Dhaka University Journal of Pharmaceutical Sciences最新文献

{"title":"Ethnopharmacological Survey of Medicinal Plants Used by Traditional Health Practitioners and Indigenous People in Chittagong Hill Tracts, Bangladesh for the Treatment of Dysentery","authors":"Sajan Das, Shupti Rani Bhadra, Muhammad Shah Mohtasim Khan, Mahfuzul Hasan, M. R. Anwar, M. Shahriar","doi":"10.3329/dujps.v21i2.63114","DOIUrl":"https://doi.org/10.3329/dujps.v21i2.63114","url":null,"abstract":"Dysentery is frequently associated with high morbidity and mortality and is found in young children and mainly affects those in developing nations. Rural people across the world trust on herbal remedies and homeopathic medicines for their primary health care on account of their easy accessibility, efficacy and exceptionally cost ampleness in relation to modern drugs. The purpose of the present study was to compile knowledge of traditional healers and indigenous people in Chittagong hill tracts, Bangladesh, including Rangamati, Bandarban and Khagrachari for the treatment of dysentery. The ethnomedicinal data was gathered from January 2019 to January 2020 through open and focused group discussions and individual meetings utilizing semi-structured questionnaire. An aggregate of 75 people were interviewed, including traditional health practitioners. Frequency and percentage were utilized to sum up the data. Relative frequency of citation (RFC) was determined and inclination positioning activities were led to appraise the significance of the revealed medicinal plants. An aggregate of 90 medicinal plants from 52 families and 79 genera were recorded during the survey. Leaves were discovered to be the most largely used plant part (35%) followed by root (19%) and herbs (40%) were the essential wellspring of medicinal plants, followed by trees (20%). The major mode of preparation is juice (68%) followed by paste (11%) and cooked form (7%). Centella asiatica scored the highest RFC value (0.773). The survey addresses the preliminary information of certain medicinal plants having anti-dysenteric property. However, further phytochemical investigation, validation and clinical trial sought to be conducted, with need given to those that scored the most elevated RFC values prior to utilizing these plants as an option in contrast to modern medicine.\u0000Dhaka Univ. J. Pharm. Sci. 21(2): 127-146, 2022 (December)","PeriodicalId":11304,"journal":{"name":"Dhaka University Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73989419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnobotanical Study on Medicinal Plants Used by the Ethnic People of Khagrachhari District, Bangladesh","authors":"Bk Sajeeb, M. Z. Uddin, R. Bachar, S. C. Bachar","doi":"10.3329/dujps.v21i2.63122","DOIUrl":"https://doi.org/10.3329/dujps.v21i2.63122","url":null,"abstract":"The present study deals with important ethnopharmacological information, both in qualitative and quantitative manners on medicinal plants of Khagrachhari district of Bangladesh. The survey was conducted in a period of six months from January 2016 to June 2016 and was interviewed among 155 ethnic people including tribal, Bengalis and 14 traditional health practitioners of eight upazillas in open and semi structured form. The most of the interviewers were Chakma (82%), Marma (8%) and the rest were Tripura (2%) and Bengalis (8%). The total ethnomedicinal plant species was 94, among them 92 were angiosperms, one was gymnosperm and one fern. The plant species belonging to 44 families and 86 generas are used to treat about 53 types of ailments. The different life forms among the species are 28 herbs, 25 trees, 24 shrubs and 17 climbers. The survey showed that the most commonly used plant part was leaves (34.55%) and the most frequent method of preparation was extraction (39.18%) against different ailments. The major treatment options of the medicinal plants of Khagrachhari hilly areas are identified from the study and recommended to take immediate measures for conservation of traditional knowledge of the area. This study showed a hopeful perception for future studies, flaking light on taking immediate measures on inventory of medicinal plants of hilly areas, documentation of verbal information, conservation of threatened plant species, sustainable management of risky areas and preservation of traditional knowledge of herbal medicine in Khagrachhari district, Bangladesh.\u0000Dhaka Univ. J. Pharm. Sci. 21(2): 217-230, 2022 (December)","PeriodicalId":11304,"journal":{"name":"Dhaka University Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82425163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality Characteristics and Αlpha-Tocopherol Content of Shea Butter Samples from Selected Markets Within Three Southwestern States of Nigeria","authors":"O. Adejumo, Temilade Arinola Edun, A. Kolapo, Olatunde Adekunle Ayodele","doi":"10.3329/dujps.v21i2.63112","DOIUrl":"https://doi.org/10.3329/dujps.v21i2.63112","url":null,"abstract":"Shea (Vitellaria paradoxa) butter samples from selected markets in Nigeria were analyzed for AOAC quality characteristics and α-tocopherol content. The α-tocopherol was determined by RP-HPLC and mg per serving and % daily values (% DV) were estimated. The ranges of acid value (AV) [mgKOH/kg], free fatty acid (FFA) [%], peroxide value (PV) [meqO2/Kg], iodine value (IV) [gI2/100g] and saponification value (SV) [mgKOH/g] were 2.20- 2.59, 1.15-1.30, 0.75-0.95, 44.43-47.85 and 170.08-259.30, respectively. The -tocopherol had a retention time of 3.561 minutes and its content ranged from 1.15-2.60 mg/100 g in the samples, but 5.25 mg/100 g for the laboratory sample. Milligram (mg) per serving and percentage dietary value were 0.16-0.74 and 1.07-4.93, respectively. Quality characteristics varied significantly (p < 0.05) both within and across different markets. Based on the PV and IV results, the marketed shea butter samples may be both food and industry-grade but failed the FFA test. Similarly, 40% of samples did not qualify for domestic consumption and food industry applications. Hence, the samples with <5% DV values cannot serve as dietary sources of α-tocopherol.\u0000Dhaka Univ. J. Pharm. Sci. 21(2): 105-115, 2022 (December)","PeriodicalId":11304,"journal":{"name":"Dhaka University Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74258783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Optimization of RP-UHPLC Method for Mesalamine Through QbD Approach","authors":"Diponkor Kumar Shill, U. Kumar, Asm Monjur Al Hossain, Md. Rezowanur Rahman, A. S. Shamsur Rouf","doi":"10.3329/dujps.v21i1.60399","DOIUrl":"https://doi.org/10.3329/dujps.v21i1.60399","url":null,"abstract":"The current study aimed at developing and optimizing a prompt, simple and efficient RP-UHPLC method based on Quality by Design (QbD) for analyzing mesalamine. Experimental design for developing the method was performed capitalizing a 32 full factorial design in Design Expert® software (Version 12, Stat-Ease Inc., USA) where the percentage of methanol in the mobile phase and flow rate of the mobile phase were considered as independent factors and studied at three levels. Retention time, tailing factor and theoretical plate count were recorded as responses to the experiment. Mesalamine was analyzed using a reversed-phase C18 column (5μm, 150 ×4.6 mm) supported by a photodiode array plus (PDA+) detector with detection at 214 nm. The optimized method involved the use of a mobile phase of pH=7.4 phosphate buffer: methanol (63.5: 36.5, v/v) and a flow rate of 1.1 ml/min. Responses recorded during experimentation exhibited an error of -0.24%, 0.376% and -0.659% from predicted values of retention time, tailing factor and theoretical plate count, respectively. Experimental models adopted for the development of the method were found statistically significant (p-value <0.05). According to ICH Q2 (R1) guidelines, the method was also found to be robust, highly sensitive, specific, accurate, precise and linear.\u0000Dhaka Univ. J. Pharm. Sci. 21(1): 77-84, 2022 (June)","PeriodicalId":11304,"journal":{"name":"Dhaka University Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74725234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative Phytochemical Screening, Fatty Acid Composition Analysis and Biological Studies of Trianthema portulacastrum L. Leaves","authors":"V. Chowdhury, Nusrat Tabassum Shristy, Md. Hasan Sofiur Rahman, T. A. Chowdhury","doi":"10.3329/dujps.v21i1.60394","DOIUrl":"https://doi.org/10.3329/dujps.v21i1.60394","url":null,"abstract":"Trianthema portulacastrum L. commonly known as ‘horse purslane’ and locally called ‘shvetapunarnava’ is an annual broadleaf plant of tropical areas throughout the world. In this study, determination of moisture and ash content of the plant leaves, as well as qualitative phytochemical test, cytotoxicity assay, antimicrobial activity, fatty acid composition, total phenolic content, total flavonoid content, total antioxidant capacity, and DPPH radical scavenging activity were carried out. Methanol extract of T. portulacastrum leaves was partitioned using Kupchan's method with different solvents of increasing polarity (n-hexane, dichloromethane, chloroform, ethyl acetate). The moisture and ash contents of the leaves were (81.74±0.49)% and (31.05±1.36)%, respectively. Initial phytochemical screening of T. portulacastrum showed the presence of alkaloids, tannins, flavonoids, and tri-terpenoids. In fatty acid composition analysis, both bound fatty acids and free fatty acids were isolated from n-hexane extract that showed the presence of the highest percentage of palmitoleic acid (67.095% and 48.843%, respectively) and stearic acid (12.14% and 20.437%, respectively). Dichloromethane and methanol extracts were found to be cytotoxic on HeLa cells in cytotoxicity assay against Vero, HeLa, and BHK-21 cell lines. The highest phenolic content was observed in ethyl acetate extract (68.55±0.038 mg/g) and the highest flavonoid content was found in chloroform extract (477.01±0.104 mg/g). The DCM fraction revealed the highest total antioxidant capacity (284.99±0.113 mg/g), and the IC50 value for ethyl acetate extract was the lowest (110.35±0.160 μg/ml) of all the extracts.\u0000Dhaka Univ. J. Pharm. Sci. 21(1): 33-43, 2022 (June)","PeriodicalId":11304,"journal":{"name":"Dhaka University Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81464601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on Some Bangladeshi Medicinal Plants with Anticancer Properties","authors":"S. Ashrafi, M. M. Masud","doi":"10.3329/dujps.v21i1.60401","DOIUrl":"https://doi.org/10.3329/dujps.v21i1.60401","url":null,"abstract":"According to WHO, cancer is one of the leading causes of death worldwide, accounting for an estimated 9.6 million deaths in 2018. More significant improvements have been made in the management and treatment of cancer, still there remains scope for the betterment of treatment procedures. Mostsynthetic anticancer drugs are known to develop resistance, show cytotoxicity against normal cells due to their non-selective nature, and cause tremendous side effects. Medicinal plants are significantly feasible sources of organic compounds, for their better availability, cheaper price, fewer side effects, and sometimes better therapeutic efficacy, which may benefit the world commercially or act as an important starting point for identifying lead compounds to develop modified derivatives. This article describes the ethnobotanical properties of 15 available medicinal plants of Bangladesh having anti-cancer properties.\u0000Dhaka Univ. J. Pharm. Sci. 21(1): 95-104, 2022 (June) ","PeriodicalId":11304,"journal":{"name":"Dhaka University Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82934217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, Characterization and Identification of Selected Microorganisms from Wildlife Geophagic Soil: A Probe of Pros and Cons","authors":"R. Adewale, Oluwatosin T Onasanya, O. A. Oguntade, Babajide R Odebiyi, O. Aki̇nsorotan, Kola S Olorunisola, S. O. Sule, Olusesi A Oso","doi":"10.3329/dujps.v21i1.60396","DOIUrl":"https://doi.org/10.3329/dujps.v21i1.60396","url":null,"abstract":"The search for novel antibiotics for treating human-wildlife infections has not stopped. This study isolated and characterized bacteria and fungi from wildlife geophagic termite mounds (TMs) using standard microbiological procedure. Four composite samples of TMs evident to be eaten by wildlife were randomly collected (TM1, TM2, TM3 and TM4) in addition with a composite forest soil (FS5) that showed no sign of consumption. With the use of appropriate media, all samples were subjected to microbiological analysis covering morphological, biochemical (for bacteria), colonial and cellular morphology (for fungi). Bacteria and fungi cells isolated and characterized from respective soil samples include; Streptomyces lydicus/Aspegillus niger (TM1), Paenibacillus polymyxa/Penicillium digitatum (TM2), Pseudomonas fluorescens/Fusarium spp. (TM3), Bacillus subtilis/Aspergillus flavus (TM4) and Acinetobacter radioresistens/Geotricihum candidum (FS5), all of which have both beneficial and harmful characteristics. Wildlife may be affected by pathogenic organisms when consuming TMs for medicinal reasons.\u0000Dhaka Univ. J. Pharm. Sci. 21(1): 53-58, 2022 (June)","PeriodicalId":11304,"journal":{"name":"Dhaka University Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78841673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Antioxidant, Antibacterial and Analgesic Activities of Syzygium cumini used in Bangladesh","authors":"Margia Sultana, Jamiuddin Ahmed, Md. Abdul Barek, Shaidul Kabir Sohag, Md. Safayet Hossain, Umme Habiba","doi":"10.3329/dujps.v21i1.60392","DOIUrl":"https://doi.org/10.3329/dujps.v21i1.60392","url":null,"abstract":"Syzygium cumini (L.) skeels (Family: Myrtaceae) is a renowned medicinal plant traditionally used in various diseases and available in Bangladesh. This investigation was aimed to explore whether this plant has any potential antioxidant, antibacterial, and analgesic effects of methanolic extracts of S. cumini (leaves and bark). Quantitative determination of methanolic extracts of leaves and bark found the total phenolic contents as 199.11 mg GAE/g DW and 204.03 mg GAE/g DW, respectively. The leaves extract possessed mild antibacterial activity (leaves: 7.00 mm at 1 mg/disc, 9.15 mm at 5 mg/disc) against two different bacteria at different concentration whereas the bark extract showed no effect. A significant writhing (leaves: 23.17 ± 1.80, p≤0.001; bark: 24.33 ± 1.15, p≤0.001) and licking effects (leaves: 8.17 ± 1.49 sec, p≤0.05; bark: 9.08 ± 1.96 sec, p≤0.05) were found at 400 mg/kg of leaves and bark extracts of this plant which is very close to standard drugs mentioned in the tables. Results of this study demonstrated that methanolic extracts of S. cumini leaf and bark possessed significant antioxidant, analgesic, and mild antibacterial like activities which tend to suggest medicinal aspects.\u0000Dhaka Univ. J. Pharm. Sci. 21(1): 15-24, 2022 (June)","PeriodicalId":11304,"journal":{"name":"Dhaka University Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82823027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative Assessment of a Customized Anti-hepatic Herbal Formulation in Bangladesh","authors":"Md. Hafizur Rahman, B. Rokeya, M. Mosihuzzaman, Md. Shahinul Haque Khan","doi":"10.3329/dujps.v21i1.60397","DOIUrl":"https://doi.org/10.3329/dujps.v21i1.60397","url":null,"abstract":"Qualitative assessment of herbal formulations is used in pre-health care of many diseases. The potency, composition and safety of herbal formulation are serious concerns in Bangladesh. Therefore, the aim of the present study was to evaluate the qualitative assessment of a customized anti-hepatic herbal formulation in Bangladesh. Isolation of compounds, toxic metals analysis, phytochemical screening, microbial test and determination of SGPT and SGOT level of hepatic model rats were focused in this study. The phytochemical screening revealed the presence of phenol, saponins and tannins. In chemical study, four known compounds were isolated from the formulation (Sodium benzoate, methyl-4-hydroxybenzoate, 4-hyroxybenzaldehyde and 4-hydroxy- 3-methoxybenzaldehyde). The results of microbial purity and toxic metals analysis were in favorable limit although the levels of SGOT and SGPT were raised non-significantly. So, based on the study it has been concluded that quality assessment is urgently required for this type of customized herbal formulations.\u0000Dhaka Univ. J. Pharm. Sci. 21(1): 59-67, 2022 (June)","PeriodicalId":11304,"journal":{"name":"Dhaka University Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84853477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Development of Clarithromycin Floating Pellets Using Sodium Alginate and HPMC","authors":"Md. Abdul Motaleb Bhuiya, K. Mazumder, Irin Dewan, Md Elias Al Mamun","doi":"10.3329/dujps.v21i1.60393","DOIUrl":"https://doi.org/10.3329/dujps.v21i1.60393","url":null,"abstract":"The purpose of our study was to achieve the gastro-retentive delivery of Clarithromycin by producing floating pellets to get a better therapeutic effect against gastrointestinal ulcers mostly caused by Hedyotis pylori. Thereby Clarithromycin floating pellets were prepared by utilizing the blending of polymers such as Sodium (Na) Alginate and Hydroxy Propyl Methyl Cellulose (HPMCK4M & HPMC K100LV). The HPMC-alginate blend containing Clarithromycin produced a hydrogel bead that was able to show buoyancy in the simulated gastric fluid. The pellets showed more than 8 hours of buoyancy depending on their polymeric ratio. In addition to the buoyancy test, several other tests like floating time (upto 12 hrs with increasing Na-Alginate), contraction ratio, particle size analysis, were performed that showed the development of acceptable floating pellets. Furthermore, SEM was performed on the prepared Clarithromycin pellet to assess their morphological characteristics. Clarithromycin floating pellets with 1.5% Na-alginate & HPMC K4M: HPMC K100LV (1:2) give the better formulation and produce pharmaceutically acceptable parameters.\u0000Dhaka Univ. J. Pharm. Sci. 21(1): 25-31, 2022 (June)","PeriodicalId":11304,"journal":{"name":"Dhaka University Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86580657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}