Noor Bekkali, Georg Beyer, A. Gasbarrini, “Agostino, Hans-Dieter Allescher – Klinikum, Garmisch-Partenkirchen GmbH, Germany Marco, Del Chiaro, L. Eusebi, Abhai Verma, Sanjay Gandhi, L. Yue, R. H. Zhengzhou Zhang, S. Chen, G. Duan, K. Yamamoto, T. Ikeya, Y. Shiratori, Tokyo, F. Di Mario, X. Yang, C. Zhu, Y. Li, X.-L. Zuo, S.-W. Zhang, R. Xu, D. Chen, P. Cheng, Z. Li, Z. Fu, Q. Jian, R. Deng, Y. Ma, Guangzhou, D. Cao, H. Liu, L. Bai, H. Tang, L. Shi, S. Zhang, Macedo Silva, V. Freitas, Sousa Magalhães, Cúrdia Gonçalves, Boal Carvalho, P. Marinho, C. Cotter, L. Zhang, W. Zhao, B. Wang, W. J. Zhong, G. Hu, Z. Feng, W. Shen, G. Shao, Y. Hsu, KaohsiungTaipei
{"title":"Contents Vol. 41, 2023","authors":"Noor Bekkali, Georg Beyer, A. Gasbarrini, “Agostino, Hans-Dieter Allescher – Klinikum, Garmisch-Partenkirchen GmbH, Germany Marco, Del Chiaro, L. Eusebi, Abhai Verma, Sanjay Gandhi, L. Yue, R. H. Zhengzhou Zhang, S. Chen, G. Duan, K. Yamamoto, T. Ikeya, Y. Shiratori, Tokyo, F. Di Mario, X. Yang, C. Zhu, Y. Li, X.-L. Zuo, S.-W. Zhang, R. Xu, D. Chen, P. Cheng, Z. Li, Z. Fu, Q. Jian, R. Deng, Y. Ma, Guangzhou, D. Cao, H. Liu, L. Bai, H. Tang, L. Shi, S. Zhang, Macedo Silva, V. Freitas, Sousa Magalhães, Cúrdia Gonçalves, Boal Carvalho, P. Marinho, C. Cotter, L. Zhang, W. Zhao, B. Wang, W. J. Zhong, G. Hu, Z. Feng, W. Shen, G. Shao, Y. Hsu, KaohsiungTaipei","doi":"10.1159/000535573","DOIUrl":"https://doi.org/10.1159/000535573","url":null,"abstract":"","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":"1202 2","pages":"I - IX"},"PeriodicalIF":2.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139019159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Digestive DiseasesPub Date : 2023-06-01DOI: 10.1016/s0168-8278(23)03167-7
Yandi Xie, Minghui Li, X. Ou, S. Zheng, Yinjie Gao, Xiaoyuan Xu, Yingsi Yang, A. Ma, Jia Li, Y. Nan, Huan‐wei Zheng, Juan Liu, Lai Wei, B. Feng
{"title":"IP10 and anti-HBc can predict virological relapse and HBsAg loss in chronic hepatitis B patients after nucleos(t)ide analogue discontinuation.","authors":"Yandi Xie, Minghui Li, X. Ou, S. Zheng, Yinjie Gao, Xiaoyuan Xu, Yingsi Yang, A. Ma, Jia Li, Y. Nan, Huan‐wei Zheng, Juan Liu, Lai Wei, B. Feng","doi":"10.1016/s0168-8278(23)03167-7","DOIUrl":"https://doi.org/10.1016/s0168-8278(23)03167-7","url":null,"abstract":"","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":"1 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48865025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Uncovering the Silent Killer: Research highlights on chronic liver diseases.","authors":"Yao-Chun Hsu","doi":"10.1159/000530349","DOIUrl":"https://doi.org/10.1159/000530349","url":null,"abstract":"<p><p>Chronic liver disease (CLD) affects approximately 1.5 billion people around the world.1 Non-alcoholic fatty liver disease (NAFLD) is the most common CLD that accounts for 59% of prevalent cases, followed by hepatitis B virus (HBV) infection (29%) and hepatitis C virus infection (9%).2 CLD is a silent killer characterized by insidious progression in hepatic necroinflammation and fibrosis that can culminate in cirrhosis and increase the risk of primary liver cancer. According to the Global Burden of Disease study, there were 2.1 million deaths attributable to CLD in 2017, with cirrhosis and liver cancer respectively responsible for 62% and 38% of the mortality.3.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9553130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elizabeth M Garcia, Sanjna N Nerurkar, Eunice X Tan, Shaun Ys Tan, Ern-Wei Peck, Sabrina Xz Quek, Readon Teh, Margaret Teng, Andrew Tran, Ee Jin Yeo, Michael Le, Connie Wong, Ramsey Cheung, Daniel Q Huang
{"title":"Characteristics and Outcomes of Elderly Hepatocellular Carcinoma Patients following Surgical Resection: Systematic Review and Meta-analysis.","authors":"Elizabeth M Garcia, Sanjna N Nerurkar, Eunice X Tan, Shaun Ys Tan, Ern-Wei Peck, Sabrina Xz Quek, Readon Teh, Margaret Teng, Andrew Tran, Ee Jin Yeo, Michael Le, Connie Wong, Ramsey Cheung, Daniel Q Huang","doi":"10.1159/000530101","DOIUrl":"https://doi.org/10.1159/000530101","url":null,"abstract":"<p><strong>Background & aims: </strong>Due to ageing of the global population, hepatocellular carcinoma (HCC) is increasingly common among elderly patients, but outcomes after curative hepatic resection are unclear. Using a metanalytic approach, we aimed to estimate overall survival (OS), recurrence free survival (RFS) and complication rates in elderly HCC patients undergoing resection.</p><p><strong>Methods: </strong>We searched PubMed, Embase, and Cochrane databases from inception to Nov 10, 2020 for studies reporting outcomes in elderly (age ≥ 65 years) patients with HCC undergoing curative surgical resection. Pooled estimates were generated using a random-effects model.</p><p><strong>Results: </strong>We screened 8,598 articles and included 42 studies (7,778 elderly patients). The mean age was 74.45 years (95% CI 72.89-76.02), 75.54% were male (95% CI 72.53-78.32) and 66.73% had cirrhosis (95% CI 43.93-83.96). The mean tumor size was 5.50 cm (95% CI 4.71-6.29) and 16.01% had multiple tumors (95% CI 10.74-23.19). The 1-year (86.02% versus 86.66%, p=0.84) and 5-year OS (51.60% versus 53.78%) between non-elderly versus elderly patients were similar. Likewise, there were no differences in the 1-year (67.32% versus 73.26%, p=0.11) and 5-year RFS (31.57% versus 30.25%, p=0.67) in non-elderly versus elderly patients. There was a higher rate of minor complications (21.95% versus 13.71%, p=0.03) among elderly patients compared with non-elderly patients, but no difference in major complications (p=0.43) Conclusion: This data shows that overall survival, recurrence and major complications after liver resection for HCC are comparable between elderly and non-elderly patients, and may inform clinical management of HCC in this population.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9103562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incidence and Mortality of Post-Polypectomy Colorectal Cancer in Patients with Low-Risk Adenomas: A Systematic Review and Meta-Analysis of Observational Studies.","authors":"Xiaoxiao Yang, Cheng Zhu, Yueyue Li, Yanqing Li, Xiuli Zuo","doi":"10.1159/000524138","DOIUrl":"https://doi.org/10.1159/000524138","url":null,"abstract":"<p><strong>Introduction: </strong>The long-term risks of post-polypectomy colorectal cancer (CRC) incidence and mortality among patients with low-risk adenomas (LRAs) are unclear. This study aimed to perform a systematic review and meta-analysis of the risk of CRC incidence and mortality following LRAs removal.</p><p><strong>Methods: </strong>We searched the PubMed, Embase, and Cochrane library for studies that reported the risk of metachronous CRC incidence and mortality after colonoscopy. The primary outcome was the risk of CRC incidence and mortality in patients with LRAs. Random-effects models were used to calculate the pooled risk ratio (RR) with a 95% confidence interval (CI).</p><p><strong>Results: </strong>Thirteen observational studies with 1,750,305 patients (45.4% male; follow-up: 4.5-16.5 years) were included. A meta-analysis of seven studies showed a higher CRC incidence in patients with LRAs than those without adenomas (per 10,000 person-years: 5.2 vs. 3.9; RR 1.25 [95% CI 1.05-1.49], I2 = 0%). However, the CRC-related death rate was not significantly different between the two groups (RR 1.13 [95% CI 0.75-1.69], I2 = 0%). When compared with the general population, the meta-analysis showed a significantly lower risk of CRC incidence in patients with LRAs (RR 0.59 [95% CI 0.45-0.77], I2 = 0%), and another three studies, which could not be pooled, showed a reduction in the risk of CRC-related death in the LRAs group.</p><p><strong>Conclusions: </strong>Patients with LRAs have a small but higher risk of post-polypectomy CRC incidence than patients without adenomas. The marginally higher absolute incidence seemed insufficient for more intensive surveillance colonoscopy, but the significant difference suggested different follow-up strategies between patients with LRAs and those without adenomas.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":"41 2","pages":"206-216"},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9374818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Video Capsule Endoscopy after Bariatric Surgery: A Tertiary Referral Center Experience.","authors":"Noam Peleg, Henit Yanai, Rachel Gingold-Belfer, Iris Dotan, Irit Avni-Biron","doi":"10.1159/000524883","DOIUrl":"https://doi.org/10.1159/000524883","url":null,"abstract":"<p><strong>Background and aim: </strong>Minimal data are available regarding the performance of video capsule endoscopy (VCE) in patients who underwent bariatric surgery. We aimed to report indications, feasibility, and safety of VCE performed after bariatric surgery, specifically focusing on diagnosis rates of Crohn's disease (CD) in this population.</p><p><strong>Methods: </strong>A retrospective analysis of all VCE procedures was performed between January 2015 and December 2019. All patients who underwent bariatric surgery prior to VCE were included. Indication for VCE, ingestion methods, completion rates, retention rates, and endoscopic findings were recorded.</p><p><strong>Results: </strong>A total of 1,255 patients underwent VCE examination during the study period, of which 31 (2.5%) underwent bariatric surgery prior to VCE. The most common bariatric surgery was laparoscopic sleeve gastrectomy (16 patients, 51.6%), and the most common indication for VCE was evaluation of iron deficiency anemia (14 patients, 45.1%). The majority of patients ingested the capsule independently, without endoscopic assistance (20, 64.5%). Although a patency capsule was not used in our cohort, no events of capsule retention were documented. Mean transit time was 4.32 h. Only 4 events of incomplete examination were recorded. Over a median follow-up of 27.5 months (IQR 13.0-34.2), 10 patients (31.2%) had a final diagnosis of CD with a median Lewis score of 225 (IQR 135-900).</p><p><strong>Conclusion: </strong>VCE is a feasible and safe procedure after bariatric surgery. Oral ingestion does not carry risk of retention. It is an effective means of diagnosis of small-bowel CD in this population.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":"41 2","pages":"233-238"},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9390762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun Takada, Yukari Uno, Koji Yamashita, Masamichi Arao, Masaya Kubota, Takashi Ibuka, Hiroshi Araki, Masahito Shimizu
{"title":"Efficacy of a Gastroscope for Cecal Intubation during Colonoscopy in Patients with Severe Sigmoid Adhesion.","authors":"Jun Takada, Yukari Uno, Koji Yamashita, Masamichi Arao, Masaya Kubota, Takashi Ibuka, Hiroshi Araki, Masahito Shimizu","doi":"10.1159/000528449","DOIUrl":"https://doi.org/10.1159/000528449","url":null,"abstract":"<p><strong>Background: </strong>Cecal intubation during colonoscopy is difficult to achieve in patients with severe sigmoid adhesions. This retrospective observational study assessed the efficacy of using a gastroscope for colonoscopy in patients with severe sigmoid adhesions. Furthermore, the ability of computed tomography (CT) to predict the possibility of cecal intubation using a gastroscope was examined.</p><p><strong>Methods: </strong>A total of 1,626 patients who underwent colonoscopy for total colon observation by one endoscopist were enrolled. Cecal intubation rate and other procedure-related outcomes were evaluated. We also investigated whether identification of the sigmoid colon pathway by CT was involved in cecal intubation rate using a gastroscope.</p><p><strong>Results: </strong>Of the enrolled patients, cecal intubation by colonoscope was not feasible in 19 patients (1.2%) because of severe sigmoid adhesions. Cecal intubation was possible in 13 patients (68.4%) using a gastroscope, and the cecal intubation rate of peritoneal carcinomatosis (0%, p < 0.01) was significantly lower than that of other causes such as a diverticulum (100%) and history of gynecologic surgery (80%). The identifiable case of the sigmoid colon pathway by horizontal section on CT showed significantly higher cecal intubation rate compared to those of unidentifiable cases (92.3% vs. 16.7%, p < 0.01).</p><p><strong>Conclusion: </strong>Using a gastroscope is effective in performing cecal intubation during colonoscopy in patients with severe sigmoid adhesions. However, in patients with sigmoid adhesions caused by peritoneal carcinomatosis, cecal intubation may be difficult, even when a gastroscope is used. The ability of CT to identify the sigmoid colon pathway may predict success of cecal intubation.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":"41 3","pages":"405-411"},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9542040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of Circular RNA Circ_0071662 in the Diagnosis and Prognosis of Hepatocellular Carcinoma and Its Response to Radiotherapy.","authors":"Xingwei Wang, Jing Zhang, Fang Luo, Yaolin Shen","doi":"10.1159/000527696","DOIUrl":"https://doi.org/10.1159/000527696","url":null,"abstract":"<p><strong>Background: </strong>Although the involvement of circular RNA Circ_0071662 in bladder cancer and esophageal cancer has been reported, its role in hepatocellular carcinoma (HCC) is unclear. The presented research aimed to study its role in HCC.</p><p><strong>Methods: </strong>This study enrolled 60 HCC patients (advanced stage), 60 hepatic angiomyolipoma patients, 60 liver abscess patients, 60 hypertrophic cardiomyopathy patients, 60 focal nodular hyperplasia patients, and 60 healthy controls (HCs). Plasma samples were obtained from all participants prior to treatment. HCC and paired nontumor samples were collected from HCC patients. HCC patients received radiotherapy and plasma samples were also collected after treatment. Gene expression was analyzed by RT-qPCR. The role of Circ_0071662 in the diagnosis of HCC was evaluated by ROC curve analysis.</p><p><strong>Results: </strong>Compared to HCs, decreased plasma expression levels of Circ_0071662 were only observed in HCC patients, but not in other patient groups. HCC tissues also exhibited decreased expression levels of Circ_0071662 compared to that in nontumor samples. Decreased plasma expression levels of Circ_0071662 separated HCC patients from HCs and other patient groups. After radiotherapy, 28 patients developed radioresistance (RR) and the rest showed no RR. Decreased plasma expression levels of Circ_0071662 were closely associated with patients' poor survival. Compared to pretreatment level, decreased plasma expression levels of Circ_0071662 were only observed in RR group. The expression levels of Circ_0071662 in plasma and tissues were closely associated with patients' tumor metastasis and tumor size.</p><p><strong>Conclusion: </strong>Circ_0071662 was downregulated in HCC and may serve as a potential biomarker to improve the diagnosis of HCC. Moreover, downregulation of Circ_0071662 is likely correlated to the development of radioresistance.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":"41 3","pages":"431-438"},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9552984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johannes Heymer, Florian Dengler, Alexander Krohn, Christina Jaki, Tobias Schilling, Martina Mueller-Schilling, Arne Kandulski, Matthias Ott
{"title":"Simulation of Aerosol and Droplet Spread during Upper Airway and Gastrointestinal Endoscopy.","authors":"Johannes Heymer, Florian Dengler, Alexander Krohn, Christina Jaki, Tobias Schilling, Martina Mueller-Schilling, Arne Kandulski, Matthias Ott","doi":"10.1159/000525482","DOIUrl":"https://doi.org/10.1159/000525482","url":null,"abstract":"<p><strong>Background and aims: </strong>Aerosols and droplets are the main vectors in transmission of highly contagious SARS-CoV-2. Invasive diagnostic procedures like upper airway and gastrointestinal endoscopy have been declared as aerosol-generating procedures. Protection of healthcare workers is crucial in times of the COVID-19 pandemic.</p><p><strong>Methods: </strong>We simulated aerosol and droplet spread during upper airway and gastrointestinal endoscopy with and without physico-mechanical barriers using a simulation model.</p><p><strong>Results: </strong>A clear plastic drape as used for central venous access markedly reduced visualized aerosol and droplet spread during endoscopy.</p><p><strong>Conclusion: </strong>A simple and cheap drape has the potential to reduce aerosol and droplet spread during endoscopy. In terms of healthcare worker protection, this may be important particularly in low- or moderate-income countries.</p>","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":"41 1","pages":"148-153"},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10608267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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