Digestion最新文献

{"title":"Erratum.","authors":"","doi":"10.1159/000549114","DOIUrl":"10.1159/000549114","url":null,"abstract":"<p><p>In the article by Ruan et al. entitled \"Clinical Application of Confocal Laser Endomicroscopy in the Diagnosis of Gastrointestinal Diseases\" [Digestion. 2025; https://doi.org/10.1159/000548414], there is an error in the affiliation of the first author. The correct affiliation of the first author, Wenli Ruan, is:The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou, Zhejiang, China.</p>","PeriodicalId":11315,"journal":{"name":"Digestion","volume":" ","pages":"467"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145631324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gas-Related Symptoms and Behaviors are Associated with Rome IV Functional Abdominal Bloating: An Internet Survey.","authors":"Yumie Kobayashi, Akinari Sawada, Yuki Hisaki, Shuhei Hosomi, Fumio Tanaka, Yasuhiro Fujiwara","doi":"10.1159/000548838","DOIUrl":"10.1159/000548838","url":null,"abstract":"<p><strong>Introduction: </strong>Functional abdominal bloating (FAB) is a bowel disorder of gut-brain interaction (DGBI) characterized by predominant bloating symptom. Given gas dynamics in the digestive tract, gas-related symptoms (belching and flatulence) and behaviors may contribute to the development of FAB. This study aimed to examine their relationships.</p><p><strong>Methods: </strong>We conducted an Internet survey for individuals aged from 18 to 79 years using a questionnaire including items on demographic and clinical characteristics, lifestyle, and gas-related symptoms and behaviors. DGBIs including FAB were diagnosed based on the Rome IV criteria. The severity of bloating was assessed using visual analog scale. Health-related quality of life (HRQOL) was evaluated using the SF-8. Logistic and multiple regression analyses identified factors associated with FAB and their bloating severity.</p><p><strong>Results: </strong>A total of 9,995 individuals were included in the analysis, in which 123 (1.2%) were classified as having FAB. HRQOL was significantly impaired in the FAB group compared to the non-FAB group. Multivariable analysis demonstrated that gas-related symptoms and behaviors such as frequent flatulence (OR: 2.55, 95% CI: 1.74-3.72, p < 0.001), frequent suppression of flatulence (OR: 2.09, 95% CI: 1.32-3.32, p = 0.002), and resisting the urge to defecate (OR: 2.77, 95% CI: 1.57-4.90, p < 0.001) were significantly and independently associated with an increased odds of FAB, in addition to lower BMI and gastroesophageal reflux disease. Younger age and resisting the urge to defecate were related to increased severity of bloating in patients with FAB.</p><p><strong>Conclusion: </strong>Gas-related symptoms and behaviors may contribute to the pathophysiology of FAB.</p>","PeriodicalId":11315,"journal":{"name":"Digestion","volume":" ","pages":"416-425"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophageal Hypervigilance and Visceral Anxiety Are Involved in Esophageal Symptom Perception in Patients with Systemic Sclerosis.","authors":"Yoshimasa Hoshikawa, Mikito Suzuki, Eri Momma, Shintaro Hoshino, Noriyuki Kawami, Masataka Kuwana, Katsuhiko Iwakiri, Masanori Atsukawa","doi":"10.1159/000546892","DOIUrl":"10.1159/000546892","url":null,"abstract":"<p><strong>Introduction: </strong>Systemic sclerosis (SSc) causes esophageal motility disorders. However, esophageal symptom severity often does not correlate with the physiological findings of high-resolution manometry (HRM) in patients with SSc. Esophageal hypervigilance and visceral anxiety play a relevant role in symptom perception in patients with gastroesophageal reflux disease and esophageal motility disorders. Therefore, the present study examined the effects of anxiety and hypervigilance, along with HRM findings, on esophageal symptom severity in patients with SSc.</p><p><strong>Methods: </strong>We reviewed the clinical data of consecutive patients with SSc who underwent HRM and were assessed using the esophageal hypervigilance and anxiety scale (EHAS) at our hospital between January 2022 and February 2025. Predictors for the Eckardt symptom score (ESS) and gastroesophageal reflux disease questionnaire (GerdQ) were investigated.</p><p><strong>Results: </strong>This study included 51 patients with SSc. Significant differences were observed in EHAS scores between patients with ESS >3 and those with ESS ≤3 (34.0 [24.0-42.0] vs. 13.0 [1.0-24.0], p = 0.003), but not in HRM findings. The EHAS score accounted for 38.2% of the variance in the ESS score. Significant differences were also observed in the EHAS score between patients with GerdQ ≥8 and those with GerdQ <8 (26.0 [14.3-32.5] vs. 13.0 [0-22.0], p = 0.011). The combined factors of the EHAS score and absent contractility accounted for 17.3% of the variance in the GerdQ score.</p><p><strong>Conclusion: </strong>Esophageal hypervigilance and anxiety may be involved in esophageal symptom severity, particularly dysphagia severity, in patients with SSc. Further studies involving interventions targeting these conditions, such as cognitive behavioral therapy, are warranted.</p>","PeriodicalId":11315,"journal":{"name":"Digestion","volume":" ","pages":"126-134"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Evaluation of the Gastroesophageal Junction and Diagnosis of Barrett's Esophagus.","authors":"Chika Kusano","doi":"10.1159/000548648","DOIUrl":"10.1159/000548648","url":null,"abstract":"<p><strong>Background: </strong>Barrett's esophagus (BE) is a recognized precursor to esophageal adenocarcinoma (EAC), yet its endoscopic diagnosis remains inconsistent worldwide. This review summarizes current challenges and recent advancements in the endoscopic diagnosis of BE, including updates from international consensus statements and emerging technologies such as image-enhanced endoscopy (IEE) and artificial intelligence (AI).</p><p><strong>Summary: </strong>This narrative review integrated international guidelines, multicenter studies, expert consensuses, including the Kyoto International Consensus and Asian Barrett Consortium data, and recent trials of diagnostic imaging and quality indicators (QIs) regarding BE surveillance.</p><p><strong>Key messages: </strong>Discrepancies in defining the gastroesophageal junction (GEJ) - notably between palisade vessels and gastric folds - contribute to the global variability of the BE diagnosis. The Kyoto International Consensus recommends using the distal end of the palisade vessels as a more stable and histologically consistent landmark. Additionally, the Prague C & M criteria offer a standardized approach to measuring the BE length; however, limitations for ultra-short-segment BE exist. IEE modalities such as linked color imaging and red dichromatic imaging enhance GEJ visualization, whereas AI systems have the potential for automated BE classification. QIs such as the neoplasia detection rate, inspection time, and adherence to biopsy protocols have been proposed to improve diagnostic consistency and outcomes. Standardizing the endoscopic definition of BE and adopting quality-based surveillance strategies are essential to improving detection and reducing variability. Incorporating IEE- and AI-based tools into routine practice may support a more reliable and efficient diagnostic pathway for BE, thus facilitating early EAC detection and prevention worldwide.</p>","PeriodicalId":11315,"journal":{"name":"Digestion","volume":" ","pages":"24-30"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological and Endoscopic Features of Non-Ampullary Duodenal Epithelial Tumors with Gastrointestinal Mixed Phenotype.","authors":"Momoko Yamamoto, Yoichi Akazawa, Nobuyuki Suzuki, Hiroya Ueyama, Shunsuke Nakamura, Yasuko Uemura, Tomoyo Iwano, Ryota Uchida, Hisanori Utsunomiya, Daiki Abe, Shotaro Oki, Atsushi Ikeda, Tsutomu Takeda, Kumiko Ueda, Mariko Hojo, Tadasuke Hashiguchi, Takashi Hashimoto, Shinji Mine, Takashi Yao, Akihito Nagahara","doi":"10.1159/000547024","DOIUrl":"10.1159/000547024","url":null,"abstract":"<p><p><p>Introduction: Non-ampullary duodenal epithelial tumors with a gastrointestinal mixed phenotype (mixed-type NADETs) have not been thoroughly analyzed. We aimed to elucidate the clinicopathological and endoscopic characteristics of mixed-type NADETs.</p><p><strong>Methods: </strong>A total of 229 NADETs from 218 patients collected from February 2010 to December 2023 were analyzed. Based on immunohistochemistry for MUC5AC, MUC6, MUC2, and CD10, the NADETs were classified into gastric phenotype (GP), gastric predominant mixed phenotype (GPP), intestinal predominant mixed phenotype (IPP), and intestinal phenotype (IP).</p><p><strong>Results: </strong>Among the 229 NADETs, there were 20, 22, 69, and 118 lesions classified as GP, GPP, IPP, and IP, respectively. Tumor location (first/second/third) was GP = 13/7/0, GPP = 12/8/2, IPP = 13/52/4, and IP = 16/94/8 (p < 0.01). Mean tumor sizes of GP, GPP, IPP, and IP were 14.7/18.5/10.9/10.3 mm (p < 0.01), respectively. The ratio of category 4/5 by Vienna classification was 50.0, 68.2, 13.0, and 2.5% (p < 0.01), respectively. In the comparisons between GP vs. GPP and IP vs. IPP, white opaque substance was significantly less frequently observed in GP than in GPP (p < 0.05), the ratio of category 4/5 was significantly higher in IPP than in IP (p < 0.01), but no significant differences were observed in tumor location, coloration, macroscopic type, and endoscopic findings including magnifying endoscopy with narrow-band imaging.</p><p><strong>Conclusion: </strong>Mixed-type NADETs (GPP and IPP) exhibited similar endoscopic and clinicopathological characteristics to their predominant phenotypes, and may have a higher malignant potential than the pure phenotypes. </p>.</p>","PeriodicalId":11315,"journal":{"name":"Digestion","volume":" ","pages":"144-154"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dialysis, Antithrombotics, and Lesion Location: Who Benefits Most from Gel Immersion Endoscopy in Gastric Endoscopic Submucosal Dissection?","authors":"Hiroki Hayashi, Takeshi Kanno, Tomonori Yano, Kazuaki Akahoshi, Jun Owada, Hiromi Sekiguchi, Takashi Ueno, Yoshie Nomoto, Hisashi Fukuda, Haruo Takahashi, Yuji Ino, Hironori Yamamoto","doi":"10.1159/000548018","DOIUrl":"10.1159/000548018","url":null,"abstract":"<p><p><p>Introduction: Gel immersion endoscopy (GIE) is a technique used to maintain a clear view during gastric endoscopic submucosal dissection. We aimed to identify cases most likely to benefit from GIE for ESD bleeding by reviewing our clinical experience and determining the associated factors.</p><p><strong>Methods: </strong>We retrospectively analyzed 470 lesions in 380 patients who underwent gastric ESD between October 2020 and March 2023. The patients were divided into conventional method (n = 433) and GIE groups (n = 37). We compared the clinical and pathological characteristics between the groups. Univariate and multivariate logistic regression analyses were used to identify factors associated with GIE use. Among the GIE group, hemostasis times under gas, water, and gel conditions were compared using the Kruskal-Wallis test.</p><p><strong>Results: </strong>Multivariate analysis revealed that dialysis (odds ratio [OR]: 15.3), concurrent antiplatelet and anticoagulant use (OR: 9.5), and tumor location in the middle third (OR: 3.5), upper third (OR: 5.7), or remnant stomach (OR: 9.3) were independently associated with GIE use. No significant differences in overall hemostasis time were observed between gas, water, or gel. Of the nine bleeding events exceeding 300 s under gas immersion, seven achieved successful hemostasis by switching to GIE, with a median of 32 s to locate the source and 140 s to complete hemostasis.</p><p><strong>Conclusion: </strong>Dialysis, combined antithrombotic use, and certain tumor locations were key factors influencing GIE for ESD bleeding. Although the overall hemostasis times did not differ, GIE may be particularly beneficial in high-risk scenarios. </p>.</p>","PeriodicalId":11315,"journal":{"name":"Digestion","volume":" ","pages":"309-317"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorectal Polyp Size Measurement Faces Infinite Possibilities: Artificial Intelligence Is the Key.","authors":"Cheng-Long Wang, Xiang-Yu Sui, Yi Zeng, Jia-Yi Wu, Jun-Jie Xing, Song Zhang, Jia-Hui Wei, Kevin Chang, Yi-Ta Wu, Zhao-Shen Li, Sheng-Bing Zhao, Yu Bai, En-Da Yu","doi":"10.1159/000547299","DOIUrl":"10.1159/000547299","url":null,"abstract":"<p><p><p>Background: Colorectal neoplasia poses a severe health threat worldwide. The accurate measurement of polyp size is essential for risk stratification, selecting polypectomy techniques, and determining the surveillance interval. Summary: The methods routinely used for measuring polyp size, including objective ex vivo measurement, subjective visual estimation by an endoscopist, and objective precise measurement using endoscopic instruments, all have limitations. Therefore, the integration of artificial intelligence (AI) with endoscopy has been explored as a promising method for measuring the size of colorectal polyps. However, current AI systems are limited to endoscopic reference media or nonprospective real-time measurements. Consequently, AI-assisted endoscopy for precise, real-time automatic measurement of colorectal polyp size holds great promise for the future. Nevertheless, further extensive studies are necessary. Key Messages: This review focuses on summarizing the advancements in colorectal polyp size research and further explores the potential of AI-assisted measurements. </p>.</p>","PeriodicalId":11315,"journal":{"name":"Digestion","volume":" ","pages":"361-371"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Management of Barrett's Esophagus and Related Neoplasia in Japan.","authors":"Yuto Shimamura, Yugo Iwaya","doi":"10.1159/000547645","DOIUrl":"10.1159/000547645","url":null,"abstract":"<p><strong>Background: </strong>Barrett's esophagus (BE)-related neoplasia remains less prevalent in Japan than in Western countries; however, its incidence is steadily rising. While multimodal treatment - typically endoscopic resection (ER) followed by ablation - is the standard of care, ER alone remains the primary treatment strategy in Japan. With advances in endoscopic techniques, endoscopic submucosal dissection (ESD) has become the mainstay for managing BE-related neoplasia. This review outlines the current Japanese approach, focusing on indications, preoperative assessment, treatment outcomes, and post-resection surveillance practices within the Japanese clinical context.</p><p><strong>Summary: </strong>Accurate endoscopic assessment, including the use of magnifying endoscopy with image-enhanced modalities, is central to Japanese practice due to the importance of complete resection of neoplasia in the absence of ablative therapy. While data on BE-related neoplasia remain relatively limited in Japan, several multicenter studies have demonstrated favorable outcomes for ESD in terms of resection quality, safety, and long-term survival, particularly in low-risk patients. However, challenges remain, including the lack of standardized surveillance protocols and considerable heterogeneity in clinical practice across institutions. The establishment of unified clinical pathways and evidence-based strategies will be essential to address the increasing burden of BE-related neoplasia in Japan.</p><p><strong>Key messages: </strong>The incidence of BE and esophageal adenocarcinoma is increasing in Japan, although still significantly lower than in Western countries. Unlike the Western standard of combining ER with radiofrequency ablation (RFA), Japanese practice relies primarily on ESD as the main curative modality. RFA is not widely available in Japan, leading to a reliance on complete resection and more aggressive ER strategies. Surveillance strategies remain inconsistent, largely due to the lower disease prevalence and limited Japan-specific clinical evidence.</p>","PeriodicalId":11315,"journal":{"name":"Digestion","volume":" ","pages":"81-90"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Approach to Early Barrett's Neoplasia: Western Perspective.","authors":"Gonzalo Latorre, David Galam Kim, Alberto Espino, Robert Bechara","doi":"10.1159/000549733","DOIUrl":"10.1159/000549733","url":null,"abstract":"<p><strong>Background: </strong>Barrett's esophagus (BE) is the replacement of normal squamous epithelium in the distal esophagus by columnar epithelium. The prognosis of esophageal adenocarcinoma depends largely on the stage at diagnosis. Advances in endoscopic imaging and quality standards have significantly improved the early detection of BE-associated neoplasia. This review summarizes current classification systems, sampling protocols, and adjunct tools for diagnosing early neoplasia in BE in Western practice.</p><p><strong>Summary: </strong>In Western practice, the diagnosis of BE relies on consensus criteria requiring endoscopic evidence and histopathological confirmation of columnar epithelium proximal to the gastroesophageal junction. However, there are discrepancies regarding the minimum BE extent and the necessity of intestinal metaplasia for diagnosis. Detecting early neoplasia in BE is challenging due to the flat and subtle nature of dysplastic lesions. High-definition white-light endoscopy (HD-WLE) is the standard modality for BE surveillance and is used to assess for characteristic features of neoplasia, including nodularity, surface irregularity, color changes, and demarcated areas. Image-enhancing techniques - such as virtual chromoendoscopy (e.g., narrow-band imaging [NBI], texture and color enhancement imaging [TXI], blue light imaging [BLI], linked color imaging [LCI]), and acetic acid chromoendoscopy - have improved dysplasia detection when applied alongside validated classification systems. Despite technological advances, random four-quadrant biopsies (4QBs) remain the standard for dysplasia detection. Estimating lesion depth is based primarily on HD-WLE, with limited contribution from chromoendoscopy and ancillary imaging techniques (i.e., endoscopic ultrasound [EUS], confocal laser endomicroscopy, optical coherence tomography).</p><p><strong>Key messages: </strong>Early Barrett's neoplasia is challenging to detect. HD-WLE and image-enhancing techniques improve visualization, but random 4QBs remain central to the diagnostic process. Lesion depth is primarily assessed using endoscopic features and, to a limited extent, ancillary techniques.</p>","PeriodicalId":11315,"journal":{"name":"Digestion","volume":" ","pages":"31-46"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145596366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Statement.","authors":"","doi":"10.1159/000549694","DOIUrl":"10.1159/000549694","url":null,"abstract":"<p><p>The article \"DYRK2 regulates epithelial-mesenchymal transition restriction in pancreatic cancer liver metastasis by inhibiting Twist\" [Digestion 2024; https://doi.org/10.1159/000541039] by Hang Pan, Yin Liu, Kejiu Bao, Yulin Wang, Yuping Zhang and Lina Zhou has been retracted by the Publisher and the Editor.After peer review, the accepted, unedited manuscript was published online as Early View. The authors did not respond to our requests and communication regarding the production process of their article despite extensive attempts at contact. As the article has not been approved by the authors for publication, we cannot publish the final version. To avoid confusion for readers we are retracting the Early View accepted, unedited manuscript.The authors did not respond to correspondence about the retraction.</p>","PeriodicalId":11315,"journal":{"name":"Digestion","volume":" ","pages":"297"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}