Dermatology Research and Practice最新文献

{"title":"Molecular Biological Verification of the Healing Effect of Biphasic Microcurrent Electrical Stimulation in Model Rats of Skin Abrasion.","authors":"Akira Sakaguchi, Yuzuru Sakaue, Shuhei Haraguchi, Daisuke Hasegawa, Rui Tsukagoshi, Kotaro Kawaguchi, Hideyuki Yamamoto","doi":"10.1155/2024/4549761","DOIUrl":"10.1155/2024/4549761","url":null,"abstract":"<p><p>In this study, we investigated the effect of biphasic microcurrent electrical stimulation (b-MES) on the epidermal healing process using a rat model of skin abrasion. We analyzed the expression levels of growth factors [fibroblast growth factor 2 (FGF2) and epidermal growth factor (EGF)] and keratin subtypes (K10) in both the b-MES and control groups at different time points after wounding. The b-MES group showed a significantly accelerated healing process of the epithelial tissue, resulting in more consistent healing as compared to the control group. A molecular biological analysis showed that the FGF2 mRNA expression level on Day 2 after wounding was significantly higher in the b-MES group, whereas the EGF mRNA expression level on Days 1, 2, and 4 after wounding was significantly lower in the b-MES group. Additionally, the K10 mRNA expression level on Days 1 and 2 after wounding was significantly higher in the b-MES group. Our study findings suggest that b-MES facilitates wound healing by regulating the growth factors. However, the precise mechanisms underlying these effects remain to be fully elucidated. Further research is needed to fully understand the therapeutic potential of b-MES and its applications in clinical setting. Clinically, m-MES requires shunting due to residual electrical charge at the application site. However, b-MES alternates polarity, leaving no charge at the site of application. Therefore, b-MES also has the advantage of being safer and allowing treatment for longer periods of time.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"4549761"},"PeriodicalIF":1.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Application of Camel Milk as a Therapeutic Ingredient in Bath Soaps and Shampoos.","authors":"Elly Oginga, Julius Toeri, Eunice Marete, Joshua Arimi","doi":"10.1155/2024/4846339","DOIUrl":"10.1155/2024/4846339","url":null,"abstract":"<p><p>The increasing worldwide market for natural-ingredient-based cosmetic toiletries is fuelled by the awareness of the dangers of synthetic cosmetics and benefits of natural-based cosmetics on the skincare and management of skin disorders. Besides naturally formulated cosmetics being biodegradable, they also contain ingredients which are chemically beneficial to human skin. Milk-based cosmetics are very promising since milk is rich in essential components such as lactoferrins, vitamins, and lactic acids, which have shown therapeutic properties against disorders such as skin cancer, acne scars, and dandruff. One of the milk that is very promising in the cosmetics industry is the camel milk. Currently, there is limited information in literature regarding the use of camel milk in cosmetics and their benefits. Camel milk stands out from bovine milk following its unique therapeutic properties and chemical composition, making it a potential ingredient for skincare and haircare products such as bath soaps and shampoos. The aim of this paper is to review the available literature on camel milk composition and evaluate the contribution of camel milk constituents to cosmetics.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"4846339"},"PeriodicalIF":1.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Signature of miR-34a/NEAT-1/p53 Axis in Mycosis Fungoides.","authors":"Reham Fares, Shimaa M Elasmer, Abeer Khalefa A, Olfat G Shaker, Samar M El-Tahlawi, Ahmed Sabri, Sara M Yaseen","doi":"10.1155/2024/3163839","DOIUrl":"10.1155/2024/3163839","url":null,"abstract":"<p><strong>Background: </strong>Mycosis fungoides (MF) is a type of cutaneous T-cell lymphoma where red rash exists on the skin. Understanding the role of miRNAs and ncRNAs in p53-response has become an open discussion, as they can regulate p53 or its downstream targets, and ncRNAs themselves.</p><p><strong>Objectives: </strong>To evaluate the serum levels of NEAT-1, miR-34a, and p53 in MF patients and its relation to healthy controls to indicate whether it has a potential role in the pathogenesis of the disease. <i>Subjects and Methods</i>. This prospective case-control study was carried out on 75 subjects subdivided into two groups, 35 MF patients (stages 1 and II) and 40 matched healthy controls. Their clinical investigations and serum biomarkers (NEAT-1, miR-34a, and p53) were measured.</p><p><strong>Results: </strong>There were significant elevations in the expression levels of both NEAT-1 (5.10 ± 1.16) and p53 (277.28 ± 62.02) in the serum of MF patients in comparison with controls (1.01 ± 0.031) and (194.29 ± 16.039), respectively, while the level of miR-34a tends to decrease in MF patients (0.24 ± 0.15). There are no significant difference between MF stages and the level of miR-34a, while in NEAT-1 and p53, there are significant differences with <i>p</i> value <0.05 between the stages and the biomarkers. There is a positive correlation between the %BSA and miR-34a and a slightly positive correlation between NEAT-1 and P53 with (<i>r</i> = 0.353, <i>p</i>=0.037) and (<i>r</i> = 0112, <i>p</i>=0.05), respectively. There were also negative correlations between disease duration and NEAT-1 with (<i>r</i> = -0.341, <i>p</i>=0.045) and between B2 microglobulin level and p53 (<i>r</i> = -0.373, <i>p</i>=0.027).</p><p><strong>Conclusion: </strong>The combination of miR-34a, NEAT-1, and p53 may be considered as potential biomarkers that play an active role in the disease process of MF for helping in its early diagnosis and stage identification as well.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"3163839"},"PeriodicalIF":1.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11343631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microevolution during Chronic Infection May Lead <i>T. asahii</i> to Coexist with the Host.","authors":"Gen Ba, Xuelian Lv, Xin Yang, Wenling Wang, Junhong Ao, Rongya Yang","doi":"10.1155/2024/5518156","DOIUrl":"10.1155/2024/5518156","url":null,"abstract":"<p><strong>Background: </strong><i>Trichosporon asahii</i> (<i>T. asahii</i>) is part of the cutaneous fungal microbiota in humans and can cause lethal opportunistic infection. During infection, microorganisms can adapt to their environment by adjusting gene expression and cellular activities.</p><p><strong>Objectives: </strong>Investigation of the microevolutionary changes in <i>T. asahii</i> during chronic infection.</p><p><strong>Methods: </strong>Two <i>T. asahii</i> strains were isolated from a chronic trichosporonosis patient between a 15-year interval, and the microevolutionary changes were compared by the immune response of dendritic cell (DC), mice survival model, and transcriptome sequencing analysis.</p><p><strong>Results: </strong>Compared with the primary <i>T. asahii</i> strain, the microevolved strain induced much lower expression of TNF-<i>α</i> by mice bone marrow-derived DC and had a much superior survival rate, a total of 2212 significantly differentially expressed genes were identified in the microevolved strain, and functional analysis showed significance in the downregulated transcription and metabolic process, especially the valine, leucine, and isoleucine degradation pathways, which were associated with pathogenicity and virulence; hence, the results were highly consistent with the decreased immunogenicity and virulence of the microevolved strain.</p><p><strong>Conclusions: </strong>These results demonstrated that the microevolution during chronic infection could induce changes in immunogenicity, virulence, and transcriptome, which might lead <i>T. asahii</i> to coexist with the host.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"5518156"},"PeriodicalIF":1.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tattoo Regret, Complications, and Removal: A Cross-Sectional Study among Tattooed Individuals in Saudi Arabia.","authors":"Hadeel Mitwalli, Nuha Alfurayh","doi":"10.1155/2024/5673785","DOIUrl":"10.1155/2024/5673785","url":null,"abstract":"<p><strong>Background: </strong>A tattoo is a pigment permanently deposited into the skin to create different patterns. The worldwide percentage of tattooed individuals, as well as the level of tattoo regret, complications, and removal, has increased. However, data from Saudi Arabia are lacking.</p><p><strong>Objective: </strong>To determine the rates of tattoo regret, complications, and removal among tattooed individuals in Saudi Arabia.</p><p><strong>Methods: </strong>A cross-sectional study using an online survey was conducted in Riyadh, Saudi Arabia. A link to the survey was distributed through social media and contained twenty questions about participants' demographics, tattoo practices, regret, removal, and complications. Data were analyzed using the Statistical Package for Social Sciences (SPSS). A <i>P</i> value <0.05 was considered statistically significant.</p><p><strong>Results: </strong>A total of 181 tattooed individuals participated in the study. Most of them were females (95.6%), and 76.7% had their first tattoo at an age over eighteen years. A total of 47.5% had one tattoo session, and the most common body site was the eyebrows (57.5%). Fifty-eight percent regretted their tattoo, and 42.5% attempted to remove it. Upper extremity tattoos were significantly associated with regret (72.3%) (<i>P</i>=0.004) and removal (56.9%) (<i>P</i>=0.003). Tattoo removal was mostly due to cultural reasons (74%). Local itching (32%), pain (22.7%), and infection (10.5%) were reported and associated with tattoo regret (<i>P</i> < 0.05). Itching was significant in 65.4% of head and neck tattoos and 41.5% of upper extremity tattoos (<i>P</i> < 0.05). Participants were aware that laser is the best method for tattoo removal.</p><p><strong>Conclusion: </strong>Among tattooed individuals in Saudi Arabia, the rate of tattoo regret and removal is high, and the most reported complication is pruritus.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"5673785"},"PeriodicalIF":1.5,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinical Trial Shows Improvement in Skin Collagen, Hydration, Elasticity, Wrinkles, Scalp, and Hair Condition following 12-Week Oral Intake of a Supplement Containing Hydrolysed Collagen.","authors":"David M Reilly, Liane Kynaston, Salma Naseem, Eva Proudman, Darcy Laceby","doi":"10.1155/2024/8752787","DOIUrl":"10.1155/2024/8752787","url":null,"abstract":"<p><strong>Background: </strong>Hydrolysed collagen supplements are reported to fight the signs of aging and improve skin appearance, but more authoritative clinical evidence is needed to support efficacy.</p><p><strong>Aim: </strong>This randomised, double-blind, placebo-controlled study evaluated the efficacy of a supplement containing hydrolysed collagen and vitamin C (Absolute Collagen, AC) on biophysical parameters and visible signs of aging for skin, scalp, and hair, when taken daily or every 48 hours.</p><p><strong>Methods: </strong>We measured dermal collagen using confocal microscopy and high-resolution ultrasound. Hydration, elasticity, wrinkles, and clinical trichoscopy were measured in parallel to expert visual grading. Efficacy measures were recorded at baseline, week 6, and week 12.</p><p><strong>Results: </strong>Following 12 weeks daily use of the AC supplement, using confocal microscopy, we observed a significant 44.6% decrease in fragmentation vs. placebo (<i>p</i> < 0.01). We also measured a change in the ultrasound LEP (low echogenic pixel) ratio comparing upper and lower dermis (-9.24 vs. -7.83, respectively, <i>p</i>=0.05), suggesting collagen improvements occurred more in the upper dermal compartment. After 12 weeks vs. placebo, skin hydration was increased by 13.8% (<i>p</i> < 0.01), R2 elasticity index was increased by 22.7% (<i>p</i><0.01), and Rz profilometry index was decreased by 19.6% (<i>p</i> < 0.01). Trichoscopy showed an average 11.0% improvement in scalp scaling and a 27.6% increase in the total number of hairs counted vs. placebo (<i>p</i>=n.s.). This was associated with a 31.9% increase in clinical grading score for hair healthy appearance (<i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>The AC supplement has shown clinical benefits for skin, scalp, and hair, when used either daily or every 48 hours, over a 12-week period.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"8752787"},"PeriodicalIF":1.5,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11254459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, and Risk Perception in Oral Isotretinoin Use: A Cross-Sectional Study from Jordan.","authors":"Mai I Al-Hawamdeh, Mariam Al-Ameri, Salli Lutfi, Nidal Muhtaseb, Rasha Takhayneh, Tasneem Awamreh","doi":"10.1155/2024/7714527","DOIUrl":"10.1155/2024/7714527","url":null,"abstract":"<p><p>The most prevalent skin condition is acne vulgaris. Recent clinical practice guidelines recommend oral isotretinoin to treat moderate-to-severe acne. The aim of this study is to assess the knowledge, attitude, and risk perception of oral isotretinoin for acne treatment. This is a cross-sectional descriptive study conducted in the country of Jordan. The study sample includes people resident in Jordan aged ≥14 years who have been treated with oral isotretinoin for acne. The study involved 373 participants who previously used oral isotretinoin for skin disorders. Most were Jordanian (89.3%), aged 19-25 (37.3%), and from the central region (82.8%). Mostly, they used isotretinoin for severe or mild acne (25.2% and 24.1%, respectively), rosacea (4.1%), or to alleviate acne scars. Surprisingly, 58.1% did not consult their specialist for side effects, and 20% shared their treatment. The average proper use score was 9.98 out of 16. A link was found between higher risk knowledge scores and proper use scores. Side effects such as nausea, irregular heartbeat, and pancreatitis affected some users (11.5%, 10.5%, 7.0%, and 3.2%, respectively). Knowledge about isotretinoin's risks varied, with percentages recognizing teratogenicity (57.7%), liver damage (52.6%), and lipid profile effects (37.2%), while 25% believed that they had no side effects. The study revealed partial adherence to oral isotretinoin guidelines, with gaps in monitoring and consultation. A positive correlation emerged between risk knowledge and proper usage, emphasizing the need for comprehensive education and monitoring strategies in isotretinoin therapy for skin disorders.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"7714527"},"PeriodicalIF":1.5,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Spectrum of Facial Granulomatous Dermatoses: Evidence from a 5-Year Study in Iran","authors":"Z. Aryanian, M. Ansari, Huda Fatima, Mona Homayouni, Azadeh Khayyat, Alireza Ghanadan, Parvaneh Hatami","doi":"10.1155/2024/9946828","DOIUrl":"https://doi.org/10.1155/2024/9946828","url":null,"abstract":"Background. Granulomatous dermatoses, particularly on facial skin, pose a diagnostic challenge, as similar histologic patterns can be produced by different causes. Aim. To evaluate the correlation between clinical suspicion and histopathological findings in various facial granulomatous dermatoses. Materials and Methods. This retrospective, cross-sectional study included all patients with the histopathological diagnosis of facial granulomatous dermatoses from the years 2016 to 2021 in an academic hospital. Demographic, clinical, and histopathologic features were reviewed and analyzed. Results. In this study, 150 histopathological records with the diagnosis of facial granulomatous dermatoses from the years 2016 to 2021 were reviewed. The most common clinical diagnosis was rosacea 34 (23.6%), followed by sarcoidosis 27 (18.8%), leishmaniasis 15 (10.4%), and granulomatous rosacea 10 (6.9%). The frequency of clinical diagnosis of rosacea (70.6), sarcoidosis (66.7), foreign body G (62.5), TB (75), pseudolymphoma (75), acne agminata (66.7), and granulomatous rosacea (70) in female patients was higher than that in males (P value = 0.03). The effect of age on the type of both clinical and histopathological diagnosis was statistically significant (P value = 0.0001 and 0.004, respectively). Conclusion. Our study contributed significantly to the understanding of the clinicopathological aspects of facial granulomatous dermatoses and advocated for a multidisciplinary approach to the diagnosis and management of these complex skin conditions.","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"93 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141278279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absence of Epidermal Antibodies in Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis Patients but Beware of Single Positive Results","authors":"Gilles F. H. Diercks, J. Meijer, M. Bolling, Sonja M. H. J. Scholtens-Jaegers, J. Bremer, Barbara Horvath","doi":"10.1155/2024/5504462","DOIUrl":"https://doi.org/10.1155/2024/5504462","url":null,"abstract":"Background. Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and potentially life-threatening mucocutaneous blistering diseases that clinically can resemble autoimmune bullous diseases. Moreover, it has been shown that autoantibodies against epidermal proteins are present in SJS/TEN. Objectives. To establish the presence of antibodies against desmosomal and hemidesmosomal proteins in confirmed SJS/TEN patients. Methods. Serum of SJS/TEN patients diagnosed based on clinical criteria, e.g., epidermal detachment with erosions and severe mucosal lesions, (suspicion of) a culprit drug, and matching histologic results was evaluated by various techniques, e.g., indirect immunofluorescence on monkey esophagus, salt split skin and rat bladder, immunoblotting (IB) and immunoprecipitation (IP), ELISAs against desmogleins and BP180, keratinocyte footprint assay, and keratinocyte binding assay. Results. A total of 28 patients were included in this study, 15 men and 13 women with a mean age of 56 years. In most patients, none of the serological tests were positive. In two patients, an elevated DSG3 titer was found suspicious for pemphigus vulgaris. Three patients had elevated NC16a titers, suggesting bullous pemphigoid. However, in all these patients, no other tests were positive and in these patients, the biopsy for direct immunofluorescence showed no evidence for an autoimmune bullous disease. Three patients showed reactivity against rat bladder rat bladder; these were, however, completely negative for A2ML1, envoplakin, and periplakin in the IB as well as the IP. Conclusions. Serological analysis for desmosomal and hemidesmosomal antibodies is reliable to rule an autoimmune bullous disease in patients with suspected SJS/TEN. However, one should not rely on one single test method since false positive results can occur. Moreover, this study also makes it less plausible that antibodies against desmosomal and/or hemidesmosomal components are involved in the pathogenesis of SJS/TEN.","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"16 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141119606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life and Psychiatric Comorbidities among Subjects Practicing Artificial Skin Depigmentation in 2020 in the City of Cotonou (Benin)","authors":"B. Degboe, M. M. D. Baloubi, N. Ntouala Noukayaba, F. Akpadjan, H. Adégbidi, F. Atadokpédé","doi":"10.1155/2024/8589329","DOIUrl":"https://doi.org/10.1155/2024/8589329","url":null,"abstract":"Introduction. The purpose of this study was to study the quality of life and psychiatric comorbidities of subjects practicing voluntary skin depigmentation in the city of Cotonou. Methods. A cross-sectional, prospective, and analytical study, based on a three-stage probabilistic sampling method, included from June to October 2020, consenting subjects over 15 years of age, practicing artificial skin depigmentation, and residing for at least one year in Cotonou. The Dermatology Life Quality Index, Rosenberg, and Hospital Anxiety and Depression scales allowed us to evaluate the quality of life and self-esteem, and identify anxiety and depression, respectively. A p value <0.05 indicated a significant result. Results. We included 330 subjects. The mean age was 33.6 ± 11.6 years and the sex ratio was 0.4. Impaired quality of life was observed in 93.7% of subjects. Anxiety was diagnosed in 11.2% and depression in 5.8% of them. Self-esteem was low or very low in 24.2%. The degree of quality of life and the alteration of self-esteem, and the frequency of anxiety and depression were proportional to the number of skin lesions, the lightening products used, and the monthly cost of the products. Conclusion. The use of several lightening products exposes patients to numerous skin lesions, which are a source of impaired quality of life and whose persistence leads to psychiatric comorbidities.","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"138 38","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140668790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}