Developmental pharmacology and therapeutics最新文献_第7页

Patient-controlled versus conventional analgesia for postsurgical pain relief in adolescents. 青少年术后镇痛的患者控制镇痛与常规镇痛比较。

Developmental pharmacology and therapeutics Pub Date : 1992-01-01 DOI: 10.1159/000457460

P D Walson, P S Graves, M E Mortensen, R A Kern, M A Torch

引用次数: 17

Wilson's disease treatment by triethylene tetramine dihydrochloride (trientine, 2HCl): long-term observations. 盐酸三烯四胺治疗肝豆状核变性:长期观察。

Developmental pharmacology and therapeutics Pub Date : 1992-01-01 DOI: 10.1159/000457456

J Morita, M Yoshino, H Watari, I Yoshida, T Motohiro, F Yamashita, Y Okano, T Hashimoto

引用次数: 12

7-Ethoxycoumarin metabolism in hepatocytes from pre- and postpubescent male rats. 雄性大鼠青春期前和青春期后肝细胞的乙氧香豆素代谢。

Developmental pharmacology and therapeutics Pub Date : 1992-01-01

L B Roochvarg, R G Thurman, F C Kauffman

引用次数: 0

Pharmacodynamics and pharmacokinetics of cyclosporin A in the newborn pig. 环孢素A在新生猪体内的药效学和药代动力学。

Developmental pharmacology and therapeutics Pub Date : 1992-01-01

P W Tsao, S Ito, P Y Wong, I C Radde, S Bryson, D S Young, J Caspi, R J Diaz, M F Martell, J M Augustine

引用次数: 0

Neonatal modulation of hepatic acid soluble sulfhydryls and xenobiotic metabolizing enzymes in suckling mice exposed translactationally to butylated hydroxyanisole. 乳鼠肝酸溶性巯基和外生代谢酶的调节翻译暴露于丁基羟基异构体。

Developmental pharmacology and therapeutics Pub Date : 1992-01-01 DOI: 10.1159/000457472

S K Chhabra, A R Rao

引用次数: 1

Effects of betamethasone and thyroid hormone on fetal rat lung maturation in vivo. 倍他米松和甲状腺激素对胎鼠肺成熟的影响。

Developmental pharmacology and therapeutics Pub Date : 1992-01-01 DOI: 10.1159/000480593

F. Moya, I. Sánchez, D. Baudy

引用次数: 2

Prostacyclin synthesis and stimulation of cyclic AMP production in ovine fetal vasculature: heterogeneity in pulmonary and systemic arteries. 前列环素合成和刺激羊胎儿血管循环AMP的产生:肺动脉和全身动脉的异质性。

Developmental pharmacology and therapeutics Pub Date : 1992-01-01 DOI: 10.1159/000480602

P. Shaul, M. Farrar, R. Magness

{"title":"Prostacyclin synthesis and stimulation of cyclic AMP production in ovine fetal vasculature: heterogeneity in pulmonary and systemic arteries.","authors":"P. Shaul, M. Farrar, R. Magness","doi":"10.1159/000480602","DOIUrl":"https://doi.org/10.1159/000480602","url":null,"abstract":"Prostacyclin (PGI2) is an important local mediator of vasomotor tone in the fetus and newborn, acting via stimulation of cAMP production by vascular smooth muscle (VSM) adenylate cyclase. In this investigation PGI2 and prostaglandin (PG) E2 synthesis and stimulation of cAMP production were compared in vitro in ovine fetal pulmonary versus systemic (mesenteric) arteries. PGI2 synthesis was similar in the pulmonary and systemic arteries (2.4 +/- 0.2 and 2.6 +/- 0.3 ng/mg protein.h, respectively), as was PGE2 synthesis (1.9 +/- 0.2 and 1.5 +/- 0.2 ng/mg protein.h, respectively); synthesis was greater for PGI2 versus PGE2 in both artery types. 65-71% of PGI2 synthesis and 51-59% of PGE2 synthesis occurred in the endothelium. Basal (nonstimulated) cAMP production was fully attenuated by indomethacin, indicating that it is mediated exclusively by endogenous PG. Basal cAMP production was 3.8-fold less in pulmonary versus systemic arteries, and this was related to a 9.7-fold difference in responsiveness to PG. A 14.7-fold difference in the response to forskolin indicates that underlying mechanism may be a disparity in the quantity and/or function of the adenylate cyclase enzyme complex. Thus, prostacyclin and PGE2 synthesis are comparable in ovine fetal pulmonary versus systemic arteries, but the cAMP response to the prostanoids is markedly greater in the latter artery type due to differences in the activation of adenylate cyclase. This heterogeneity in VSM intracellular signalling may contribute to differential vasomotor tone and responses in the fetal pulmonary and systemic circulation.","PeriodicalId":11160,"journal":{"name":"Developmental pharmacology and therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84157348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Developmental pharmacology and therapeutics Pub Date : 1992-01-01 DOI: 10.1159/000480591

J. Raj, P. Kaapa, J. Anderson

{"title":"Age-related differences in vascular effects of pentoxifylline in isolated perfused ferret lungs.","authors":"J. Raj, P. Kaapa, J. Anderson","doi":"10.1159/000480591","DOIUrl":"https://doi.org/10.1159/000480591","url":null,"abstract":"We have determined the magnitude and sites of action of pentoxifylline (PTX), a methylxanthine derivative, in the adult and 3- to 4-week old ferret pulmonary circulation. Lungs of 8 ferrets, four 3- to 4-week-old and 4 adult, were isolated and perfused with blood. During perfusion, blood flow was kept constant, as were airway and left atrial pressures (6 and 8 cm H2O respectively, zone 3 conditions). In all lungs, pulmonary artery pressure was measured continuously and the circulation was partitioned into arteries, microvessels and veins, by measurement of pressures in 20-50 microns diameter subpleural arterioles and venules using the micropipette-servonulling method. Pressures were obtained in each lung during baseline, after vasoconstriction with hypoxia, and again after the infusion of PTX, 20 mg/kg, during hypoxia. We found that with hypoxia, total vascular resistance increased by approximately 90% in both adult and neonatal lungs; arterial and venous resistances increased by 100-180% in both age groups, with little change in microvascular resistance. PTX resulted in a significant decrease in total vascular resistance, due to a decrease in resistance in both arteries and veins. The decrease in resistance with PTX was greater in adult lungs (of the increase in resistance induced by hypoxia, 80% was eliminated by PTX) than in 3- to 4-week old lungs (51% elimination of tone induced by hypoxia). This difference was mainly due to a smaller reduction in arterial resistance with PTX in 3- to 4-week-old lungs. We conclude that PTX is a powerful pulmonary vasodilator in ferrets and that its effectiveness as a vasodilator depends on the age of the animal, the older animal showing greater responsiveness.","PeriodicalId":11160,"journal":{"name":"Developmental pharmacology and therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79826392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Developmental pharmacology and therapeutics Pub Date : 1992-01-01 DOI: 10.1159/000480603

M. Yoshida, J. Latifpour, R. Weiss

引用次数: 7

Atrial natriuretic peptide in newborn piglets with a patent ductus arteriosus. 新生仔猪动脉导管未闭心房利钠肽的研究。

Developmental pharmacology and therapeutics Pub Date : 1992-01-01 DOI: 10.1159/000457477

T A Malone, B S Stonestreet, M Goddard, R Sicard, J C Werner, W Oh

{"title":"Atrial natriuretic peptide in newborn piglets with a patent ductus arteriosus.","authors":"T A Malone, B S Stonestreet, M Goddard, R Sicard, J C Werner, W Oh","doi":"10.1159/000457477","DOIUrl":"https://doi.org/10.1159/000457477","url":null,"abstract":"<p><p>Atrial natriuretic peptide (ANP) is a hormone involved in fluid and blood pressure homeostasis. We studied the effects of left-to-right shunting through a patent ductus arteriosus on blood pressure changes and plasma ANP concentrations in newborn piglets. In five experimental piglets, the ductus arteriosus was bathed with PGE1 and infiltrated with formalin to maintain its patency. In four age-matched control piglets, the ductus arteriosus was ligated. Plasma ANP concentrations and blood pressure determinations were obtained prior to (base-line) and 25 +/- 1 h (day 1), and 48 +/- 1 h (day 2) after surgery. Radionuclide-microsphere determinations of left-to-right patent ductus arteriosus shunts were performed on days 1 and 2 in the 5 piglets with a patent ductus arteriosus. Plasma ANP concentrations were significantly elevated in the left atrium on day 1 and the right atrium on day 2 in the PDA piglets. No correlation was demonstrated between plasma ANP concentrations and right or left atrial pressures. We conclude that left and right plasma atrial ANP concentrations are significantly elevated in newborn piglets with left-to-right patent ductus arteriosus shunts.</p>","PeriodicalId":11160,"journal":{"name":"Developmental pharmacology and therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000457477","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12514422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1