Digestive and Liver Disease最新文献_第4页

ITA-MASLD: A national observational study to characterize the profile of patients with MASLD in specialistic care in Italy. ITA-MASLD：一项全国性的观察性研究，旨在描述意大利专科护理中MASLD患者的概况。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-09-15 DOI: 10.1016/j.dld.2025.08.092

Elisabetta Bugianesi, Silvio Buscemi, Patrizia Burra, Vincenza Calvaruso, Amalia Gastaldelli, Giacomo Germani, Fabio Marra, Mario Masarone, Luca Miele, Gianluca Perseghin, Marcello Persico, Salvatore Petta, Rodolfo Sacco, Giorgio Sesti, Gianluca Svegliati Baroni, Giovanni Targher, Luca Valenti, Umberto Vespasiani-Gentilucci, Roberto Vettor, Stefano Rosato, Luigina Ferrigno, Brigitta Buttari, Benedetta Mattioli, Maria Giovanna Quaranta, Loreta A Kondili

{"title":"ITA-MASLD: A national observational study to characterize the profile of patients with MASLD in specialistic care in Italy.","authors":"Elisabetta Bugianesi, Silvio Buscemi, Patrizia Burra, Vincenza Calvaruso, Amalia Gastaldelli, Giacomo Germani, Fabio Marra, Mario Masarone, Luca Miele, Gianluca Perseghin, Marcello Persico, Salvatore Petta, Rodolfo Sacco, Giorgio Sesti, Gianluca Svegliati Baroni, Giovanni Targher, Luca Valenti, Umberto Vespasiani-Gentilucci, Roberto Vettor, Stefano Rosato, Luigina Ferrigno, Brigitta Buttari, Benedetta Mattioli, Maria Giovanna Quaranta, Loreta A Kondili","doi":"10.1016/j.dld.2025.08.092","DOIUrl":"10.1016/j.dld.2025.08.092","url":null,"abstract":"Metabolically-dysfunction-associated steatotic liver disease (MASLD) is a growing public health concern in Italy. Despite its prevalence, MASLD is often underdiagnosed and excluded from prevention strategies. Early detection and multidisciplinary management are crucial for addressing its systemic impact. To provide robust real-world evidence, the Istituto Superiore di Sanità and the Italian Association for the Study of the Liver (AISF), in collaboration with SID, SIGE, SIMI, SIO, CLEO, and AIGO, have launched ITA-MASLD, the first nationwide, multicenter, prospective observational study on MASLD in Italy. The study consecutively enrols adult patients with MASLD under specialist care in hepatology, internal medicine, diabetology, and obesity clinics across the country. Standardised electronic case report forms capture demographic, metabolic, and social determinants of health, alongside non-invasive and histological assessments of liver disease severity, comorbidities, treatments, and outcomes. More than 100 clinical centres are connected through a harmonised web-based system, ensuring data quality and enabling national representativeness and sub-studies. The ITA-MASLD study aims to characterise the clinical and epidemiological profile, as well as the social determinants, of MASLD in Italy, focusing also on unmet needs and regional disparities. It will generate predictive models for progression, cost-effectiveness analyses, and evidence to guide early detection, personalised care, and health policy.","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What's new in IBD research? Refining the agenda: Outcomes, patient-centered care, and technology. IBD研究有什么新进展？改进议程：结果、以患者为中心的护理和技术。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-09-13 DOI: 10.1016/j.dld.2025.08.084

Giuseppe Privitera, Cristina Bezzio, Alessandro Armuzzi

引用次数: 0

A case of colorectal malakoplakia in a patient with cytomegalovirus-associated refractory ulcerative colitis. 巨细胞病毒相关难治性溃疡性结肠炎伴结直肠斑疹1例。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-09-13 DOI: 10.1016/j.dld.2025.08.086

Shinichiro Kawatoko, Hidetaka Yamamoto, Yuta Fuyuno, Junji Umeno

引用次数: 0

A bridge over troubled waters: How can we manage patients with hepatocellular carcinoma from immunotherapy to liver transplantation? 跨越麻烦水域的桥梁：我们如何管理肝细胞癌患者从免疫治疗到肝移植？

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-09-13 DOI: 10.1016/j.dld.2025.08.080

Mario Capasso, Edoardo G Giannini, Filomena Morisco

引用次数: 0

Diagnostic approach to genetically-determined cholestatic liver diseases in adult patients. 成年患者基因决定的胆汁淤积性肝病的诊断方法。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-09-13 DOI: 10.1016/j.dld.2025.08.088

Toni Herta, Thomas Berg

引用次数: 0

A prospective study of duodenal laparoscopy-endoscopy cooperative surgery for superficial duodenal tumors, including periampullary and medial wall lesions. 十二指肠内镜-腹腔镜联合手术治疗十二指肠浅表性肿瘤，包括壶腹周围及内侧壁病变的前瞻性研究。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-09-13 DOI: 10.1016/j.dld.2025.08.087

Takaya Shimura, Naomi Sugimura, Mika Kitagawa, Makiko Sasaki, Shigeki Fukusada, Shinnosuke Harata, Tomotaka Okubo, Hiroyuki Sagawa, Shuji Takiguchi, Hiromi Kataoka

{"title":"A prospective study of duodenal laparoscopy-endoscopy cooperative surgery for superficial duodenal tumors, including periampullary and medial wall lesions.","authors":"Takaya Shimura, Naomi Sugimura, Mika Kitagawa, Makiko Sasaki, Shigeki Fukusada, Shinnosuke Harata, Tomotaka Okubo, Hiroyuki Sagawa, Shuji Takiguchi, Hiromi Kataoka","doi":"10.1016/j.dld.2025.08.087","DOIUrl":"https://doi.org/10.1016/j.dld.2025.08.087","url":null,"abstract":"Background: Duodenal laparoscopy-endoscopy cooperative surgery (D-LECS) is a novel technique involving duodenal endoscopic submucosal dissection (ESD) followed by laparoscopic seromuscular suturing. However, D-LECS has not been standardized due to limited data.Methods: This single-center prospective study enrolled 20 patients with superficial nonampullary duodenal tumors (SNADETs) located in the descending or transverse part from August 2019 to December 2023. The primary endpoint was the clinical success rate of d-LECS, defined as the completion of scheduled D-LECS with complete resection and closure of the post-ESD ulcer. ESD was performed by the single endoscopist.Results: The median tumor size was 30 mm, with a median treatment time of 296 min for total D-LECS and 115 min for ESD. The clinical success rate was 100 %, with 100 % en bloc resection, 80 % R0 resection, and no recurrence. Eight lesions were located in the medial wall, including five periampullary tumors, all of which achieved complete closure of post-ESD ulcers by combining endoscopic clipping with laparoscopic suturing. Intraoperative perforation occurred in three cases but was immediately repaired with laparoscopic suturing. No postoperative perforations or bleeding were observed.Conclusion: D-LECS is a minimally invasive and safe treatment for SNADTs, allowing for en bloc resection with a low risk of recurrence.","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic dysfunction associated steatotic liver disease (MASLD) treatment: Does lifestyle still matter? 代谢功能障碍相关脂肪变性肝病（MASLD）的治疗：生活方式是否仍然重要？

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-09-12 DOI: 10.1016/j.dld.2025.08.006

Felice Cinque , Anna Ludovica Fracanzani , Rosa Lombardi

引用次数: 0

Liver transplantation in people living with HIV - methodological considerations and future directions. HIV感染者的肝移植——方法学考虑和未来方向。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-09-12 DOI: 10.1016/j.dld.2025.08.078

Umer Sajid, Maheen Sheraz, Minahil Zaheer, Muneeba Umar

引用次数: 0

Liver transplantation in people living with HIV: Author's reply to comments. HIV感染者的肝移植：作者对评论的回复。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-09-12 DOI: 10.1016/j.dld.2025.08.083

Ubaldo Visco Comandini, Massimo Puoti, Gian Piero Guerrini

引用次数: 0

Author's reply: "Step-wise" progression in understanding the long-term outcomes of TIPS in BCS. 作者回复：理解TIPS治疗BCS的长期结果的“阶梯式”进展。

IF 3.8 3区医学

Digestive and Liver Disease Pub Date : 2025-09-12 DOI: 10.1016/j.dld.2025.08.082

Shekhar Swaroop, Sagnik Biswas, Shalimar

引用次数: 0