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Chemical Composition and Therapeutic Effects of Several Astragalus Species (Fabaceae). 几种黄芪（豆科）的化学成分和治疗效果。
Doklady Biological Sciences Pub Date : 2024-10-01 Epub Date: 2024-08-11 DOI: 10.1134/S0012496624701096
N K Klichkhanov, M N Suleimanova
{"title":"Chemical Composition and Therapeutic Effects of Several Astragalus Species (Fabaceae).","authors":"N K Klichkhanov, M N Suleimanova","doi":"10.1134/S0012496624701096","DOIUrl":"10.1134/S0012496624701096","url":null,"abstract":"<p><p>The review integrates information on the component composition and biological activity of some Astragalus L. (Fabaceae) species from studies reported over the past 5-7 years. The aerial and underground parts of 34 Astragalus species contain triterpene saponins, flavonoids, polysacharides, tannins, free organic acids, higher fatty acids, vitamins, trace elements, and other constituents. Among the Astragalus species, A. membranaceus (Fisch.) Bunge is the best studied in terms of component composition and biological activity. Anti-inflammatory, immunomodulatory, antioxidant, anticancer, cardioprotective, and hepathoprotective activities have been experimentally detected in total bioactive substances, fractions, and individual compounds extracted from various parts of A. membranaceus and A. membranaceus var. mongholicus in vitro and in vivo. The composition and biological effects of other Astragalus species are still poorly understood. The review summarizes the recent advances in studying new compounds extracted from Astragalus species and their biological activities.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"172-186"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total Mineral Content in Raw Materials of Ten Medicinal Plants from Roadside Biotopes of Voronezh Oblast. 沃罗涅日州路边生物群落中十种药用植物原材料的总矿物质含量。
Doklady Biological Sciences Pub Date : 2024-10-01 Epub Date: 2024-08-11 DOI: 10.1134/S0012496624701126
N A Dyakova
{"title":"Total Mineral Content in Raw Materials of Ten Medicinal Plants from Roadside Biotopes of Voronezh Oblast.","authors":"N A Dyakova","doi":"10.1134/S0012496624701126","DOIUrl":"10.1134/S0012496624701126","url":null,"abstract":"<p><p>The total mineral content was studied in medicinal plants from roadside and railside biotopes of the Voronezh region. Pharmacopoeial plant raw materials of 10 species were evaluated: roots of Taraxacum officinale F.H. Wigg and Arctium lappa L.; herb of Polygonum aviculare L., Artemisia absinthium L., Leonurus quinquelobatus Gilib., and Achillea millefolium L.; leaves of Urtica dioica L. and Plantago major L.; and flowers of Tanacetum vulgare L. and Tilia cordata Mill. Plant raw materials were collected near roads and railways of various types in the periods specified in regulatory documents. The total ash content in plant material was used to determine the minimum allowable distances from various roads and railways for collecting plant material. The minimum allowable distance from heavy-traffic motorways was recommended to be 210 m in the forest zone, 240 m in the forest-steppe zone, and 380 m in the steppe zone. A distance of at least 80 m was recommended for secondary low-speed roads and railways.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"149-155"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Component Composition and Features of Biological Activity of Viscum album (Viscaceae). 粘菌科植物粘菌的成分组成和生物活性特征。
Doklady Biological Sciences Pub Date : 2024-10-01 Epub Date: 2024-08-11 DOI: 10.1134/S0012496624701072
S L Adzhiakhmetova, N M Chervonnaya, D I Pozdnyakov, O I Popova, E T Oganisyan
{"title":"Component Composition and Features of Biological Activity of Viscum album (Viscaceae).","authors":"S L Adzhiakhmetova, N M Chervonnaya, D I Pozdnyakov, O I Popova, E T Oganisyan","doi":"10.1134/S0012496624701072","DOIUrl":"10.1134/S0012496624701072","url":null,"abstract":"<p><p>The review summarizes the data on the chemical composition and some features of biological activity of the European mistletoe Viscum album L. (Viscaceae Batsch). Among secondary metabolites, viscotoxins, lectins, carbohydrates, amino acids, flavonoids, triterpene acids, and nitrogenous compounds predominate in V. album. Mistletoe extracts and their indivdiual components exert various biological activities, including antitumor, immunomodulatory, and antidiabetic activities, and improve cognitive functions.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"116-132"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dependence of Pinus sylvestris (Pinaceae) Radial Growth on Meteorological Conditions and Anthropogenic Air Pollution: Data from Northwestern Part of Murmansk Oblast. 松科植物径向生长与气象条件和人为空气污染的关系：摩尔曼斯克州西北部的数据。
Doklady Biological Sciences Pub Date : 2024-10-01 Epub Date: 2024-08-11 DOI: 10.1134/S0012496624701151
I V Romashkin, N V Genikova, A M Kryshen, S A Moshnikov, N V Polikarpova
{"title":"Dependence of Pinus sylvestris (Pinaceae) Radial Growth on Meteorological Conditions and Anthropogenic Air Pollution: Data from Northwestern Part of Murmansk Oblast.","authors":"I V Romashkin, N V Genikova, A M Kryshen, S A Moshnikov, N V Polikarpova","doi":"10.1134/S0012496624701151","DOIUrl":"10.1134/S0012496624701151","url":null,"abstract":"<p><p>The influence of meteorological factors and anthropogenic air pollution on the radial growth of the Scots pine Pinus sylvestris L. was studied as dependent on the distance from the Pechenganickel mining and metallurgical plant (Nikel, Murmansk region). Three (control, buffer, and impact) zones of the pollution gradient were identified based on the contents of main polluting elements (S, Ni, and Cu) in the forest litter. A significant weakening of pine stands was observed in the impact zone and attributed to the combined effect of long-term anthropogenic pollution of the 1970s and unfavorable weather events of the mid-1980s. As the emission decreased from 1988 to 2018, the radial increment of P. sylvestris was observed to increase significantly (by up to 44%) in the impact zone and to remain much the same in the control and buffer zones. More recently, the radial increment of trees in the impact zone reached and even exceeded the values observed in the control zone, although the trees examined were relatively old. The finding demonstrated again the high adaptive capacity of P. sylvestris.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"205-217"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of Anthropogenic Pollutants in Adipose Tissue of the Caspian Seal Pusa caspica Gmelin, 1788 by High-Resolution Accurate Mass Spectrometry. 利用高分辨率精确质谱法测定里海海豹 Pusa caspica Gmelin, 1788 脂肪组织中的人为污染物。
Doklady Biological Sciences Pub Date : 2024-10-01 Epub Date: 2024-08-11 DOI: 10.1134/S0012496624600180
A A Shelepchikov, A D Kudryavtseva, E S Brodsky, E Ya Mir-Kadyrova, M A Solovyeva, F V Klimov, V V Rozhnov
{"title":"Determination of Anthropogenic Pollutants in Adipose Tissue of the Caspian Seal Pusa caspica Gmelin, 1788 by High-Resolution Accurate Mass Spectrometry.","authors":"A A Shelepchikov, A D Kudryavtseva, E S Brodsky, E Ya Mir-Kadyrova, M A Solovyeva, F V Klimov, V V Rozhnov","doi":"10.1134/S0012496624600180","DOIUrl":"10.1134/S0012496624600180","url":null,"abstract":"<p><p>Tissue contamination with persistent organic pollutants (POPs) in organisms proved possible to comprehensively characterize in a single test by combining gas chromatography and high-resolution accurate mass spectrometry. Adipose tissue samples were collected from two Caspian seals (Pusa caspica Gmelin, 1788) found dead on the Caspian Sea shore in 2020. Organochlorine pesticides, primarily DDT and HCH, and polychlorinated biphenyls (PCBs) were major pollutants found in the Caspian seals. The distribution of metabolites indicated the absence of recent pesticide use. The PCB content was relatively high, but still at the lower limit of the range of values determined previously, as was also the case with pesticides. Chlordanes, polychlorinated naphthalenes, and polybrominated diphenyl ethers were detected in minor quantities and were therefore not considered to be major pollutants of the Caspian seal. The pollutant levels were below a threshold at which a distinct effect on seal health can be expected. High-resolution accurate mass (HRAM) spectrometry was found to provide a convenient tool for both targeted and nontargeted analyses of a wide range of organic pollutants in a single experiment.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finds of Skulls of Juvenile Kurdalagonus maicopicus (Cetacea, Cetotheriidae) in the Upper Miocene of the Republic of Adygea. 在阿迪格共和国上新世发现幼年库尔达拉贡鱼头骨（鲸目动物，Cetotheriidae）。
Doklady Biological Sciences Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1134/S0012496624701011
K K Tarasenko
{"title":"Finds of Skulls of Juvenile Kurdalagonus maicopicus (Cetacea, Cetotheriidae) in the Upper Miocene of the Republic of Adygea.","authors":"K K Tarasenko","doi":"10.1134/S0012496624701011","DOIUrl":"10.1134/S0012496624701011","url":null,"abstract":"<p><p>Fragments of two skulls of young cetotheriid baleen whales were described from the Fortep'yanka 2 locality (Russia, Republic of Adygea, Maikop district, Fortep'yanka River valley, Upper Miocene, Upper Sarmatian, Blinovskaya Formation). The finds were attributed to Kurdalagonus maicopicus (Spasskii, 1951) based on the morphology of the posterior (mastoid) process of the petrosal bone, the structure of the posterior edge of the temporal fossa, and the S-like shape of the supraoccipital ridges. The skull proportions and the degree of suture closure made it possible to determine the individual age of the whales within a year. New finds significantly complement the data on the structure of the sutures of the lateral wall of the skull and age-related variability of cranial morphology in representatives of the genus Kurdalagonus.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"73-76"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined Effect of Basic Antiherpetic Drugs with a New Inhibitor of the Terminase Complex of Herpes Simplex Virus Type 1 in Vero Cell Cultures. 基本抗带状疱疹药物与 1 型单纯疱疹病毒终末酶复合物新抑制剂在 Vero 细胞培养物中的联合作用
Doklady Biological Sciences Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1134/S0012496624701035
V L Andronova, G A Galegov, O A Vozdvizhenskaya, G L Levit, V P Krasnov, V N Charushin
{"title":"Combined Effect of Basic Antiherpetic Drugs with a New Inhibitor of the Terminase Complex of Herpes Simplex Virus Type 1 in Vero Cell Cultures.","authors":"V L Andronova, G A Galegov, O A Vozdvizhenskaya, G L Levit, V P Krasnov, V N Charushin","doi":"10.1134/S0012496624701035","DOIUrl":"10.1134/S0012496624701035","url":null,"abstract":"<p><p>Carriers of herpes simplex virus type 1 (HSV-1) account for more than 90% of the global population. Infection manifests itself in the formation of blisters and ulcers on the face or genitals and can cause blindness, encephalitis, and generalized infection. All first- and second-line modern antiherpetic drugs selectively inhibit viral DNA polymerase. The purine-benzoxazine conjugate LAS-131 ((S)-4-[6-(purin-6-yl)aminohexanoyl]-7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine), which we have described earlier, uses the large subunit of the HSV-1 terminase complex as a biotarget and selectively inhibits HSV-1 reproduction in vitro. Basically new results were for the first time obtained to characterize the combined effect on human herpesvirus infection for LAS-131 used in combination with practically significant antiviral compounds, including the nucleoside analogs acyclovir (ACV), penciclovir (PCV), ganciclovir (GCV), brivudine (BVdU), iododeoxyuridine (IdU), and adenine arabinoside (Ara-A); the nucleoside phosphonate analog cidofovir (CDV); and the pyrophosphate analog foscarnet (FOS). A cytopathic effect (CPE) inhibition assay showed that the drug concentration that inhibited the virus-induced CPE by 50% decreased by a factor of 2 (an additive effect, FOS) or more (a synergistic effect; ACV, PCV, GCV, IdU, BVdU, Ara-A, and CDV) when the drugs were used in combination with LAS-131. Nonpermissive conditions for HSV-1 reproduction were thus created at lower drug concentrations, opening up new real possibilities to control human herpesvirus infection.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"55-58"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fauna and Landscapes of the Southern Minusinsk Basin (Southern Siberia) at the End of the Late Pleistocene. 晚更新世末期米努辛斯克盆地南部（南西伯利亚）的动物群和地貌。
Doklady Biological Sciences Pub Date : 2024-08-01 Epub Date: 2024-06-10 DOI: 10.1134/S0012496624701059
D G Malikov
{"title":"Fauna and Landscapes of the Southern Minusinsk Basin (Southern Siberia) at the End of the Late Pleistocene.","authors":"D G Malikov","doi":"10.1134/S0012496624701059","DOIUrl":"10.1134/S0012496624701059","url":null,"abstract":"<p><p>Paleolandscapes of the first half of MIS 2 or the Last Glacial Maximum (LGM) were reconstructed based on the study of the first mammoth fauna locality found in the Abakan River valley and a comparison with other localities of the South Minusinsk Basin. Sediments of the Uytag geological section under study included silt interlayers underlain and overlain by sandstone rock slack fragments and were interpreted as weakly eroded diluvium. Studies of the Uytag locality made it possible to clarify the time and range of distribution in southern Siberia for several mammals (Ovis ammon, Equus ferus, Marmota baibacina, Sicista subtilis, Lagurus lagurus, and Microtus gregalis) and the Pleistocene bird Aquila chrysaetos. The age of the locality was confirmed by radiocarbon dating. The species composition of the Uytag fauna was similar to that of other localities of the same age and region. All known localities and single finds of faunal remains indicate that open steppe landscapes were widely developed in the South Minusinsk Basin during the LGM.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"82-87"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Keeping and Behavior of the Acorn Worm Saccoglossus mereschkowskii (Hemichordata, Enteropneusta) in Laboratory Conditions. 橡子虫 Saccoglossus mereschkowskii（半知觉虫类，Enteropneusta）在实验室条件下的饲养和行为。
Doklady Biological Sciences Pub Date : 2024-08-01 Epub Date: 2024-06-10 DOI: 10.1134/S0012496624701047
A I Lukinykh, O V Ezhova, D A Klochikhina, O M Katanova, V V Malakhov
{"title":"Keeping and Behavior of the Acorn Worm Saccoglossus mereschkowskii (Hemichordata, Enteropneusta) in Laboratory Conditions.","authors":"A I Lukinykh, O V Ezhova, D A Klochikhina, O M Katanova, V V Malakhov","doi":"10.1134/S0012496624701047","DOIUrl":"10.1134/S0012496624701047","url":null,"abstract":"<p><p>A box was designed to keep the acorn worm Saccoglossus mereschkowskii in laboratory conditions for 60 days and to monitor its behavior and feeding. Locomotion and construction of burrows in the sediment were found to be due to peristaltic movements of the proboscis, which periodically changes its shape from cylindrical to mushroom-like, and vice versa. Worms built U-shaped burrows connected with burrows of neighbor worms by flank anastomoses, thus producing a branched system of passages in a sediment layer up to 8 cm deep. The system is of importance for aeration of the upper sediment layer. When a worm is feeding, the proboscis sticks out from the anterior opening of the burrow and stretches along the surface of the sediment. Organic particles adhere to mucus secreted by the epidermal epithelium of the proboscis and are transported by ciliary beating to a furrow between the collar and proboscis, where the mouth is located.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"77-81"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complete Mitochondrial Genome of Clupeonella abrau (Maliatsky, 1930) (Clupeiformes), an Endemic Freshwater Fish from the Lake Abrau (Russia). 俄罗斯阿布拉乌湖特有淡水鱼 Clupeonella abrau (Maliatsky, 1930) (Clupeiformes) 的完整线粒体基因组。
Doklady Biological Sciences Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1134/S0012496624700996
D P Karabanov, D D Pereboev, B D Efeykin, Yu V Kodukhova, A A Kotov
{"title":"Complete Mitochondrial Genome of Clupeonella abrau (Maliatsky, 1930) (Clupeiformes), an Endemic Freshwater Fish from the Lake Abrau (Russia).","authors":"D P Karabanov, D D Pereboev, B D Efeykin, Yu V Kodukhova, A A Kotov","doi":"10.1134/S0012496624700996","DOIUrl":"10.1134/S0012496624700996","url":null,"abstract":"<p><p>The Abrau sprat (tyulka or sardelka) Clupeonella abrau (Maliatsky, 1930) is an endemic fish of the Lake Abrau (Krasnodar Krai, Russia). The full C. abrau mitochondrial genome (16 650 bp) showed a gene arrangement conserved in Clupeidae and 98.8% similarity with the mitochondrial genome of the related species Black and Caspian Sea sprat C. cultriventris from the Black Sea. The COX1 gene sequence was additionally studied in a museum specimen collected in the Lake Abrau in 1938. Variability in modern Abrau sprat COX1 gene locus was estimated at approximately 0.15%, the difference between C. abrau and C. cultriventris was 1.2%, and the difference between the museum and modern C. abrau specimens from the Lake Abrau was 0.92%. The study confirmed that the Abrau sprat is present in the fish community and is capable of reproducing in the lake. Various scenarios were proposed to explain colonization of the Lake Abrau by C. abrau.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"63-68"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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