己酮茶碱在离体灌注雪貂肺血管效应的年龄相关性差异。

J. Raj, P. Kaapa, J. Anderson
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引用次数: 4

摘要

我们已经确定了甲黄嘌呤衍生物己酮可可碱(PTX)在成年和3- 4周龄雪貂肺循环中的作用的大小和部位。8只雪貂,4只3 ~ 4周龄,4只成年雪貂,分离肺并灌注血液。灌注时血流保持恒定,气道和左心房压保持恒定(分别为6和8 cm H2O, 3区条件)。采用微移液管-伺服法测量20 ~ 50微米直径胸膜下小动脉和小静脉的压力,连续测量各肺的肺动脉压,将循环分为动脉、微血管和静脉。分别在基线、缺氧时血管收缩后和缺氧时输注PTX (20mg /kg)后测量各组肺压力。我们发现,在缺氧情况下,成人和新生儿肺部的总血管阻力增加了约90%;两组动脉和静脉阻力均增加100-180%,微血管阻力变化不大。PTX导致总血管阻力显著降低,因为动脉和静脉的阻力都降低了。PTX对成人肺阻力的降低(缺氧引起的阻力增加,PTX消除80%)大于3- 4周龄肺阻力的降低(缺氧引起的张力消除51%)。这种差异主要是由于在3至4周大的肺中,PTX的动脉阻力降低较小。我们得出结论,PTX在雪貂中是一种强大的肺血管扩张剂,其作为血管扩张剂的有效性取决于动物的年龄,年龄越大的动物表现出更强的反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age-related differences in vascular effects of pentoxifylline in isolated perfused ferret lungs.
We have determined the magnitude and sites of action of pentoxifylline (PTX), a methylxanthine derivative, in the adult and 3- to 4-week old ferret pulmonary circulation. Lungs of 8 ferrets, four 3- to 4-week-old and 4 adult, were isolated and perfused with blood. During perfusion, blood flow was kept constant, as were airway and left atrial pressures (6 and 8 cm H2O respectively, zone 3 conditions). In all lungs, pulmonary artery pressure was measured continuously and the circulation was partitioned into arteries, microvessels and veins, by measurement of pressures in 20-50 microns diameter subpleural arterioles and venules using the micropipette-servonulling method. Pressures were obtained in each lung during baseline, after vasoconstriction with hypoxia, and again after the infusion of PTX, 20 mg/kg, during hypoxia. We found that with hypoxia, total vascular resistance increased by approximately 90% in both adult and neonatal lungs; arterial and venous resistances increased by 100-180% in both age groups, with little change in microvascular resistance. PTX resulted in a significant decrease in total vascular resistance, due to a decrease in resistance in both arteries and veins. The decrease in resistance with PTX was greater in adult lungs (of the increase in resistance induced by hypoxia, 80% was eliminated by PTX) than in 3- to 4-week old lungs (51% elimination of tone induced by hypoxia). This difference was mainly due to a smaller reduction in arterial resistance with PTX in 3- to 4-week-old lungs. We conclude that PTX is a powerful pulmonary vasodilator in ferrets and that its effectiveness as a vasodilator depends on the age of the animal, the older animal showing greater responsiveness.
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