Dermatology Research and Practice最新文献

{"title":"Review on the Application of Biologic Factors in Atopic Dermatitis and Chronic Spontaneous Urticaria.","authors":"Aikaterini Salavoura","doi":"10.1155/drp/5283760","DOIUrl":"10.1155/drp/5283760","url":null,"abstract":"<p><strong>Purpose: </strong>The use of biologic factors in atopic dermatitis (AD) and chronic spontaneous urticaria (CSU).</p><p><strong>Methods: </strong>Data from different phase clinical trials, including RCTs and observational and real-world evidence, which were published in PubMed, were classified according to parameters evaluating AD and CSU. The keywords included the scientific names of different biological factors, AD and CSU.</p><p><strong>Results: </strong>Recalcitrant cases of AD and chronic CSU are rare, but they impose a burden on the lives of patients and a significant treatment cost. Monoclonal antibodies are currently used to treat a variety of autoimmune skin disorders. However, direct application of previous experience to AD and CSU was not applicable, because AD etiology involves a number of cytokine networks, and CSU seems to be related to a disorganized cytokine background.</p><p><strong>Conclusions: </strong>Dupilumab is ans FDA- and EMA-approved monoclonal antibody, which is effective in 40%-60% of severe AD cases. FDA/EMA-approved are also baricitinib, upadacitinib, and tralokinumab, which could be used as an alternative option. As our knowledge of the endotypes of the disease expands, precision medicine will be applied for the best results. Omalizumab has been used in clinical trials and real-life cases to treat CSU, but a debate on the efficacy of the monoclonal is frequently reported. However, EACCI's current guidelines for the disease include omalizumab as an add-on treatment for recalcitrant cases.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2026 ","pages":"5283760"},"PeriodicalIF":2.0,"publicationDate":"2026-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of <i>Gynostemma pentaphyllum</i> Extract in Combating H₂O₂-Induced Oxidative Stress and Preventing Hair Graying.","authors":"Xiaojin Liu, Lei Chang, Yaqian Qiu, Xiaobing Lv, Tiancheng Ji","doi":"10.1155/drp/1775262","DOIUrl":"10.1155/drp/1775262","url":null,"abstract":"<p><strong>Objectives: </strong>Hair graying, often linked to aging (oxidative stress), has gained significant attention due to its social implications and the desire for a youthful appearance. Currently, there is no effective solution. The objective of this study was to determine whether <i>Gynostemma pentaphyllum</i> (Thunb.) Makino extract (GP) can mitigate the effects of H₂O₂-induced oxidative stress in melanocytes and evaluate its potential as a treatment for hair graying.</p><p><strong>Methods: </strong>Oxidative stress models were established using B16 melanoma cells and C57BL/6 mice. GP treatment's effects on cell viability, melanocyte apoptosis, intracellular reactive oxygen species (ROS) levels, melanin production, tyrosinase activity, total superoxide dismutase (SOD) activity, and the Wnt/β-catenin signaling pathway were assessed. In animal experiments, the protective effects of GP on mouse hair follicles were evaluated.</p><p><strong>Results: </strong>GP treatment enhanced cell viability, decreased melanocyte apoptosis, reduced intracellular ROS levels, increased melanin production, boosted tyrosinase and SOD activity, and potentially modulated the Wnt/β-catenin signaling pathway. In animal experiments, GP significantly protected mouse hair follicles from H₂O₂-induced damage.</p><p><strong>Conclusion: </strong>The findings suggest that GP has potential as a treatment for hair graying by mitigating H₂O₂-induced oxidative stress in melanocytes, highlighting its therapeutic potential in addressing oxidative stress-related hair graying.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2026 ","pages":"1775262"},"PeriodicalIF":2.0,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13247306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiaging Potential of <i>Peronema canescens</i> Jack Leaf Extract: A Natural Ingredient in Topical Skincare Formulation.","authors":"Rahmiati, Ringga Novelmi, Vivi Efrianova, Tyas Asih Surya Mentari, Siska Miga Dewi, Febri Silvia, Hayatunnufus, Rahmi Oktarina, Dony Novaliendry, Merita Yanita, Murni Astuti","doi":"10.1155/drp/6361781","DOIUrl":"10.1155/drp/6361781","url":null,"abstract":"<p><strong>Background: </strong><i>Peronema canescens</i> Jack (Sungkai) leaves contain antioxidant compounds with potential antiaging properties, yet their application in topical skincare formulations remains underexplored.</p><p><strong>Objectives: </strong>This study aimed to analyze the potential of <i>P. canescens</i> leaf extract as an antiaging cream ingredient and characterize its phytochemical profile, antioxidant activity, and cream formulation properties.</p><p><strong>Methods: </strong>Dried Sungkai leaves (250 g) were extracted via maceration using 70% ethanol for 72 h. Phytochemical screening employed standard reagent tests for flavonoids, phenolics, saponins, alkaloids, steroids, and terpenoids. Antioxidant activity was assessed using the DPPH radical scavenging method. Three antiaging cream formulations containing 0.02% (F1), 0.04% (F2), and 0.06% (F3) extract were prepared and evaluated for organoleptic properties, pH, homogeneity, adhesion, and dispersion. Stability was tested using six freeze-thaw cycles.</p><p><strong>Results: </strong>The extraction yield was 18.10%. Phytochemical analysis revealed the presence of flavonoids, phenolics, saponins, and steroids, while terpenoids and alkaloids were absent. The extract demonstrated very strong antioxidant activity with an IC₅₀ value of 21.98 ± 1.23 ppm, compared to vitamin C (IC₅₀ = 4.12 ± 0.34 ppm). All cream formulations exhibited acceptable pH values (F1: 5.54 ± 0.06, F2: 5.16 ± 0.12, and F3: 5.01 ± 0.05), good homogeneity, adequate adhesion (F1: 13.93 ± 0.88 s to 12.68 ± 0.76 s; F2: 16.67 ± 1.02 s to 15.50 ± 0.94 s; and F3: 17.33 ± 1.15 s to 16.41 ± 1.08 s), and appropriate dispersion (F1: 4.92 ± 0.15 to 6.20 ± 0.22 cm; F2: 4.82 ± 0.18 to 6.30 ± 0.25 cm; and F3: 4.67 ± 0.12 to 6.15 ± 0.20 cm). However, adhesion and dispersion stability decreased after storage, indicating the need for formulation optimization.</p><p><strong>Conclusions: </strong><i>P. canescens</i> leaf extract exhibits very strong antioxidant activity and can be formulated into stable antiaging creams. Further optimization is required to enhance long-term stability of adhesion and dispersion properties.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2026 ","pages":"6361781"},"PeriodicalIF":2.0,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13214512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between the Frequency of Hair Shampooing and the Condition of Hair and Scalp Among the Population of Saudi Arabia.","authors":"Nouf Bin Rubaian, Fawzeyah Alnakhli, Lama M Albelowi, Asrar Alharbi, Danah Alnajjar, Deemah S AlHuraish","doi":"10.1155/drp/3472173","DOIUrl":"10.1155/drp/3472173","url":null,"abstract":"<p><strong>Objective: </strong>The appearance of our physical features, including our hair, holds great significance in our lives. Shampooing is a widely adopted practice for improving hair condition. However, there is an ongoing debate regarding the impact of shampooing frequency on hair and scalp health. This study aimed to investigate the relationship between the frequency of hair shampooing and the condition of both hair and scalp.</p><p><strong>Methods: </strong>A cross-sectional study design was employed to gather data through online survey questionnaires administered in Arabic and targeted at Saudi Arabian citizens. The study included a sample size of 4796 participants from various clinics across Saudi Arabia. Descriptive statistics were utilized to analyze the data, calculating frequencies and percentages for different groups. Chi-square tests and inferential analysis were conducted to determine the association between variables.</p><p><strong>Results: </strong>The study identified a significant correlation between hair type and hair problems. Long hair and hairstyles with curls were associated with higher rates of hair breakage and daily hair loss. The findings demonstrated that the frequency of hair shampooing directly influenced the condition of both hair and scalp. Increased shampooing frequency was found to improve hair and scalp conditions.</p><p><strong>Conclusion: </strong>In conclusion, this study establishes that a higher frequency of shampooing enhances the condition of both hair and scalp. Therefore, we recommend that individuals aiming to enhance their physical appearance should consider increasing the frequency of shampoo usage.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2026 ","pages":"3472173"},"PeriodicalIF":2.0,"publicationDate":"2026-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13199680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148028322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and Optimization of Voriconazole Gel 0.25% for Topical Delivery in Terbinafine Resistance Dermatophytosis: In Vitro and Pilot Animal Study.","authors":"Saman Ahmad Nasrollahi, Mahsa Fattahi, Ensieh Lotfali, Atefeh Naeimifar, Fatemeh Amiri, Aliasghar Ghaderi, Pegah Tamimi, Shayan Zamani, Ali Khamesipoor, Alireza Firooz","doi":"10.1155/drp/5995621","DOIUrl":"10.1155/drp/5995621","url":null,"abstract":"<p><strong>Background: </strong>There have been several reports of patients with chronic recalcitrant diseases, rare presentations, recurrent relapses, and treatment failure. This study aimed to formulate and evaluate the safety profile of topical voriconazole (VCZ) gel 0.25% for effective drug delivery to the skin as an adjuvant therapy in cases of extensive dermatophytosis.</p><p><strong>Methods and materials: </strong>VCZ 0.25% topical gel was manufactured by Carbomer, and its characteristics such as pH, viscosity, density, and microbial growth were examined at 40 ± 2°C/75 ± 5% RH for six months. The animals were divided into three groups (2:2:2) randomly. The hair from the back of guinea pigs (test sites: 2 cm²) was shaven, and their skin was scraped slightly using a single-use scalpel. Afterward, terbinafine drug-resistant <i>Arthroderma benhamiae</i> suspension (50 μL) was inoculated to a 2 cm² surface area of the shaven skin.</p><p><strong>Results: </strong>Agar culture of scrapings from the area indicated the infection development. The fabricated VCZ topical gel exhibited acceptable stability. The VCZ 0.25% gel was proved to be an effective treatment in a time-dependent base, in comparison with terbinafine (1%) as a positive control (<i>p</i> < 0.05). Furthermore, using gel base VCZ 0.25% reduced the period of full treatment of <i>A. benhamiae</i> infection to five days, compared with the 12-day complete cure by terbinafine.</p><p><strong>Conclusion: </strong>Results from the present study indicated that gel-based VCZ could be utilized as topical therapy for dermatophytosis. Due to the increase of drug-resistant dermatophyte spp., indications of gel base VCZ 0.25% for treating dermatophytosis are believed to increase accordingly.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2026 ","pages":"5995621"},"PeriodicalIF":2.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13100490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Electrosurgery Combined With 50% TCA Application in Patients With Rhinophyma.","authors":"Gulsen Akoglu, Ahmet Tecik","doi":"10.1155/drp/4957519","DOIUrl":"10.1155/drp/4957519","url":null,"abstract":"<p><strong>Introduction: </strong>Rhinophyma causes significant cosmetic problems and social stigmatization. This study aimed to evaluate outcomes of electrosurgery combined with 50% trichloroacetic acid (TCA) treatment.</p><p><strong>Methods: </strong>The medical files and photographs of six patients who underwent rhinophyma electrosurgery combined with 50% TCA application were retrospectively analyzed. Demographic and clinical features of the patients, rhinophyma severity, posttreatment wound care, and treatment outcomes were reviewed. The cosmetic outcomes were evaluated with the physician's cosmetic evaluation scale and the patient's cosmetic satisfaction scale.</p><p><strong>Results: </strong>All six patients were male, with a mean age of 66.5 ± 3.5 years and a disease duration ranging from 3 to 21 years. The RHISI scores were 4 in two patients and 5 in four patients. All patients tolerated the whole process well. After electrosurgery, bismuth subgallate (BS) powder was poured for wound care. The BS coat remained until it dried and detached spontaneously from the skin after approximately 10 days. Subsequently, collagen gel was applied twice daily for 7-17 days. The mean time from the procedure day to the day of complete re-epithelialization was 24.0 ± 4.7 days. Only one patient had marked scarring on alar regions, one had no complications, and the remaining four had only minimal, nondisturbing skin changes in limited areas. Patients' cosmetic satisfaction scores ranged from 7 (satisfied) to 10 (extremely satisfied).</p><p><strong>Conclusion: </strong>Electrosurgery combined with 50% TCA application may provide a practical, well-tolerated, and low-cost treatment option in selected patients with rhinophyma. Postoperative wound care with topical BS powder and collagen gel serves a postoperative healing period of approximately three to 4 weeks.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2026 ","pages":"4957519"},"PeriodicalIF":2.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13261533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pruritus in Hemodialysis Patients in a Sub-Saharan African Country: Benin-Associated Skin Conditions and Other Factors in 2023 in Three Hemodialysis Centers.","authors":"Dégboé Bérénice, Tounouga Dahlia Noelle, Gbénou Fabrice Mahouéna, Lossou Eric, Hazoumè Rodrigue, Vigan Jacques, Atadokpèdé Félix","doi":"10.1155/drp/4482167","DOIUrl":"10.1155/drp/4482167","url":null,"abstract":"<p><strong>Introduction: </strong>Pruritus is a frequent and debilitating complication in hemodialysis patients. Its pathophysiology remains poorly understood. This study aimed to describe the factors associated with pruritus in three hemodialysis centers in 2023.</p><p><strong>Methods: </strong>This was a prospective, descriptive, and analytical cross-sectional study. It included 245 patients aged 18 years and older, undergoing hemodialysis for at least three months, hemodynamically stable, and who had provided informed consent. Pruritus intensity was assessed using the Itch-Numeric Rating Scale (Itch-NRS). Statistical analysis was performed using Stata 17, with a significance level set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>The prevalence of pruritus among hemodialysis patients was 40.41%. The mean age of participants was 52.75 years, with a sex ratio of 1.78. Pruritus was most often mild to moderate (90.91%), generalized (48.48%), or diffuse (51.52%) and had been present for at least 1 year in 67.67% of cases. The most frequently associated dermatoses were xeroderma (88.88%), nail abnormalities (77.14%), and diffuse hyperpigmentation (27.27%).Univariate analysis identified protective factors such as vitamin D supplementation, absence of anuria, absence of diffuse skin hyperpigmentation, absence of alopecia, and absence of nail abnormalities (<i>p</i> = 0.003-0.042; OR = 0.17-0.58). Multivariate analysis showed that prolonged duration of hemodialysis, the use of an arteriovenous fistula, severe xeroderma, and the presence of Beau's lines (<i>p</i> ≤ 0.039) increased the risk of pruritus in hemodialysis patients. Conversely, the use of oral antidiabetic agents was significantly associated with a reduced risk of pruritus (<i>p</i> = 0.003; OR = 0.25).</p><p><strong>Conclusion: </strong>Pruritus is a common and chronic condition in hemodialysis patients, adversely affecting their quality of life. The main risk factors identified were severe xeroderma, prolonged duration of hemodialysis, use of an arteriovenous fistula, and the presence of Beau's lines, whereas the use of oral antidiabetic medications appeared to be protective. A better understanding of the pathophysiology of pruritus in hemodialysis patients could help improve its management and enhance patient comfort.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2026 ","pages":"4482167"},"PeriodicalIF":2.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Corticosteroid Phobia in Childhood Atopic Dermatitis: A Study Using the TOPICOP Score.","authors":"Mateja Starbek Zorko, Vid Bukovec, Tanja Fantulin","doi":"10.1155/drp/7996688","DOIUrl":"10.1155/drp/7996688","url":null,"abstract":"<p><strong>Background: </strong>Topical corticosteroid phobia (CSP) is a significant barrier to the effective treatment of atopic dermatitis (AD). This is the first study to evaluate the CSP prevalence among parents of children with AD in Slovenia and to identify contributing factors.</p><p><strong>Methods: </strong>We conducted a cross-sectional study between March 2021 and December 2023. Parents of children with dermatologist-confirmed AD, aged 3 months to 18 years, completed the validated TOPICOP questionnaire, supplemental questions and the (F)DLQI questionnaire. The SCORAD index was used to assess the severity of their children's AD disease. Statistical analyses included the Shapiro-Wilk test, two-tailed independent <i>t</i>-test, ANOVA, followed by Tukey post hoc testing and the Pearson correlation coefficient.</p><p><strong>Results: </strong>Among 117 parents (81.2% mothers), the mean TOPICOP score was 48.2% (SD 15.1). Fear was the highest-scoring TOPICOP domain (53.7%). CSP was significantly higher in parents of children with more severe AD based on SCORAD (<i>p</i> = 0.033) and in families with higher (F)DLQI scores (<i>r</i> = 0.311, <i>p</i> = 0.002). Notably, our results suggest that parents of children in single-parent households had significantly higher CSP (<i>p</i> = 0.035), a novel finding that warrants cautious interpretation due to the small subgroup size. Information obtained online about the potential dangers of topical corticosteroids (TCS) correlated with higher CSP (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>CSP is prevalent among Slovenian parents of children with AD and is particularly pronounced in cases of more severe disease and single-parent households, a novel and previously undescribed finding. Given that CSP is often influenced by nonmedical information sources, structured education and support by all healthcare providers is essential.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2026 ","pages":"7996688"},"PeriodicalIF":2.0,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Tecar Therapy in the Treatment of Skin Flaccidity and Localized Abdominal Fat-Clinical and Controlled Study.","authors":"Stephani de Almeida, Isabella Benatti Santiago, Cintia Cristina Santi Martignago, Michele Akemi Nishioka, Patricia Brassolatti, Jéssica Helena Franco Dorigatti, Fabiele Chieregato, Ana Carolina Araruna Alves, Stephany Luanna Queiroga Farias, Patricia Froes Meyer, José Ricardo de Souza","doi":"10.1155/drp/5531539","DOIUrl":"10.1155/drp/5531539","url":null,"abstract":"<p><p>It is known that when an electrical stimulus is greater than 10 kHz, our body converts this electrical energy into thermal energy, and due to this fact, one of the therapies that has been showing good results is therapeutic, capacitive, and resistive energy transfer (tecar therapy), but there is still little evidence about its action on area of aesthetics. Therefore, the objective of this study was to evaluate the safety and efficacy of tecar therapy for the reduction of localized fat and improvement of skin flaccidity in the abdomen region. A controlled clinical trial was carried out with 48 women equally divided into 2 distinct groups, with (G-1) received treatment with tecar therapy and (G-2) considered the control. Ten treatment sessions were performed once a week. The volunteers were evaluated at three different times using anthropometric data, adipometry, and ultrasound (US), in addition to histological analysis of the adipose tissue performed on one of the volunteers. In the results of the adipometry and US, a decrease was observed both in the comparison between the groups and between the baseline and the end of the treatment for the supra and infra umbilical region. In the histological analysis, it was observed that the G1 showed positive markers for moderate chronic inflammation, indicating degeneration of the adipose tissue with a large number of fibroblasts and newly formed blood vessels in the integumentary tissue. With this, it was possible to conclude that tecar therapy proved to be a safe and effective resource in the treatment of sagging skin and reduction of superficial adipose tissue. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT05020054.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2026 ","pages":"5531539"},"PeriodicalIF":2.0,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Quality of Life and Treatment Practice Among Melasma Patients in Nepal.","authors":"Samiksha Pokhrel, Sabina Sankhi, Shishir Paudel, Anisha Chalise, Nirmal Raj Marasine","doi":"10.1155/drp/6380885","DOIUrl":"10.1155/drp/6380885","url":null,"abstract":"<p><strong>Background: </strong>Melasma is chronic, acquired hypermelanosis that commonly appears on sun-exposed areas of the skin. Although it is asymptomatic, it can significantly affect patients' psychosocial and emotional well-being, ultimately reducing their quality of life. This study aimed to assess the factors associated with quality of life and treatment practices among melasma patients in Nepal.</p><p><strong>Methods: </strong>A hospital-based cross-sectional study was conducted among 174 melasma patients visiting Nepal Skin Hospital, Kathmandu, from March to August 2023. The Melasma Area and Severity Index (MASI) score and the Melasma Quality of Life (MELASQoL) scale were used to evaluate melasma severity and quality of life, respectively. Statistical analyses included descriptive statistics, independent <i>t</i>-tests, one-way ANOVA, and multiple linear regression to identify factors associated with quality of life among women with melasma.</p><p><strong>Results: </strong>The mean (±SD) MELASQoL score was 51.89. Most participants reported feeling frustrated (81.5%), embarrassed (78.8%), depressed (95.40%), and less productive (83.9%) due to melasma. Female gender, illiteracy, both current and previous OCP use, women with multiple pregnancies, lighter skin Types (III and IV), longer disease duration, and moderate MASI scores were significantly associated with higher MELASQoL values (<i>p</i> < 0.05). Sunscreen (97.7%) was the most prescribed treatment, followed by tranexamic acid (78.7%), hydroquinone (76.4%), antioxidants (71.3%), and chemical peels (69.0%).</p><p><strong>Conclusion: </strong>Melasma has a significant psychosocial impact on affected individuals in Nepal. Disease severity, use of oral contraceptive pills, number of pregnancies, disease duration, education, and skin type significantly influenced quality of life. The strong association between disease severity and MELASQoL underscores the importance of integrating psychosocial assessment into clinical management. Sunscreen followed by tranexamic acid, hydroquinone, antioxidants, chemical peels, multivitamins, and retinoids was the predominant treatment approaches.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2026 ","pages":"6380885"},"PeriodicalIF":2.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12886184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}