Digestive and Liver Disease最新文献

{"title":"Author's reply: “Prevalence and outcomes of arthritis in pediatric IBD: A study from the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition”","authors":"Saverio Pochesci , Luca Scarallo , Paolo Lionetti","doi":"10.1016/j.dld.2025.05.003","DOIUrl":"10.1016/j.dld.2025.05.003","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 7","pages":"Page 1519"},"PeriodicalIF":4.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiparametric magnetic resonance imaging may improve detection of patients with at-risk MASH: Real world experience in hepatology clinics.","authors":"Meaghan M Phipps, Tatiana Hage, Emily Truong, Ju Dong Yang, Lauren Nicolosi, Andrea Dennis, Elizabeth Shumbayawonda, Prashant Pandya, Julia Wattacheril","doi":"10.1016/j.dld.2025.05.023","DOIUrl":"https://doi.org/10.1016/j.dld.2025.05.023","url":null,"abstract":"<p><strong>Background: </strong>Early identification of patients with metabolic dysfunction-associated steatotic liver disease (MASLD) at risk for metabolic dysfunction-associated steatohepatitis (MASH) and/or advanced fibrosis (AF) can prevent disease progression. Non-invasive tests are useful to help identify at-risk patients. Current guidelines recommend primarily using the Fibrosis-4 (FIB-4) score for risk stratification. We aimed to evaluate the potential benefits of utilizing multiparametric magnetic resonance (mpMR) imaging to improve the detection of patients with at-risk MASLD.</p><p><strong>Methods: </strong>In a prospective multicenter observational study, patients with MASLD who received mpMR as part of standard clinical care were included. Patient demographics and clinical, laboratory, and imaging data were extracted. Comparisons were made between the current guidelines for patients with suspected or established MASLD based on initial FIB-4 and risk stratification with mpMR. A cT1 of ≥800 ms was considered an indicator of high risk for progression.</p><p><strong>Results: </strong>Of 102 patients with MASLD at two large academic centers, 77 % had low FIB-4 (<1.3 for ≤65, and <2 for >65). 58 % of patients with low FIB-4 had cT1 ≥800 ms, indicating increased risk for MASH (63.5 % in ≤65, 48.1 % in >65). Among those ≤65, those with cT1 ≥800 ms were more likely to be women (63.6 % v. 36.4 %, p < 0.01) and had higher rates of diabetes (30.3 % v. 5.3 %, p = 0.03). Dyslipidemia was common (65 % of patients), but only 51.5 % were on lipid-lowering therapy.</p><p><strong>Conclusion: </strong>In this real-world application of mpMR, over half of patients stratified as low risk by FIB-4 had cT1 suggesting increased risk for developing MASH or AF. Incorporation of mpMR earlier in the algorithm for patients with suspected or established MASLD may improve the identification of those with at-risk disease, allowing for earlier intervention to prevent progression and complications.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular complications in inflammatory bowel disease: moving from recognition to personalised prevention.","authors":"Wenbin Dai","doi":"10.1016/j.dld.2025.05.013","DOIUrl":"https://doi.org/10.1016/j.dld.2025.05.013","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations in evaluating the association between combined oral contraceptives and gastroparesis.","authors":"Yi Ding, Shuying Wang","doi":"10.1016/j.dld.2025.05.015","DOIUrl":"https://doi.org/10.1016/j.dld.2025.05.015","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding updated pagination in previously published articles","authors":"","doi":"10.1016/j.dld.2025.05.017","DOIUrl":"10.1016/j.dld.2025.05.017","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1362-1363"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Title Page /Editorial Board","authors":"","doi":"10.1016/S1590-8658(25)00763-7","DOIUrl":"10.1016/S1590-8658(25)00763-7","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages i-ii"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic fat density and post-ERCP pancreatitis: A complex relationship or a novel predictor?","authors":"Amir Farah ,&nbsp;Amir Mari","doi":"10.1016/j.dld.2025.02.019","DOIUrl":"10.1016/j.dld.2025.02.019","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1352-1353"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “A comprehensive RCT in screening, surveillance, and diagnostic AI-assisted colonoscopies (ACCENDO-Colo study)” [Digestive and Liver Disease 57 (2025) 762-9]","authors":"Cristiano Spada ,&nbsp;Daniele Salvi ,&nbsp;Clarissa Ferrari ,&nbsp;Cesare Hassan ,&nbsp;Federico Barbaro ,&nbsp;Nicoletta Belluardo ,&nbsp;Leonardo Minelli Grazioli ,&nbsp;Sebastian Manuel Milluzzo ,&nbsp;Nicola Olivari ,&nbsp;Luigi Giovanni Papparella ,&nbsp;Silvia Pecere ,&nbsp;Eugenia Vittoria Pesatori ,&nbsp;Lucio Petruzziello ,&nbsp;Stefania Piccirelli ,&nbsp;Alessandro Quadarella ,&nbsp;Paola Cesaro ,&nbsp;Guido Costamagna","doi":"10.1016/j.dld.2025.02.029","DOIUrl":"10.1016/j.dld.2025.02.029","url":null,"abstract":"","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Page 1361"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of adipose body composition using an artificial intelligence-based CT Protocol and its association with severe acute pancreatitis in hospitalized patients","authors":"Pedro Cortés ,&nbsp;Tyler A. Mistretta ,&nbsp;Brittany Jackson ,&nbsp;Caroline G. Olson ,&nbsp;Ahmed M. Al Qady ,&nbsp;Fernando F. Stancampiano ,&nbsp;Panagiotis Korfiatis ,&nbsp;Jason R. Klug ,&nbsp;Dana M. Harris ,&nbsp;J. Dan Echols ,&nbsp;Rickey E. Carter ,&nbsp;Baoan Ji ,&nbsp;Heather D. Hardway ,&nbsp;Michael B. Wallace ,&nbsp;Vivek Kumbhari ,&nbsp;Yan Bi","doi":"10.1016/j.dld.2025.02.010","DOIUrl":"10.1016/j.dld.2025.02.010","url":null,"abstract":"<div><h3>Background/Objectives</h3><div>The clinical utility of body composition in predicting the severity of acute pancreatitis (AP) remains unclear. We aimed to measure body composition using artificial intelligence (AI) to predict severe AP in hospitalized patients.</div></div><div><h3>Methods</h3><div>We performed a retrospective study of patients hospitalized with AP at three tertiary care centers in 2018. Patients with computer tomography (CT) imaging of the abdomen at admission were included. A fully automated and validated abdominal segmentation algorithm was used for body composition analysis. The primary outcome was severe AP, defined as having persistent single- or multi-organ failure as per the revised Atlanta classification.</div></div><div><h3>Results</h3><div>352 patients were included. Severe AP occurred in 35 patients (9.9%). In multivariable analysis, adjusting for male sex and first episode of AP, intermuscular adipose tissue (IMAT) was associated with severe AP, OR = 1.06 per 5 cm², p = 0.0207. Subcutaneous adipose tissue (SAT) area approached significance, OR = 1.05, p = 0.17. Neither visceral adipose tissue (VAT) nor skeletal muscle (SM) was associated with severe AP. In obese patients, a higher SM was associated with severe AP in unadjusted analysis (86.7 vs 75.1 and 70.3 cm² in moderate and mild, respectively p = 0.009).</div></div><div><h3>Conclusion</h3><div>In this multi-site retrospective study using AI to measure body composition, we found elevated IMAT to be associated with severe AP. Although SAT was non-significant for severe AP, it approached statistical significance. Neither VAT nor SM were significant. Further research in larger prospective studies may be beneficial.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1218-1225"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of immune checkpoint inhibitor-related pancreatic injury with pancreatitis in patients with advanced malignancies","authors":"Takaya Suzuki ,&nbsp;Kazuyuki Mizuno ,&nbsp;Takafumi Yamamoto ,&nbsp;Takanori Ito ,&nbsp;Takuya Ishikawa ,&nbsp;Takashi Honda ,&nbsp;Shusuke Akamatsu ,&nbsp;Makoto Ishii ,&nbsp;Yuichi Ando ,&nbsp;Hiroki Kawashima","doi":"10.1016/j.dld.2025.02.027","DOIUrl":"10.1016/j.dld.2025.02.027","url":null,"abstract":"<div><h3>Background/Purpose</h3><div>Immune checkpoint inhibitor (ICIs) therapy can cause immune checkpoint inhibitor-related pancreatic injury (ICI-PI). This study aimed to elucidate the clinical characteristics of ICI-PI and explore treatment approaches.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed data from patients with malignancies treated with ICIs at Nagoya University Hospital between September 2014 and June 2023. ICI-PI and pancreatitis were identified and classified using the Common terminology Criteria for Adverse Events (CTCAE) ver.5.0, and the patients with ICI-PI with/without pancreatitis were analyzed.</div></div><div><h3>Results</h3><div>This study included data from 930 patients treated with ICIs. Of these, eight (0.85 %) and 10 (1.08 %) patients were diagnosed with ICI-PI without and with pancreatitis, respectively. Five of the 10 patients received standard pancreatitis treatment, while three received additional glucocorticoid therapy. One patient experienced recurrent pancreatitis and developed a pancreatic pseudocyst, which improved after high-dose glucocorticoid treatment. ICI rechallenge was pursued in five patients. Two patients received ICIs without an interval.</div></div><div><h3>Conclusions</h3><div>ICI-PI with pancreatitis is rare but has become more prevalent with the increasing use of ICIs. Future prospective multicenter studies are needed to confirm these findings and develop standardized diagnostic and treatment protocols.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1230-1237"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}