Current vascular pharmacology最新文献_第9页

Implementation and Importance of Cardiac Rehabilitation for Cardiac Patients in Saudi Arabia: A Systematic Review. 沙特阿拉伯心脏病患者心脏康复的实施和重要性：系统综述。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230623115529

Raheeq Hadi Ahmed, Bussma Ahmed Bugis

{"title":"Implementation and Importance of Cardiac Rehabilitation for Cardiac Patients in Saudi Arabia: A Systematic Review.","authors":"Raheeq Hadi Ahmed, Bussma Ahmed Bugis","doi":"10.2174/1570161121666230623115529","DOIUrl":"10.2174/1570161121666230623115529","url":null,"abstract":"Objective: Cardiac rehabilitation (CR) has progressed over the years from a basic monitoring procedure for a safe return to physical activity to a multidisciplinary strategy that emphasizes patient education, specifically for designed exercise training, risk factor management, and the general health of cardiac patients.Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting was used for this systematic review. The studies included were retrieved via an electronic search of Google Scholar and PubMed using the following terms: cardiac rehabilitation (CR), cardiac diseases, coronary artery bypass graft, heart failure, cardiac rehabilitation guidelines, rehabilitation, recovery of function, cardiac rehabilitation importance, cardiac rehabilitation outcomes, physical therapy modalities, secondary prevention, physical medicine, and cardiac rehabilitation phases.Results: Publications (n=24) that included worldwide standards demonstrating the implementation of CR programs in a variety of scenarios were reviewed. These publications are based on well-defined guidelines that represent best practices from several cardiology societies, which use varying valid programs by comparing those guidelines with CR/secondary prevention programs.Conclusion: Several indications have been used in the development of the CR program, with the goal of regaining autonomy and increasing physical, psychological, and social activities. With the Saudi Vision 2030 initiatives for health national transformation programs, there are targets set to ensure the reduction and prevention of noncommunicable diseases and to reduce cardiovascular disease risks by initiating an accredited CR program and guidelines for Saudi Arabia.","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":"224-233"},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9739557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiometabolic Risk, Peripheral Arterial Disease and Cardiovascular Events in Polycystic Ovary Syndrome: Time to Implement Systematic Screening and Update the Management. 多囊卵巢综合征的心脏代谢风险、外周动脉疾病和心血管事件：是时候实施系统筛查和更新管理了。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/0115701611269146230920073301

Andrej Janez, Rok Herman, Pavel Poredos, Dimitri P Mikhailidis, Ales Blinc, Miso Sabovic, Katica Bajuk Studen, Mateja Kaja Jezovnik, Gerit-Holger Schernthaner, Panagiotis Anagnostis, Pier Luigi Antignani, Mojca Jensterle

{"title":"Cardiometabolic Risk, Peripheral Arterial Disease and Cardiovascular Events in Polycystic Ovary Syndrome: Time to Implement Systematic Screening and Update the Management.","authors":"Andrej Janez, Rok Herman, Pavel Poredos, Dimitri P Mikhailidis, Ales Blinc, Miso Sabovic, Katica Bajuk Studen, Mateja Kaja Jezovnik, Gerit-Holger Schernthaner, Panagiotis Anagnostis, Pier Luigi Antignani, Mojca Jensterle","doi":"10.2174/0115701611269146230920073301","DOIUrl":"10.2174/0115701611269146230920073301","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine disorder in women of reproductive age. It presents with gynaecologic, metabolic, and psychologic manifestations. The dominant drivers of pathophysiology are hyperandrogenism and insulin resistance. Both conditions are related to cardiometabolic risk factors, such as obesity, hypertension, dyslipidaemia, hyperglycaemia, type 2 and gestational diabetes, nonalcoholic fatty liver disease and obstructive sleep apnoea. Women with PCOS of reproductive age consistently demonstrated an elevated risk of subclinical atherosclerosis, as indicated by different measurement methods, while findings for menopausal age groups exhibited mixed results. Translation of subclinical atherosclerosis into the increased incidence of peripheral arterial disease and major cardiovascular (CV) events is less clear. Although several expert groups have advised screening, the CV risk assessment and prevention of CV events are frequently underdiagnosed and overlooked aspects of the management of PCOS. A combination of lifestyle management and pharmacotherapy, including the promising new era of anti-obesity medicine, can lead to improvements in cardiometabolic health.","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":"424-432"},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41116528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Role of Cytochrome C Oxidase 5A (COX5A) against Mitochondrial Disorder and Oxidative Stress in VSMC Phenotypic Modulation and Neointima Formation. 细胞色素C氧化酶5A (COX5A)对线粒体紊乱和氧化应激在VSMC表型调节和内膜形成中的保护作用

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230315142507

Haijing Guan, Jingwen Sun, Xiuying Liang, Wenjuan Yao

{"title":"Protective Role of Cytochrome C Oxidase 5A (COX5A) against Mitochondrial Disorder and Oxidative Stress in VSMC Phenotypic Modulation and Neointima Formation.","authors":"Haijing Guan, Jingwen Sun, Xiuying Liang, Wenjuan Yao","doi":"10.2174/1570161121666230315142507","DOIUrl":"https://doi.org/10.2174/1570161121666230315142507","url":null,"abstract":"Background: The pathological role of cytochrome c oxidase 5A (COX5A) in vascular neointima formation remains unknown.Aim: This study aims to investigate the role of COX5A on platelet-derived growth factor BB (PDGFBB)- mediated smooth muscle phenotypic modulation and neointima formation and clarify the molecular mechanisms behind this effect.Methods: For in vitro assays, human aortic vascular smooth muscle cells (HA-VSMCs) were transfected with pcDNA3.1-COX5A and COX5A siRNA to overexpress and knockdown COX5A, respectively. Mitochondrial complex IV activity, oxygen consumption rate (OCR), H2O2 and ATP production, reactive oxygen species (ROS) generation, cell proliferation, and migration were measured. For in vivo assays, rats after balloon injury (BI) were injected with recombinant lentivirus carrying the COX5A gene. Mitochondrial COX5A expression, carotid arterial morphology, mitochondrial ultrastructure, and ROS were measured.Results: The results showed that PDGF-BB reduced the level and altered the distribution of COX5A in mitochondria, as well as reduced complex IV activity, ATP synthesis, and OCR while increasing H2O2 synthesis, ROS production, and cell proliferation and migration. These effects were reversed by overexpression of COX5A and aggravated by COX5A knockdown. In addition, COX5A overexpression attenuated BI-induced neointima formation, muscle fiber area ratio, VSMC migration to the intima, mitochondrial ultrastructural damage, and vascular ROS generation.Conclusion: The present study demonstrated that COX5A protects VSMCs against phenotypic modulation by improving mitochondrial respiratory function and attenuating mitochondrial damage, as well as reducing oxidative stress, thereby preventing neointima formation.","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":"21 2","pages":"128-142"},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9751118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine Disorders and Peripheral Arterial Disease: A Series of Reviews. 内分泌紊乱和外周动脉疾病:一系列综述。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230516141319

Pavel Poredoš, Gerit Holger Schernthaner, Ales Blinc, Dimitri P Mikhailidis, Pier Luigi Antignani, Panagiotis G Anagnostis, Mojca Jensterle, Katica Bajuk Studen, Miso Šabović, Mateja Kaja Jezovnik

引用次数: 0

Testosterone and Peripheral Arterial Disease. 睾酮与外周动脉疾病。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230809143023

Aleš Blinc, Gerit Holger Schernthaner, Pavel Poredoš, Panagiotis Anagnostis, Mojca Jensterle, Katica Bajuk Studen, Pier Luigi Antignani, Dimitri P Mikhailidis, Mišo Šabović

{"title":"Testosterone and Peripheral Arterial Disease.","authors":"Aleš Blinc, Gerit Holger Schernthaner, Pavel Poredoš, Panagiotis Anagnostis, Mojca Jensterle, Katica Bajuk Studen, Pier Luigi Antignani, Dimitri P Mikhailidis, Mišo Šabović","doi":"10.2174/1570161121666230809143023","DOIUrl":"10.2174/1570161121666230809143023","url":null,"abstract":"Testosterone levels in men begin declining in the early years of adulthood, with a 1-2% reduction/year. Low testosterone levels in men are associated with obesity, metabolic syndrome, diabetes mellitus, dyslipidaemia, hypertension and increased cardiovascular mortality. However, observational studies of testosterone levels in males and their relationship with peripheral arterial disease (PAD) have yielded mixed results; only some cohorts show a clear association with low free testosterone levels. This discrepancy may, in part, be due to methodological issues with estimating free testosterone but also to different effects of testosterone on the vessel wall and metabolism. While testosterone improves glycaemic control, has anti-obesity effects and induces vasodilation, it also stimulates platelet aggregation and increases the haematocrit. Androgen deprivation treatment for advanced prostate cancer may be associated with elevated cardiovascular risk, as is testosterone abuse for performance enhancement. On the other hand, judicious treatment of male hypogonadism or testosterone treatment of trans-men appears to be safe.","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":"297-303"},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9996946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aortic Intima-Media Thickness is Increased in Neonates of Mothers with Gestational Diabetes Mellitus: The Role of Thioredoxin-Interacting Protein as a Marker of Oxidative Stress. 妊娠期糖尿病母亲的新生儿主动脉内膜中膜厚度增加：硫氧还蛋白相互作用蛋白作为氧化应激标志物的作用。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230727150854

Pinelopi Triantafyllidou, Anna Papadopoulou, Eirini Thymara, Vassiliki Papaevangelou, George Mastorakos, Anastasios Papadimitriou, Sophia Kalantaridou, Constanine A Stratakis, Efthymia Alexopoulou

{"title":"Aortic Intima-Media Thickness is Increased in Neonates of Mothers with Gestational Diabetes Mellitus: The Role of Thioredoxin-Interacting Protein as a Marker of Oxidative Stress.","authors":"Pinelopi Triantafyllidou, Anna Papadopoulou, Eirini Thymara, Vassiliki Papaevangelou, George Mastorakos, Anastasios Papadimitriou, Sophia Kalantaridou, Constanine A Stratakis, Efthymia Alexopoulou","doi":"10.2174/1570161121666230727150854","DOIUrl":"10.2174/1570161121666230727150854","url":null,"abstract":"Background: Offspring exposed in foetal life to gestational diabetes mellitus (GDM) are at increased risk for future metabolic diseases.Objective: To explore the prognostic role of abdominal aorta intima-media thickness (aIMT) in neonates exposed to GDM as a possible biomarker for later atherogenesis and its possible correlation with thioredoxin- interacting protein (TXNIP), a protein involved in oxidative stress.Methods: In this prospective, observational study, mother-infant pairs were studied in 2 groups (57 patients with GDM and 51 controls without GDM). TXNIP levels were measured in the placenta, as well as in the umbilical and neonatal blood. The data were correlated with aIMT in neonates.Results: aIMT was increased in GDM offspring (patients: median [range]=0.39 mm [0.31-0.46] vs controls: median=0.28 mm [0.23-0.33]; p=0.001) and remained significant after adjusting for possible confounders (e.g., triglycerides, blood pressure, vitamin D, birth weight and gender; β coefficient=0.131 p=0.049). TXNIP levels were increased in trophoblasts (p=0.001) and syncytiotrophoblasts (p=0.001) and were decreased in endothelial cells (p=0.022) in GDM offspring vs controls. Moreover, TXNIP levels in trophoblasts positively correlated with aIMT (r=0.369; p=0.001). TXNIP levels in umbilical/ neonatal blood were not associated with GDM.Conclusion: Increased aIMT was demonstrated in the offspring of mothers with GDM. Non-invasive measurement of aIMT could be used as a biomarker to identify children at increased risk for atherogenesis later in life. This information may encourage early preventive measures. TXNIP may be associated with GDM and/or aIMT.","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":"234-245"},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10255603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1. 维生素在心血管健康中的作用：了解事实 - 第 1 部分。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230912155548

Antonis A Manolis, Theodora Manolis, Helen Melita, Antonis S Manolis

{"title":"Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1.","authors":"Antonis A Manolis, Theodora Manolis, Helen Melita, Antonis S Manolis","doi":"10.2174/1570161121666230912155548","DOIUrl":"10.2174/1570161121666230912155548","url":null,"abstract":"Cardiovascular (CV) disease (CVD) is a major cause of morbidity and mortality world-wide, thus it is important to adopt preventive interventions. Observational data demonstrating CV benefits of vitamin supplements, advanced by self-proclaimed experts have resulted in ~50% of Americans reporting the use of multivitamins for health promotion; this practice has led to a multi-billion-dollar business of the multivitamin-industry. However, the data on the extensive use of multivitamins show no consistent benefit for CVD prevention or all-cause mortality, while the use of certain vitamins might prove harmful. Thus, the focus of this two-part review is on the attributes or concerns about specific vitamins on CVD. In Part 1, the CV effects of specific vitamins are discussed, indicating the need for further supportive evidence of potential benefits. Vitamin A preserves CV homeostasis as it participates in many biologic functions, including atherosclerosis. However, supplementation could potentially be harmful. Betacarotene, a pro-vitamin A, conveys pro-oxidant actions that may mitigate any other benefits. Folic acid alone and certain B-vitamins (e.g., B1/B2/B6/B12) may reduce CVD, heart failure, and/or stroke, while niacin might increase mortality. Vitamin C has antioxidant and cardioprotective effects. Vitamin D may confer CV protection, but all the data are not in agreement. Combined vitamin E and C have antiatherogenic effects but clinical evidence is inconsistent. Vitamin K seems neutral. Thus, there are individual vitamin actions with favorable CV impact (certain B-vitamins and vitamins C and D), but other vitamins (β-carotene, niacin) may potentially have deleterious effects, which also holds true for high doses of fat-soluble vitamins (A/D/E/K).","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":"378-398"},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10223830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Emerging Role of CircRNAs in Atherosclerosis. 环状rna在动脉粥样硬化中的新作用。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230106153857

Jing Yang, Shuling Rong

引用次数: 1

Analysis of the Research Hotspot of Exosomes in Cardiovascular Disease: A Bibliometric-based Literature Review. 心血管疾病外泌体研究热点分析：基于文献计量学的文献综述。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/0115701611249727230920042944

Jing Cui, Yiwen Li, Mengmeng Zhu, Yanfei Liu, Yue Liu

{"title":"Analysis of the Research Hotspot of Exosomes in Cardiovascular Disease: A Bibliometric-based Literature Review.","authors":"Jing Cui, Yiwen Li, Mengmeng Zhu, Yanfei Liu, Yue Liu","doi":"10.2174/0115701611249727230920042944","DOIUrl":"10.2174/0115701611249727230920042944","url":null,"abstract":"Objective: To investigate the current status and development trend of research on exosomes in cardiovascular disease (CVD) using bibliometric analysis and to elucidate trending research topics.Methods: Research articles on exosomes in CVD published up to April 2022 were retrieved from the Web of Science database. Data were organized using Microsoft Office Excel 2019. CiteSpace 6.1 and VOSviewer 1.6.18 were used for bibliometric analysis and result visualization.Results: Overall, 256 original research publications containing 190 fundamental research publications and 66 clinical research publications were included. \"Extracellular vesicle\" was the most frequent research keyword, followed by \"microrna,\" \"apoptosis,\" and \"angiogenesis.\" Most publications were from China (187, 73.05%), followed by the United States (57, 22.27%), the United Kingdom (7, 2.73%), and Japan (7, 2.73%). A systematic review of the publications revealed that myocardial infarction and stroke were the most popular topics and that exosomes and their contents, such as microRNAs (miRNAs), play positive roles in neuroprotection, inhibition of autophagy and apoptosis, promotion of angiogenesis, and protection of cardiomyocytes.Conclusion: Research on exosomes in CVD has attracted considerable attention, with China having the most published studies. Fundamental research has focused on CVD pathogenesis; exosomes regulate the progression of CVD through biological processes, such as the inflammatory response, autophagy, and apoptosis. Clinical research has focused on biomarkers for CVD; studies on using miRNAs in exosomes as disease markers for diagnosis could become a future trend.","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":"316-345"},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41095659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Athyros and Colleagues: Inflammation and LDL Reduction. 对动脉粥样硬化及其同事的反应:炎症和LDL降低。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230118115539

Rodrigo Damián García, Joana Antonela Asensio, Diahann Jeanette Perdicaro, María de Los Ángeles Peral

引用次数: 0