Diabetic Medicine最新文献

{"title":"Variation in effectiveness of the NHS Diabetes Prevention Programme in people diagnosed with non-diabetic hyperglycaemia by age, sex, BMI, and deprivation: A matched cohort analysis of 69,801 people","authors":"Rathi Ravindrarajah,&nbsp;Matt Sutton,&nbsp;Peter Bower,&nbsp;Evangelos Kontopantelis","doi":"10.1111/dme.70037","DOIUrl":"https://doi.org/10.1111/dme.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The NHS Diabetes Prevention Programme (DPP) is a behaviour-change programme aimed at adults diagnosed with non-diabetic hyperglycaemia (NDH), who are at higher risk of developing type 2 diabetes mellitus (Diabetes). This paper explores the heterogeneity in the effectiveness of the DPP by age, sex, BMI, and practice location deprivation (IMD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Matched cohort analysis with random-effects parametric survival models, evaluating the association between referral to the DPP and conversion to diabetes, with interactions fitted for age, sex, BMI, and IMD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>18,470 patients referred to the programme were matched to 51,331 controls. None of the interactions of patient characteristics with referrals were statistically significant. For women, the difference in the HR of conversion to diabetes, compared to men, was HR = 0.94 (95% CI: 0.81, 1.08, <i>p</i> = 0.38); For those aged [18–34], HR = 0.79 (95% CI: 0.34, 1.84, <i>p</i> = 0.58) and aged [75–84] HR = 0.86 (95% CI:0.66, 1.12, <i>p</i> = 0.26) compared to those aged [55–64]. The HR for conversion was 0.88 (95% CI:0.62, 1.26, <i>p</i> = 0.49) for those with a BMI ≥ (25–29.9) kg/m² and HR = 0.76 (95% CI:0.54, 1.06, <i>p</i> = 0.10) in those with a BMI ≥ 30 kg/m² compared to BMI &lt; 25 kg/m². Finally, for the most deprived IMD quintile, compared to the least deprived, the difference in the conversion was HR = 1.31 (95% CI: 0.98, 1.73, <i>p</i> = 0.06).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The DPP was effective in reducing conversion rates from NDH to diabetes as shown in our previous study results. The intervention appeared to be similarly effective by age, sex, BMI, and deprivation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 7","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dme.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sleep duration and obesity in patients with type 2 diabetes: A longitudinal study","authors":"Esraa A. Makhdom,&nbsp;Alisha Maher,&nbsp;Ryan Ottridge,&nbsp;Mathew Nicholls,&nbsp;Asad Ali,&nbsp;Brendan G. Cooper,&nbsp;Ramzi A. Ajjan,&nbsp;Srikanth Bellary,&nbsp;Wasim Hanif,&nbsp;Fahmy Hanna,&nbsp;David Hughes,&nbsp;Vijay Jayagopal,&nbsp;Rajni Mahto,&nbsp;Mayank Patel,&nbsp;James Young,&nbsp;Ananth U. Nayak,&nbsp;Mimi Z. Chen,&nbsp;Julie Kyaw-Tun,&nbsp;Susana Gonzalez,&nbsp;Ravikanth Gouni,&nbsp;Anuradhaa Subramanian,&nbsp;Nicola J. Adderley,&nbsp;Abd A. Tahrani","doi":"10.1111/dme.70051","DOIUrl":"10.1111/dme.70051","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Obesity is prevalent in patients with type 2 diabetes (T2D) and negatively impacts diabetes outcomes. While studies in the general population have established a link between sleep duration and obesity, this relationship in T2D remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To assess the association between sleep duration and adiposity in patients with T2D.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective study of adults enrolled in the SLEEP T2D study from 13 UK NHS Trusts. Sleep duration was self-reported using the Pittsburgh Sleep Quality Index (PSQI) and categorized as short (≤ 6 h/ night), long (&gt; 9 h/night) or (normal &gt; 6-9 h/night). Adiposity was assessed using body mass index (BMI) and waist circumference.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 229 patients (61% male, mean age 61.2 (<span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>±</mo>\u0000 </mrow>\u0000 </semantics></math>11.7) years, 63.7% with BMI ≥ 30 kg/m²). At baseline, sleep duration negatively correlated with BMI (<i>r</i> = −0.27, <i>p</i> &lt; 0.001) and waist circumference (<i>r</i> = −0.25, <i>p</i> = 0.001). After adjusting for potential confounders in different models, short sleep duration was associated with higher BMI (β = −1.01; <i>p</i> = 0.006) and waist circumference (β = −1.91; <i>p</i> = 0.01). Following a median follow-up of 26.5 months, short sleep at baseline was associated with a 5% or more gain in BMI (adjusted OR 10.03; 95% CI 1.55–64.84; <i>p</i> = 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Short sleep duration is associated with higher adiposity measures (BMI and waist circumference) and weight gain in patients with T2D. Addressing sleep duration may reduce the burden of obesity in T2D, and future studies in this area are warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dme.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical implications of a history of pre-eclampsia in women with type two diabetes mellitus","authors":"Madeline C. Pearson,&nbsp;Huan Wang,&nbsp;Colin E. Murdoch,&nbsp;Alexander S. F. Doney","doi":"10.1111/dme.70046","DOIUrl":"10.1111/dme.70046","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The consequences of pre-eclampsia (PE) are not limited to pregnancy; a single episode predisposes mothers to serious future health outcomes. Little is known about how PE impacts the course of type 2 diabetes (T2D) and associated microvascular diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Scottish Care Information for Diabetes data for individuals with diabetes in NHS Tayside and Fife was linked with Scottish maternity morbidity records. A nested case–control study compared BMI, HDL cholesterol, systolic blood pressure(SBP) and HbA1c measures at T2D diagnosis between women with prior pregnancies from 1921 to 2022 affected or unaffected by PE using linear regression and adjusted for the other aforementioned variables. Cox regression models assessed how a PE history influenced the risk of future microvascular complications following T2D diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 6055 women were eligible: 726 (12%) had a PE-pregnancy and 5329 (88%) had only PE-free pregnancies, with ~20 years between pregnancy and T2D diagnosis. At T2D diagnosis, women with a PE history had higher BMI (38.3 kg/m² vs. 35.7 kg/m², <i>p</i> &lt; 0.001), higher SBP (139 mmHg vs. 135 mmHg, <i>p</i> &lt; 0.001), lower HDL cholesterol (1.18 mmol/L vs. 1.21 mmol/L, <i>p</i> = 0.002) and were diagnosed 3.2 years earlier (<i>p</i> &lt; 0.001). A PE history was associated with increased microvascular disease risk (HR 1.26 95% CI 1.12–1.42, <i>p</i> &lt; 0.001): diabetic retinopathy (HR 1.22 95% CI 1.07–1.38, <i>p</i> = 0.003); chronic kidney disease (HR 1.35 95% CI 1.06–1.71, <i>p</i> = 0.016); diabetic proteinuric kidney disease (HR 2.45 95% CI 1.03–5.81, <i>p</i> &lt; 0.001). Women with a PE history were ~5 years younger when they developed cardiovascular disease (55.7 years vs. 60.6 years, <i>p</i> &lt; 0.001) and all-cause death (60.1 years vs. 65.6 years, <i>p</i> &lt; 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>At T2D diagnosis, women with a PE history are younger, with more severe clinical presentations and increased risk of developing T2D microvascular complications. This highlights the crucial need for changes to the long-term care of this high-risk group, with aggressive risk-factor management and continued clinical assessment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dme.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe hypertriglyceridaemia and lipaemia retinalis in a child presenting with diabetic ketoacidosis","authors":"Kathryn Kimber,&nbsp;Eleanor Crawley,&nbsp;Stephanie Jones","doi":"10.1111/dme.70026","DOIUrl":"10.1111/dme.70026","url":null,"abstract":"","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity-related glomerulopathy: How it happens and future perspectives","authors":"Jian-Wen Samuel Lee-Boey,&nbsp;Jia-Kai Tan,&nbsp;Zhan-Foong Lim,&nbsp;Francesco Zaccardi,&nbsp;Kamlesh Khunti,&nbsp;Majid Ezzati,&nbsp;Edward W. Gregg,&nbsp;Lee-Ling Lim","doi":"10.1111/dme.70042","DOIUrl":"10.1111/dme.70042","url":null,"abstract":"<p>Obesity-related glomerulopathy (ORG) is an emerging complication of excess adiposity. Its incidence rises alongside the obesity pandemic. Up to 40% of individuals can be affected by ORG, irrespective of the status of glomerular filtration rate and albuminuria. ORG is a distinct histological diagnosis based on kidney biopsy, showing classical features of an enlarged glomerulus with and without focal segmental glomerulosclerosis in the perihilar region seen with all categories of obesity. About 10% of individuals with ORG may progress to end-stage kidney disease. The invasive nature of kidney biopsy highlights the need for non-invasive biomarkers for improved screening, diagnosis and risk prediction of ORG. These biomarkers may narrow the gaps in the management of ORG by improving: (1) screening, diagnosis and differentiation of ORG from non-ORG conditions; (2) risk prediction and stratification of individuals at risk of progression to end-stage kidney disease including the detection of trajectories of progression; (3) monitoring of treatment safety and effectiveness and (4) development of novel therapeutic targets. In the present review, we discussed the pathophysiology, emerging biomarkers (such as kidney injury molecule-1 [KIM-1], uromodulin, klotho, circulating microRNA-21 [miR-21]) and future treatment strategies (metabolic surgery, sodium-glucose cotransporter-2 inhibitors, incretin-based therapy and non-steroidal mineralocorticoid antagonists) of ORG.</p>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dme.70042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited impact of the PEP1 structured physical activity program on perceived barriers to physical activity in people living with type 1 diabetes","authors":"C. Guédet,&nbsp;S. Tagougui,&nbsp;C. Suppère,&nbsp;V. Boudreau,&nbsp;M.-E. Mathieu,&nbsp;A.-S. Brazeau,&nbsp;R. Rabasa-Lhoret","doi":"10.1111/dme.70044","DOIUrl":"10.1111/dme.70044","url":null,"abstract":"&lt;p&gt;Physical activity (PA) has many benefits for people living with type 1 diabetes (T1D), including improved glycemic control and reduced cardiovascular risk.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Despite these advantages, only 32% of people living with T1D (pwT1D) meet PA recommendations.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; In 2008, Brazeau et al. identified fear of hypoglycemia as the primary barrier to PA in pwT1D.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Subsequent studies have echoed these findings, suggesting that education and promotion of PA may help mitigate these barriers.&lt;span&gt;&lt;sup&gt;2, 3&lt;/sup&gt;&lt;/span&gt; Brazeau et al. developed 3 months ‘physical exercise promotion’ (PEP1) programme aiming to increase PA levels.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Although no significant change in objectively measured PA level was reported, participants in the intervention group presented a trend toward increased intention to practice PA post-intervention and at the 1-year follow-up (both &lt;i&gt;p&lt;/i&gt; = 0.07). However, whether perceived barriers to PA were reduced remains unclear.&lt;/p&gt;&lt;p&gt;To address this question, the data from the PEP-1 study&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; were analyzed for participants who completed the Barriers to Physical Activity in Type 1 Diabetes (BAPAD) questionnaire at baseline, post-intervention, and 1-year follow-up. The BAPAD questionnaire, validated by Dubé et al.,&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; calculates an average score over the first 11 items. Each item is scored on a scale of 1–7, with 7 indicating more barriers. Inclusion criteria were age between 18 and 65 years, a T1D diagnosis for at least 12 months, and less than 150 min of physical activity per week at baseline. Exclusion criteria included major microvascular and macrovascular complications in the previous 6 months and pregnancy. Participants were randomized into two groups: control group and intervention group. All participants received brochures with information on the benefits of PA and how to incorporate it into their daily lives. The intervention group consisted of 12 sessions divided into two parts: 60 min of different activities (cardiovascular, muscular and flexibility) to initiate PA and introduce participants to a variety of exercises and sports, and 30 min of advice on PA and glycemic management in relation to PA. BAPAD scores were compared before the intervention, after the intervention and 1 year after inclusion using the MIXED procedure for repeated measures in SPSS statistical software.&lt;/p&gt;&lt;p&gt;Data was available for 41 participants; 21 completed the intervention group, and 20 the control group. The rate of attendance at the sessions in the intervention group was 82 ± 12%. Mean BAPAD scores for the intervention group changed from 2.7 ± 1.0 at baseline to 2.5 ± 0.7 post intervention and remained at 2.5 ± 1.1 at the 1-year follow-up, while control group scores changed from 2.8 ± 1.0 at baseline to 2.5 ± 0.9 post intervention and then to 2.7 ± 0.9 at the 1-year follow-up. No significant difference was observed in BAPAD scor","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 7","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dme.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facilitators and barriers to establishing lactation among women with diabetes?","authors":"Denise McGuinness,&nbsp;Usha Daniel,&nbsp;Denise O. Brien","doi":"10.1111/dme.70045","DOIUrl":"10.1111/dme.70045","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To identify the facilitators and barriers to establishing lactation among women with diabetes in pregnancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A qualitative descriptive study involving face-to-face semi-structured interviews with 13 postpartum women. An inductive, data-driven content analysis approach was utilised. This study followed the consolidated criteria for reporting qualitative research (COREQ) guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Facilitators to breastfeeding and establishing lactation among women with diabetes included antenatal colostrum harvesting during the antenatal period and support from health care professionals. Barriers included emotional self-efficacy challenges and a lack of support from healthcare professionals in the hospital setting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Women with diabetes report further challenges establishing breastfeeding due to delayed lactogenesis ll (secretory activation), hypoglycaemia and self-efficacy challenges. Given the adverse health risks for mother and infant associated with not breastfeeding, women with diabetes require individualised person-centred lactation care plans to maximise their opportunity to experience a successful breastfeeding journey.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 8","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dme.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and facilitators to attending postpartum diabetes screening among women with previous gestational diabetes in China: A qualitative analysis","authors":"Jing Huang,&nbsp;Rita Forde,&nbsp;Angus Forbes,&nbsp;Judith Parsons","doi":"10.1111/dme.70043","DOIUrl":"10.1111/dme.70043","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Gestational diabetes mellitus (GDM) is a common complication of pregnancy associated with a higher risk of developing type 2 diabetes (T2DM) in the future. Postpartum diabetes screening is important to identify glucose intolerance and introduce diabetes prevention support. However, screening uptake is suboptimal, including in China where the prevalence of GDM is high. There is limited evidence on the barriers and facilitators to screening uptake among Chinese women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To explore the barriers and facilitators of postpartum diabetes screening uptake among Chinese women with GDM to inform the development of an intervention to increase screening attendance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Women with current or previous GDM were recruited from social network platforms and pregnancy groups in China. Data were collected using semi-structured interviews and analysed using Framework Analysis to identify themes related to the barriers and facilitators for screening uptake.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-four women with current (<i>n</i> = 4) or previous (<i>n</i> = 20) GDM participated. The postpartum glucose screening attendance rate was 35% among those with previous GDM. Screening uptake was influenced by: risk awareness of T2DM and its complications, interactions with healthcare providers (HCPs), screening-related factors (understanding and beliefs, accessibility and acceptability of the test) and motivation to maintain personal health, which was influenced by fear of T2DM, lack of symptoms, confidence in self management without support, and prioritisation of the child's needs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Postpartum screening uptake after GDM could be boosted through raising risk awareness, more constructive communication from HCPs, increasing the acceptability and accessibility of screening procedures, and addressing psychological factors related to attendance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 8","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dme.70043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"m6A demethylase ALKBH5 reduces ferroptosis in diabetic retinopathy through the m6A-YTHDF1-ACSL4 axis","authors":"Qinghui Liao,&nbsp;Yan Li,&nbsp;Meijing Cui,&nbsp;Min Liu","doi":"10.1111/dme.70033","DOIUrl":"10.1111/dme.70033","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Diabetic retinopathy (DR) represents the main ocular complication of diabetes. Targeting ferroptosis is a promising treatment of choice for various diabetic complications. N6-methyladenosine (m6A) demethylase alkylation repair homolog protein 5 (ALKBH5) functions as a pivotal regulator of ferroptosis, and we investigated its role and molecular mechanisms in ferroptosis in DR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A DR mouse model was developed by streptozotocin (STZ) intraperitoneal injection. High glucose (HG)-induced human retinal pigment epithelial cells (ARPE-19) were used as a DR model <i>in vitro</i>. ALKBH5, YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) and acyl-CoA synthetase long-chain family member 4 (ACSL4) expression levels were examined by RT-qPCR and Western blot. The biological functions of ALKBH5 <i>in vitro</i> and <i>in vivo</i> were investigated by gain-of-function and loss-of-function analyses. ALKBH5's downstream regulatory mechanisms were detected by bioinformatics analysis, RNA pull-down, MeRIP-qPCR and actinomycin D assay.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>ALKBH5 was under-expressed while YTHDF1 and ACSL4 were up-regulated in the retinal tissues of STZ-induced DR mice and HG-stimulated ARPE-19 cells. Ectopically expressed ALKBH5 or YTHDF1 knockdown partially reversed the increased ferroptosis <i>in vitro</i> and <i>in vivo</i>, evidenced by decreased levels of Fe²⁺, malondialdehyde and reactive oxygen species yet increased glutathione level. ALKBH5 mediated m6A modification of ACSL4 mRNA and disrupted its stability in a YTHDF1-dependent manner. Importantly, <i>in vivo</i> data demonstrated that overexpression of ALKBH5 or YTHDF1 knockdown repressed ferroptosis and alleviated DR by down-regulating ACSL4.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that ALKBH5 may delay DR progression by reducing ferroptosis through the m6A-YTHDF1-ACSL4 axis, offering therapeutic paradigms for the treatment of DR.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 8","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No COVID-19 pandemic-associated increase of childhood type 1 diabetes incidence in Western Australia","authors":"Ewan Cameron,&nbsp;Aveni Haynes,&nbsp;Song Zhang","doi":"10.1111/dme.70047","DOIUrl":"10.1111/dme.70047","url":null,"abstract":"","PeriodicalId":11251,"journal":{"name":"Diabetic Medicine","volume":"42 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}