Current vascular pharmacology最新文献_第7页

The Emerging Role of CircRNAs in Atherosclerosis. 环状rna在动脉粥样硬化中的新作用。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230106153857

Jing Yang, Shuling Rong

引用次数: 1

Protective Role of Cytochrome C Oxidase 5A (COX5A) against Mitochondrial Disorder and Oxidative Stress in VSMC Phenotypic Modulation and Neointima Formation. 细胞色素C氧化酶5A (COX5A)对线粒体紊乱和氧化应激在VSMC表型调节和内膜形成中的保护作用

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230315142507

Haijing Guan, Jingwen Sun, Xiuying Liang, Wenjuan Yao

{"title":"Protective Role of Cytochrome C Oxidase 5A (COX5A) against Mitochondrial Disorder and Oxidative Stress in VSMC Phenotypic Modulation and Neointima Formation.","authors":"Haijing Guan, Jingwen Sun, Xiuying Liang, Wenjuan Yao","doi":"10.2174/1570161121666230315142507","DOIUrl":"https://doi.org/10.2174/1570161121666230315142507","url":null,"abstract":"Background: The pathological role of cytochrome c oxidase 5A (COX5A) in vascular neointima formation remains unknown.Aim: This study aims to investigate the role of COX5A on platelet-derived growth factor BB (PDGFBB)- mediated smooth muscle phenotypic modulation and neointima formation and clarify the molecular mechanisms behind this effect.Methods: For in vitro assays, human aortic vascular smooth muscle cells (HA-VSMCs) were transfected with pcDNA3.1-COX5A and COX5A siRNA to overexpress and knockdown COX5A, respectively. Mitochondrial complex IV activity, oxygen consumption rate (OCR), H2O2 and ATP production, reactive oxygen species (ROS) generation, cell proliferation, and migration were measured. For in vivo assays, rats after balloon injury (BI) were injected with recombinant lentivirus carrying the COX5A gene. Mitochondrial COX5A expression, carotid arterial morphology, mitochondrial ultrastructure, and ROS were measured.Results: The results showed that PDGF-BB reduced the level and altered the distribution of COX5A in mitochondria, as well as reduced complex IV activity, ATP synthesis, and OCR while increasing H2O2 synthesis, ROS production, and cell proliferation and migration. These effects were reversed by overexpression of COX5A and aggravated by COX5A knockdown. In addition, COX5A overexpression attenuated BI-induced neointima formation, muscle fiber area ratio, VSMC migration to the intima, mitochondrial ultrastructural damage, and vascular ROS generation.Conclusion: The present study demonstrated that COX5A protects VSMCs against phenotypic modulation by improving mitochondrial respiratory function and attenuating mitochondrial damage, as well as reducing oxidative stress, thereby preventing neointima formation.","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9751118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine Disorders and Peripheral Arterial Disease: A Series of Reviews. 内分泌紊乱和外周动脉疾病:一系列综述。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230516141319

Pavel Poredoš, Gerit Holger Schernthaner, Ales Blinc, Dimitri P Mikhailidis, Pier Luigi Antignani, Panagiotis G Anagnostis, Mojca Jensterle, Katica Bajuk Studen, Miso Šabović, Mateja Kaja Jezovnik

引用次数: 0

Testosterone and Peripheral Arterial Disease. 睾酮与外周动脉疾病。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230809143023

Aleš Blinc, Gerit Holger Schernthaner, Pavel Poredoš, Panagiotis Anagnostis, Mojca Jensterle, Katica Bajuk Studen, Pier Luigi Antignani, Dimitri P Mikhailidis, Mišo Šabović

{"title":"Testosterone and Peripheral Arterial Disease.","authors":"Aleš Blinc, Gerit Holger Schernthaner, Pavel Poredoš, Panagiotis Anagnostis, Mojca Jensterle, Katica Bajuk Studen, Pier Luigi Antignani, Dimitri P Mikhailidis, Mišo Šabović","doi":"10.2174/1570161121666230809143023","DOIUrl":"10.2174/1570161121666230809143023","url":null,"abstract":"Testosterone levels in men begin declining in the early years of adulthood, with a 1-2% reduction/year. Low testosterone levels in men are associated with obesity, metabolic syndrome, diabetes mellitus, dyslipidaemia, hypertension and increased cardiovascular mortality. However, observational studies of testosterone levels in males and their relationship with peripheral arterial disease (PAD) have yielded mixed results; only some cohorts show a clear association with low free testosterone levels. This discrepancy may, in part, be due to methodological issues with estimating free testosterone but also to different effects of testosterone on the vessel wall and metabolism. While testosterone improves glycaemic control, has anti-obesity effects and induces vasodilation, it also stimulates platelet aggregation and increases the haematocrit. Androgen deprivation treatment for advanced prostate cancer may be associated with elevated cardiovascular risk, as is testosterone abuse for performance enhancement. On the other hand, judicious treatment of male hypogonadism or testosterone treatment of trans-men appears to be safe.","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9996946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1. 维生素在心血管健康中的作用：了解事实 - 第 1 部分。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230912155548

Antonis A Manolis, Theodora Manolis, Helen Melita, Antonis S Manolis

{"title":"Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1.","authors":"Antonis A Manolis, Theodora Manolis, Helen Melita, Antonis S Manolis","doi":"10.2174/1570161121666230912155548","DOIUrl":"10.2174/1570161121666230912155548","url":null,"abstract":"Cardiovascular (CV) disease (CVD) is a major cause of morbidity and mortality world-wide, thus it is important to adopt preventive interventions. Observational data demonstrating CV benefits of vitamin supplements, advanced by self-proclaimed experts have resulted in ~50% of Americans reporting the use of multivitamins for health promotion; this practice has led to a multi-billion-dollar business of the multivitamin-industry. However, the data on the extensive use of multivitamins show no consistent benefit for CVD prevention or all-cause mortality, while the use of certain vitamins might prove harmful. Thus, the focus of this two-part review is on the attributes or concerns about specific vitamins on CVD. In Part 1, the CV effects of specific vitamins are discussed, indicating the need for further supportive evidence of potential benefits. Vitamin A preserves CV homeostasis as it participates in many biologic functions, including atherosclerosis. However, supplementation could potentially be harmful. Betacarotene, a pro-vitamin A, conveys pro-oxidant actions that may mitigate any other benefits. Folic acid alone and certain B-vitamins (e.g., B1/B2/B6/B12) may reduce CVD, heart failure, and/or stroke, while niacin might increase mortality. Vitamin C has antioxidant and cardioprotective effects. Vitamin D may confer CV protection, but all the data are not in agreement. Combined vitamin E and C have antiatherogenic effects but clinical evidence is inconsistent. Vitamin K seems neutral. Thus, there are individual vitamin actions with favorable CV impact (certain B-vitamins and vitamins C and D), but other vitamins (β-carotene, niacin) may potentially have deleterious effects, which also holds true for high doses of fat-soluble vitamins (A/D/E/K).","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10223830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the Research Hotspot of Exosomes in Cardiovascular Disease: A Bibliometric-based Literature Review. 心血管疾病外泌体研究热点分析：基于文献计量学的文献综述。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/0115701611249727230920042944

Jing Cui, Yiwen Li, Mengmeng Zhu, Yanfei Liu, Yue Liu

{"title":"Analysis of the Research Hotspot of Exosomes in Cardiovascular Disease: A Bibliometric-based Literature Review.","authors":"Jing Cui, Yiwen Li, Mengmeng Zhu, Yanfei Liu, Yue Liu","doi":"10.2174/0115701611249727230920042944","DOIUrl":"10.2174/0115701611249727230920042944","url":null,"abstract":"Objective: To investigate the current status and development trend of research on exosomes in cardiovascular disease (CVD) using bibliometric analysis and to elucidate trending research topics.Methods: Research articles on exosomes in CVD published up to April 2022 were retrieved from the Web of Science database. Data were organized using Microsoft Office Excel 2019. CiteSpace 6.1 and VOSviewer 1.6.18 were used for bibliometric analysis and result visualization.Results: Overall, 256 original research publications containing 190 fundamental research publications and 66 clinical research publications were included. \"Extracellular vesicle\" was the most frequent research keyword, followed by \"microrna,\" \"apoptosis,\" and \"angiogenesis.\" Most publications were from China (187, 73.05%), followed by the United States (57, 22.27%), the United Kingdom (7, 2.73%), and Japan (7, 2.73%). A systematic review of the publications revealed that myocardial infarction and stroke were the most popular topics and that exosomes and their contents, such as microRNAs (miRNAs), play positive roles in neuroprotection, inhibition of autophagy and apoptosis, promotion of angiogenesis, and protection of cardiomyocytes.Conclusion: Research on exosomes in CVD has attracted considerable attention, with China having the most published studies. Fundamental research has focused on CVD pathogenesis; exosomes regulate the progression of CVD through biological processes, such as the inflammatory response, autophagy, and apoptosis. Clinical research has focused on biomarkers for CVD; studies on using miRNAs in exosomes as disease markers for diagnosis could become a future trend.","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41095659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Pilot Study Suggesting Several Benefits of Alpha Lipoic Acid in Patients with Diabetes. 一项初步研究表明α硫辛酸对糖尿病患者有几种益处。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230210100920

Athyros G Vasilios, Sfikas George, Koumaras Charalambos, Athyrou Valasia

引用次数: 0

Twin Anemia-Polycythemia Sequence (TAPS): From Basic Research to Clinical Practice. 双胞胎贫血-红细胞增多症序列(TAPS):从基础研究到临床实践。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230131112930

Joana da Silva Rocha, Luís Guedes-Martins, Ana Cunha

{"title":"Twin Anemia-Polycythemia Sequence (TAPS): From Basic Research to Clinical Practice.","authors":"Joana da Silva Rocha, Luís Guedes-Martins, Ana Cunha","doi":"10.2174/1570161121666230131112930","DOIUrl":"https://doi.org/10.2174/1570161121666230131112930","url":null,"abstract":"Twin pregnancy is associated with an increased risk of perinatal and maternal complications, and early establishment of the chorionicity type defines this risk. In monochorionic (MC) pregnancies, the fetuses share the same placental mass and exhibit vascular anastomoses crossing the intertwin membrane, and the combination and pattern of anastomoses determine the primary clinical picture and occurrence of future complications. Twin Anemia-Polycythemia Sequence (TAPS) was first described in 2006 after fetoscopic laser surgery in twin-to-twin transfusion syndrome (TTTS) twins, and in 2007, the first spontaneous cases were reported, recognizing TAPS as an individualized vascular identity in fetofetal transfusion syndromes. There are two types of TAPS: spontaneous (3-5%) and iatrogenic or postlaser (2-16%). TAPS consists of small diameter arteriovenous anastomoses (<1 mm) and low-rate, small-caliber AA anastomoses in the absence of amniotic fluid discordances. There are certain antenatal and postnatal diagnostic criteria, which have progressively evolved over time. New, additional secondary markers have been proposed, and their reliability is being studied. The best screening protocol for TAPS in MC twins is still a matter of debate. This review provides a survey of the relevant literature on the epidemiology, vascular pathophysiology, underlying hemodynamic factors that regulate mismatched vascular connections, and diagnostic criteria of this condition. The aim is to increase awareness and knowledge about this recently identified and frequently unrecognized and misdiagnosed pathology.","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9971405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Athyros and Colleagues: Inflammation and LDL Reduction. 对动脉粥样硬化及其同事的反应:炎症和LDL降低。

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666230118115539

Rodrigo Damián García, Joana Antonela Asensio, Diahann Jeanette Perdicaro, María de Los Ángeles Peral

引用次数: 0

Non-alcoholic Fatty Liver Disease in Children. 儿童非酒精性脂肪性肝病

IF 4.5 3区医学

Current vascular pharmacology Pub Date : 2023-01-01 DOI: 10.2174/1570161121666221118155136

Emir Muzurović, Stergios Polyzos, Dimitri Mikhailidis, Sanja Borozan, Dušanka Novosel, Oleg Cmiljanić, Nataša Kadić, Christos Mantzoros

引用次数: 5