Developmental and comparative immunology最新文献

{"title":"Modulation of innate immunity, antioxidant capacity, intestinal barrier and disease resistant in common carp by dietary sodium acetate.","authors":"Wenshan Cui, Xiaobei Liu, Xiao Yuan, Ruizhe Hou, Xianfeng Wang, Hongxia Jiang, Junchang Feng","doi":"10.1016/j.dci.2026.105621","DOIUrl":"https://doi.org/10.1016/j.dci.2026.105621","url":null,"abstract":"<p><p>This study examined the effects of sodium acetate (SA) on immunity, antioxidant status, intestinal barrier function, and disease resistance in juvenile common carp. A 1-week short-term gavage trial was first conducted using SA concentrations of 0, 0.25%, 0.5%, 1.0%, 1.5%, and 2.0%. SA at various doses enhanced immune and antioxidant responses, with optimal gavage ranges of 0.87%-1.04% and 0.92%-1.20%, respectively. Subsequently, an 8-week feeding trial was performed with five groups: two controls (CK, CK+, 0% SA) and three SA-supplemented groups (0.5%, 1.0%, 1.5%), with three replicates per group (n=30). After feeding, serum D-LA, ET-1, 5-HT and DAO did not differ significantly (P > 0.05). However, SA supplementation significantly increased immune indices [TNF-α (1.0%), IL-1β (0.5-1.5%), IL-6 (1.0-1.5%), IL-10 (1.0-1.5%), TGF-β (1.0%), NO (1.0-1.5%), LZM (1.0-1.5%), AKP (1.0-1.5%)], hepatopancreatic antioxidant parameters [T-AOC (1.5%), SOD (0.5%), CAT (0.5-1.5%), GSH-Px (0.5-1.0%), GSH (1.0-1.5%)], and intestinal tight junction gene expression [zo-1 (0.5-1.0%), occluding (0.5-1.5%), claudin-1 (0.5%)], while decreasing MDA (0.5-1.0%) (P < 0.05). After infection, Aeromonas hydrophila triggered inflammatory responses and oxidative stress by significantly elevating the contents of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and NO, as well as the activities of LZM and AKP and related antioxidant indices (P < 0.05), down-regulating the expression of intestinal tight junction protein genes and increasing intestinal permeability, thereby impairing intestinal integrity and ultimately reducing the survival rate to 29.80% (P < 0.05). In contrast, dietary SA supplementation significantly reversed these changes: it reduced the levels or activities serum immune indicators, hepatopancreas antioxidant indices and intestinal permeability markers (P < 0.05). Moreover, the levels of anti-inflammatory cytokines (IL-10, TGF-β), the expression of intestinal tight junction proteins, and the survival rate were all significantly higher in the SA-supplemented group than in the infected control (CK+) group (P < 0.05). Collectively, these results demonstrate that dietary SA supplementation enhances innate immunity, antioxidant capacity, intestinal barrier function, and disease resistance in juvenile common carp, and the recommended dosage is 1.0%.</p>","PeriodicalId":11228,"journal":{"name":"Developmental and comparative immunology","volume":" ","pages":"105621"},"PeriodicalIF":2.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between host and parasite: The microbiome of Varroa destructor and its relationship with honey bees.","authors":"Anna Marzec-Grządziel, Grzegorz Borsuk","doi":"10.1016/j.dci.2026.105617","DOIUrl":"https://doi.org/10.1016/j.dci.2026.105617","url":null,"abstract":"<p><p>The study of the microbiome of the mite Varroa destructor is crucial for understanding parasite-host interactions and their potential health implications for honey bees (Apis mellifera). The aim of this research was to characterize the microbial diversity of Varroa destructor populations collected from the body surface of honey bees and compare it with microbiome of Apis mellifera. DNA isolation was performed using standard methods, followed by next-generation sequencing (NGS) of the V3-V4 region of the 16S rRNA gene. The obtained bioinformatic data underwent taxonomic analysis, enabling the identification of dominant bacterial genera present in the Varroa and Apis mellifera microbiome. Results revealed significant microbial diversity, with dominance primarily by bacteria belonging to the families Acetobacteraceae, Morganellaceae, and Segniliparaceae. The identified bacteria may play a critical role in the pathogenicity of Varroa destructor, directly or indirectly affecting the health and condition of bees. These findings provide new insights into potential therapeutic and preventive targets for protecting bee colonies against the detrimental effects of Varroa mites.</p>","PeriodicalId":11228,"journal":{"name":"Developmental and comparative immunology","volume":"179 ","pages":"105617"},"PeriodicalIF":2.4,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative molecular characterisation of myeloid cathelicidins reveals subspecies-level diversification in indigenous livestock.","authors":"Jini Roy, Varuna P Panicker, Vrindha Madhavan, R Uma, M V Chinnu, K N Chaithanya, Sulfiya Ummer Farooq, M Shynu, M Manoj, John Abraham","doi":"10.1016/j.dci.2026.105619","DOIUrl":"https://doi.org/10.1016/j.dci.2026.105619","url":null,"abstract":"<p><p>Innate immune-related genes are shaped by strong selection pressures due to host-pathogen co-evolution, yet the evolutionary trajectory of cathelicidin antimicrobial (AMP) gene is poorly understood. Despite their central role in innate immunity, the extent of sequence diversification of myeloid cathelicidins across livestock subspecies remains unclear. Present study investigated inter-breed and inter-species level sequence variations of myeloid cathelicidin gene in Vechur cattle (Bos taurus indicus), Ankamali pig (Sus scrofa domesticus), Naked neck chicken (Gallus gallus domesticus) and compared them with their counterparts Bos taurus taurus, Large White Yorkshire (Sus scrofa domesticus), and White leghorn (Gallus gallus domesticus). Sequence and phylogenetic analysis revealed limited divergence and variations confined only to the subspecies level. Two Vechur-derived peptides vBMAP-27 (Vechur cattle Bovine Myeloid Antimicrobial Peptide) and vBMAP-28 displayed single amino acid substitutions at its active motif, whereas vBMAP-34, Ankamali pig and Naked neck chicken sequences were highly conserved. Single amino-acid substitutions altered predicted physicochemical properties, suggesting potential functional modulation. Cathelicidin gene evolution demonstrated by purifying selection, highlighting subtle genetic variation within immune-related gene could contribute to adaptive resilience in locally evolved local livestock breeds.</p>","PeriodicalId":11228,"journal":{"name":"Developmental and comparative immunology","volume":"179 ","pages":"105619"},"PeriodicalIF":2.4,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Resilience and immunity in animals.","authors":"Nguyen T K Vo, Yamila Carpio, Alberto Cuesta","doi":"10.1016/j.dci.2026.105618","DOIUrl":"10.1016/j.dci.2026.105618","url":null,"abstract":"","PeriodicalId":11228,"journal":{"name":"Developmental and comparative immunology","volume":" ","pages":"105618"},"PeriodicalIF":2.4,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The exploration of the immune mechanism of interferon-γ from Nibea albiflora and the functional characteristics of its receptor 2.","authors":"Hanbing Yuan, Yongxin Liu, Xu Zhou, Dongdong Xu, Changfeng Chi, Zhenming Lü, Huihui Liu","doi":"10.1016/j.dci.2026.105609","DOIUrl":"10.1016/j.dci.2026.105609","url":null,"abstract":"<p><p>Interferon-gamma (IFN-γ) serves as an inflammatory cytokine essential for modulating innate and cell-mediated immune responses by associating with a receptor complex composed of IFNGR1 and IFNGR2. In this research, the entire cDNA of IFNGR2 from Nibea albiflora was cloned and functionally analyzed (referred to as NaIFNGR2), with the complete cDNA sequence measuring 924 bp and encoding 307 amino acids. The phylogenetic analysis and multiple sequence alignment revealed a significant similarity of NaIFNGR2 with homologous sequences found in other bony fish, especially within the FNⅢ domain and the transmembrane region. Real-time PCR analysis revealed that NaIFNGR2 was consistently expressed across all examined tissues, including the head-kidney, spleen, liver, kidney, gill, muscle, and blood, with the highest levels found in the gills. Following stimulation with Polyinosinic-polycytidylic acid (Poly (I:C)), Vibrio alginolyticus, or Vibrio parahaemolyticus, the mRNA levels of NaIFNGR2 showed an increase in a time-dependent manner. Subcellular localization studies indicated that NaIFNGR2 resided on the cell membrane and NaIFN-γ, once synthesized within the cell, was transported to the membrane to interact with NaIFNGR2. Additionally, NaIFNGR1 and NaIFNGR2 were completely co-localized on the cell membrane, which was consistent with the findings that NaIFNGR1 and NaIFNGR2 could form a heterodimeric complex. Being treated with the NaIFN-γ recombinant protein, both alone and in combination with LPS, various concentrations of NaIFN-γ were non-toxic to the growth of RAW 264.7 macrophages and significantly promoted their proliferation. The expression levels of IL-1β, IL-6, and TNF-α proteins were markedly upregulated in a concentration- and time-dependent manner following 24 and 48 h of combined stimulation. Furthermore, the secretion of nitric oxide (NO) was significantly increased after 36 and 48 h of stimulation, highlighting the regulatory effect of NaIFN-γ on macrophages and its influence on the inflammatory response. Collectively, the findings indicated that the NaIFN-γ ligand-receptor system was present in N. albiflora and played a crucial role in the immune response to pathogenic bacterial infections, enhancing our comprehension of the function of IFN-γ within the immunomodulatory processes of teleosts.</p>","PeriodicalId":11228,"journal":{"name":"Developmental and comparative immunology","volume":" ","pages":"105609"},"PeriodicalIF":2.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in research on fish virus receptors.","authors":"Zhihui Jia, Rong Huang, Juhong Xie, Liangming Chen, Bin Gui, Yongming Li, Lanjie Liao, Yaping Wang","doi":"10.1016/j.dci.2026.105603","DOIUrl":"10.1016/j.dci.2026.105603","url":null,"abstract":"<p><p>The specific recognition between a virus and a cell receptor is the initial step of viral invasion, profoundly influencing the virus's host range and pathogenicity, and it is a critical aspect of understanding and controlling viral diseases in fish. This review systematically summarizes the research progress on receptors for major fish RNA viruses and DNA viruses. It reveals the sophisticated strategies viruses have evolved to utilize a variety of host molecules (such as fibronectin, LamR, Nectin, HSP proteins, VDAC2/RACK1, etc.) as receptors. Concurrently, it has been found that different viruses exhibit convergence in their entry mechanisms, such as the common use of heparan sulfate as an initial attachment factor or reliance on clathrin-mediated endocytosis(CME)for internalization. However, this systematic comparison also clearly highlights the current knowledge gaps, namely that the specific protein receptors for several key viruses (PRV, IHNV, VHSV, MSRV, ISKNV, SGIV, CCV) remain unidentified. To address these gaps, clarifying the commonalities and differences in entry mechanisms across various viruses is essential for guiding future research. By reviewing the biological roles of these receptors and the current experimental toolsets, this paper demonstrates that advancing research in this field not only provides a theoretical foundation for revealing viral pathogenesis but also identifies crucial targets for the development of antiviral drugs, novel vaccines, and precise control strategies such as disease-resistant breeding.</p>","PeriodicalId":11228,"journal":{"name":"Developmental and comparative immunology","volume":" ","pages":"105603"},"PeriodicalIF":2.4,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune and protective effects of recombinant multi-epitopes vaccine against infectious spleen and kidney necrosis virus in pearl gentian grouper (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatus)","authors":"Xinxin Liu ,&nbsp;Yun Sun ,&nbsp;Zikai He ,&nbsp;Bo Li ,&nbsp;Wenye Song ,&nbsp;Hongli Liu ,&nbsp;Caoying Wei ,&nbsp;Ying Wu ,&nbsp;Zhenjie Cao ,&nbsp;Chen Zhang ,&nbsp;Yongcan Zhou","doi":"10.1016/j.dci.2026.105570","DOIUrl":"10.1016/j.dci.2026.105570","url":null,"abstract":"<div><div>The capsid protein (CP), the primary structural component and key antigen of infectious spleen kidney necrosis virus (ISKNV), remains poorly characterized in terms of its antigenic epitopes. These epitopes, typically ∼20 amino acid residues in length, are specific chemical groups determining antigenic specificity. To address this gap, we employed immunoinformatics to analyze CP epitopes. Subsequently, a multi-epitope vaccine targeting ISKNV (MEV) was designed, constructed, and screened. Immune response evaluation revealed that the predicted three T lymphocyte and five B lymphocyte epitopes exhibited antigenicity, non-toxicity, and non-allergenicity. Fusion of these epitopes yielded the MEV vaccine. In grouper trials, MEV vaccination significantly upregulated mRNA expression of immune-related genes (<em>IL-1β</em>, <em>TNF-α</em>, <em>CD4</em>, <em>CD8α</em>, <em>MHC-</em>Iα, <em>MHC-</em>IIα) and markedly increased total IgM levels, indicating induction of both cellular and humoral immunity. Crucially, MEV conferred significantly higher resistance against ISKNV challenge compared to CP immunization, achieving 85.33% survival rate. Furthermore, MEV vaccination significantly reduced viral loads in the spleen and head kidney. This study presents an economical, rapid, safe, and effective strategy for aquatic vaccine development, positioning MEV as a highly promising candidate for preventing infectious spleen kidney necrosis disease.</div></div>","PeriodicalId":11228,"journal":{"name":"Developmental and comparative immunology","volume":"177 ","pages":"Article 105570"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146161895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress and immune responses in whiteleg shrimp (Penaeus vannamei) under ozone nanobubbles exposure","authors":"Phan Trong Binh ,&nbsp;Phan Thi Van ,&nbsp;Nguyen Huu Nghia ,&nbsp;Nguyen Minh Quan ,&nbsp;Vu Thi Trang ,&nbsp;Pham Hong Nhat ,&nbsp;Pham Thai Giang","doi":"10.1016/j.dci.2026.105569","DOIUrl":"10.1016/j.dci.2026.105569","url":null,"abstract":"<div><div>Ozone nanobubbles (NB-O₃) have recently emerged as a promising technology in aquaculture for improving water quality and disease control. However, their impacts on shrimp remain poorly understood, particularly regarding their effects on biochemical processes. This study evaluated the effects of NB-O₃ on growth performance, immune responses, oxidative stress, and HSP70 gene expression in whiteleg shrimp (<em>Penaeus vannamei</em>). Shrimp were cultured for 21 days in control and NB-O₃-treated tanks. Growth indices, water quality variables, total hemocyte counts (THC), antioxidant enzyme activities (catalase (CAT), glutathione peroxidase (GPx)), malondialdehyde (MDA), and HSP70 expression in hepatopancreas were assessed. Results showed that NB-O₃ significantly improved final body weight, weight gain, and average daily growth rate compared with the control (p &lt; 0.05). Water quality was enhanced in NB-O₃ tanks, with the reduction of NH₃-N, NO₂-N, COD, and Vibrio counts. THC increased markedly in the NB-O₃ group during the early experimental phase. Antioxidant enzyme activities (CAT and GPx) were significantly elevated under NB-O₃ treatment, while MDA levels were lower at the end of the trial, indicating reduced oxidative damage. HSP70 expression in hepatopancreas peaked at day 1 in the NB-O₃ group, suggesting an instantaneous stress response, but declined thereafter, reflecting shrimp adaptation. These findings demonstrate that NB-O₃ improves water quality, enhances antioxidant and immune responses, and promotes growth in <em>P. vannamei</em>, supporting its potential application as a sustainable aquaculture technology. Overall, this study highlights NB-O₃ as an eco-friendly approach to enhance shrimp health and productivity in intensive culture systems.</div></div>","PeriodicalId":11228,"journal":{"name":"Developmental and comparative immunology","volume":"177 ","pages":"Article 105569"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing p53 structural insights of variants in vertebrates that interfere its regulatory interaction with Mdm2","authors":"Umesh Kalathiya,&nbsp;Natalia Marek-Trzonkowska,&nbsp;Monikaben Padariya","doi":"10.1016/j.dci.2026.105554","DOIUrl":"10.1016/j.dci.2026.105554","url":null,"abstract":"<div><div>The tumor suppressor p53, transcriptionally regulates several target genes, and in the absence of cellular stress its basal protein levels are tightly regulated by Mdm2 (Murine double minute 2). Species with functional p53 are less prone to cancer, and in mammals this oncogene has a multifunctional role towards cancer tolerance. Herein, we examined naturally evolving p53 protein across vertebrates with its negative regulator, along with exploring their structural properties. Several mammalian species contain conserved p53 amphipathic α-helical BOX-I, DNA-binding domain (DBD), and basic domains, whereas <em>Loxodonta africana</em> (elephant) exhibits the lowest sequence similarities. Vertebrates with notable insertion in the DBD or disordered BOX-I regions gained a unique structural orientation, that can potentiate to escape Mdm2 negative regulation. Comprehending molecular details, we constructed an Mdm2 pharmacophore model that can interact with a specific set of p53 isoforms. To explore potential use of BOX-I derived linear motifs as peptidomimetic molecules targeting Mdm2 we assessed their binding affinity, as well as the effect of temperature over the p53-Mdm2 complex. Conformational changes adopted by p53 variants identify crucial residues within the FxxxW/GxxL motif. These residues face the Mdm2 pocket and may enhance binding affinity, even under thermal change. Mdm2 was found mutated heavily in carcinoma, and its variant can have a significant role when associating with p53. Our findings demonstrate a natural living model, to utterly contribute to the mechanistic understanding of the role of p53 in its activation, giving insight on structural properties aiming to target these biomarkers in cancer therapeutics.</div></div>","PeriodicalId":11228,"journal":{"name":"Developmental and comparative immunology","volume":"176 ","pages":"Article 105554"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145997540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In mosquitoes, warmer temperature reverses the aging-dependent decrease in nitric oxide synthase activity, modifying the expression of oxidative stress and immune genes","authors":"Lindsay E. Martin,&nbsp;Norbu Y. Shastri,&nbsp;Tania Y. Estévez-Lao,&nbsp;Seokin Yang,&nbsp;Julián F. Hillyer","doi":"10.1016/j.dci.2026.105556","DOIUrl":"10.1016/j.dci.2026.105556","url":null,"abstract":"<div><div>In mosquitoes, reactive oxygen and nitrogen species (ROS and RNS) are immune effectors, byproducts of metabolism, and regulators of homeostasis. However, imbalances in ROS and RNS cause oxidative stress. Given that warmer temperature accelerates the aging-dependent weakening of immunity, we hypothesized that temperature and aging interactively modify the production of ROS/RNS like nitric oxide, and their effects. We tested this in <em>Anopheles gambiae</em> by rearing mosquitoes at 27C, 30C and 32C, and assessing phenotypes at 1, 5, 10 and 15 days of adulthood. Using NADPH diaphorase staining, we show that, in mosquitoes infected with bacteria, warmer temperature increases the activity of nitric oxide synthase (NOS; produces nitric oxide), while aging decreases NOS activity. Importantly, during late aging, warmer temperature reverses the aging-dependent decline in NOS activity. By mining an RNAseq dataset, we uncovered that warmer temperature and aging interact to increase the expression of both <em>NOS</em> and <em>JNK</em>, which are involved in immunity and oxidative stress. Additionally, warmer temperature and aging interact to downregulate expression of genes encoding antimicrobial effectors and superoxide detoxification enzymes, but upregulate expression of genes involved in hydrogen peroxide detoxification. Finally, manipulating nitric oxide production modifies the expression of immune genes in a temperature and age dependent manner. These findings suggest that heightened oxidative stress caused by warmer temperature accelerates senescence.</div></div>","PeriodicalId":11228,"journal":{"name":"Developmental and comparative immunology","volume":"176 ","pages":"Article 105556"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}