Drug Metabolism Reviews最新文献_第7页

Mass spectrometry based protein biomarkers and drug target discovery and clinical diagnosis in Age-Related progressing neurodegenerative diseases. 年龄相关进展性神经退行性疾病中基于质谱的蛋白质生物标志物和药物靶点发现与临床诊断。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2022-02-01 Epub Date: 2022-01-24 DOI: 10.1080/03602532.2022.2029475

Ishita Agrawal, Pallavi Tripathi, Shyamasri Biswas

{"title":"Mass spectrometry based protein biomarkers and drug target discovery and clinical diagnosis in Age-Related progressing neurodegenerative diseases.","authors":"Ishita Agrawal, Pallavi Tripathi, Shyamasri Biswas","doi":"10.1080/03602532.2022.2029475","DOIUrl":"https://doi.org/10.1080/03602532.2022.2029475","url":null,"abstract":"Neurodegenerative diseases correspond to overly complex health disorders that are driven by intersecting pathophysiology that are often trapped in vicious cycles of degeneration and cognitive decline. The usual diagnostic route of these diseases is based on postmortem examination that involves identifying pathology that is specific to the disease in the brain. However, in such cases, accurate diagnosis of the specific disease is limited because clinical disease presentations are often complex that do not easily allow to discriminate patient's cognitive, behavioral, and functional impairment profiles. Additionally, an early identification and therapeutic intervention of these diseases is pivotal to slow the progression of neurodegeneration and extend healthy life span. Mass spectrometry-based techniques have proven to be hugely promising in biological sample analysis and discovery of biomarkers including protein and peptide biomarkers for potential drug target discovery. Recent studies on these biomarkers have demonstrated their potential for applications in early diagnostics and identifying therapeutic targets to battle against neurodegenerative diseases. In this review, we have presented principles of mass spectrometry (MS) and the associated workflows in analyzing and imaging biological samples for discovery of biomarkers. We have especially focused on age-related progressing neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's disease (PD), Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FTD) and the related MS-based biomarker developments for these diseases. Finally, we present a future perspective discussing the potential research directions ahead.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"54 1","pages":"22-36"},"PeriodicalIF":5.9,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39917390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Cell-Biomaterial constructs for wound healing and skin regeneration. 用于伤口愈合和皮肤再生的细胞-生物材料结构。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2022-02-01 Epub Date: 2022-04-02 DOI: 10.1080/03602532.2021.2025387

Ingrid Safina, Luke T Childress, Srinivas R Myneni, Kieng Bao Vang, Alexandru S Biris

{"title":"Cell-Biomaterial constructs for wound healing and skin regeneration.","authors":"Ingrid Safina, Luke T Childress, Srinivas R Myneni, Kieng Bao Vang, Alexandru S Biris","doi":"10.1080/03602532.2021.2025387","DOIUrl":"https://doi.org/10.1080/03602532.2021.2025387","url":null,"abstract":"Over the years, conventional skin grafts, such as full-thickness, split-thickness, and pre-sterilized grafts from human or animal sources, have been at the forefront of skin wound care. However, these conventional grafts are associated with major challenges, including supply shortage, rejection by the immune system, and disease transmission following transplantation. Due to recent progress in nanotechnology and material sciences, advanced artificial skin grafts-based on the fundamental concepts of tissue engineering-are quickly evolving for wound healing and regeneration applications, mainly because they can be uniquely tailored to meet the requirements of specific injuries. Despite tremendous progress in tissue engineering, many challenges and uncertainties still face skin grafts in vivo, such as how to effectively coordinate the interaction between engineered biomaterials and the immune system to prevent graft rejection. Furthermore, in-depth studies on skin regeneration at the molecular level are still not fully understood; as a consequence, the development of novel biomaterial-based systems that interact with the skin at the core level has also been slow. This review will discuss (1) the biological aspects of wound healing and skin regeneration, (2) important characteristics and functions of biomaterials for skin regeneration applications, and (3) synthesis and applications of common biomaterials for skin regeneration. Finally, the current challenges and future directions of biomaterial-based skin regeneration will be addressed.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"54 1","pages":"63-94"},"PeriodicalIF":5.9,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39896309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Through a glass, darkly? HepaRG and HepG2 cells as models of human phase I drug metabolism. 透过玻璃，黑暗地?HepaRG和HepG2细胞作为人类I期药物代谢模型。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2022-02-01 Epub Date: 2022-02-23 DOI: 10.1080/03602532.2022.2039688

Lesley A Stanley, C Roland Wolf

{"title":"Through a glass, darkly? HepaRG and HepG2 cells as models of human phase I drug metabolism.","authors":"Lesley A Stanley, C Roland Wolf","doi":"10.1080/03602532.2022.2039688","DOIUrl":"https://doi.org/10.1080/03602532.2022.2039688","url":null,"abstract":"The pharmacokinetic and safety assessment of drug candidates is becoming increasingly dependent upon in vitro models of hepatic metabolism and toxicity. Predominant among these is the HepG2 cell line, although HepaRG is becoming increasingly popular because of its perceived closer resemblance to human hepatocytes. We review the functionality of these cell lines in terms of Phase I protein expression, basal cytochrome P450-dependent activity, and utility in P450 induction studies. Our analysis indicates that HepG2 cells are severely compromised: proteomic studies show that they express few key proteins in common with hepatocytes and they lack drug-metabolizing capacity. Differentiated HepaRGs are more hepatocyte-like than HepG2s, but they also have limitations, and it is difficult to assess their utility because of the enormous variability in data reported, possibly arising from the complex differentiation protocols required to obtain hepatocyte-like cells. This is exacerbated by the use of DMSO in the induction protocol, together with proprietary supplements whose composition is a commercial secret. We conclude that, while currently available data on the utility of HepaRG generates a confusing picture, this line does have potential utility in drug metabolism studies. However, to allow studies to be compared directly a standardized, reproducible differentiation protocol is essential and the cell line's functionality in terms of known mechanisms of P450 regulation must be demonstrated. We, therefore, support the development of regulatory guidelines for the use of HepaRGs in induction studies as a first step in generating a database of consistent, reliable data.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"54 1","pages":"46-62"},"PeriodicalIF":5.9,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39941805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The relationship between UGT1A1 gene & various diseases and prevention strategies. UGT1A1基因与多种疾病的关系及预防策略

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2022-02-01 Epub Date: 2021-11-22 DOI: 10.1080/03602532.2021.2001493

Dan Liu, Qi Yu, Qing Ning, Zhongqiu Liu, Jie Song

{"title":"The relationship between UGT1A1 gene & various diseases and prevention strategies.","authors":"Dan Liu, Qi Yu, Qing Ning, Zhongqiu Liu, Jie Song","doi":"10.1080/03602532.2021.2001493","DOIUrl":"https://doi.org/10.1080/03602532.2021.2001493","url":null,"abstract":"UDP-glucuronyltransferase 1A1 (UGT1A1) is a member of the Phase II metabolic enzyme family and the only enzyme that can metabolize detoxified bilirubin. Inactivation and very low activity of UGT1A1 in the liver can be fatal or lead to lifelong Gilbert's syndrome (GS) and Crigler-Najjar syndrome (CN). To date, more than one hundred UGT1A1 polymorphisms have been discovered. Although most UGT1A1 polymorphisms are not fatal, which diseases might be associated with low activity UGT1A1 or UGT1A1 polymorphisms? This scientific topic has been studied for more than a hundred years, there are still many uncertainties. Herein, this article will summarize all the possibilities of UGT1A1 gene-related diseases, including GS and CN, neurological disease, hepatobiliary disease, metabolic difficulties, gallstone, cardiovascular disease, Crohn's disease (CD) obesity, diabetes, myelosuppression, leukemia, tumorigenesis, etc., and provide guidance for researchers to conduct in-depth study on UGT1A1 gene-related diseases. In addition, this article not only summarizes the prevention strategies of UGT1A1 gene-related diseases, but also puts forward some insights for sharing.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"54 1","pages":"1-21"},"PeriodicalIF":5.9,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39757878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

GSTM1 and GSTT1 polymorphisms in healthy volunteers - a worldwide systematic review. 健康志愿者的GSTM1和GSTT1多态性——一项全球系统综述。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2022-02-01 Epub Date: 2022-02-15 DOI: 10.1080/03602532.2022.2036996

Giovana Nakanishi, Laísa S Bertagnolli, Murilo Pita-Oliveira, Mariana M Scudeler, Sabrina Torres-Loureiro, Thaís Almeida-Dantas, Maria Laura C Alves, Heithor S Cirino, Fernanda Rodrigues-Soares

{"title":"GSTM1 and GSTT1 polymorphisms in healthy volunteers - a worldwide systematic review.","authors":"Giovana Nakanishi, Laísa S Bertagnolli, Murilo Pita-Oliveira, Mariana M Scudeler, Sabrina Torres-Loureiro, Thaís Almeida-Dantas, Maria Laura C Alves, Heithor S Cirino, Fernanda Rodrigues-Soares","doi":"10.1080/03602532.2022.2036996","DOIUrl":"10.1080/03602532.2022.2036996","url":null,"abstract":"The GSTM1 and GSTT1 genes encode homonymous enzymes, which are responsible for the detoxification of several substances potentially harmful to the human body, such as air pollution, drugs, pesticides, and tobacco. However, some individuals may present a complete deletion of these genes and, consequently, an enzyme deficiency leading to an inadequate metabolism and, therefore, a higher susceptibility to some clinical conditions. Interethnic variations have also been described for both genes, making necessary the study of the deletion frequencies of GSTM1 and GSTT1 in different populations around the world. So, the aim of this study was to enable the synthesis and discussion of the main population differences of GSTM1 and GSTT1 polymorphisms in healthy volunteers. Searches were performed in the PubMed database, including 533 articles and 178,566 individuals in the analyses. We found an overrepresentation of European individuals and studies, and an underrepresentation of non-European ethnicities. Moreover, there are significant frequency differences among distinct ethnic groups: East Asians present the highest frequencies worldwide for GSTM1 and GSTT1 deletions, which could suggest higher disorders risk for this population; in contrast, Sub-Saharan Africans presented the lowest frequency of GSTM1 worldwide, corroborating evolution inferences performed previously for other genes codifying metabolism enzymes. Also, admixture is a relevant component when analyzing frequency values for both genes, but further studies focusing on this subject are warranted.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"54 1","pages":"37-45"},"PeriodicalIF":5.9,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39877606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The annoying flaws of gerontological research. 老年学研究中恼人的缺陷。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2022-02-01 Epub Date: 2022-02-04 DOI: 10.1080/03602532.2022.2035393

Magomed Khaidakov, Valeria Troshina, Dmitry Menglet, Yusef Yusef, Alexander Plotkin

引用次数: 0

Pharmacology of apocynin: a natural acetophenone. 罗布宁的药理作用:一种天然的苯乙酮。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2021-11-01 Epub Date: 2021-03-10 DOI: 10.1080/03602532.2021.1895203

Shreya R Savla, Ankit P Laddha, Yogesh A Kulkarni

{"title":"Pharmacology of apocynin: a natural acetophenone.","authors":"Shreya R Savla, Ankit P Laddha, Yogesh A Kulkarni","doi":"10.1080/03602532.2021.1895203","DOIUrl":"https://doi.org/10.1080/03602532.2021.1895203","url":null,"abstract":"Apocynin is a naturally occurring acetophenone, found in the roots of Apocynum cannabinum and Picrorhiza kurroa. Various chemical and pharmaceutical modifications have been carried out to enhance the absorption and duration of action of apocynin, like, formulation of chitosan-based apocynin-loaded solid lipid nanoparticles, chitosan-oligosaccharide based nanoparticles, and biodegradable polyanhydride nanoparticles. Apocynin has been subjected to a wide range of experimental screening and has proved to be useful for amelioration of a variety of disorders, like diabetic complications, neurodegeneration, cardiovascular disorders, lung cancer, hepatocellular cancer, pancreatic cancer, and pheochromocytoma. Apocynin has been primarily reported as an NADPH oxidase (NOX) inhibitor and prevents translocation of its p47phox subunit to the plasma membrane, observed in neurodegeneration and hypertension. However, recent studies highlight its off-target effects that it is able to function as a scavenger of non-radical oxidant species, which is relevant for its activity against NOX 4 mediated production of hydrogen peroxide. Additionally, apocynin has shown inhibition of eNOS-dependent superoxide production in diabetic cardiomyopathy, reduction of NLRP3 activation and TGFβ/Smad signaling in diabetic nephropathy, diminished VEGF expression and decreased retinal NF-κB activation in diabetic retinopathy, inhibition of P38/MAPK/Caspase3 pathway in pheochromocytoma, inhibition of AKT-GSK3β and ERK1/2 pathways in pancreatic cancer, and decreased FAK/PI3K/Akt signaling in hepatocellular cancer. This review aims to discuss the pharmacokinetics and mechanisms of the pharmacological actions of apocynin.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"53 4","pages":"542-562"},"PeriodicalIF":5.9,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03602532.2021.1895203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25468432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Janus nanoparticles: an efficient intelligent modern nanostructure for eradicating cancer. Janus纳米粒子:用于根除癌症的高效智能现代纳米结构。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2021-11-01 Epub Date: 2021-02-09 DOI: 10.1080/03602532.2021.1878530

Farshid Gheisari, Mostafa Shafiee, Milad Abbasi, Ali Jangjou, Peyman Izadpanah, Ahmad Vaez, Ali Mohammad Amani

{"title":"Janus nanoparticles: an efficient intelligent modern nanostructure for eradicating cancer.","authors":"Farshid Gheisari, Mostafa Shafiee, Milad Abbasi, Ali Jangjou, Peyman Izadpanah, Ahmad Vaez, Ali Mohammad Amani","doi":"10.1080/03602532.2021.1878530","DOIUrl":"https://doi.org/10.1080/03602532.2021.1878530","url":null,"abstract":"In the modern age, the struggle to generate appropriate bio-based materials and nano-scaled colloidal particulates for developed application domains, has already resulted in remarkable attempts in the advancement of regulated size and shape, anisotropy, and characteristics of nanostructures. The bottom-up development strategies of components are among the most important science areas throughout nanotechnology, in which the designed building blocks are often utilized to generate novel structures by random self-assembly. In biomedical applications, Janus nanoparticles (JNPs) are necessary. This is due to their effective stimulus-responsive properties, tunable structure, biocompatibility, containing two surfaces with various hydrophobic characteristics and distinct functional groups. Featuring two parts with differing hydrophobicity has been the most critical aspect of the Janus amphiphilic particles. Development of JNPs has been afforded, using imaging agents (e.g. gold (AU) for photoacoustic imaging processing (PAI), silver for surface-enhanced Raman scattering (SERS), and Fe3O4 and MnO2 to magnetic resonance imaging (MRI)). It is also to be mentioned that a number of other properties become salient - properties such as integration imaging factors into JNPs (like quantum dots, fluorescent dyes), multiple imaging methods for screening and diagnosis application can indeed be accomplished. Janus nanostructures have been promising platforms for bioengineering as therapeutic carriers, drug delivery vehicles, and biosensor equipment; they may also be employed for the transport of bioactive hydrophilic and hydrophobic materials. The main production approaches and major advancement of JNPs in the biomedical sector and cancer therapy will be described in this paper.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"53 4","pages":"592-603"},"PeriodicalIF":5.9,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03602532.2021.1878530","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25348496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition. 通过抑制细胞色素P450 3A提高治疗性草药成分的口服生物利用度。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2021-11-01 Epub Date: 2021-04-27 DOI: 10.1080/03602532.2021.1917598

Junmei Chen, Jinman Liu, Yueyue Huang, Ruoyu Li, Cuiru Ma, Beiping Zhang, Fanchang Wu, Wenqian Yu, Xue Zuo, Yong Liang, Qi Wang

{"title":"Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition.","authors":"Junmei Chen, Jinman Liu, Yueyue Huang, Ruoyu Li, Cuiru Ma, Beiping Zhang, Fanchang Wu, Wenqian Yu, Xue Zuo, Yong Liang, Qi Wang","doi":"10.1080/03602532.2021.1917598","DOIUrl":"https://doi.org/10.1080/03602532.2021.1917598","url":null,"abstract":"Herbal plants typically have complex compositions and diverse mechanisms. Among them, bioactive constituents with relatively high exposure in vivo are likely to exhibit therapeutic efficacy. On the other hand, their bioavailability may be influenced by the synergistic effects of different bioactive components. Cytochrome P450 3A (CYP3A) is one of the most abundant CYP enzymes, responsible for the metabolism of 50% of approved drugs. In recent years, many therapeutic herbal constituents have been identified as CYP3A substrates. It is more evident that CYP3A inhibition derived from the herbal formula plays a critical role in improving the oral bioavailability of therapeutic constituents. CYP3A inhibition may be the mechanism of the synergism of herbal formula. In this review, we explored the multiplicity of CYP3A, summarized herbal monomers with CYP3A inhibitory effects, and evaluated herb-mediated CYP3A inhibition, thereby providing new insights into the mechanisms of CYP3A inhibition-mediated oral herb bioavailability.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"53 4","pages":"491-507"},"PeriodicalIF":5.9,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03602532.2021.1917598","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38921398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Toxicity mechanisms of nanoparticles in the male reproductive system. 纳米颗粒在男性生殖系统中的毒性机制。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2021-11-01 Epub Date: 2021-05-14 DOI: 10.1080/03602532.2021.1917597

Khaled Habas, Eşref Demir, Chongye Guo, Martin H Brinkworth, Diana Anderson

{"title":"Toxicity mechanisms of nanoparticles in the male reproductive system.","authors":"Khaled Habas, Eşref Demir, Chongye Guo, Martin H Brinkworth, Diana Anderson","doi":"10.1080/03602532.2021.1917597","DOIUrl":"https://doi.org/10.1080/03602532.2021.1917597","url":null,"abstract":"The field of nanotechnology has allowed for increasing nanoparticle (NP) exposure to the male reproductive system. Certain NPs have been reported to have adverse consequences on male germ and somatic cells. Germ cells are the bridge between generations and are responsible for the transmission of genetic and epigenetic information to future generations. A number of NPs have negative impacts on male germ and somatic cells which could ultimately affect fertility or the ability to produce healthy offspring. These impacts are related to NP composition, modification, concentration, agglomeration, and route of administration. NPs can induce severe toxic effects on the male reproduction system after passing through the blood-testis barrier and ultimately damaging the spermatozoa. Therefore, understanding the impacts of NPs on reproduction is necessary. This review will provide a comprehensive overview on the current state of knowledge derived from the previous in vivo and in vitro research on effects of NPs on the male reproductive system at the genetic, cellular, and molecular levels.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"53 4","pages":"604-617"},"PeriodicalIF":5.9,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03602532.2021.1917597","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38993551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20