Dermatology最新文献

{"title":"Erratum.","authors":"","doi":"10.1159/drm/ackag019","DOIUrl":"https://doi.org/10.1159/drm/ackag019","url":null,"abstract":"<p><p>In the article, \"Epidemiology of Pruritus: Global Burden of Disease Research from 1990 to 2021 and Future Trend Predictions\". [Dermatology. 2025;241(5-6):547-556. https://doi.org/10.1159/000547821] by Wang et al., the authors identified an error in the data used to generate Figure 4. During preparation of the figure, incorrect data from the Global Burden of Disease (GBD) 2021 dataset were used. Specifically, during the generation of the frontier analysis/bibliometric-style figure, the authors inadvertently reused a script that had been configured for an earlier inflammatory bowel disease (IBD) analysis.Fig. 4.Frontier analysis based on the sociodemographic index (SDI) and age-standardized disability-adjusted life years rate (ASDR) due to pruritus. a Frontier analysis based on SDI and pruritus ASDR from 1990 to 2021. b Frontier analysis based on SDI and pruritus ASDR in 2021.The authors have since regenerated Figure 4 and repeated the key analytical steps using datasets from other GBD publications. They reproduced results consistent with those reports (DOIs: 10.1177/20420188241227295 and 10.1097/JS9.0000000000001071), confirming that the data handling procedures, code, and outputs are now functioning as intended.The original sentence read:\"The five countries or regions with the largest effective gaps from the frontier included the Netherlands, Germany, Canada, the USA, and Iceland. Conversely, the five countries or regions with the smallest effective gaps included Yemen, Papua New Guinea, Timor-Leste, Lao People's Democratic Republic, and Somalia (Fig. 4).\"The corrected sentence should read:\"The five countries or regions with the largest effective gaps from the frontier included Taiwan (Province of China), Turkey, Lithuania, Canada, and the United States of America. Conversely, the five countries or regions with the smallest effective gaps included Somalia, Niger, Nepal, Haiti, and Bangladesh (Fig. 4).\"The corrected Figure 4 is shown here.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1"},"PeriodicalIF":3.6,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149037074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotypic and Phenotypic Profiles of Babies with Collodion Membrane in a Tertiary Care Center in Riyadh, Saudi Arabia.","authors":"Abdullah Alsaleam, Faisal Alghubaywi, Aljohara Alkhenaizan, Rahaf Bashihab, Sultan Al-Khenaizan, Mohammed AlBalwi","doi":"10.1159/drm/ackag008","DOIUrl":"https://doi.org/10.1159/drm/ackag008","url":null,"abstract":"<p><p>This study conducted a retrospective analysis of 21 patients diagnosed with Collodion Membrane (CM) at a tertiary care center in Riyadh, Saudi Arabia. CM is a rare neonatal condition characterized by a shiny, parchment-like membrane covering the newborn and is associated with genetic disorders related to cornification. Introduction CM is a membrane resembling a parchment that envelops the body of neonates and is frequently associated with genetic epidermal differentiation disorders (EDD). This study aimed to outline the genetic and clinical attributes of CM in Saudi Arabia. Methods This retrospective study was performed at King Abdulaziz Medical City (KAMC) in Riyadh, Saudi Arabia, with approval from the Institutional Review Board of the King Abdullah International Medical Research Center. Informed consent was waived because of the retrospective nature of the study. The participants were patients diagnosed with CM between January 2001 and December 2024. Study data were retrieved from the BestCare® electronic medical record system through chart review. The data collected included demographic information, consanguinity status, duration of NICU stay, clinical features, treatments administered, genetic analyses, and associated conditions. Results 21 patients, of whom 14 were female (66.6%), participated. Consanguinity was documented in all patients (100%). Erythroderma was the most prevalent sign, observed in 12 patients (57.1%). The most frequently identified pathogenic variant was Ceramide Synthase 3 (𝘊𝘌𝘙𝘚3), detected in seven patients (33.3%), while lamellar ichthyosis was the predominant underlying condition, affecting nine patients (42.8%). Conclusion In this cohort of patients with CM, the identified gene mutations were associated with variations in clinical course and outcomes. 𝘊𝘌𝘙𝘚3 mutations were the most frequently detected and were most commonly observed in patients with lamellar ichthyosis, whereas 𝘛𝘎𝘔1 mutations were associated with more severe phenotypes.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1"},"PeriodicalIF":3.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Treatment Response to Adalimumab and Secukinumab in Chinese Adults with Hidradenitis Suppurativa: A Retrospective Cohort Study.","authors":"Yanyu Du, Jipang Zhan, Renliang He, Lian Zhang","doi":"10.1159/drm/ackag020","DOIUrl":"10.1159/drm/ackag020","url":null,"abstract":"<p><strong>Introduction: </strong>Biologic therapies have transformed the management of moderate-to-severe hidradenitis suppurativa (HS). However, real-world comparative data on treatment response between adalimumab and secukinumab in Chinese patients remain limited. This study describes the real-world treatment response patterns of adalimumab versus secukinumab in adult Chinese patients with HS in a descriptive, exploratory cohort analysis.</p><p><strong>Methods: </strong>This single-center retrospective descriptive cohort study included adult patients (≥18 years) with moderate-to-severe HS treated with adalimumab (n = 25) or secukinumab (n = 46). The primary endpoint was HiSCR50 at week 16. Secondary endpoints included HiSCR50 at week 12 and safety outcomes. Due to the small sample size and non-randomized design, formal adjusted between-group comparison was not performed.</p><p><strong>Results: </strong>A total of 71 adult patients were included (adalimumab: n = 25; secukinumab: n = 46). At week 12, HiSCR50 was achieved by 72.0% (18/25) of the adalimumab group and 63.0% (29/46) of the secukinumab group (p = 0.618). By week 16, the adalimumab group showed a decline to 56.0% (14/25), while the secukinumab group maintained 65.2% (30/46, p = 0.611). These differences were not statistically significant and should be interpreted as descriptive observations only.</p><p><strong>Conclusion: </strong>Both adalimumab and secukinumab demonstrated rapid early response in this Chinese HS cohort. Within the 16-week observation window, a numerical trend toward more stable response was observed in the secukinumab group; however, given the retrospective design, small sample sizes, and absence of propensity score adjustment, no causal or comparative superiority conclusions can be drawn. These findings are hypothesis-generating and require validation in larger prospective studies.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1"},"PeriodicalIF":3.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educating the Future Dermatology Workforce for Global Healthcare Delivery: Strategies and Resources to Prepare Dermatology Residents for Engagement in Global Work.","authors":"Maya Akbik, Brianna Spiegel, Richard Tran, Beatrix Thompson, Vinod E Nambudiri","doi":"10.1159/drm/ackag021","DOIUrl":"10.1159/drm/ackag021","url":null,"abstract":"<p><strong>Background: </strong>Skin and subcutaneous diseases affect up to 900 million individuals worldwide, ranking as the eighteenth leading cause of disability-adjusted life years internationally. The burden is particularly pronounced in low- and middle-income countries, where access to specialized dermatologic care is limited and the prevalence of neglected tropical diseases (NTDs) is high. With increasing globalization, preparing dermatology trainees to deliver care in diverse international settings has become essential.</p><p><strong>Summary: </strong>This narrative review outlines strategies, resources, and approaches to prepare dermatology residents for global health engagement. Key educational modalities include teledermatology training for remote consultation and cultural exposure, international clinical rotations at partner institutions, and formal academic partnerships emphasizing bidirectional exchange. Integration of health policy and health delivery science training equips residents to address system-level barriers in resource-limited settings. Critical implementation strategies include securing funding through organizations such as the International Alliance for Global Health Dermatology (GLODERM), International League of Dermatological Societies (ILDS), and American Academy of Dermatology (AAD), alongside training on diverse skin types and NTDs. Comprehensive assessment frameworks measuring knowledge, attitudes, and practices across pre-deployment, during-rotation, and post-deployment phases ensure meaningful competency development.</p><p><strong>Key messages: </strong>Structured global health education during dermatology residency serves three tractable goals: reducing skin disease burden in resource-limited settings through direct clinical service, cultivating residents' sustained commitment to global health work beyond training, and building lasting capacity within host-country institutions. Multimodal training approaches combining teledermatology, international rotations, and didactic curricula prepare residents for ethical and effective global engagement. Sustainable partnerships with international institutions and robust assessment methodologies are fundamental to developing a globally competent dermatology workforce capable of addressing worldwide skin disease burden.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1"},"PeriodicalIF":3.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Skin and Gut Microbiome in Hidradenitis Suppurativa.","authors":"Aditya K Gupta, Amanda Liddy, Ditte Marie L Saunte, Vincent Piguet, Gregor Jemec","doi":"10.1159/drm/ackag018","DOIUrl":"https://doi.org/10.1159/drm/ackag018","url":null,"abstract":"<p><p>Recent evidence indicates that both the bacterial composition of the skin and gut microbiota may contribute to the pathogenesis and progression of hidradenitis suppurativa (HS). Several studies have identified alterations in the skin bacterial microbiota, including an increased abundance of anaerobic taxa such as Prevotella spp. and Porphyromonas spp., alongside a reduction in commensal species like Cutibacterium spp., changes that may promote chronic inflammation and biofilm formation. Comparative analyses of lesional versus non-lesional skin have also revealed enrichment of bacterial pathways related to cell growth, DNA replication, and mismatch repair, suggesting enhanced microbial proliferation within HS lesions. Emerging evidence further suggests the presence of bacterial gut dysbiosis in HS, with some studies reporting reduced microbial diversity and lower abundance of protective genera Ruminococcaceae, and Lachnospiraceae families. Efforts to modulate the skin and gut microbiota in HS are underway, exploring approaches such as dietary modification, antibiotic usage, and probiotic supplementation. Moreover, comorbid conditions frequently associated with HS appear to influence disease severity and may mediate the relationship between microbial imbalance and systemic inflammation. Despite these insights, current research remains fragmented, characterized by small sample sizes, heterogeneous study designs, and a scarcity of robust interventional data.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1"},"PeriodicalIF":3.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Sunscreen Products for Babies and Children with Those for Adults.","authors":"Céline Couteau, Anne Philippe, Jean-Michel Galharret, Laurence Coiffard","doi":"10.1159/000551079","DOIUrl":"10.1159/000551079","url":null,"abstract":"<p><strong>Introduction: </strong>Topical sun protection is one of the methods used to prevent skin cancer. It is recommended that teenagers and children use sunscreen when exposed to the sun. For babies, the use of sunscreens is strongly discouraged before the age of 6 months.</p><p><strong>Methods: </strong>The aim of this work is to compare baby sunscreens with adult products in order to evaluate their safety and effectiveness. The sample of products studied includes both conventional and organic products, i.e., products that are certified by organisations like Ecocert. In these analyses, we used Welch's tests to compare the mean between two categories of sunscreen.</p><p><strong>Results: </strong>At the 5% level, organic creams contain significantly fewer filters and ingredients than conventional creams. The percentage of organic products with ethyl alcohol is also significantly lower than conventional products. For the number of allergens, the difference between organic and conventional creams is not significant. The number of filters in organic creams is significantly lower than in conventional baby creams, which themselves contain significantly fewer than in conventional adult creams. For the other characteristics (number of allergens, ingredients, and presence of ethyl alcohol), there is no significant difference between organic and conventional baby creams, which are themselves significantly different from conventional adult creams.</p><p><strong>Conclusion: </strong>More precisely, the conventional and organic baby creams are made with significantly fewer ingredients and allergens than the conventional adult creams, but the proportion of creams containing ethyl alcohol is lower in the organic creams than in the conventional baby and adult creams, which are not significantly different.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-7"},"PeriodicalIF":3.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trio-Based Whole-Exome Sequencing Identifies Convergent Epithelial Junction-Related Pathways in Syndromic Hidradenitis Suppurativa.","authors":"Chiara Moltrasio, Paola M Tricarico, Elena M Nardacchione, Ronald Moura, Sara Roncarà, Francesca Satolli, Flavia Manzo Margiotta, Valentina Dini, Angelo V Marzano, Sergio Crovella","doi":"10.1159/drm/ackag016","DOIUrl":"10.1159/drm/ackag016","url":null,"abstract":"<p><strong>Introduction: </strong>Hidradenitis suppurativa (HS)-related autoinflammatory syndromes, simply termed syndromic HS (sHS), represent a group of rare immune-mediated inflammatory disorders in which HS coexists with systemic or cutaneous autoinflammatory features like PASH (pyoderma gangrenosum [PG], acne, and HS), PAPASH (PASH, pyogenic arthritis), PASS (PG, acne, HS, and ankylosing spondylitis), and SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis). In recent years, genetic studies identified several novel pathogenic variants underlying sHS; however, most investigations rely exclusively on affected individuals' sequencing, and the absence of parental genomic information limits the possibility of determining inheritance patterns.</p><p><strong>Methods: </strong>This study aimed to address these gaps; we performed trio-based whole-exome sequencing on five individuals diagnosed with sHS and their unaffected parents.</p><p><strong>Results: </strong>The pathway related to epidermal adhesion and desmosome organization was the most represented across our cohort, encompassing seven genes: DSC3, DSG1, FAT1, LAMA3, MICALL2, PLEC, and TJP2. Integrin-extracellular matrix (ECM) adhesion signaling pathway, represented by ten genes (CSPG4, FERMT3, ITGA3, LAMA3, LAMA5, LIMS2, LTBP3, PLEC, TGM2, and TNC), was also retrieved. Also, variants affecting innate immune pathways, including cytokine signaling and antigen presentation, have been observed.</p><p><strong>Conclusion: </strong>Our exploratory findings suggest that genetically heterogeneous variants in syndromic HS converge on biological processes involving epithelial junction organization, ECM interactions and innate immune regulation. Although not establishing a unique pathogenic mechanism, these observations identify epithelial barrier biology as a candidate pathway warranting validation in larger cohorts and functional studies.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1"},"PeriodicalIF":3.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resorcinol in Dermatology: Reassessing a Legacy Topical Therapy for Contemporary Clinical Use.","authors":"Omar Raheel, Natalie Asemi, Aarushi Gulati, Victoria McGuirt, Maham Usmani, Steven R Feldman","doi":"10.1159/drm/ackag017","DOIUrl":"10.1159/drm/ackag017","url":null,"abstract":"<p><strong>Background: </strong>Resorcinol is a phenolic topical agent with a long history in dermatology, but its role in contemporary practice has narrowed substantially. This review summarizes the mechanism, formulation considerations, clinical applications, safety profile, and future relevance of topical resorcinol.</p><p><strong>Summary: </strong>Resorcinol has keratolytic, antiseptic, antifungal, anti-inflammatory, and tyrosinase-inhibitory properties that support its use in acne, hidradenitis suppurativa, chemical peels, hyperkeratotic disorders, and pigmentary conditions. Despite historical use in acne, current evidence and guideline support are limited, and resorcinol remains largely absent from routine acne management. In contrast, topical resorcinol has a more defined role in mild to moderate hidradenitis suppurativa, particularly as a nonantibiotic option for localized inflammatory lesions. Safety concerns, especially thyroid toxicity, have contributed to its decline. However, reported systemic toxicity largely involved prolonged high-dose application to ulcerated or compromised skin, which differs from limited modern dermatologic use. Practical barriers, including lack of commercial availability at clinically relevant concentrations and dependence on compounding, also limit adoption.</p><p><strong>Key messages: </strong>Resorcinol may be better viewed as an underused legacy compound rather than an obsolete therapy.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1"},"PeriodicalIF":3.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Epidermal and Dermal Expression of Human β-Defensin-3 in Paired Lesional and Non-Lesional Psoriatic Skin.","authors":"Fatima Zahra Elfatoiki, Imane Tabyaoui, Farida Marnissi, Latifa Badre, Zineb Serhier, Mohamed Bennani Othmani, Soumiya Chiheb, Hassan Fellah, Nadia Tahiri Jouti","doi":"10.1159/drm/ackag009","DOIUrl":"10.1159/drm/ackag009","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis is a chronic immune-mediated skin disorder characterized by both epidermal hyperproliferation and sustained inflammation. Despite disrupted skin barrier function, psoriatic plaques are rarely associated with infections, a resistance largely attributed to the overexpression of antimicrobial peptides (AMPs), including human β-defensin-3 (hBD-3), a key effector of the innate immune response. This study aimed to evaluate and compare the expression profile of hBD-3 in lesional and non-lesional skin of Moroccan psoriatic patients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 33 patients with plaque psoriasis. hBD-3 expression was evaluated by immunohistochemistry using a semi-quantitative approach. Comparative analyses were performed to assess epidermal layer expression (ELE) and dermal lymphocytic infiltration (DIL).</p><p><strong>Results: </strong>Approximately 86.7% of lesional psoriatic samples showed hBD-3 ELE throughout all epidermal layers, whereas in healthy skin, hBD-3 expression was predominantly detected (82.8%) in all layers except the stratum corneum. Moderate to strong hBD-3-positive DIL characterized lesional sites, whereas non-lesional dermis showed predominantly weak or absent DIL. The paired McNemar-Bowker test revealed a significantly higher epidermal (p < 0.0001) and dermal (p = 0.0034) immunohistochemical expression of hBD-3 in lesioned areas compared to healthy skin.</p><p><strong>Conclusion: </strong>Our findings confirm the overexpression of hBD-3 in lesional skin and reveal, for the first time, to the best of our knowledge, its significant presence in dermal lymphocytes, as a result of the inflammatory microenvironment of psoriatic disease.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1"},"PeriodicalIF":3.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey-Based Research: When Artificial Intelligence and Dermatologists Disagree, What Do Patients Choose?","authors":"Inês Tribolet de Abreu, Filipe Silva Monteiro, Gustavo Almeida Silva, Inês Pereira Amaral, Ivânia Soares, Miguel Duarte Reis","doi":"10.1159/drm/ackag015","DOIUrl":"10.1159/drm/ackag015","url":null,"abstract":"<p><strong>Introduction: </strong>Artificial intelligence (AI) shows significant promise in dermatology, particularly in image-based diagnostics. However, patient perceptions and trust in AI compared to dermatologists remain poorly understood.</p><p><strong>Methods: </strong>A cross-sectional survey study was conducted among adult patients attending the dermatology department of two hospitals in Lisbon between October 2024 and May 2025. The survey included 12 questions assessing technological literacy, attitudes toward AI, and responses to two hypothetical clinical scenarios involving conflicting recommendations from AI and dermatologists.</p><p><strong>Results: </strong>A total of 196 patients participated. Most respondents were technologically literate, though 78.6% were unfamiliar with AI applications in dermatology. While 61.3% believed AI could improve diagnostic accuracy, only 7.2% of participants agreed that it could replace dermatologists. In clinical scenarios with conflicting recommendations, most patients preferred seeking a second opinion from another dermatologist rather than following AI advice.</p><p><strong>Conclusion: </strong>Patients view AI as a potentially valuable supportive tool in dermatology but place greater trust in human expertise. These findings highlight the importance of framing AI as an adjunct to, rather than a substitute for, dermatologists in clinical practice.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1"},"PeriodicalIF":3.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}