Dermatology Research and Practice最新文献

{"title":"Histopathological Patterns of Cutaneous and Mucocutaneous Leishmaniasis Due to <i>L. aethiopica</i>.","authors":"Abay Atnafu, Zewditu Chanyalew, Sofia Yimam, Meaza Zeleke, Shimelis Negussie, Selfu Girma, Aklilu Melaku, Menberework Chanyalew","doi":"10.1155/drp/5267606","DOIUrl":"10.1155/drp/5267606","url":null,"abstract":"<p><p><b>Background:</b> Cutaneous leishmaniasis (CL) is an endemic disease in Ethiopia, mainly caused by <i>L. aethiopica</i>. Limited reports are available related to histopathological features of the skin lesion caused by <i>L. aethiopica</i>. This study aimed to analyze the histopathological features of CL due to <i>L. aethiopica</i>. <b>Materials and Methods:</b> A similar cohort polymerase chain reaction (PCR) confirmed CL patients from a previous own study, who were prospectively enrolled from All Africa Leprosy, Tuberculosis and Rehabilitation Training (ALERT) Hospital Addis Ababa, Kela Health Center in Gurage Zone, Siliti Health Center in Silit zone of southern nations and nationalities, as well as Ankober Health Center in Amhara region was used for data analysis. The histopathology was analyzed by performing hematoxylin and eosin (H&E) staining to look for the presence of general and specific histopathology patterns of the disease. Descriptive statistics was utilized using SPSS version 26.0 (SPSS, Inc., Chicago, United States of America). <b>Results:</b> Amastigotes were observed in skin biopsies of 29% (<i>n</i> = 2) mucocutaneous leishmaniasis (MCL) and 58% (<i>n</i> = 6) localized cutaneous leishmaniasis (LCL) patients. Diffused inflammatory cell infiltrate was observed in the dermal compartment of 77% (<i>n</i> = 20) samples while the remaining 23% (<i>n</i> = 6) had patchy or nodular inflammatory cell infiltrate. The dominant type of inflammatory cell infiltrate in the dermal compartments is macrophages and lymphocytes with a similar proportion, 23/26 (88.5%), followed by plasma cells, 21/26 (80.8%). Among all cases, 38.5% (<i>n</i> = 10) of them were categorized under the Type I pattern while Types IV and V patterns were reported in 26.9% (<i>n</i> = 7) and 34.6% (<i>n</i> = 9) of the remaining samples, respectively. The study found statistically significant correlations between necrosis and MCL (<i>p</i>=0.01), unorganized granulomas and LCL (<i>p</i>=0.04), and the presence of eosinophils and giant cell Langerhans with MCL (<i>p</i>=0.002 and <i>p</i> < 0.001, respectively). <b>Conclusion:</b> In our study, the histopathological patterns of the CL caused by <i>L. aethiopica</i> were shown to have a dermal change that was characterized by a domination of diffused inflammatory cell infiltrate. Most of the cell types in the infiltrate were macrophages and lymphocytes. In addition, amastigote resided in the histiocyte with a varying degree of intensity, and both the organized and unorganized granulomas were shown with a considerable proportion.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"5267606"},"PeriodicalIF":1.5,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Sample Storage Envelopes in Collecting Scales From the Skin and Nails for Mycology Laboratory Diagnosis of Superficial Fungal Infection.","authors":"Lalita Matthapan, Sumanas Bunyaratavej, Charussri Leeyaphan, Pantaree Kobkurkul, Thrit Hutachoke, Supisara Wongdama, Suthasanee Prasertsook, Bawonpak Pongkittilar, Chatisa Panyawong, Waranyoo Prasong, Akkarapong Plengpanich","doi":"10.1155/2024/6325772","DOIUrl":"10.1155/2024/6325772","url":null,"abstract":"<p><p><b>Background:</b> Fungal cultures are unavailable in many hospitals. The development of an effective sample storage solution for timely transportation would improve management of patients with superficial fungal skin and nail infections. <b>Objectives:</b> This study aimed to evaluate the efficacy of sample storage envelopes to preserve skin and nail samples for timely microscopic examination and culture for superficial fungal infections. <b>Methods:</b> Patients aged 18 years and above with suspected superficial fungal infections were enrolled. The samples were divided into four envelopes. The baseline 20% potassium hydroxide (KOH) examination and fungal culture served as reference points. The stored samples were reexamined on Days 3, 7, 14, and 28. <b>Results:</b> The study included 90 patients with suspected superficial fungal infections (45 skin and 45 nail lesions). Reference KOH examinations showed branching septate hyphae in 36 (80.0%) for skin and 35 (77.8%) for nail infections. Reference fungal cultures were positive for the growth of dermatophyte and nondermatophyte molds in 34 (75.6%) and 28 (62.2%) in skin and nail infections, respectively. Sample storage envelopes maintained 100% sensitivity and specificity for up to 28 days with KOH examination for both skin and nail samples. On Day 28, the fungal culture sensitivity was 70.6% for the skin and 64.3% for the nail samples, with specificities of 100.0% and 88.2%, respectively. <b>Conclusions:</b> Sample storage envelopes effectively maintained diagnostic accuracy for up to 28 days with KOH examination for both skin and nail samples. Given the high specificity even on Day 28 for fungal culture, transferring samples within 28 days remains a reliable practice.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"6325772"},"PeriodicalIF":1.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Vitamin D₃ Derivative (Calcipotriol) Versus Intralesional Vitamin D₃ in the Treatment of Cutaneous Warts: A Clinical Therapeutic Comparative Trial.","authors":"Rand A Almuhyi, Khalil I Alhamdi, Dooha K Alhamdi","doi":"10.1155/2024/5236290","DOIUrl":"https://doi.org/10.1155/2024/5236290","url":null,"abstract":"<p><p><b>Background:</b> Cutaneous warts are epidermal proliferations caused by human papillomavirus. There are a variety of treatment options for warts with different success rates. Intralesional vitamin D₃ injection is an innovative treatment option for warts, and several studies have examined its efficacy. To the best of our knowledge, this is the first study to compare the two modalities of vitamin D₃ in wart treatment. <b>Objective:</b> To evaluate and compare the efficacy of topical vitamin D₃ derivative (calcipotriol) and intralesional vitamin D₃ in the treatment of warts. <b>Patients and Methods:</b> This is an open-label, therapeutic, comparative, clinical study involving 56 patients with warts. The patients were randomly divided into two equal groups (<i>n</i> = 28). Group A was treated with topical calcipotriol ointment (0.005%) twice daily for a period of 8 weeks, while Group B was treated with intralesional injection of 0.2-0.3 mL of vitamin D₃ (300,000 I.U. per ampule) for 4 sessions (2 weeks apart). The patients were followed every 2 weeks during treatment and then 3 months after the last visit. <b>Results:</b> The percentage of patients who showed a complete response in Group A was higher than that of Group B (95% vs. 59%). Furthermore, 9 patients out of 13 (69.2%) who showed a complete response in Group B required a period of 8 weeks, while only 2 patients out of 21 (9.5%) in Group A required the same period. In addition, side effects were more in Group B. Moreover, no recurrence was observed in Group A, while in Group B, it was seen in 2 (11%) patients. <b>Conclusions:</b> Both topical and intralesional vitamin D₃ are effective in the treatment of warts, with topical vitamin D₃ having better efficacy, faster, less side effects, and less risk of recurrence.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"5236290"},"PeriodicalIF":1.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of Demographic and Clinical Criteria Between Male and Female Patients With Pemphigus Referred to a Referral Hospital in Iran.","authors":"Zeinab Aryanian, Kamran Balighi, Nafiseh Esmaeli, Maryam Daneshpazhooh, Nasim Mazloomi Tootoonchi, Zahra Razavi, Fereshteh Beigmohammadi, Umamah Gul, Azadeh Khayyat, Parvaneh Hatami","doi":"10.1155/2024/9572303","DOIUrl":"10.1155/2024/9572303","url":null,"abstract":"<p><p><b>Background:</b> Pemphigus is a rare autoimmune disease characterized by the formation of blisters on the skin and mucous membranes, caused by autoantibodies against desmoglein, a key protein in cell adhesion. This study aims to compare demographic and clinical criteria between male and female patients with pemphigus referred to a referral hospital, utilizing data from the pemphigus diseases registry. <b>Method:</b> This retrospective cross-sectional analysis focused on several key aspects age at disease onset, severity (measured by the Pemphigus Disease Area Index [PDAI]), types of pemphigus, duration of disease, and diagnostic criteria including the presence of antidesmoglein antibodies and findings from direct immunofluorescence (DIF). By examining these variables among a cohort selected based on their diagnosis of pemphigus, the study aimed to identify significant gender differences in disease manifestation, diagnosis, and progression. This approach is crucial for tailoring more effective gender-specific management and treatment strategies for this rare autoimmune condition. <b>Results:</b> In a comprehensive analysis of 1218 pemphigus patients in the year 2021 from the hospital's registry, comprising 543 males (44.6%) and 675 females (55.4%), significant gender differences were identified in 9 out of 44 variables examined. The study revealed that males had a higher age at disease onset, more frequent clinical manifestations in the head, neck, and trunk areas, and greater severity of disease as measured by the PDAI score compared to females. Conversely, females exhibited higher instances of mucosal manifestations and a higher PDAI score for mucosal erosion blister of the lower gingiva. No significant gender differences were found in 21 variables, including the overall age of patients, specific clinical manifestations across various mucous membranes, types of pemphigus, and PDAI scores for mucosal erosions in particular locations, indicating a nuanced gender impact on the presentation and severity of pemphigus that necessitates tailored clinical approaches. <b>Conclusion:</b> The study highlights significant gender differences in the presentation and severity of pemphigus, underscoring the importance of gender-specific approaches in the diagnosis and management of this condition. The findings contribute valuable insights into the complex nature of pemphigus and underline the necessity for further research to understand the underlying mechanisms driving these differences.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"9572303"},"PeriodicalIF":1.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and Prognostic Values of Skin Lesions in Patients with COVID-19.","authors":"Mahmoud A Rageh, Ibrahim H E Yousef, Yaser Hosny Ali Elewa, Mofreh Mansour, Omar AbdelHady Omar Ahmed, Sameh Fawzy Fahmy, Ahmad Saeed Aladl, Mohamed Amer, Emad El Rewiny, Manar Elsayed Sallam, Amr Mohammad Ammar, Salma S Mohammed, Ahmed Shawky","doi":"10.1155/2024/4975523","DOIUrl":"https://doi.org/10.1155/2024/4975523","url":null,"abstract":"<p><p>The dermatological manifestations of the coronavirus cause severe acute respiratory syndrome. The current study investigates the morphological and histopathological relationship between the emergence of skin lesions and the severity of COVID-19 across the course of the disease via a cross-sectional study. There were skin lesions (maculopapular rash, vesiculobullous lesions, urticarial lesions, cutaneous thromboembolic \"CT,\" and erythema multiforme-like lesions \"EM-like\") in confirmed COVID-19 instances. A total of 150 patients of both sexes were evaluated morphologically and were classified as early (44% of the total) or late based on the emergence of respiratory symptoms (one week before or two weeks after, respectively). The early and late diagnostic groups represented 44% and 56% of the total patients, respectively. Patients with no skin lesion and one skin lesion showed a significant correlation with disease timeline early and late stages (<i>X</i>2 = 22.38, <i>P</i> < 0.001; <i>X2</i> = 4.432, <i>P</i> < 0.001, respectively). CT and EM-like were correlated with the disease severity, <i>X</i>2 = 50.51, <i>P</i> < 0.001; <i>X</i>2 = 19.186, <i>P</i> ≤ 0.001, respectively. In conclusion, our data suggested that the onset of dermatological lesions that developed during the COVID-19 pandemic may be a useful diagnostic and prognostic tool for COVID-19 severity. Therefore, a thorough examination of the skin may save time and bring physicians to an accurate diagnosis and, as a result, prompt treatment.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"4975523"},"PeriodicalIF":1.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiologic, Clinical and Mycological Profile of Onychomycosis in the Hospital Setting in Benin.","authors":"Fabrice Akpadjan, Yolande Sissinto Savi De Tove, Aminath Fèmie Tidjani, Cordule Balola, Laura Dotsop, Bérénice Degboe, Nadège Agbessi, Christiane Koudoukpo, Hugues Adegbidi, Félix Atadokpede, Florencia do Ango-Padonou","doi":"10.1155/2024/1056753","DOIUrl":"10.1155/2024/1056753","url":null,"abstract":"<p><p><b>Introduction:</b> Onychomycosis accounts for 50% of nail disorders and remains one of the most frequent reasons for consultation in dermatology. Several factors favour the development of onychomycosis, such as age, morphological abnormalities of the nails, immunodeficiency and certain underlying pathologies. The aim was to study the epidemiological and diagnostic profile of onychomycosis in patients treated in the dermatology and venerology department of the Benin referral hospital. <b>Patients and Methods:</b> This was a retrospective study conducted from 2003 to 2022, covering patients treated for onychomycosis in the Dermatology-Venerology University Clinic at the National University Hospital Center Hubert Koutoukou Maga (NUHC-HKM) in Cotonou. <b>Results:</b> During the study period, 389 new patients were seen for onychopathy, 301 of whom had a clinical suspicion of onychomycosis. Of these, 128 were confirmed by mycological examination, giving a hospital frequency of onychomycosis of 32.90% compared with onychopathy. The mean age was 44.93 ± 12.50 years; the patients were predominantly female, with a sex ratio (M/F) of 0.41. Aesthetic complaints (76.47%) were the most frequent reason for consultation, and the nail of the hand was the most common lesion location. Melanonychia was the most frequent morphological anomaly, and distolateral subungual onychomycosis was the most frequent clinical form. Yeasts (86.92%) were the most isolated group of fungi, followed, respectively, by moulds (08.44%) and dermatophytes (04.64%). <i>Candida albicans</i> (21.52%) was the most common species. <b>Conclusion:</b> Onychomycosis is relatively uncommon in hospitals in Benin. This is underestimated because most patients with a clinical suspicion of onychomycosis do not undergo a mycological examination before being put on antifungal treatment.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"1056753"},"PeriodicalIF":1.5,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude of Psoriasis and Its Associated Factors, and Quality of Life of Psoriasis Patients among Patients Who Attend Dermatology Clinic at Tibebe Ghion Comprehensive Specialized and Addis Alem Primary Hospitals, North West Ethiopia, 2022: Institution-Based Cross-Sectional Study.","authors":"Wosen Ketema, Solomon Ketema Bogale, Eyob Ketema Bogale","doi":"10.1155/2024/5560174","DOIUrl":"https://doi.org/10.1155/2024/5560174","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is a common immune-mediated papulosquamous inflammatory skin disease characterized by well-demarcated, erythematous silvery scaly plaques. Prevalence rates of psoriasis showed a worldwide variation and have been reported to range between 0.09% and 5.1%. It has been associated with several intrinsic as well as extrinsic factors and has a detrimental effect on health-related quality of life. Studies on the burden, factors associated with it, and quality of life of psoriasis are limited in the study area.</p><p><strong>Objectives: </strong>To assess the magnitude, factors associated with it, and quality of life of psoriasis patients.</p><p><strong>Methods: </strong>Institution-based cross-sectional study was conducted among patients who attend dermatology clinics at Tibebe Ghion comprehensive specialized and Addis Alem primary hospitals from June 8 to September 5, 2022. Systematic random sampling was applied to select study participants until the sample size (318) was fulfilled. A structured interviewer-administered questionnaire was used to collect data. Collected data were coded and entered into EPI data version 3.1 and then exported to SPSS version 27 for analysis. Descriptive statistics and logistic regression analysis were done.</p><p><strong>Result: </strong>The mean age of study participants was 22.5 with a standard deviation (SD) of 18.2 years. The proportion of psoriasis was 5.3% with a 95% CI (3.1%, 8.4%). Stressful life events (AOR = 3.32, 95% CI (1.12, 9.86)) and alcohol consumption (AOR = 3.73, 95% CI (1.03, 13.51)) were significantly associated with psoriasis. Seven (41.2%) psoriasis patients had a large effect on their quality of life. The mean dermatology quality of life index (DLQI) was 9.82.</p><p><strong>Conclusion: </strong>The proportion of psoriasis in this study was comparable to earlier international and Ethiopian studies, but greater than studies from other African countries. Stressful life events and alcohol consumption were significantly associated with psoriasis. The majority of psoriasis patients had a large negative effect on their quality of life.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"5560174"},"PeriodicalIF":1.5,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Biological Verification of the Healing Effect of Biphasic Microcurrent Electrical Stimulation in Model Rats of Skin Abrasion.","authors":"Akira Sakaguchi, Yuzuru Sakaue, Shuhei Haraguchi, Daisuke Hasegawa, Rui Tsukagoshi, Kotaro Kawaguchi, Hideyuki Yamamoto","doi":"10.1155/2024/4549761","DOIUrl":"10.1155/2024/4549761","url":null,"abstract":"<p><p>In this study, we investigated the effect of biphasic microcurrent electrical stimulation (b-MES) on the epidermal healing process using a rat model of skin abrasion. We analyzed the expression levels of growth factors [fibroblast growth factor 2 (FGF2) and epidermal growth factor (EGF)] and keratin subtypes (K10) in both the b-MES and control groups at different time points after wounding. The b-MES group showed a significantly accelerated healing process of the epithelial tissue, resulting in more consistent healing as compared to the control group. A molecular biological analysis showed that the FGF2 mRNA expression level on Day 2 after wounding was significantly higher in the b-MES group, whereas the EGF mRNA expression level on Days 1, 2, and 4 after wounding was significantly lower in the b-MES group. Additionally, the K10 mRNA expression level on Days 1 and 2 after wounding was significantly higher in the b-MES group. Our study findings suggest that b-MES facilitates wound healing by regulating the growth factors. However, the precise mechanisms underlying these effects remain to be fully elucidated. Further research is needed to fully understand the therapeutic potential of b-MES and its applications in clinical setting. Clinically, m-MES requires shunting due to residual electrical charge at the application site. However, b-MES alternates polarity, leaving no charge at the site of application. Therefore, b-MES also has the advantage of being safer and allowing treatment for longer periods of time.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"4549761"},"PeriodicalIF":1.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shedding Light on Shadows: A Cross-Sectional Analysis of Genital Psoriasis and Its Effects on Thai Individuals.","authors":"Prameyuda Watchirakaeyoon, Pantaree Kobkurkul, Kanokvalai Kulthanan, Chayada Chaiyabutr, Chanisada Wongpraparut, Leena Chularojanamontri, Narumol Silpa-Archa","doi":"10.1155/2024/7006796","DOIUrl":"https://doi.org/10.1155/2024/7006796","url":null,"abstract":"<p><strong>Background: </strong>Limited knowledge exists about genital psoriasis in Thai individuals.</p><p><strong>Objectives: </strong>This study aimed to assess the clinical features of genital psoriasis and its effects on quality of life and sexual health in Thai patients.</p><p><strong>Materials and methods: </strong>A cross-sectional, self-administered question-based study was conducted at Siriraj Hospital. Participants were psoriasis patients older than 18 years of age with past or current genital involvement. The study assessed quality of life and sexual health.</p><p><strong>Results: </strong>Among the 50 patients, 33 (66%) were female. The mean (standard deviation) age was 45.4 (±13.4) years. Genital psoriasis was active in 34% of the participants. The mons pubis (48.5%) and labia majora (18.2%) were the most frequently affected sites in females, while in males, the penile shaft (52.9%) and glans (47.1%) were the most common sites. Itch-related symptoms predominated, affecting 82% of patients. The median dermatology life quality index score was 6.5 for females and 10 for males. A sexual health survey revealed that 54% of participants had low self-esteem. This issue was more pronounced in males, with 76.5% reporting lower self-esteem compared to 42.4% of females (<i>P</i>=0.022). Males were also more inclined to postpone or avoid marriage (47.1% vs. 15.6%, <i>P</i>=0.038) and more embarrassed about sexual activities (63.6% vs. 14.3%, <i>P</i>=0.017). In addition, males were more inclined to avoid sexual encounters due to their genital condition. Notably, 42.9% of all patients had never disclosed to a doctor that they had genital psoriasis.</p><p><strong>Conclusions: </strong>Genital psoriasis impacts quality of life and sexual function, with male patients being particularly impacted. Improved awareness of these issues among health professionals might increase patient satisfaction.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"7006796"},"PeriodicalIF":1.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11405103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Application of Camel Milk as a Therapeutic Ingredient in Bath Soaps and Shampoos.","authors":"Elly Oginga, Julius Toeri, Eunice Marete, Joshua Arimi","doi":"10.1155/2024/4846339","DOIUrl":"10.1155/2024/4846339","url":null,"abstract":"<p><p>The increasing worldwide market for natural-ingredient-based cosmetic toiletries is fuelled by the awareness of the dangers of synthetic cosmetics and benefits of natural-based cosmetics on the skincare and management of skin disorders. Besides naturally formulated cosmetics being biodegradable, they also contain ingredients which are chemically beneficial to human skin. Milk-based cosmetics are very promising since milk is rich in essential components such as lactoferrins, vitamins, and lactic acids, which have shown therapeutic properties against disorders such as skin cancer, acne scars, and dandruff. One of the milk that is very promising in the cosmetics industry is the camel milk. Currently, there is limited information in literature regarding the use of camel milk in cosmetics and their benefits. Camel milk stands out from bovine milk following its unique therapeutic properties and chemical composition, making it a potential ingredient for skincare and haircare products such as bath soaps and shampoos. The aim of this paper is to review the available literature on camel milk composition and evaluate the contribution of camel milk constituents to cosmetics.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"4846339"},"PeriodicalIF":1.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}