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VALIDATION OF A SIMPLES METHOD FOR SIMULTANEOUS DETERMINATION OF LIPOIC ACID AND RESVERATROL BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY 高效液相色谱法同时测定硫辛酸和白藜芦醇的方法验证
Drug Analytical Research Pub Date : 2018-09-14 DOI: 10.22456/2527-2616.82578
I. Guerreiro, Samuel Davies, S. Guterres, S. Berlitz
{"title":"VALIDATION OF A SIMPLES METHOD FOR SIMULTANEOUS DETERMINATION OF LIPOIC ACID AND RESVERATROL BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY","authors":"I. Guerreiro, Samuel Davies, S. Guterres, S. Berlitz","doi":"10.22456/2527-2616.82578","DOIUrl":"https://doi.org/10.22456/2527-2616.82578","url":null,"abstract":"A high-performance liquid chromatography-ultraviolet (HPLC-UV) method was developed and validated for simultaneous determination of Resveratrol (RSV) and Lipoic Acid (LA). A C18 column was used with a mobile phase consisting of acetonitrile and 0.01M phosphoric acid (60:40). The detection wavelength was at 235 nm. The method was specific in the presence of pharmaceutical excipients widely used in solid dosage forms or lipid-core nanocapsules. The results demonstrated linearity between 5 and 50 µg/mL for RSV and 30 and 120 µg/mL for LA. The method presented precision and accuracy (RSD <5%). In addition, the developed method was considered robust. Therefore, the developed method can be applied successfully for simultaneous determination of RSV and LA in the proposed conditions, with a potential application to assay both drugs in several dosage forms.","PeriodicalId":11314,"journal":{"name":"Drug Analytical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73862839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
LC-MS/MS METHOD FOR THE SIMULTANEOUS DETERMINATION OF CEFEPIME AND TAZOBACTAM IN DOG PLASMA Lc-ms / ms法同时测定狗血浆中头孢吡肟和他唑巴坦的含量
Drug Analytical Research Pub Date : 2018-09-14 DOI: 10.22456/2527-2616.84357
K. Patil, Sukanta K. Naik, Vineet S. Zope, R. Chavan, R. Yeole
{"title":"LC-MS/MS METHOD FOR THE SIMULTANEOUS DETERMINATION OF CEFEPIME AND TAZOBACTAM IN DOG PLASMA","authors":"K. Patil, Sukanta K. Naik, Vineet S. Zope, R. Chavan, R. Yeole","doi":"10.22456/2527-2616.84357","DOIUrl":"https://doi.org/10.22456/2527-2616.84357","url":null,"abstract":"A high performance liquid chromatography (HPLC) method with tandem mass spectrometric detection (MS/MS) has been developed and validated for the simultaneous quantification of cefepime and tazobactam in dog plasma. The method was developed on amide column with isocratic elution. The developed method is simple and economic in terms of sample preparation. The method is specific, sensitive, accurate, precise and robust. The method was successfully applied for pre-clinical pharmaco-kinetic studies in dogs. The Tmax was found to be 0.5 hr, the mean Cmax and AUC(0-12) displayed dose proportionate response.","PeriodicalId":11314,"journal":{"name":"Drug Analytical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74679381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
FEASIBILITY STUDY FOR ANTISEPTIC GEL FORMULATIONS INCORPORATING THE ESSENTIAL OILS CYMBOPOGON CITRATUS (DC.) STAPF. AND CARYOPHYLLUS AROMATICUS L. 含香茅精油的防腐凝胶制剂的可行性研究STAPF。和香石竹。
Drug Analytical Research Pub Date : 2018-09-14 DOI: 10.22456/2527-2616.77118
L. Vinciguerra, C. Rohr, Graziela Heberlé
{"title":"FEASIBILITY STUDY FOR ANTISEPTIC GEL FORMULATIONS INCORPORATING THE ESSENTIAL OILS CYMBOPOGON CITRATUS (DC.) STAPF. AND CARYOPHYLLUS AROMATICUS L.","authors":"L. Vinciguerra, C. Rohr, Graziela Heberlé","doi":"10.22456/2527-2616.77118","DOIUrl":"https://doi.org/10.22456/2527-2616.77118","url":null,"abstract":"Recent years have seen an increase in the search by the pharmaceutical industry for products and active ingredients of natural origin. Additionally, there is a need for the creation of new market products such as antiseptics, used to prevent or reduce the risk of infection by inhibiting the proliferation of microorganisms. The objective of this study was to produce two antiseptic gels by incorporating into each of them individually an essential oil, namely lemongrass and cloves, and subsequently evaluating the antimicrobial activity by minimum inhibitory concentration (MIC) testing. The oils and gels were tested in parallel and resulted in a similar profile that can be observed in the inhibition concentration. This was a preliminary study that merits further investigation, which may progress to stability testing and evaluation of lower concentrations incorporated into the gel base.","PeriodicalId":11314,"journal":{"name":"Drug Analytical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90708475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
ANALYTICAL METHOD BY LIQUID CHROMATOGRAPHY TO ASSAY PIPERINE ASSOCIATED IN NANOEMULSIONS 液相色谱法测定纳米乳中胡椒碱的含量
Drug Analytical Research Pub Date : 2018-09-14 DOI: 10.22456/2527-2616.80366
M. Motta, A. Schneider, C. Codevilla, C. R. Menezes, C. B. Silva
{"title":"ANALYTICAL METHOD BY LIQUID CHROMATOGRAPHY TO ASSAY PIPERINE ASSOCIATED IN NANOEMULSIONS","authors":"M. Motta, A. Schneider, C. Codevilla, C. R. Menezes, C. B. Silva","doi":"10.22456/2527-2616.80366","DOIUrl":"https://doi.org/10.22456/2527-2616.80366","url":null,"abstract":"This work aimed to develop and validate a simple, fast and low cost analytical method for the quantification of the bioactive piperine in nanoemulsions by high performance liquid chromatography with UV detection. Nanoemulsions were prepared by spontaneous emulsification and their physicochemical properties were evaluated. Considering the chromatographic conditions, the mobile phase was composed by methanol:water (70:30, v/v), Gemini® C18 column, and UV detection at 343 nm. The method was linear in the concentration range of 5-50 μg mL-1 (r = 0.9999), specific, precise (repeatability of RSD 0.38 % and intermediate precision of RSD 1.11 %), accurate (101.3 %) and robust. Nanoemulsions showed nanometric droplet size, polidispersity index below 0.11 and negative zeta potential. The piperine content in the samples was 0.99 ± 0.01 mg mL-1. Regarding these features, the analytical conditions proposed in this work were adequate and effective to determine the piperine content in nanoemulsions.","PeriodicalId":11314,"journal":{"name":"Drug Analytical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88111136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
SECOND-ORDER DERIVATIVE UV SPECTROPHOTOMETRIC AND RP-HPLC METHODS FOR THE ANALYSIS OF VILDAGLIPTIN AND APPLICATION FOR DISSOLUTION STUDY 二阶导数紫外分光光度法和反相高效液相色谱法分析维格列汀及其溶出度研究
Drug Analytical Research Pub Date : 2018-09-14 DOI: 10.22456/2527-2616.86511
A. Barden, B. Piccoli, N. Volpato, M. Steppe
{"title":"SECOND-ORDER DERIVATIVE UV SPECTROPHOTOMETRIC AND RP-HPLC METHODS FOR THE ANALYSIS OF VILDAGLIPTIN AND APPLICATION FOR DISSOLUTION STUDY","authors":"A. Barden, B. Piccoli, N. Volpato, M. Steppe","doi":"10.22456/2527-2616.86511","DOIUrl":"https://doi.org/10.22456/2527-2616.86511","url":null,"abstract":"This study describes two analytical methods, by second-order derivative UV spectrophotometric by HPLC, for determination of vildagliptin, a drug used for treatment of type 2 Diabetes Mellitus that belongs to a therapeutic class called inhibitors of dipeptidyl peptidase 4. The methods were validated in accordance with ICH and USP requirements. Analyses by UV derivative method were performed at 220 nm, which was the zero crossing point of excipient solutions. HPLC was optimized and the analysis was carried out using a Zorbax Eclipse Plus RP-C8 column (150 mm × 4.6 mm, 5 μm), detection at 207 nm, and potassium phosphate buffer solution pH 7.0 : acetonitrile (85:15, v/v) as mobile phase. In dissolution test, the conditions used were 0.01 mol L-1 hydrochloric acid in 900 mL of dissolution medium, USP apparatus 2 (paddle) and 50 rpm stirring speed. Both methods were successfully applied for analysis of dissolution samples from marketed vildagliptin tablets.","PeriodicalId":11314,"journal":{"name":"Drug Analytical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76908998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
DEVELOPMENT AND VALIDATION OF A SIMPLE AND FAST METHOD FOR SULFONAMIDES, TETRACYCLINES AND MACROLIDES IN HONEY USING LC-MS/MS lc-ms / ms快速测定蜂蜜中磺胺类、四环素类和大环内酯类物质的方法的建立与验证
Drug Analytical Research Pub Date : 2018-09-14 DOI: 10.22456/2527-2616.84248
Cristina Ribeiro, M. T. Martins, L. Jank, F. Barreto, R. Hoff, J. Arsand
{"title":"DEVELOPMENT AND VALIDATION OF A SIMPLE AND FAST METHOD FOR SULFONAMIDES, TETRACYCLINES AND MACROLIDES IN HONEY USING LC-MS/MS","authors":"Cristina Ribeiro, M. T. Martins, L. Jank, F. Barreto, R. Hoff, J. Arsand","doi":"10.22456/2527-2616.84248","DOIUrl":"https://doi.org/10.22456/2527-2616.84248","url":null,"abstract":"Antibacterial are widely used in veterinary applications for diseases treatment and prophilatic purposes. Inadequate uses of these drugs can lead of undesirable residues in honey for consumption. In Brazil, the legal authorities set a maximum residue limit (MRL) for different compound in honey, ranging from 10 to 20 ng ml-1. The monitoring of antibacterials is a concern, since it constitutes a risk to human health and collaborates with the growth of resistant bacteria. Brazil has the National Residue Control Plan (NRCP) to ensure that the products traded are compliant with the safety and quality criteria required by consumers. The goal of this work was to develop and validate a method suitable to determine sulfonamides, tetracyclines and macrolides in honey, using liquid chromatography tandem mass spectrometry. The main objective was to develop an efficient technique, combining simplicity, speed and low cost, since the method will be employed in routine analysis. Recoveries between 36 to 139% were obtained. Good linearity (r2) above 0.95, considering three different days, for all drugs was achieved in concentrations ranging from 0 to 200% of the MRL. Intraday and inter-day precision with CV% (n=6) lower than 18%, in agreement with specifications were obtained in concentrations ranging from 0.5 to 1.5 MRL, except for erythromycin. Accuracy was between 97 to 108%. Limits of quantitation for macrolides were 2.5 ng g-1and for sulfonamides and tetracyclines were 5 ng g-1. Decision limit (CCα) was evaluated and the results obtained were between 12.9 to 28.1 ng g-1. The detection capability (CCβ) obtained was between 15.8 to 36.3 ng g-1. The proposed method demonstrated to be suitable for this intended purpose and will contribute to antibacterial honey monitoring.","PeriodicalId":11314,"journal":{"name":"Drug Analytical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81899578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
MICROBIOLOGICAL ASSAY FOR THE DETERMINATION OF CEFPIROME IN RAW MATERIAL AND INJECTABLE PREPARATION 原料和注射制剂中头孢匹罗的微生物测定方法
Drug Analytical Research Pub Date : 2018-09-14 DOI: 10.22456/2527-2616.84473
T. P. Oppe, Júlia Menegola, E. Schapoval
{"title":"MICROBIOLOGICAL ASSAY FOR THE DETERMINATION OF CEFPIROME IN RAW MATERIAL AND INJECTABLE PREPARATION","authors":"T. P. Oppe, Júlia Menegola, E. Schapoval","doi":"10.22456/2527-2616.84473","DOIUrl":"https://doi.org/10.22456/2527-2616.84473","url":null,"abstract":"Cefpirome is a fourth-generation cephalosporin active against a broad spectrum of gram-negative and gram-positive bacterial infections. The present work describe the development and validation of a simple, sensitive and specific agar diffusion bioassay applying cylinder-plate method for quantification of cefpirome in raw material and powder for injectable preparation. The validation method yielded good results and included linearity, precision, accuracy and specificity. The assay is based on the inhibitory effect of cefpirome upon the strain of Kocuria rizophila ATCC 9341 as the test microorganism. The result of assay were treated statistically by ANOVA and the response graphs for standard and sample solutions were linear (r = 0.9948) in the range of 0.3 – 1.2 µg mL-1, precise (intra-assay: RSD = 0.11; inter-assay: RSD = 0.18) and accurate (mean recovery value = 99.41%). A preliminary stability study of cefpirome showed that the microbiological assay is specific for the determination cefpirome in the presence of its degradation products. The proposed microbiological method allows the quantitation of cefpirome in pharmaceutical dosage form and raw material and can be used for the drug analysis in routine quality control.","PeriodicalId":11314,"journal":{"name":"Drug Analytical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84954397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Simultaneous analysis of dapagliflozin and its three related impurities by stability-indicating UPLC method and in vitro toxicity evaluation 稳定性指示UPLC法同时分析达格列净及其3种相关杂质及体外毒性评价
Drug Analytical Research Pub Date : 2008-08-21 DOI: 10.22456/2527-2616.128661
L. Bueno, J. W. Manoel, M. Koetz, A. Henriques, M. Steppe, E. Schapoval
{"title":"Simultaneous analysis of dapagliflozin and its three related impurities by stability-indicating UPLC method and in vitro toxicity evaluation","authors":"L. Bueno, J. W. Manoel, M. Koetz, A. Henriques, M. Steppe, E. Schapoval","doi":"10.22456/2527-2616.128661","DOIUrl":"https://doi.org/10.22456/2527-2616.128661","url":null,"abstract":"","PeriodicalId":11314,"journal":{"name":"Drug Analytical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75634239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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