Forum Dermatologicum最新文献

Topical solutions for androgenetic alopecia: evaluating efficacy and safety 雄激素性脱发的局部解决方案：疗效和安全性评估

Forum Dermatologicum Pub Date : 2024-07-25 DOI: 10.5603/fd.101208

Mateusz Michał Koralewicz, Olga Agnieszka Szatkowska

引用次数: 0

The use of botulinum toxin in the treatment of androgenetic alopecia 肉毒杆菌毒素在雄激素性脱发治疗中的应用

Forum Dermatologicum Pub Date : 2024-07-23 DOI: 10.5603/fd.100354

Natalia Welc, Rafał Olejniczak, Magdalena Jałowska

引用次数: 0

Complications associated with needle-based medical aesthetic procedures: clinical and medico-legal aspects from the Polish perspective 与针式医疗美容手术相关的并发症：从波兰角度看临床和医疗法律问题

Forum Dermatologicum Pub Date : 2024-07-22 DOI: 10.5603/fd.100842

Katarzyna Beutler, Szymon Rzepczyk, Bartosz Bijata, Jędrzej Lewandowski, Beata Bożek, Paweł Świderski

引用次数: 0

Facial herpes zoster complicated by cerebral oedema in the course of encephalitis 脑炎过程中并发脑水肿的面部带状疱疹

Forum Dermatologicum Pub Date : 2024-06-13 DOI: 10.5603/fd.100328

Julia Ceryn, Aleksandra Siekierko, Justyna Ceryn, N. Bień, J. Narbutt, A. Lesiak

引用次数: 0

Refractory bullous pemphigoid during treatment with pembrolizumab in the first-line treatment of advanced non-small cell lung cancer 帕姆单抗一线治疗晚期非小细胞肺癌期间的难治性大疱性类风湿关节炎

Forum Dermatologicum Pub Date : 2024-06-05 DOI: 10.5603/fd.100000

Renata Olech, Monika Rychlik-Grabowska, Sławomir Mańdziuk

{"title":"Refractory bullous pemphigoid during treatment with pembrolizumab in the first-line treatment of advanced non-small cell lung cancer","authors":"Renata Olech, Monika Rychlik-Grabowska, Sławomir Mańdziuk","doi":"10.5603/fd.100000","DOIUrl":"https://doi.org/10.5603/fd.100000","url":null,"abstract":"Dermatological toxicity is one of the most common immune-related adverse events (irAEs) of treatment with immune checkpoint inhibitors (ICIs). Bullous pemphigoid (BP) is a rare and serious complication of these drugs that can be difficult to establish, as its initial symptoms may be indistinguishable from mild skin lesions. This paper presents the case of a 68-year-old patient who developed BP after receiving one of the ICI therapies, pembrolizumab, for advanced non-small cell lung cancer (NSCLC). After approximately 7 months of therapy, a grade 3 skin toxicity in the Common Terminology Criteria for Adverse Events (CTCAE) occurred in the form of rash and pruritus. Pembrolizumab was then held and prednisone and antihistamines were introduced. When dermal toxicity improved to grade 1, pembrolizumab was resumed and prednisone was kept at a dose of 10 mg. Immunotherapy was discontinued 3 months later, after the recurrence of grade 3 skin toxicity symptoms. When the patient developed blisters filled with clear fluid, dermatologists suspected pembrolizumab-induced bullous pemphigoid. Bullous pemphigoid was subsequently confirmed using a direct immunofluorescence test and histopathological examination. The patient’s skin condition improved after the use of steroid therapy and methotrexate, and the cancer process stabilized for over one year. Cancer progression and deterioration of the patient’s general condition were observed approximately 4 months after the termination of pembrolizumab therapy. The paper also discusses the key aspects of ICIs-induced BP, especially pembrolizumabinduced BP in the first-line treatment of metastatic NSCLC. Early diagnosis of skin lesions and the initiation of appropriate treatment may lead to better outcomes for patients and prevent disruptions in immunotherapy. Forum","PeriodicalId":112619,"journal":{"name":"Forum Dermatologicum","volume":"43 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141384722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choose your biopsy site wisely — the utility of dermoscopy in the diagnosis of Bowen’s disease of the face 明智选择活检部位--皮肤镜在面部鲍温氏病诊断中的应用

Forum Dermatologicum Pub Date : 2024-04-15 DOI: 10.5603/fd.99280

Irena Wojtowicz, Karolina Krawczyk-Wołoszyn, Elżbieta Ostańska, Adam Reich, Magdalena Żychowska

引用次数: 0

Vulvar syringomas — an underrecognized condition 外阴鞘膜瘤--一种未得到充分认识的疾病

Forum Dermatologicum Pub Date : 2024-04-10 DOI: 10.5603/fd.98897

Kinga Kołcz, Ewa Kaznowska, Adam Reich, Magdalena Żychowska

引用次数: 0

Discoid lupus erythematosus and cutaneous squamous cell carcinoma 盘状红斑狼疮和皮肤鳞状细胞癌

Forum Dermatologicum Pub Date : 2024-03-06 DOI: 10.5603/fd.99390

Michał Dec, H. Arasiewicz

引用次数: 0

Topical treatment of acne using a compounded medication based on clindamycin 使用基于克林霉素的复合药物局部治疗痤疮

Forum Dermatologicum Pub Date : 2023-10-30 DOI: 10.5603/fd.96176

Mikołaj Eryk Łanocha, Beata Bergler-Czop

{"title":"Topical treatment of acne using a compounded medication based on clindamycin","authors":"Mikołaj Eryk Łanocha, Beata Bergler-Czop","doi":"10.5603/fd.96176","DOIUrl":"https://doi.org/10.5603/fd.96176","url":null,"abstract":"Clindamycin, a lincosamide antibiotic, is widely used in the treatment of bacterial infections. It acts by inhibiting protein synthesis inbacteria, primarily targeting the peptidyl transferase centre in the bacterial ribosome. It exhibits bacteriostatic activity, inhibiting bacterialgrowth, and at higher doses, it can be bactericidal. In the treatment of acne vulgaris, clindamycin not only exerts direct antibacterialeffects but also possesses anti-inflammatory and immunomodulatory properties. It reduces the growth of Cutibacterium acnes and inhibitsthe production of proteins and lipases, which contribute to skin inflammation. Clindamycin also enhances bacterial opsonization andphagocytosis and reduces neutrophil chemotaxis. Combination therapy with benzoyl peroxide can help minimize antibiotic resistance.Topical clindamycin, often in combination with benzoyl peroxide or retinoids, is recommended in treatment for mild to moderate papulopustularacne. In hidradenitis suppurativa clindamycin improves disease control and reduces cutaneous lesions, particularly superficialones like papules and pustules. Various topical preparations containing clindamycin are available commercially, including gels, lotions, andcombination products with tretinoin or benzoyl peroxide. Additionally, the registration of clindamycin as a pharmaceutical raw materialallows for compounding personalized formulations, providing a cost-effective alternative. Compounded medications can be tailored toindividual patient needs and increase treatment effectiveness.","PeriodicalId":112619,"journal":{"name":"Forum Dermatologicum","volume":"442 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of tattoos in dermatology 皮肤病学对纹身的评估

Forum Dermatologicum Pub Date : 2023-09-29 DOI: 10.5603/fd.a2023.0016

Justyna Putek, Justyna Szczęch, Przemysław Pacan, Adam Reich

{"title":"Assessment of tattoos in dermatology","authors":"Justyna Putek, Justyna Szczęch, Przemysław Pacan, Adam Reich","doi":"10.5603/fd.a2023.0016","DOIUrl":"https://doi.org/10.5603/fd.a2023.0016","url":null,"abstract":"Introduction: Over the past decades, tattoos have become increasingly popular probably in most European countries. This study aimed to find out people’s motivations for getting tattoos and when they decide to get them. Material and methods: This was a cross-sectional questionnaire study developed through the cooperation of a psychiatrist and a dermatologist. More than 400 volunteers with tattoos were assessed. The majority of analyzed subjects started tattooing in their twenties (mean age ± SD: 21.6 ± 5.9 years). Results: The majority of subjects indicated aesthetic reasons as the main reason for tattooing (44.5% women vs . 29.6% men; p < 0.05). The most popular tattoo motifs were animal motifs (18.9% women vs . 10.4% men; p < 0.001), plant motifs (18.0% women vs. 1.8% men; p > 0.05) and lettering (18.0% women vs . 15.3% men; p > 0.05). A total of 423 (91.5%) respondents planned to get more tattoos in the future. Conclusions: Based on the study results, it can be concluded that tattooing is currently mainly done to mostly performed to beautify the human body. If tattooing should be assessed in terms of its medical significance, the Tattoo Severity Scale can be used, given its good reproducibility and relevance.","PeriodicalId":112619,"journal":{"name":"Forum Dermatologicum","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135248138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0