Dermatology最新文献

{"title":"Implementation of a multidisciplinary medical-surgical consultation in hidradenitis suppurativa improves patient journey and time to surgery.","authors":"Carmen García-Moronta, Francisco Javier León-Pérez, Sofía Haselgruber, Alberto Soto-Moreno, Alberto Carrillo-Acosta, Obdulia Cañadas-Moreno, Irene Navas-Martínez, Ignacio Puche-Sanz, Carlos Cuenca-Barrales, Salvador Arias-Santiago, Alejandro Molina-Leyva","doi":"10.1159/000544999","DOIUrl":"https://doi.org/10.1159/000544999","url":null,"abstract":"<p><p>Introduction Surgery is a crucial part in the treatment of hidradenitis suppurativa (HS). The integration of surgical and medical treatment is sometimes difficult to achieve as it involves different specialists. The aim of this study is to describe and evaluate the role of a multidisciplinary medical-surgical consultation for patients with HS. Methods We performed a cohort study to describe patient characteristics, assess referral reasons, analyse decisions made during the multidisciplinary consultation and evaluate its impact on time to surgery and disease control. Results The profile of the patient referred to the multidisciplinary consultation is a man with severe disease. The lesions prompting referral were usually located on the lower part of the body. Surgery was indicated in 73.91% of patients. In terms of medical treatment, 30.43% of patients underwent modifications to their biological therapy, including the introduction of a new biologic drug and target (23.91%) or dosage changes (6.52%). There was a significant reduction in the waiting time to be operated by general surgery after the implementation of this consultation (420.65 vs 167 days). Conclusions The results of this study suggest that the presence of a multidisciplinary surgical consultation in HS may be useful in treating patients with complex structural disease, optimising resources and improving comprehensive patient care. Additionally, it can have a positive impact on time to surgery, which is highly relevant for a progressive disease such as HS.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dose-response relationship between tobacco smoking and hidradenitis suppurativa: results from an observational study of 1689 patients.","authors":"Marine Chastagner, Léa Donzier, Farida Benhadou, Axel P Villani, Philippe Guillem","doi":"10.1159/000545833","DOIUrl":"https://doi.org/10.1159/000545833","url":null,"abstract":"<p><strong>Introduction: </strong>Available studies show conflicting results on the relationship between smoking characteristics (age at beginning, importance of consumption) and disease characteristics (disease onset, phenotype and severity).The objective of the study was to better understand the influence of smoking on HS characteristics.</p><p><strong>Methods: </strong>The clinical characteristics and smoking habits of 1689 HS patients were assessed and compared between never-, past-, and active-smokers using Student's t, Fischer's exact, and χ² tests. Association analyses were done using Spearman's method and logistic regressions.</p><p><strong>Results: </strong>There was a positive association between the mean age at smoking onset and the mean age at HS onset (ρ=0.4; p<0.001). Smokers were associated with a more severe disease: the number of affected sites was positively associated with the number of pack-years (ρ=0.126, p=0.0002). There was also a significant association between active-smoking and a poorer quality of life (p<0.001), as well as increased pain during HS flares (p<0.003).</p><p><strong>Conclusion: </strong>Smoking early is associated to earlier onset of HS and heavy HS smokers develop a more severe disease in a dose-response manner. These results may support evidence-based counselling efforts for smoking cessation in HS patients and patients at risk of HS.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-20"},"PeriodicalIF":3.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are JAK1 inhibitors safe from infection for patients with atopic dermatitis? They inhibit the functions of G-CSF and interferons.","authors":"Hiroshi Katayama","doi":"10.1159/000546432","DOIUrl":"https://doi.org/10.1159/000546432","url":null,"abstract":"","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-6"},"PeriodicalIF":3.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective study of nevus-associated melanoma in situ.","authors":"Clio Dessinioti, Angelliki Befon, Mihaella Plaka, Aikaterini Niforou, Katerina Kypreou, Electra Nicolaidou, Antonina Lingria, Alexander Stratigos","doi":"10.1159/000546226","DOIUrl":"https://doi.org/10.1159/000546226","url":null,"abstract":"<p><strong>Introduction: </strong>The frequency and type of nevus association in histology in melanoma in situ (MIS) is unclear.</p><p><strong>Methods: </strong>We performed a retrospective study to investigate the characteristics, frequency and type of adjacent nevus in histology (common or dysplastic) in MIS. Lentigo maligna (LM) and in situ acral lentiginous melanomas (ALM) were excluded.</p><p><strong>Results: </strong>From 1991 to 2023, there were 448 available non-lentigo maligna/non-ALM MIS. MIS were nevus-associated (NAM-MIS) in 353 cases (79%). Of these cases, 326 NAM-MIS (94%) had dysplastic nevus remnants. Among the dysplastic nevus-MIS, 176 (54%) were adjacent with severely dysplastic nevus. Nevus-associated MIS vs de novo MIS were more frequently located on the trunk (54% vs 36%), and less frequently located on the head/neck (8% vs 11%) (p=0.02).</p><p><strong>Conclusions: </strong>Nevus association is a common finding in MIS and almost all of nevus-associated MIS were associated with a dysplastic nevus. These findings may indicate an evolution from severely dysplastic nevus to MIS, and also reflect the equivalent histopathological classification and support their previously proposed biological equivalence as not obligate precursors of invasive melanomas.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-8"},"PeriodicalIF":3.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Analysis of the Electronic Waste Produced by Dermatological Clinics.","authors":"Ryan Scheinkman, Lauren Dender, Jasmine Kannikal, Leah Farhadi, Sheila Sharifi, Keyvan Nouri","doi":"10.1159/000546225","DOIUrl":"https://doi.org/10.1159/000546225","url":null,"abstract":"<p><strong>Background: </strong>Medical waste significantly impacts the environment and contributes to climate change. While the environmental effects of medical waste are well documented, the impact of electronic waste (e-waste) in dermatology generated by the rapid turnover of medical devices, incorporation of new technologies into practice, and the impact of dermatological office equipment waste is often overlooked.</p><p><strong>Summary: </strong>In this article, we describe various sources of medical waste in dermatology clinics, estimate the volume of e-waste and clinical carbon footprint produced by dermatology, and propose solutions for recycling waste to mitigate environmental and human health risks associated with poor waste management practices.</p><p><strong>Key messages: </strong>Incorporating the use of recycling programs in dermatology clinics targeted at minimizing e-waste is a multi-step process that involves: (a) Sorting electrical waste components, (b) Pre-processing hazardous materials for removal, (c) Dismantling equipment for material recycling or disposal, (d) Processing materials for neutralization and disposal of hazardous agents, (e) Recycling elements and devices with preserved utility, and (f) Disposal of unsalvageable or hazardous articles for destruction or discardment. While there is a gradual evolution toward eco-friendly product design, the establishment of health-conscious industry standards and endorsing responsible waste-management practices are essential in the interim reduce the health and environmental impacts of e-waste by dermatology clinics and the healthcare footprint at large.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-8"},"PeriodicalIF":3.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for the development of a Core Outcome Set for Inherited Ichthyosis (COSII).","authors":"Vanya S V J Rossel, Jason Shourick, Maria C Bolling, Anna M G Pasmooij, Karin Veldman, Jamie J Kirkham, Juliette Mazereeuw-Hautier, Antoni H Gostyński","doi":"10.1159/000546035","DOIUrl":"https://doi.org/10.1159/000546035","url":null,"abstract":"<p><p>Introduction Inherited ichthyosis comprise a group of rare keratinization disorders caused by abnormal epidermal barrier function. Ichthyosis is yet incurable and current treatments mainly focus on alleviating symptoms such as scaling, erythema and pruritus. Recent developments show promising results for interventions based on the immune-phenotype like biologicals or pathogenesis-based therapies such as gene therapy. However, the lack of uniform reporting and variety of treatment outcomes may complicate performing and comparing efficacy studies. The core outcome set for inherited ichthyosis (COSII) aims to develop a core outcome set (COS), i.e. the minimum of outcomes that should be measured and reported in effectiveness research, including a minimum set of baseline characteristics. Methods The COSII project will follow the guidelines from the Core Outcome Measures in Effectiveness Trials (COMET) initiative including the Core Outcome Set-STAndards for Development (COS-STAD) recommendations and the Core Outcome Set Standardised Protocol (COS-STAP) checklist. The COS development methodology, including this protocol, follows guidance of the CHORD COUSIN Collaboration 'C3'. The first stage of this project involves identifying a possible list of outcomes through performing a scoping literature review and conducting interviews with patient(s) (representatives). This list will be presented to five different stakeholders groups: healthcare professionals, researchers, patient(s) (representatives), industry representatives and regulators. All stakeholders will rate the importance of each outcome in a three-round eDelphi survey. Ultimately, a virtual consensus meeting will be convened to finalize the COS. Ethical approval was obtained prior to the start of this project from the Medical Ethics Committee board at Maastricht University Medical Centre (METC 2022-3192). Informed consent will be asked prior to enrolment in the eDelphi. This study is registered with the COMET. The results will be distributed via a peer-reviewed journal, communicated to all relevant parties and showcased at national and international conferences. Conclusion This will be the first COS for inherited ichthyosis research in accordance with the Core Outcome Measures in Effectiveness Trials initiative. The development of a COS aims to improve consistency of reporting and the heterogeneity of outcomes in ichthyosis research.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-12"},"PeriodicalIF":3.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Upadacitinib Efficacy in the Treatment of Atopic Dermatitis of Sensitive Areas.","authors":"Niccolò Gori, Marco Galluzzo, Andrea Chiricozzi, Teresa Grieco, Camilla Chello, Filomena Russo, Ersilia Tolino, Flavia Pigliacelli, Anna Maria Mazzotta, Marina Talamonti, Claudia Paganini, Giacomo Caldarola, Barbara Cocuroccia, Flaminia Antonelli, Luisa Boeti, Domenico Giordano, Luca Bianchi, Clara De Simone, Giovanni Pellacani, Ketty Peris","doi":"10.1159/000545227","DOIUrl":"10.1159/000545227","url":null,"abstract":"<p><strong>Introduction: </strong>The treatment of atopic dermatitis (AD) affecting sensitive areas (head and neck, hands, and genitalia) remains a significant challenge, even with the advent of the current range of biologic therapies. Upadacitinib, a selective inhibitor of the JAK1 enzyme, showed promising results in the treatment of AD located in sensitive areas in clinical trials. The aim of this multicenter observational study was to better characterize the effectiveness of upadacitinib in sensitive areas, using specific clinimetric tools.</p><p><strong>Methods: </strong>In this multicenter observational retrospective and prospective study, we enrolled 74 adult patients (41 women and 37 men, with a mean age of 33.8 years), affected by moderate to severe AD with the involvement of at least one sensitive area, treated with upadacitinib with at least 16 weeks.</p><p><strong>Results: </strong>Over the course of the 52-week study period, upadacitinib demonstrated remarkable efficacy in the reduction of AD symptoms and associated clinical manifestations in sensitive areas.</p><p><strong>Conclusion: </strong>Our study demonstrates a significant benefit for patients with AD affecting sensitive areas when treated with upadacitinib, supporting its use first-line therapeutic choice for this specific subset of patients.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-7"},"PeriodicalIF":3.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of interpretable machine learning algorithm to predict lymph node metastasis in cutaneous malignant melanoma.","authors":"Xinyue Wang, Wentao Liu, Wei Wei, Runkai Mao, Dan Li, Menglin Lu, Xiao Shen, Peng Chen","doi":"10.1159/000545959","DOIUrl":"https://doi.org/10.1159/000545959","url":null,"abstract":"<p><strong>Introduction: </strong>Cutaneous malignant melanoma (CMM) is the most lethal form of skin cancer worldwide. The precise prediction of lymph node metastasis is critical for personalized treatment and improved patient outcomes. However, no prior study has employed interpretable machine learning techniques to predict lymph node metastasis in CMM. This study aimed to utilize interpretable machine learning to integrate multidimensional data from the Surveillance, Epidemiology, and End Results (SEER) database-encompassing clinical characteristics, pathological information, and biomarkers of CMM-to construct various predictive models for lymph node metastasis.</p><p><strong>Methods: </strong>We constructed six machine learning models to predict lymph node metastasis using clinical, pathological, and biomarker data from 2448 patients with CMM in the SEER database.These models comprise a support vector machine, random forest (RF), XGBoost, LightGBM, adaptive boosting, and gradient boosting decision tree. The primary influential factors were identified using Gaussian Naive Bayes and gradient boosting algorithms. Shapley additive explanations (SHAP) analysis facilitates visual interpretation in individual patients. Model performance was evaluated based on accuracy, sensitivity, specificity, Brier score, and area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>The RF algorithm exhibited the highest predictive performance with an AUC of 0.897, accuracy of 0.821, sensitivity of 0.876, specificity of 0.765, and Brier score of 0.086. The primary influential variables were T stage, chemotherapy, ulceration, pretreatment lactate dehydrogenase (LDH) levels, and radiation therapy. SHAP analysis confirmed a significant association and highlighted the critical function of (LDH) as a predictive biomarker.</p><p><strong>Conclusion: </strong>This study successfully established an accurate predictive model for lymph node metastasis in patients with CMM using machine-learning techniques, offering a significant reference to aid clinician treatment decisions.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-24"},"PeriodicalIF":3.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing ex vivo skin imaging: 3D characterization of skin tumors with ex vivo LC-OCT. A pilot study.","authors":"Pau Rosés-Gibert, Jean-Luc Perrot, Javiera Pérez-Anker, Christian Dorado Cortez, Carmen Orte Cano, Elisa Cinotti, Véronique Del Marmol, Margot Fontaine, Jilliana Monnier, Pietro Rubegni, Linda Tognetti, Mariano Suppa, Susana Puig, Josep Malvehy","doi":"10.1159/000545960","DOIUrl":"https://doi.org/10.1159/000545960","url":null,"abstract":"<p><p>Introduction Numerous imaging techniques, such as Reflectance Confocal Microscopy (RCM), Optical Coherence Tomography (OCT), and Line-field Confocal OCT (LC-OCT), are available for skin evaluation. However, there remains a need for improved imaging methods to better understand tumor histology and enhance surgical margin detection. This study aimed to evaluate the quality of ex vivo LC-OCT images in cutaneous tumors, describe their morphological features, and correlate the findings with dermoscopy, in vivo RCM, and histology.</p><p><strong>Methods: </strong>A prospective study was conducted from June 2022 to July 2023, including patients aged ≥18 years with cutaneous tumors on the trunk or limbs. Clinical, dermoscopic, RCM, ex vivo LC-OCT, and histopathological images were collected from 10 tumors, including melanomas, seborrheic keratoses, basal cell carcinomas, and melanocytic nevi.</p><p><strong>Results: </strong>Ex vivo LC-OCT produced high-quality images equivalent to those from in vivo devices, enabling three-dimensional visualization of excised tumors. The images displayed cellular resolution with strong correlations to confocal microscopy and histology.</p><p><strong>Conclusions: </strong>Ex vivo LC-OCT shows promise for improving the evaluation of cutaneous tumors and may enhance dermato-oncological surgery, particularly in margin control.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-18"},"PeriodicalIF":3.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlighting Migration in Dermatology: Population characteristics among patients seen in a dermatological out-patient clinic in Southern Sweden.","authors":"Amna Elyas, Åke Svensson, Francesca Sampogna, Slobodan Zdravkovic, Jörg Kupfer, Florence Dalgard","doi":"10.1159/000545938","DOIUrl":"https://doi.org/10.1159/000545938","url":null,"abstract":"<p><p>Introduction Migration is an increasing phenomenon and associated with a physical and psychosocial burden on individuals. Little is known about migration and skin health. The objective of this study is to describe the characteristics of patients regarding migration background and dermatological morbidity among adults seen in a dermatological out-patient clinic in Malmo, Sweden. Methods An observational cross-sectional study was performed in 2017. Dermatological outpatients completed questionnaires and were examined by a dermatologist. Sociodemographic variables including ethnicity and migration status were assessed by self-report. Ethnicity was assessed with country of birth. General and physical health and details about skin disease were self-reported. Stress was assessed by the Perceived Stress Scale (PSS) and with items assessing stressful life events and economic difficulties. Depression and anxiety were assessed with The Patient Health Questionnaire-2 (PHQ-2) and The General Anxiety Disorder Assessment-2 (GAD-2). Results 250 patients were included. 24% were foreign born (FB) reporting 41 different countries of birth. Mean duration of living in Sweden was 24.4 years. Compared to non-foreign born (NFB) patients, FB patients were more stressed (PSS mean 17.5 vs 15.3, p = 0.044), had more economic difficulties (31.0% vs 14.6%, p = 0.005) and more anxiety (39.7% vs 24.9%, p = 0.03). There were significantly fewer patients with psoriasis in FB and more with connective tissue disease. FB rated skin disease severity significantly higher than NFB patients Conclusion This study reports the multi-ethnic population in an out-patient dermatological clinic in Malmo, Sweden and the difference in distribution of dermatological conditions among FB patients and NFB patients as well as the burden of disease, with higher levels of stress and anxiety in FB patients. These issues will be investigated further by our group in a larger multicentre study.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}