Digestive Diseases最新文献_第9页

Celiac Disease and the Risk of Micronutrient Deficiencies in Ethnic Minority Populations: A Retrospective Cohort Study. 乳糜泻与少数民族人群微量营养素缺乏的风险：一项回顾性队列研究

IF 2 4区医学

Digestive Diseases Pub Date : 2024-01-01 Epub Date: 2024-06-05 DOI: 10.1159/000539179

Kara DiJoseph, Scott Weismiller, Paddy Ssentongo, Shannon Dalessio, Kofi Clarke

{"title":"Celiac Disease and the Risk of Micronutrient Deficiencies in Ethnic Minority Populations: A Retrospective Cohort Study.","authors":"Kara DiJoseph, Scott Weismiller, Paddy Ssentongo, Shannon Dalessio, Kofi Clarke","doi":"10.1159/000539179","DOIUrl":"10.1159/000539179","url":null,"abstract":"Introduction: Celiac disease (CD) is a chronic immune-mediated disorder triggered by gluten ingestion in genetically predisposed individuals. Historically, CD was primarily recognized and described as a disease of the Caucasian population. Data from a national survey in 2015 revealed that 0.79% of the population was formally diagnosed with celiac disease, with the non-Hispanic white population having a prevalence of 4-8 times higher than other underrepresented races. Although there is evidence that CD affects minorities at higher than reported rates, there is little data on its effects on minority populations. Our study aimed to characterize celiac-related complications among underrepresented populations in a large health database.Methods: We performed a cohort study among patients aged ≥18, utilizing the TriNetX US Collaborative Network. Two cohorts of patients (minority and non-Hispanic white) with CD were identified between 2016 and 2021. Cohorts were propensity scores matched on demographics and baseline clinical characteristics. Outcomes were assessed up to 1 year after the index event (CD diagnosis), including vitamin/mineral deficiencies and hospital visits. Data were analyzed using the TriNetX Analytics function.Results: Each group was matched with 817 patients. Compared to the non-Hispanic white population, the minority group had a similar incidence of iron, vitamin B, and zinc deficiencies. The minority group had a higher risk of vitamin D deficiency, anemia secondary to iron deficiency, inpatient hospital stays, and emergency department visits.Conclusion: Our results indicate that minority patients with celiac disease have a higher incidence of vitamin D and iron deficiency.","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"414-418"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychological, Psychiatric, and Organic Brain Manifestations of Celiac Disease. 乳糜泻的心理、精神和大脑器质性表现。

IF 2 4区医学

Digestive Diseases Pub Date : 2024-01-01 Epub Date: 2024-06-11 DOI: 10.1159/000534219

Edward J Ciaccio, Anne R Lee, Jessica Lebovits, Randi L Wolf, Suzanne K Lewis, Carolina Ciacci, Peter H R Green

{"title":"Psychological, Psychiatric, and Organic Brain Manifestations of Celiac Disease.","authors":"Edward J Ciaccio, Anne R Lee, Jessica Lebovits, Randi L Wolf, Suzanne K Lewis, Carolina Ciacci, Peter H R Green","doi":"10.1159/000534219","DOIUrl":"10.1159/000534219","url":null,"abstract":"Introduction: Celiac disease is an autoimmune condition that affects approximately 1% of the population worldwide. Although its main impact often concerns the small intestine, resulting in villous atrophy and nutrient malabsorption, it can also cause systemic manifestations, particularly when undiagnosed or left untreated.Method: Attention is directed to the possible psychological, psychiatric, and organic brain manifestations of celiac disease. Specific topics related to the influence and risk of such manifestations with respect to celiac disease are defined and discussed. Overall, eighteen main topics are considered, sifted from over 500 references.Results: The most often studied topics were found to be the effect on quality of life, organic brain dysfunction and ataxia, epilepsy, Down syndrome, generalized psychological disorders, eating dysfunction, depression, and schizophrenia. For most every topic, although many studies report a connection to celiac disease, there are often one or more contrary studies and opinions. A bibliographic analysis of the cited articles was also done. There has been a sharp increase in interest in this research since 1990. Recently published articles tend to receive more referencing, up to as many as 15 citations per year, suggesting an increasing impact of the topics. The number of manuscript pages per article has also tended to increase, up to as many as 12 pages. The impact factor of the publishing journal has remained level over the years.Conclusion: This compendium may be useful in developing a consensus regarding psychological, psychiatric, and organic brain manifestations that can occur in celiac disease and for determining the best direction for ongoing research focus.","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"419-444"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Statement. 撤回声明。

IF 2 4区医学

Digestive Diseases Pub Date : 2024-01-01 Epub Date: 2024-05-14 DOI: 10.1159/000539156

引用次数: 0

Association Study between SNPs in MST1 and MST2 and H. pylori Infection as well as Noncardia Gastric Carcinogenesis. MST1和MST2基因中的SNPs与幽门螺杆菌感染以及非贲门胃癌发生之间的关联研究。

IF 2 4区医学

Digestive Diseases Pub Date : 2024-01-01 Epub Date: 2024-01-31 DOI: 10.1159/000536507

Licong Ma, Fang Gao, Wenjie Dong, Qiang Song, Yanbin Jia

{"title":"Association Study between SNPs in MST1 and MST2 and H. pylori Infection as well as Noncardia Gastric Carcinogenesis.","authors":"Licong Ma, Fang Gao, Wenjie Dong, Qiang Song, Yanbin Jia","doi":"10.1159/000536507","DOIUrl":"10.1159/000536507","url":null,"abstract":"Introduction: Gastric cancer (GC) remains a global health challenge, and H. pylori infection is a main risk factor for noncardia GC. The present study aimed to investigate the association between single nucleotide polymorphisms (SNPs) in mammalian sterile 20-like kinase 1 (MST1) and MST2, H. pylori (H. pylori) infection, and the risk of noncardia gastric cancer (GC).Methods: A case-control study was conducted using enzyme-linked immunosorbent assay (ELISA) and TaqMan method to detect the titer of anti-H. pylori antibody in normal human serum and genotype 9 SNPs of MST1 and MST2 genes among 808 samples. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between SNPs and H. pylori infection, as well as the risk of noncardia gastric cancer in codominant, dominant, overdominant, recessive, and log-additive genetic models. Haplotypes were constructed using the Haploview 4.2 software.Results: The CC genotype of MST2 SNP rs10955176 was associated with a reduced risk of H. pylori infection compared to the TT + CT genotype. None of other SNPs were associated with H. pylori infection. The TT genotype of MST2 SNP rs7827435 was associated with a reduced risk of noncardia gastric cancer compared to the AA + AT genotype. None of the SNPs were associated with noncardia gastric cancer. There were no associations between haplotypes and H. pylori infection or the risk of noncardia gastric cancer.Conclusions: The CC genotype of rs10955176 and the TT genotype of rs7827435 may serve as protective factors against H. pylori infection and noncardia gastric cancer risk, respectively.","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"230-239"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considerations for Colorectal Neoplasia Detection in Inflammatory Bowel Disease Clinical Trials. 炎症性肠病临床试验中结肠肿瘤检测的注意事项。

IF 2.3 4区医学

Digestive Diseases Pub Date : 2024-01-01 Epub Date: 2023-09-27 DOI: 10.1159/000533395

Mira M Yang, Keith Usiskin, Harris A Ahmad, Shabana Ather, Antoine Sreih, James B Canavan, Francis A Farraye, Christopher Ma

{"title":"Considerations for Colorectal Neoplasia Detection in Inflammatory Bowel Disease Clinical Trials.","authors":"Mira M Yang, Keith Usiskin, Harris A Ahmad, Shabana Ather, Antoine Sreih, James B Canavan, Francis A Farraye, Christopher Ma","doi":"10.1159/000533395","DOIUrl":"10.1159/000533395","url":null,"abstract":"Background: High-quality colonoscopic surveillance can lead to earlier and increased detection of colorectal neoplasia in patients with inflammatory bowel disease (IBD). In IBD clinical trials, endoscopy is used to assess mucosal disease activity before and after treatment but also provides an opportunity to surveil for colorectal neoplasia during follow-up.Summary: Best practices for colorectal cancer identification in IBD clinical trials require engagement and collaboration between the clinical trial sponsor, site endoscopist and/or principal investigator, and central read team. Each team member has unique responsibilities for maximizing dysplasia detection in IBD trials.Key messages: Sponsors should work in accordance with scientific guidelines to standardize imaging procedures, design the protocol to ensure the trial population is safeguarded, and oversee trial conduct. The site endoscopist should remain updated on best practices to tailor sponsor protocol-required procedures to patient needs, examine the mucosa for disease activity and potential dysplasia during all procedures, and provide optimal procedure videos for central read analysis. Central readers may detect dysplasia or colorectal cancer and a framework to report these findings to trial sponsors is essential. Synergistic relationships between all team members in IBD clinical trials provide an important opportunity for extended endoscopic evaluation and colorectal neoplasia identification.","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"12-24"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41107713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Outcomes between a Basket Catheter and a Balloon Catheter for Endoscopic Common Bile Duct Stone Removal. 篮状导管和球囊导管用于内镜下胆总管结石切除的疗效比较。

IF 2.3 4区医学

Digestive Diseases Pub Date : 2024-01-01 Epub Date: 2023-10-07 DOI: 10.1159/000534458

Hirokazu Saito, Hajime Iwasaki, Hisashi Itoshima, Yoshihiro Kadono, Takashi Shono, Kentaro Kamikawa, Atsushi Urata, Jiro Nasu, Masayoshi Uehara, Ikuo Matsushita, Tatsuyuki Kakuma, Shunpei Hashigo, Shuji Tada

{"title":"Comparison of Outcomes between a Basket Catheter and a Balloon Catheter for Endoscopic Common Bile Duct Stone Removal.","authors":"Hirokazu Saito, Hajime Iwasaki, Hisashi Itoshima, Yoshihiro Kadono, Takashi Shono, Kentaro Kamikawa, Atsushi Urata, Jiro Nasu, Masayoshi Uehara, Ikuo Matsushita, Tatsuyuki Kakuma, Shunpei Hashigo, Shuji Tada","doi":"10.1159/000534458","DOIUrl":"10.1159/000534458","url":null,"abstract":"Introduction: Evidence for the outcomes of endoscopic retrograde cholangiopancreatography (ERCP) between a basket catheter and a balloon catheter for endoscopic common bile duct stone (CBDS) removal is lacking. This study aimed to compare ERCP outcomes using a basket catheter and a balloon catheter for endoscopic CBDS removal.Methods: This multicenter retrospective study included 904 consecutive patients with native papilla who underwent endoscopic stone removal for CBDS ≤10 mm using a basket catheter and/or a balloon catheter at three institutions in Japan. ERCP outcomes between the basket and balloon groups were compared using inverse probability of treatment weighting (IPTW) method.Results: ERCP-related adverse events occurred in 6.5% (29/449) and 7.7% (35/455) of patients in the basket and balloon groups, respectively (IPTW-adjusted p = 0.52). The incidences of post-ERCP pancreatitis, cholangitis, and perforation were similar in the basket and balloon groups (3.8% vs. 2.9%, 1.3% vs. 0.9%, and 0.7% vs. 0.7%, respectively). However, bleeding incidences were significantly higher in the balloon group than in the basket group (3.3% vs. 0.7%, IPTW-adjusted p = 0.012). Successful complete stone removal at one ERCP session using a single catheter was achieved in 17.8% (80/449) in the basket group and in 81.3% (370/455) in the balloon group (IPTW-adjusted p < 0.001).Discussion: A balloon catheter is more likely to complete stone extraction for CBDS ≤10 mm with a single catheter at one endoscopic stone removal session. However, the risk for post-ERCP bleeding is higher in the balloon group than in the basket group.","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"87-93"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41094031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thalidomide for the Management of Gastrointestinal Bleeding in a Palliative Care Setting. 综述文章：沙利度胺在姑息治疗环境中治疗胃肠道出血。

IF 2.3 4区医学

Digestive Diseases Pub Date : 2024-01-01 Epub Date: 2023-10-26 DOI: 10.1159/000533437

Elisabeth Fabian, Oliver Königsbrügge, Guenter J Krejs, Matthias Unseld

{"title":"Thalidomide for the Management of Gastrointestinal Bleeding in a Palliative Care Setting.","authors":"Elisabeth Fabian, Oliver Königsbrügge, Guenter J Krejs, Matthias Unseld","doi":"10.1159/000533437","DOIUrl":"10.1159/000533437","url":null,"abstract":"Background: Palliative care patients frequently present with clinically significant gastrointestinal bleeding. Due to the existence of confounding comorbidities and a remarkably reduced state of general health in many cases, the management of gastrointestinal bleeding in this population is often challenging.Summary: This review summarizes and discusses the role of thalidomide in gastrointestinal bleeding with a special focus on palliative care patients. In addition, an illustrative case report is presented. Thalidomide may be beneficial in gastrointestinal bleeding by exerting antiangiogenic effects. The drug has an acceptable safety profile. Side effects like neurotoxicity may limit its use but can be monitored safely. Due to thalidomide's thrombin generation potential, patients managed with thalidomide-containing regimes should be closely monitored for deep venous thrombosis. Given its teratogenicity, thalidomide should not be administered to women of childbearing potential who are not using adequate contraception.Key message: Physicians caring for patients in a palliative care setting should be aware of thalidomide as an effective therapeutic option when endoscopy fails to find a bleeding source or for those patients who cannot or refuse to undergo endoscopy but present with recurrent or obscure gastrointestinal bleeding.","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"113-126"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54228226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validating the Baveno Elastography Criteria of Advanced Liver Fibrosis in Two-Dimensional Shear Wave Elastography: A Prospective Pathology-Based Study. 在二维剪切波弹性成像中验证晚期肝纤维化的 Baveno 弹性成像标准：基于病理学的前瞻性研究

IF 2 4区医学

Digestive Diseases Pub Date : 2024-01-01 Epub Date: 2024-05-02 DOI: 10.1159/000539167

Chia-Chang Chen, Yao-Kuang Huang, Ren-Ching Wang, Jing-Tong Fu, Shou-Wu Lee, Hsin-Ju Tsai, Sheng-Shun Yang, Teng-Yu Lee

{"title":"Validating the Baveno Elastography Criteria of Advanced Liver Fibrosis in Two-Dimensional Shear Wave Elastography: A Prospective Pathology-Based Study.","authors":"Chia-Chang Chen, Yao-Kuang Huang, Ren-Ching Wang, Jing-Tong Fu, Shou-Wu Lee, Hsin-Ju Tsai, Sheng-Shun Yang, Teng-Yu Lee","doi":"10.1159/000539167","DOIUrl":"10.1159/000539167","url":null,"abstract":"Introduction: The Baveno criteria for assessing advanced liver fibrosis were mainly determined by transient elastography (TE), and its pathology-based validation studies in two-dimensional shear wave elastography (2D-SWE) remain limited. We aimed to validate the Baveno criteria through use of 2D-SWE.Method: Consecutive patients who underwent liver biopsies for various benign liver diseases were prospectively recruited. Liver stiffness measurement (LSM) was simultaneously evaluated by TE and 2D-SWE. The optimal cutoff value to predict advanced liver fibrosis was determined by the Youden Index, and the diagnostic performance was estimated using area under the receiver operating characteristic (AUROC) analysis.Results: A total of 101 patients were enrolled having a median age of 55.0 (IQR: 46.0-63.5) years, with 53 (52.48%) of them being male. Using <9 and >14 kPa as the optimal dual cutoffs, the AUROC values in TE and 2D-SWE were 0.92 (95% CI: 0.83-0.97) and 0.93 (95% CI: 0.84-0.98), respectively (p = 0.61). The sensitivity and specificity of LSM by TE/2D-SWE achieved rates of 94.44%/94.44% and 86.00%/88.00%, respectively. However, using the Baveno criteria, the AUROC values in TE and 2D-SWE could remain achieving 0.91 (95% CI: 0.82-0.97) and 0.93 (95% CI: 0.84-0.98), respectively (p = 0.36). The sensitivity and specificity in TE/2D-SWE were 88.24%/88.24% and 86.79%/90.57%, respectively.Conclusion: This study establishes the compatibility of the Baveno dual cutoff criteria with 2D-SWE, positioning it as an easily used criteria in clinical practice and research.","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"452-460"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Internet Available Patient Information on Chronic Pancreatitis Using the Ensuring Quality Information for Patients Tool: A Systematic Search and Evaluation. 使用确保患者信息质量的工具评估慢性胰腺炎的互联网可用患者信息:系统的搜索和评估。

IF 2.3 4区医学

Digestive Diseases Pub Date : 2024-01-01 Epub Date: 2023-11-13 DOI: 10.1159/000535073

Sebastian M Staubli, Shahi Ghani, Harriet Louise Walker, Giuseppe K Fusai, Dimitri A Raptis

{"title":"Assessment of Internet Available Patient Information on Chronic Pancreatitis Using the Ensuring Quality Information for Patients Tool: A Systematic Search and Evaluation.","authors":"Sebastian M Staubli, Shahi Ghani, Harriet Louise Walker, Giuseppe K Fusai, Dimitri A Raptis","doi":"10.1159/000535073","DOIUrl":"10.1159/000535073","url":null,"abstract":"Introduction: Chronic pancreatitis (CP) is a relevant chronic medical problem whereby delayed presentation and poor patient understanding can cause adverse effects. Quality of patient information available on the internet about CP is not known.Methods: A systematic review of the information about CP available online using the search term \"chronic pancreatitis\" in using the search engine Google has been conducted. The quality of the top 100 websites returned from this search term was analysed using the validated Ensuring Quality Information for Patients (EQIP) tool (maximum score 36). Additional items were included in the website analysis specific to CP.Results: In total, 45 websites were eligible for analysis. The median EQIP score of the websites was 16 (interquartile range 12-19.5). The majority of websites originated from the USA and the United Kingdom with 31 and 11 websites, respectively. Provision of additional information was inconsistent, with most websites covering information regarding aetiology and advocating alcohol and tobacco cessation, but only few reporting on more complex issues.Conclusion: Internet available information about CP is of limited quality. There is an immediate need for high quality, patient targeted, and informative literature accessible on the internet about this topic.","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"70-77"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92153268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of Colorectal Lung Metastases: Two Centers Retrospective Study. 大肠癌肺转移的治疗：两个中心的回顾性研究

IF 2 4区医学

Digestive Diseases Pub Date : 2024-01-01 Epub Date: 2024-10-15 DOI: 10.1159/000539927

Myrtle F Krul, Jan M van Rees, Amihan M de Boer, Karlijn K Neve, Cornelis Verhoef, Koert F D Kuhlmann, Tarik R Baetens, Tineke E Buffart, Joost L Knegjens, Houke M Klomp, Theo J M Ruers, Marianne de Vries, Joost Rothbarth, Esther van Meerten, Joost J M E Nuyttens, Dirk Grünhagen, Niels F M Kok

{"title":"Treatment of Colorectal Lung Metastases: Two Centers Retrospective Study.","authors":"Myrtle F Krul, Jan M van Rees, Amihan M de Boer, Karlijn K Neve, Cornelis Verhoef, Koert F D Kuhlmann, Tarik R Baetens, Tineke E Buffart, Joost L Knegjens, Houke M Klomp, Theo J M Ruers, Marianne de Vries, Joost Rothbarth, Esther van Meerten, Joost J M E Nuyttens, Dirk Grünhagen, Niels F M Kok","doi":"10.1159/000539927","DOIUrl":"10.1159/000539927","url":null,"abstract":"Introduction: Clear guidelines for colorectal lung metastasis (LM) treatment are not available. This study aimed to provide insight into the treatment strategies and efficacy of local and systemic therapy in patients with LM eligible for (potentially) curative treatment.Methods: This was a retrospective study of patients with ≤5 LM discussed in two tertiary referral centers. Patient and tumor characteristics were compared between treatment groups. Treatment strategies were compared between centers and survival data between treatment groups, local treatment modalities, and treating centers.Results: Ninety-two patients (median 2 LMs) were included. Seventy-one (77%) patients underwent local treatment (17 surgery, 13 ablation, 38 radiotherapy, 3 combination of local treatments) and 21 (23%) with systemic therapy alone. The latter group more frequently had extrapulmonary metastases (81.0% vs. 26.8%, p < 0.001) and synchronous presentation of LM (23.8% vs. 7.0%, p = 0.045). Choice of local versus systemic therapy and time to start treatment after diagnosis (median 109 days, IQR 44-240 vs. 88 days, IQR 53-168) were comparable between centers. Three-year survival rates did not differ between treatment groups, local treatment modalities, or treating centers.Conclusion: Treatment strategies and oncological outcomes were rather similar between centers. Survival outcomes were not different between locally and systemically treated patients.","PeriodicalId":11294,"journal":{"name":"Digestive Diseases","volume":" ","pages":"538-547"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0