Drug Metabolism Reviews最新文献_第10页

What dominates the changeable pharmacokinetics of natural sesquiterpene lactones and diterpene lactones: a review focusing on absorption and metabolism. 天然倍半萜内酯和二萜内酯药代动力学变化的主导因素:以吸收和代谢为主的综述。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2021-02-01 Epub Date: 2020-12-21 DOI: 10.1080/03602532.2020.1853151

Ziwei Yu, Ziqiang Chen, Qijuan Li, Ke Yang, Zecheng Huang, Wenjun Wang, Siyu Zhao, Huiling Hu

{"title":"What dominates the changeable pharmacokinetics of natural sesquiterpene lactones and diterpene lactones: a review focusing on absorption and metabolism.","authors":"Ziwei Yu, Ziqiang Chen, Qijuan Li, Ke Yang, Zecheng Huang, Wenjun Wang, Siyu Zhao, Huiling Hu","doi":"10.1080/03602532.2020.1853151","DOIUrl":"https://doi.org/10.1080/03602532.2020.1853151","url":null,"abstract":"Sesquiterpene lactones (STLs) and diterpene lactones (DTLs) are two groups of common phytochemicals with similar structures. It's frequently reported that both exhibit changeable pharmacokinetics (PK) in vivo, especially the unstable absorption and extensive metabolism. However, the recognition of their PK characteristics is still scattered. In this review, representative STLs (atractylenolides, alantolactone, costunolide, artemisinin, etc.) and DTLs (ginkgolides, andrographolide, diosbulbins, triptolide, etc.) as typical cases are discussed in detail. We show how the differences of treatment regimens and subjects alter the PK of STLs and DTLs, with emphasis on the effects from absorption and metabolism. These compounds tend to be quite permeable in intestinal epithelium, but gastrointestinal pH and efflux transporters (represented by P-glycoprotein) have great impact and result in the unstable absorption. As the only characteristic functional moiety, the metabolic behavior of lactone ring is not dominant. The α, β-unsaturated lactone moiety has the strongest metabolic activity. While with the increase of low-activity saturated lactone moieties, the metabolism is led by other groups more easily. The phase I (oxidation, reduction and hydrolysis reaction) and II metabolism (conjugation reaction) are both extensive. CYP450s, mainly CYP3A4, are largely involved in biotransformation. However, only UGTs (UGT1A3, UGT1A4, UGT2B4 and UGT2B7) has been mentioned in studies about phase II metabolic enzymes. Our work offers a beneficial reference for promoting the safety evaluation and maximizing the utilization of STLs and DTLs.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"53 1","pages":"122-140"},"PeriodicalIF":5.9,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03602532.2020.1853151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38619698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Recent biotechnological approaches for treatment of novel COVID-19: from bench to clinical trial. 治疗新型COVID-19的最新生物技术方法:从实验室到临床试验。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2021-02-01 Epub Date: 2020-11-23 DOI: 10.1080/03602532.2020.1845201

Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Najmeh Parvin, Ahmad Gholami, Seeram Ramakrishna, Navid Omidifar, Mohsen Moghadami, Wei-Hung Chiang, Sargol Mazraedoost

{"title":"Recent biotechnological approaches for treatment of novel COVID-19: from bench to clinical trial.","authors":"Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Najmeh Parvin, Ahmad Gholami, Seeram Ramakrishna, Navid Omidifar, Mohsen Moghadami, Wei-Hung Chiang, Sargol Mazraedoost","doi":"10.1080/03602532.2020.1845201","DOIUrl":"https://doi.org/10.1080/03602532.2020.1845201","url":null,"abstract":"The global spread of the novel coronavirus (SARS-CoV-2) and increasing rate of mortality among different countries has raised the global concern regarding this disease. This illness is able to infect human beings through person-to-person contact at an extremely high rate. World Health Organization proclaimed that COVID-19 disease is known as the sixth public health emergency of international concern (30 January 2020) and also as one pandemic (12 March 2020). Owing to the rapid outbreak of COVID-19 worldwide, health authorities focused on discovery of effective prevention and treatment techniques for this novel virus. To date, an effective drug for reliable treatment of COVID-19 has not been registered or introduced to the international community. This review aims to provide recently presented techniques and protocols for efficient treatment of COVID-19 and investigate its morphology and treatment/prevention approaches, among which usage of antiviral drugs, anti-malarial drugs, corticosteroids, and traditional medicines, biotechnological drugs (e.g. combination of HCQ and azithromycin, remdesivir, interferons, novaferon, interferon-alpha-1b, thymosin, and monoclonal antibodies) can be mentioned.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"53 1","pages":"141-170"},"PeriodicalIF":5.9,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03602532.2020.1845201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38654130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Moonlighting in drug metabolism. 兼职药物代谢。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2021-02-01 Epub Date: 2020-12-28 DOI: 10.1080/03602532.2020.1858857

Philip G Board, M W Anders

引用次数: 3

CYP1A2 and tobacco interaction: a major pharmacokinetic challenge during smoking cessation. CYP1A2 与烟草的相互作用：戒烟过程中药代动力学的一大挑战。

IF 3.4 2区医学

Drug Metabolism Reviews Pub Date : 2021-02-01 Epub Date: 2021-01-04 DOI: 10.1080/03602532.2020.1859528

Malcolm Barrangou-Poueys-Darlas, Marylène Guerlais, Edouard-Jules Laforgue, Ronan Bellouard, Marion Istvan, Pascale Chauvin, Jean-Yves Guillet, Pascale Jolliet, Matthieu Gregoire, Caroline Victorri-Vigneau

{"title":"CYP1A2 and tobacco interaction: a major pharmacokinetic challenge during smoking cessation.","authors":"Malcolm Barrangou-Poueys-Darlas, Marylène Guerlais, Edouard-Jules Laforgue, Ronan Bellouard, Marion Istvan, Pascale Chauvin, Jean-Yves Guillet, Pascale Jolliet, Matthieu Gregoire, Caroline Victorri-Vigneau","doi":"10.1080/03602532.2020.1859528","DOIUrl":"10.1080/03602532.2020.1859528","url":null,"abstract":"Smoking cessation is underestimated in terms of drug interactions. Abrupt smoking cessation is common in cases of emergency hospitalization and restrictions of movement. Tobacco is a known cytochrome P450 1A2 (CYP1A2) inducer, its consumption and withdrawal can lead to major pharmacokinetic drug interactions. Nevertheless, references do exist, but may have different results between them. The objective of our work was to establish the broadest and most consensual list as possible of CYP1A2 substrates treatments and propose a pharmacological approach. We searched the widest possible list of CYP1A2 substrates based on various international references. We compared the references and defined probability and reliability scores of our results to sort the substances based on the scores. For the 245 substances identified as CYP1A2 substrates, we focused on the 63 CYP1A2 substrates with both probability and reliability scores >50%. Our work establishes adaptive pharmacological approaches for the management of patients initiating smoking cessation which must be integrated into the management of smoking cessation. Pharmacologists can now adopt adaptive pharmacological approaches to complement patient-specific clinical information about smoking cessation by considering pharmacokinetic risk. This work establishes an unprecedented list. It should guide in the care of patients initiating smoking cessation to prevent pharmacokinetic drug interactions.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"53 1","pages":"30-44"},"PeriodicalIF":3.4,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38715060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2021-02-01 Epub Date: 2021-03-29 DOI: 10.1080/03602532.2021.1907078

引用次数: 0

Cytochrome P450 expression and regulation in the brain. 细胞色素P450在大脑中的表达和调控。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2021-02-01 Epub Date: 2020-12-27 DOI: 10.1080/03602532.2020.1858856

Wojciech Kuban, Władysława Anna Daniel

{"title":"Cytochrome P450 expression and regulation in the brain.","authors":"Wojciech Kuban, Władysława Anna Daniel","doi":"10.1080/03602532.2020.1858856","DOIUrl":"https://doi.org/10.1080/03602532.2020.1858856","url":null,"abstract":"The regulation of brain cytochrome P450 enzymes (CYPs) is different compared with respective hepatic enzymes. This may result from anatomical bases and physiological functions of the two organs. The brain is composed of a variety of functional structures built of different interconnected cell types endowed with specific receptors that receive various neuronal signals from other brain regions. Those signals activate transcription factors or alter functioning of enzyme proteins. Moreover, the blood-brain barrier (BBB) does not allow free penetration of all substances from the periphery into the brain. Differences in neurotransmitter signaling, availability to endogenous and exogenous active substances, and levels of transcription factors between neuronal and hepatic cells lead to differentiated expression and susceptibility to the regulation of CYP genes in the brain and liver. Herein, we briefly describe the CYP enzymes of CYP1-3 families, their distribution in the brain, and discuss brain-specific regulation of CYP genes. In parallel, a comparison to liver CYP regulation is presented. CYP enzymes play an essential role in maintaining the levels of bioactive molecules within normal ranges. These enzymes modulate the metabolism of endogenous neurochemicals, such as neurosteroids, dopamine, serotonin, melatonin, anandamide, and exogenous substances, including psychotropics, drugs of abuse, neurotoxins, and carcinogens. The role of these enzymes is not restricted to xenobiotic-induced neurotoxicity, but they are also involved in brain physiology. Therefore, it is crucial to recognize the function and regulation of CYP enzymes in the brain to build a foundation for future medicine and neuroprotection and for personalized treatment of brain diseases.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"53 1","pages":"1-29"},"PeriodicalIF":5.9,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03602532.2020.1858856","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38746283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Dioscorea bulbifera L.-induced hepatotoxicity and involvement of metabolic activation of furanoterpenoids. 黄薯蓣诱导的肝毒性及其与呋喃萜类代谢激活的关系。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2020-11-01 Epub Date: 2020-08-06 DOI: 10.1080/03602532.2020.1800724

Hui Li, Ying Peng, Jiang Zheng

{"title":"Dioscorea bulbifera L.-induced hepatotoxicity and involvement of metabolic activation of furanoterpenoids.","authors":"Hui Li, Ying Peng, Jiang Zheng","doi":"10.1080/03602532.2020.1800724","DOIUrl":"https://doi.org/10.1080/03602532.2020.1800724","url":null,"abstract":"The rhizome of Dioscorea bulbifera L. (DBL) is a popular traditional herb in the treatment of goiters, breast lumps, and tumors. Unfortunately, DBL can give rise to severe hepatotoxicity. More than 100 cases of liver injury, due to the usage of DBL in China, have been reported in the past half-century. The main toxic components of DBL are furanoditerpenoids diosbulbin B (DSB) as well as 8-epidiosbulbin E (EEA). This toxic effect requires metabolic oxidation of the furan ring mediated by cytochrome P450 enzymes, and the P450 3A subfamily is the main enzyme responsible for the reported hepatotoxicity. cis-Enedial intermediates resulting from furan ring oxidation can react with nucleophilic sites of macromolecules, such as protein and DNA, which may trigger the toxicities. This review illustrates the liver injury induced by DBL including metabolic activation of DSB and EEA, the essential components responsible for DBL-induced hepatotoxicity, along with biochemical mechanisms of their toxic actions. It will facilitate the development of approaches to prevent and intervene in liver injury induced by DBL for its safe use in clinical practice.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"52 4","pages":"568-584"},"PeriodicalIF":5.9,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03602532.2020.1800724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38231544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Antiviral drugs and plasma therapy used for Covid-19 treatment: a nationwide Turkish algorithm. 用于治疗Covid-19的抗病毒药物和血浆疗法:土耳其全国算法

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2020-11-01 Epub Date: 2020-08-06 DOI: 10.1080/03602532.2020.1803907

Hayrunnisa Nadaroglu

{"title":"Antiviral drugs and plasma therapy used for Covid-19 treatment: a nationwide Turkish algorithm.","authors":"Hayrunnisa Nadaroglu","doi":"10.1080/03602532.2020.1803907","DOIUrl":"https://doi.org/10.1080/03602532.2020.1803907","url":null,"abstract":"The Coronavirus outbreak described as COVID-19 is an insidious and enormous biohazard which began to be noticed in November 2019. When the virus was determined to cause serious upper respiratory tract infections resulting in death, pandemics were declared in the world. As of today, the number of cases exceeded 221 thousand people in Turkey, the number of patients who died had reached 5526. In more than 200 countries around the world, 15.1 million people fight the disease, while the number of people recovered is over 9.134 million, and the number of deaths has exceeded 620 thousand. The top 5 countries in the world are USA, Brazil, Russia, India and Spain. The countries with the highest number of cases after America (approximately 4 million 28 thousand) are Brazil (approximately 2 million 166 thousand), India (about 1 million 195 thousand), Russia (approximately 789 thousand), South Africa (approximately 382 thousand). In addition, the number of deaths and cases caused by Covid 19 continues to increase day by day. In this review, it was aimed to discuss that Covidien-19 against antiviral drugs used in the struggle across the globe and plasma treatment options about the current state of knowledge and Turkey algorithm by comparing the therapeutic treatment options.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"52 4","pages":"531-539"},"PeriodicalIF":5.9,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03602532.2020.1803907","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38233962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Regulation of cytochrome P450 enzyme activity and expression by nitric oxide in the context of inflammatory disease. 炎症性疾病中一氧化氮对细胞色素P450酶活性和表达的调节

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2020-11-01 Epub Date: 2020-09-08 DOI: 10.1080/03602532.2020.1817061

Edward T Morgan, Cene Skubic, Choon-Myung Lee, Kaja Blagotinšek Cokan, Damjana Rozman

引用次数: 15

HLA transgenic mice: application in reproducing idiosyncratic drug toxicity. HLA转基因小鼠:在复制特异性药物毒性中的应用。

IF 5.9 2区医学

Drug Metabolism Reviews Pub Date : 2020-11-01 Epub Date: 2020-08-27 DOI: 10.1080/03602532.2020.1800725

Takeshi Susukida, Shigeki Aoki, Tomohiro Shirayanagi, Yushiro Yamada, Saki Kuwahara, Kousei Ito

{"title":"HLA transgenic mice: application in reproducing idiosyncratic drug toxicity.","authors":"Takeshi Susukida, Shigeki Aoki, Tomohiro Shirayanagi, Yushiro Yamada, Saki Kuwahara, Kousei Ito","doi":"10.1080/03602532.2020.1800725","DOIUrl":"https://doi.org/10.1080/03602532.2020.1800725","url":null,"abstract":"Various types of transgenic mice carrying either class I or II human leukocyte antigen (HLA) molecules are readily available, and reports describing their use in a variety of studies have been published for more than 30 years. Examples of their use include the discovery of HLA-specific antigens against viral infection as well as the reproduction of HLA-mediated autoimmune diseases for the development of therapeutic strategies. Recently, HLA transgenic mice have been used to reproduce HLA-mediated idiosyncratic drug toxicity (IDT), a rare and unpredictable adverse drug reaction that can result in death. For example, abacavir-induced IDT has successfully been reproduced in HLA-B*57:01 transgenic mice. Several reports using HLA transgenic mice for IDT have proven the utility of this concept for the evaluation of IDT using various HLA allele combinations and drugs. It has become apparent that such models may be a valuable tool to investigate the mechanisms underlying HLA-mediated IDT. This review summarizes the latest findings in the area of HLA transgenic mouse models and discusses the current challenges that must be overcome to maximize the potential of this unique animal model.","PeriodicalId":11307,"journal":{"name":"Drug Metabolism Reviews","volume":"52 4","pages":"540-567"},"PeriodicalIF":5.9,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03602532.2020.1800725","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38311272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6