Forum Dermatologicum最新文献

{"title":"Postępowanie w przypadku podejrzanych zmian skórnych. Praktyczne wskazówki dla lekarzy specjalności nieonkologicznych","authors":"W. Wysocki, W. Owczarek, G. Dyduch, E. Wójtowicz, J. Narbutt, A. Jeziorski, Wojciech Zegarski, A. Marszałek, M. Krzakowski, P. Rutkowski","doi":"10.5603/fd.2021.0009","DOIUrl":"https://doi.org/10.5603/fd.2021.0009","url":null,"abstract":"","PeriodicalId":112619,"journal":{"name":"Forum Dermatologicum","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128380306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kąpiele z podchlorynem sodu w atopowym zapaleniu skóry i ich wpływ na mikrobiom skóry","authors":"Klaudia Tutka, Adam Reich","doi":"10.5603/fd.2021.0011","DOIUrl":"https://doi.org/10.5603/fd.2021.0011","url":null,"abstract":"Introduction: Atopic dermatitis (AD) is a disease of multifactorial ethology. However, the bacterial microflora of the skin, especially Staphylococcus aureus, plays an important role in its the pathogenesis. Continuously, new therapies are sought which will block factors exacerbating the disease and significantly support the AD treatment. The aim of the study was to determine the effect of sodium hypochlorite baths on the eradication of St. aureus from the skin and to assess their effect on AD severity. Material and methods: The study was conducted among 56 patients suffering from AD. A half of the patients were randomly assigned to the group treated with sodium hypochlorite baths (study group) in addition to the standard therapy of AD, the remaining patients were treated with conventional treatment (control group). The severity of the disease and the intensity of the itch were assessed in each patient at the time of enrollment into the study and 6 weeks later. A skin smear was taken for microbiological examination with pathogen identification and semi-quantitative evaluation of the isolated bacteria strains. Results: Patients using baths in diluted sodium hypochlorite showed a greater improvement of AD severity compared to those using conventional treatment only (relative EASI improvement: 42.0% ± 32.9% vs. –33.1% ± 88.6%, p < 0.01; relative SCORAD improvement: 33.5 ± 25.9% vs. –6.7 ± 36.8%, p < 0.001). Additionally, a greater reduction of itch was observed in the study group compared to the control group (ΔNRS: 1.8 ± 2.2 vs. 0.7 ± 2.2, p = 0.04) as well as significant improvement of quality of life was noted (study group: mean DLQI before treatment: 12.7 ± 6.7 points, mean DLQI after treatment: 7.3 ± 5.4, p < 0.001; control group: mean DLQI before treatment: 10.8 ± 7.5 points, mean DLQI after treatment: 8.7 ± 5.6, p < 0.82). However, the relationship between the applied therapy and the eradication of St. aureus has not been confirmed. Conclusions: Bathing in diluted sodium hypochlorite allowed to reduce the intensity of AD and to improve the quality of life, while ensuring good tolerability and safety of the therapy. However, no significant effect of the therapy was observed on the reduction of the number of St. aureus colonies on the skin.","PeriodicalId":112619,"journal":{"name":"Forum Dermatologicum","volume":"25 21","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120842400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pierwotny chłoniak skóry z limfocytów T u kobiety w ciąży — wyzwanie terapeutyczne","authors":"A. Ciesielka, P. Plata, Katarzyna Kosior, Adam Reich","doi":"10.5603/FD.A2021.0005","DOIUrl":"https://doi.org/10.5603/FD.A2021.0005","url":null,"abstract":"Primary cutaneous lymphomas represent a heterogeneous group of lymphoproliferative disorders. Here, we have demonstrated a case of the primary cutaneous T-cell lymphoma (CTCL) in a 28-year-old pregnant woman. The patient is demonstrated because of aggressive clinical course, and therapeutic difficulties of CTCL during pregnancy. CTCL are a group of rarely occurring neoplasms and the presence of CTCL during pregnancy can be an additional diagnostic and therapeutic challenge that needs multidisciplinary healthcare approach.","PeriodicalId":112619,"journal":{"name":"Forum Dermatologicum","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117146421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nowe kryteria klasyfikacyjne tocznia rumieniowatego układowego według Europejskiej Ligi Przeciwreumatycznej/Amerykańskiego Kolegium Reumatologicznego 2019","authors":"Izabela Machlarz, Adam Reich","doi":"10.5603/FD.A2020.0021","DOIUrl":"https://doi.org/10.5603/FD.A2020.0021","url":null,"abstract":"Toczen rumieniowaty ukladowy (SLE, systemic lupus erythematosus ) jest chorobą autoimmunologiczną mogącą zajmowac niemal wszystkie narządy. Diagnostyke SLE utrudnia mnogośc objawow klinicznych wystepujących w roznych przedzialach czasowych, niespecyficzne odchylenia w badaniach laboratoryjnych oraz cechy histopatologiczne, ktore mogą wystepowac rowniez w innych jednostkach chorobowych. Duze znaczenie w rozpoznaniu SLE ma stwierdzenie obecności przeciwcial przeciwko wlasnym antygenom, zwlaszcza przeciwcial przeciwjądrowych. Szybkie rozpoznanie choroby i wdrozenie odpowiedniego leczenia jest kluczowe dla uzyskania sukcesu terapeutycznego i pozwala zapobiec wielu powiklaniom. W 2018 opracowano kolejne kryteria klasyfikacyjne SLE, tzw. kryteria EULAR/ACR-2019, bazujące co prawda na poprzednich kryteriach SLICC i ACR, jednakze znacząco je zmieniające. Kryteria te podzielono na 7 domen klinicznych i 3 domeny immunologiczne. Kryterium wstepnym jest przynajmniej jednokrotne stwierdzenie u pacjenta przeciwcial przeciwjądrowych w mianie ≥ 1:80, a nastepnie uzyskanie ≥ 10 punktow zgodnie z ustaloną punktacją, w tym spelnienie minimum jednego kryterium z domeny klinicznej. Do obliczania sumy punktow wybiera sie z kazdej domeny objaw o najwiekszej liczbie punktow.","PeriodicalId":112619,"journal":{"name":"Forum Dermatologicum","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131355544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Śródskórne iniekcje acetonidu triamcynolonu w leczeniu Zespołu Grahama-Little’a — opis przypadku","authors":"Aleksandra Siekierko, Justyna Ceryn, M. Skibińska, A. Lesiak","doi":"10.5603/FD.A2020.0020","DOIUrl":"https://doi.org/10.5603/FD.A2020.0020","url":null,"abstract":"Graham-Little-Piccardi-Lasseur syndrome (GLPLS) is a rare lichen planopillaris defined by scarring alopecia, loss of pubic and axillary hairs and progressive development of follicular papules located on the whole body. Topical or systemic corticosteroids, cysclosporine or hydroxychlorquina are the treatments usually proposed. We describe the effectiveness of intralesional triamcinolone acetonide in concentration of 8 mg/mL with oral acitretin 10 mg/day combined with topical 0.05% clobetasol propionate ointment in a patient with GLPLS. After 2 months of treatment, reduction of perifollicular erythema and follicular hyperkeratotic papules were observed with no new area of alopecia. We believe that intralesional triamcinolone acetonide could be an effective treatment by limiting the progression of the disease.","PeriodicalId":112619,"journal":{"name":"Forum Dermatologicum","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132418806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zmiany skórne w COVID-19 — opis przypadku","authors":"L. B. Urbanowicz","doi":"10.5603/FD.A2020.0022","DOIUrl":"https://doi.org/10.5603/FD.A2020.0022","url":null,"abstract":"The paper presents a case of a 35-year-old woman with a history on the COVID-19. This disease was confirmed by PCR test. The woman’s medical history revelated endometriosis, cardiac arrhythmia and hypercholesterolemia. The first symptoms of COVID-19 were lower abdominal pain and diarrhoea, and in the next days — severe headache, muscle and joint pain, body weakness, dry cough, chest pains and many others. On the thirteenth day, the infection occurred to skin lesions on the face. The treatment applied resulted in clinical improvement.","PeriodicalId":112619,"journal":{"name":"Forum Dermatologicum","volume":"352 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122842290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pierwotna amyloidoza skórna — opis przypadku","authors":"Kamila Jaworecka, Robert Kijowski, Elżbieta Ostańska, Piotr Mazur-Chromiak, Adam Reich","doi":"10.5603/FD.A2020.0018","DOIUrl":"https://doi.org/10.5603/FD.A2020.0018","url":null,"abstract":"Amyloidosis refers to a group of diseases in which tissues and organs accumulate amyloid — a protein with an abnormal structure, which leads to impairment of their function. There are systemic forms of amyloidosis, involving the internal organs and skin, and cutaneous ones, where the disease process affects only the skin. Here, we present a case of a seventy-year-old woman diagnosed with primary cutaneous amyloidosis.","PeriodicalId":112619,"journal":{"name":"Forum Dermatologicum","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122460216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wpływ COVID-19 na skórę: objawy zakażenia, osutki polekowe oraz zapalenie kontaktowe","authors":"M. Niedźwiedź, M. Skibińska","doi":"10.5603/FD.2020.0024","DOIUrl":"https://doi.org/10.5603/FD.2020.0024","url":null,"abstract":"SARS-CoV-2 infection is currently one of the major health problems worldwide. Cutaneous manifestations related to COVID-19 affect from 5 to 24% of patients and are described as pseudo-chilblain, maculopapular, urticarial, vesicular, purpuric and necrotic. Physicians’ attention was drawn to the occurrence of symptoms resembling those of Kawasaki disease. Majority of the medications used in COVID-19 therapy have antiviral and/or immunomodulatory properties and may cause side effects including drug rashes. The necessity of personal protective equipment usage among not only healthcare workers but also in the general population causes the more frequent occurrence of contact and allergic dermatitis. The study aims to present current knowledge on all aspects of SARS-CoV-2 infection related to the skin that dermatologists may encounter.","PeriodicalId":112619,"journal":{"name":"Forum Dermatologicum","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122374075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related graying of the hair — a brief summary of potential mechanisms","authors":"Monika Armatys, A. Kłosowicz, A. Wojas-Pelc","doi":"10.5603/FD.A2020.0017","DOIUrl":"https://doi.org/10.5603/FD.A2020.0017","url":null,"abstract":"Graying of the hair is one of the most eye-catching phenotypic changes related to the chronological aging. During the last decades, scientists have engaged in research that has increased our understanding of different mechanisms of aging of a hair follicle, however many aspects of this process remain unclear. Progressive hypopigmentation of the hair shaft has been associated with decrease in number of melanocytes and tyrosinase hypoactivity in the hair bulb along with the depletion of melanocyte stem cells (MSCs) in the bulge area. Pathogenesis of graying may involve oxidative damage and incompetent MSCs maintenance. Moreover, other factors such as defective melanosomal transfer as well as insufficient neuroendocrine stimulation of MSCs and melanogenesis are hypothesized to play an important role.","PeriodicalId":112619,"journal":{"name":"Forum Dermatologicum","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114605370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skuteczny duet w terapii miejscowej łuszczycy — połączenie kalcypotriolu z dipropionianem betametazonu w tradycyjnej formie maści","authors":"A. Lesiak, Justyna Ceryn, Magdalena Ciążyńska","doi":"10.5603/FD.2020.0023","DOIUrl":"https://doi.org/10.5603/FD.2020.0023","url":null,"abstract":"Exclusive local therapy is a sufficient treatment option for most mild cases of psoriasis. It is estimated that even 70–80% of patients do not require systemic treatment or light therapy, and topical medications effectively control the symptoms of the disease. Moreover, topical medications are also an essential treatment option in addition to systemic therapy for moderate to severe psoriasis. The most common medications used in local therapy are glucocorticosteroids and vitamin D analogues. These substances show the highest efficiency among all drugs available on the market, while maintaining a favorable toxicity profile. A significant advantage of these medications is also the ease of use, which significantly affects the compliance with medical recommendations and regular use of the preparation by patients. The different mechanism of action of the two drugs makes this unique combination of calcipotriol and betamethasone dipropionate particularly effective at any stage of the pathogenesis of psoriasis. Due to their strong antiproliferative, immunomodulating and immunostatic effects, this duo is currently recommended by the Polish Dermatological Society as a first-line preparation in the local treatment of smooth skin, hands and feet. The ointment ensures rapid penetration of active substances, strongly moisturizing, reducing skin atrophy, which is an additional benefit for patients with psoriasis. The study analyzes the effectiveness, safety and mechanism of action of medications containing calcipotriol with betamethasone dipropionate in the local therapy of psoriasis in the light of current literature data, with particular emphasis on the form of ointment.","PeriodicalId":112619,"journal":{"name":"Forum Dermatologicum","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115111819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}