Dermatology最新文献

{"title":"Prevalence of Hidradenitis Suppurativa in Oman.","authors":"Waleed Al Maharbi, Pernille Lindsø Andersen, Dorra Bouazzi, Cecilia E Medianfar, Robin Christensen, Gregor B E Jemec","doi":"10.1159/000540156","DOIUrl":"10.1159/000540156","url":null,"abstract":"<p><strong>Introduction: </strong>This study, conducted as part of the Global Hidradenitis Suppurativa Atlas (GHiSA) initiative, aimed to ascertain the prevalence of hidradenitis suppurativa (HS) in Oman and to assess its demographic distribution, adhering to standardized methodology for consistency across participating sites.</p><p><strong>Methods: </strong>A multicenter approach was undertaken, encompassing primary care within a general practice clinic, along with two secondary surgical clinics at Sumail Hospital and Seeb polyclinic in Oman. Informed written and oral consent were diligently obtained from study participants. Data collection involved the translation of the questionnaire into Arabic and meticulous examination conducted by qualified physicians. Recruitment transpired from July 2022 to September 2022, targeting healthy adults accompanying patients, with rigorous adherence to predefined exclusion criteria.</p><p><strong>Results: </strong>Among the 500 initially selected participants, 484 questionnaires were subjected to rigorous analysis, following the exclusion of 16 due to data incompleteness. The estimated prevalence of HS in Oman was found to be 2.1% (95% CI: 1.1-3.8%), with a pronounced predilection toward the female demographic. Notably, the median age of participants with HS was significantly lower than that of their healthy counterparts. Regional distribution analysis revealed the axillary region as the most commonly affected site for both genders. The questionnaire-based diagnostic approach exhibited a sensitivity of 1.00 and a specificity of 0.73, indicating its efficacy in HS diagnosis.</p><p><strong>Conclusion: </strong>This study yields critical insights into the epidemiology of HS in Oman, conclusively establishing a prevalence rate of 2.1%. The high sensitivity and specificity of the questionnaire-based diagnostic tool emphasize its clinical utility. These findings collectively emphasize the imperative for comprehensive education and awareness campaigns among healthcare professionals to foster early detection and tailored intervention strategies. To further enrich our understanding of HS pathophysiology and optimize patient management, larger prospective investigations are warranted.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-5"},"PeriodicalIF":3.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hidradenitis Suppurativa in Poland.","authors":"Klaudia Knecht-Gurwin, Adam Gurwin, Tomasz Wróbel, Dorra Bouazzi, Cecilia E Medianfar, Robin Christensen, Gregor B E Jemec, Jacek C Szepietowski, Łukasz Matusiak","doi":"10.1159/000541951","DOIUrl":"10.1159/000541951","url":null,"abstract":"<p><strong>Introduction: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by recurrent boils or abscesses. Its prevalence varies globally, yet specific data from Poland are limited. This study aimed to determine the prevalence of HS among adults in Poland, utilizing standardized methods as part of the Global Hidradenitis Suppurativa Atlas (GHiSA) initiative.</p><p><strong>Methods: </strong>This monocenter study was conducted at the Internal Medicine Departments of University Hospital of Wroclaw. In the study, participants were individuals accompanying patients administered to the hospital, excluding individuals under 18 years old, pregnant women, and those deemed incapable of participating. A self-administered screening questionnaire for HS diagnosis was utilized. Physical examinations and Hurley score assessments were conducted for participants reporting HS symptoms. In addition, approximately 10% of participants who did not report any HS symptoms were tested to determine the false-negative response rate. Statistical analysis was performed using R Project for Statistical Computing and Statistica 13.3 software.</p><p><strong>Results: </strong>Out of 940 adults approached, 932 participated in the study. 21 participants reported HS symptoms, with 14 individuals diagnosed with HS upon examination. Additionally, 1 participant without reported symptoms was diagnosed with HS. The estimated prevalence of HS among the Polish adult population was 1.61% (95% CI: 0.90-2.50%). The screening questionnaire exhibited a sensitivity and specificity of 93%, with a positive predictive value of 67% and a negative predictive value of 99%.</p><p><strong>Conclusion: </strong>This study shed some light on the prevalence of HS in Poland, indicating that it is a more common condition than previously reported in the literature. It can contribute to understanding the epidemiology of HS in Poland and may aid in improving diagnosis and management strategies for affected individuals.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-9"},"PeriodicalIF":3.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of a Questionnaire Screening Test in Assessing the Prevalence of Hidradenitis Suppurativa in Sydney, Australia.","authors":"James Pham, Akshay Flora, Emily Kay Kozera, Cecilia E Medianfar, Dorra Bouazzi, Robin Christensen, Gregor B E Jemec, John W Frew","doi":"10.1159/000540455","DOIUrl":"10.1159/000540455","url":null,"abstract":"<p><strong>Introduction: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with significant patient burden and impact on quality of life. Australia has a population of over 25 million people, with an estimated 29% of people born overseas. Previous studies have estimated the prevalence of HS in Australia to be approximately 0.67%, but methodological issues limit the accuracy of this estimate. This study was a part of the Global Hidradenitis Suppurativa Atlas (GHiSA) initiative, aiming to objectively quantify the prevalence of HS in Australia.</p><p><strong>Methods: </strong>The methodology followed the previously published GHiSA methodology. A validated questionnaire was used to identify patients likely to have a diagnosis of HS. Screen-positive patients as well as a selection of screen-negative patients underwent clinical examination by a single physician experienced in the identification, diagnosis and management of HS to further validate the sensitivity and specificity of the questionnaire.</p><p><strong>Results: </strong>A total of 1,657 eligible healthy accompanying adults were approached, of whom 1,002 consented for inclusion in the study (60.5%). A total of 9 were survey screen-positive for HS, representing a prevalence of 0.9% (95% CI: 0.5%-1.7%).</p><p><strong>Conclusions: </strong>This single tertiary referral center study identified an HS prevalence of 0.9% in Australia. The methods address the deficiencies in other methodologies and provide insight into the prevalence of HS globally as part of the GHiSA initiative.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-5"},"PeriodicalIF":3.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Hidradenitis Suppurativa Epidemiology: Exploring Themes and Gaps beyond Europe, Australia, and the USA.","authors":"Cecilia E Medianfar, Lauren I Fernandez, Dorra Bouazzi, Gregor B E Jemec","doi":"10.1159/000542389","DOIUrl":"10.1159/000542389","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Although a prevalence estimate has been proposed, this is based largely on studies from Europe, USA, and Australia. As literature on HS is scarce beyond these populations, our knowledge on epidemiology and clinical presentation from these areas are limited.</p><p><strong>Summary: </strong>A narrative literature search was conducted on the PubMed Medline database on November 6th, 2023, to examine HS epidemiological data from Asia, Latin America, North America, Africa, and Oceania, excluding articles from Europe, USA, and Australia. Relevant data (e.g., prevalence, gender distribution, age, smoking status) were extracted. A total of 26 articles were included: three from Africa, four from Latin America, one from North America, 18 from Asia, and none from Oceania. Prevalence varied widely, from 0.41% in Brazil to 3.2% in Greenland. Female predominance was noted in Latin America and Greenland, while male predominance was observed in Asia. Smoking rates varied significantly, from 0% in Ghana to 93.8% in Greenland.</p><p><strong>Key messages: </strong>(1) There is a notable lack in epidemiological HS data from large areas of the globe, particularly from Africa, Latin America, and Oceania. Further, significant heterogeneity in methodology and data reporting leads to inconsistencies in the comparability of the available data; (2) there are notable differences in gender distribution of HS across regions, with female predominance seen in Latin America and Greenland, while male predominance is more common in East Asia; (3) obesity and smoking, factors commonly described as risk factors for HS, where not consistently described across the studies, suggesting possible regional differences in risk factors; (4) it is crucial to encourage HS research globally to improve understanding, diagnosis, and treatment options for this significant disease.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-12"},"PeriodicalIF":3.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnoracial and Geographic Disparities in Global Atopic Dermatitis Clinical Trials: An Update.","authors":"Caitlyn B Dagenet, Sahar Davoudi, Kyla N Price, Jennifer L Hsiao, Vivian Y Shi","doi":"10.1159/000547224","DOIUrl":"https://doi.org/10.1159/000547224","url":null,"abstract":"<p><p>Introduction Atopic dermatitis (AD) disproportionally impacts skin of color (SOC) patients, particularly Black/African American children. The number of global AD clinical trials is growing exponentially as the AD medication pipeline expands. Thus, we aimed to provide an update on racial, ethnic, and geographical disparities in global AD trials. Methods Race, ethnicity, and location data were extracted from phase 2 and 3 randomized, double-blind, placebo-controlled trials investigating AD therapies from 07/2019 to 12/2023 on ClinicalTrials.gov. To provide an update, data was compared to published data from Price et al. from January 2009 to July 2019. Results Twenty-four completed, randomized controlled trials (RCT) met the search criteria. North America hosted the highest percentage of RCTs. The majority of participants were White, followed by Asian, and Black/African American. Conclusion Despite growing awareness of how AD affects SOC patients, the majority of participants in AD clinical trials are still White. Further efforts to increase reporting and enrollment of diverse participants is critical to further improving clinical trial participant diversity.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-8"},"PeriodicalIF":3.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased risk of heart failure among patients with bullous pemphigoid: A nationwide cohort study.","authors":"Tai-Li Chen, Wan-Ting Huang, Chen-Yi Wu, Ching-Hui Loh, Huei-Kai Huang, Ching-Chi Chi","doi":"10.1159/000547272","DOIUrl":"https://doi.org/10.1159/000547272","url":null,"abstract":"<p><strong>Background: </strong>Bullous pemphigoid (BP) and heart failure (HF) share similar mechanisms involving chronic inflammation. Nevertheless, the association of BP with HF has been unclear. This study aimed to investigate the association of BP with incident HF.</p><p><strong>Methods: </strong>We conducted a nationwide cohort study included adults aged ≥ 20 years from Taiwan's National Health Insurance Research Database between 2011 and 2019. Adults with newly-diagnosed BP and matched controls were included. A Cox regression model considering stabilized inverse probability weighting was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident HF in association with BP. Stratified analyses according to age and sex were conducted. Multiple sensitivity analyses were also performed.</p><p><strong>Results: </strong>Among 39,835 subjects, 975 patients in the BP cohort and 2,311 patients in the non-BP cohort developed HF, with incidence rates of 46.1 and 16.9 per 1,000 person-years, respectively. Adults with BP had a significantly increased risk of incident HF (HR 2.63; 95% CI 2.44-2.83) compared to those without BP. The association remained significant in the age- and sex-stratified analyses. Multiple sensitivity analyses confirmed the robustness of our primary analyses.</p><p><strong>Conclusion: </strong>BP is associated with an increased risk for HF. Early detection of HF and cardiology consultation among patients with BP presenting relevant symptoms may be implicated in the current practice.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-23"},"PeriodicalIF":3.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hidradenitis Suppurativa in Serbia: Validation of a Screening Questionnaire.","authors":"Ivana Jocic, Branko Dujovic, Lidija Kandolf, Dorra Bouazzi, Cecilia E Medianfar, Robin Christensen, Gregor B E Jemec, Zeljko Mijuskovic","doi":"10.1159/000539877","DOIUrl":"10.1159/000539877","url":null,"abstract":"<p><strong>Introduction: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by painful nodules and rupturing abscesses causing sinus tunnels and scarring, most commonly in the axilla, inguinal, perianal, and submammary areas. The global prevalence varies considerably, ranging from 0.00033% to 4.1%. To date, no epidemiological studies on HS have been conducted in Serbia. The aim of the study was to determine the prevalence of HS in Serbia.</p><p><strong>Methods: </strong>This research is a monocentric study initiated by the Global Hidradenitis Suppurativa Atlas (GHISA), conducted at the Military Medical Academy in Belgrade, and is part of the GHISA project. The study included healthy companions of the patients who filled out a validated questionnaire in the local language in which they reported their gender, age, weight, height, cigarette consumption, and the presence of painful nodules on the skin of the body folds. All people who reported having the changes defined in the questionnaire and every tenth person who said there were no changes were examined by experienced dermatologists and final year dermatology residents.</p><p><strong>Results: </strong>In the study, among 490 respondents, 4 were confirmed as HS, the point prevalence was 0.82%. HS was diagnosed equally in women and men. All patients had a BMI above normal, which is a known risk factor for HS. The affected regions in the HS group were the axilla and groin. The screening questionnaire had a sensitivity of 0.5 (2/4), a specificity of 0.93 (62/67), a positive predictive value of 0.29 (2/7), and a negative predictive value of 0.97 (62/64).</p><p><strong>Conclusion: </strong>The prevalence of HS in Belgrade, Serbia is 0.82%. The disease occurs equally frequently in both sexes. The HS screening questionnaire proves to be an appropriate instrument for population surveys.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-6"},"PeriodicalIF":3.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hidradenitis Suppurativa in Skopje, North Macedonia.","authors":"Ivana Tusheva, Vesna Brishkoska Boshkovski, Dorra Bouazzi, Cecilia E Medianfer, Robin Christensen, Gregor B E Jemec, Vesna Trajkova, Irena Dimitrovska, Ana Ristovska-Dimitrovska, Katerina Damevska","doi":"10.1159/000539140","DOIUrl":"10.1159/000539140","url":null,"abstract":"<p><strong>Introduction: </strong>Hidradenitis suppurativa (HS) exhibits varying prevalence globally, markedly influenced by geographical and ethnic distinctions. This study, part of the Global Hidradenitis Suppurativa Atlas (GHiSA) initiative, aimed to assess the prevalence of HS in North Macedonia and contribute to the global epidemiology of this complex dermatological disorder.</p><p><strong>Methods: </strong>Conducted at City General Hospital \"8th September\" in Skopje, North Macedonia, from March 23, 2023, to May 30, 2023, this single-center study enrolled 597 healthy adults using a validated screening questionnaire. The participants were selected from accompanied outpatients and visitors of hospitalized patients in various departments, excluding the dermatology department. The questionnaire consisted of questions leading to the diagnosis of HS, particularly about the presence of boils, and it was administered as an interview by dermatology residents under the supervision of dermatologists. Participants who tested positive on the screening questionnaire were examined by dermatologists.</p><p><strong>Results: </strong>Out of 600 participants, 597 successfully completed the questionnaire (291 male and 301 female), and among them, 5 individuals (3 male and 2 female) were identified as having HS. This indicates an HS prevalence rate of 0.84%. Demographic analysis showed a male predominance in the HS group, with a median age of onset at 36 years (42.0 in the control group). Smoking and higher BMI were associated with HS. Notably, the study identified HS cases among participants initially screening negative, emphasizing the complexity of diagnosis. The diagnostic questionnaire demonstrated a sensitivity of 0.60 and a specificity of 0.84.</p><p><strong>Conclusion: </strong>This epidemiological study contributes to the global understanding of HS prevalence, demographic characteristics, and associated factors. With a rate of 0.84%, HS remains a significant concern. The observed male predominance in HS incidence deviates from global trends.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-6"},"PeriodicalIF":3.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Prevalence of Hidradenitis Suppurativa.","authors":"Gabrielle R Vinding, Mohammed Saiful Islam Bhuiyan","doi":"10.1159/000542381","DOIUrl":"10.1159/000542381","url":null,"abstract":"","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-2"},"PeriodicalIF":3.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hidradenitis Suppurativa in Fars Province, Iran.","authors":"Farhad Handjani, Nasrin Saki, Mohammad Mahdi Parvizi, Roya Radanfar, Dorra Bouazzi, Cecilia E Medianfar, Robin Christensen, Gregor B E Jemec","doi":"10.1159/000540422","DOIUrl":"10.1159/000540422","url":null,"abstract":"<p><strong>Introduction: </strong>Hidradenitis suppurativa (HS) is a persistent and inflammatory skin condition that greatly diminishes the quality of life of the patients and frequently develops because of occlusion of the hair follicles. This study aimed to determine the prevalence of HS among the Iranian population residing in Fars province.</p><p><strong>Methods: </strong>This study was a cross-sectional study that was conducted at Shahid Faghihi Clinic at Shiraz University of Medical Sciences, Iran. The study included over 18-year-old healthy individuals who accompanied patients that had attended our center for non-dermatological care. The interviewers handed out a screening questionnaire on HS to the study participants, and then those individuals who were suspicious of having HS were examined by a dermatologist to verify if the individual has HS. The dermatologist also examined 10% of participants who reported no HS symptoms to reduce bias. The data analysis was conducted by using RStudio version 1.3.1093.</p><p><strong>Results: </strong>The results of our study indicated that 3 out of the 990 study participants suffered from HS, putting the prevalence of HS at 0.3% (95% CI: 0.10%-0.89%). After physically examining 3 questionnaire-positive HS individuals, we confirmed their assertion (sensitivity: 1.0). After screening 10% of the individuals negative for HS, the specificity was 0.83, positive predictive value was 0.13, and negative predictive value was 1. Moreover, this study found that the participants with and without HS had similar characteristics in terms of gender, age, and body mass index.</p><p><strong>Conclusion: </strong>It seems that the prevalence of HS in Iran is lower in comparison with many other countries. Gender, age, and BMI were similar in HS and non-HS participants. Future research is recommended to evaluate the other characteristics of this disease in Iran.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-6"},"PeriodicalIF":3.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}