use of cefazolin.","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":"5 1","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2018-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40800-018-0080-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35989491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Acquired Methemoglobinemia Associated with Topical Lidocaine Administration: A Case Report. 获得性高铁血红蛋白血症与局部利多卡因相关:1例报告。

Drug Safety - Case Reports Pub Date : 2018-04-07 DOI: 10.1007/s40800-018-0081-4

Hawkins C Gay, Ansel Philip Amaral

引用次数: 4

Investigation of the Pharmaceutical Care in One Elderly Parkinson's Disease Patient with Psychotic Symptoms. 1例老年帕金森病患者精神病性症状的药学服务调查

Drug Safety - Case Reports Pub Date : 2018-04-06 DOI: 10.1007/s40800-018-0082-3

Chun-Ping Gu, Yue-Liang Xie, Yin-Juan Liao, Cui-Fang Wu, Sheng-Feng Wang, Yu-Lu Zhou, Su-Jie Jia

{"title":"Investigation of the Pharmaceutical Care in One Elderly Parkinson's Disease Patient with Psychotic Symptoms.","authors":"Chun-Ping Gu, Yue-Liang Xie, Yin-Juan Liao, Cui-Fang Wu, Sheng-Feng Wang, Yu-Lu Zhou, Su-Jie Jia","doi":"10.1007/s40800-018-0082-3","DOIUrl":"10.1007/s40800-018-0082-3","url":null,"abstract":"A 66-year-old male patient with a 10-year course of Parkinson's disease (PD) was admitted for hallucination lasting a half a month. After treatment with levodopa/carbidopa, selegiline, and piribedil, the patient's motor symptoms were improved while no significant effects were observed on psychotic symptoms. A clinical pharmacist analyzed the pharmacologic and pharmacokinetic characteristics of selegiline and piribedil, summarized the scheme of PD with psychotic symptoms in the literature, and discovered that selegiline might potentiate psychotic side effects of piribedil, while the use of levodopa/carbidopa cannot be ruled out either. Finally, the clinical pharmacist proposed to reduce the dosage of levodopa/carbidopa, increase the dosage of selegiline and quetiapine, and discontinue piribedil. The clinician accepted this suggestion. After the adjustment of medication, the patient's motor symptoms were absolutely improved and the psychotic symptoms were notably improved. This case study suggests that long-term treatment with levodopa/carbidopa and piribedil, along with the progression of the disease itself, could contribute to the emergence of psychotic symptoms in PD. Additionally, selegiline could potentiate psychotic side effects of piribedil. Neurology clinical pharmacists should work alongside neurology clinicians at the bedside to optimize pharmacotherapy, improve patient safety, and contribute to scholarly efforts.","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":"5 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2018-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40800-018-0082-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35984427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Intravenous Lipid Emulsion Overdose in Infancy: A Case Report and Overview of Opportunities, Challenges and Prevention. 婴儿静脉注射脂乳过量:一例报告及机遇、挑战和预防概述。

Drug Safety - Case Reports Pub Date : 2018-03-19 DOI: 10.1007/s40800-018-0079-y

Wasim Khasawneh, Salar Bani Hani

{"title":"Intravenous Lipid Emulsion Overdose in Infancy: A Case Report and Overview of Opportunities, Challenges and Prevention.","authors":"Wasim Khasawneh, Salar Bani Hani","doi":"10.1007/s40800-018-0079-y","DOIUrl":"https://doi.org/10.1007/s40800-018-0079-y","url":null,"abstract":"Medication errors remain among the major problems seen in hospitals. Such errors can relate to the prescription, dispensation, or administration of drugs. Human factors account for most of these mistakes, but other factors such as infusion pump programming defects should always be considered. Worldwide, medication errors have been reported to affect 2-30% of patients, depending on the institution. Intravenous lipid emulsion (ILE) infusion is frequently used as part of total parenteral nutrition in patients of all ages with feeding and gastrointestinal issues. ILE overdose has been previously reported, with variable clinical outcomes. We report a case of accidental ILE (Intralipid) overdose in a 3-month-old male infant who fully recovered after single-volume blood exchange transfusion. We also review reported cases and summarize potential solutions for ILE overdose. Our review indicates that ILE infusion is a high-risk medication, and opportunities for errors remain even in the best hospital set-ups. Attention should be directed towards proper prescription, dosing, dispensation, and administration. Most of the cases indicate the safety breach was at the nursing drug-administration level, with improper pump use or programming, together with other fluid infusion rate switching, being the main possible defects. Strategies targeting the areas of weakness in the drug-delivery pathway are needed. Special attention should be paid towards nursing duties and working hours. In addition, nursing staff should receive frequent education sessions and should be required to pass competency modules regularly. An error-prevention plan should be established and implemented. This plan needs full collaboration between physicians, pharmacists, and nursing staff.","PeriodicalId":11364,"journal":{"name":"Drug Safety - Case Reports","volume":"5 1","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2018-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40800-018-0079-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35927524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Hyperprogressive Disease and Early Hypereosinophilia After Anti-PD-1 Treatment: A Case Report. 抗pd -1治疗后的超进行性疾病和早期嗜酸性粒细胞增多1例报告。

Drug Safety - Case Reports Pub Date : 2018-03-13 DOI: 10.1007/s40800-018-0078-z

Mario Occhipinti, Rosa Falcone, Concetta Elisa Onesti, Paolo Marchetti

引用次数: 14

Ventricular Tachycardia Triggered by Loperamide and Famotidine Abuse. 洛哌丁胺和法莫替丁滥用引发室性心动过速。

Drug Safety - Case Reports Pub Date : 2018-02-17 DOI: 10.1007/s40800-018-0077-0

Timothy R Larsen, Jedediah McMunn, Hala Ahmad, Soufian T AlMahameed

引用次数: 8