2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)最新文献_第2页

Cooperative thin filament activation of a kinetic model of cardiac sarcomere dynamics 协同细丝激活心肌肌节动力学的动力学模型

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-04-17 DOI: 10.1109/NEBEC.2015.7117191

J. Raghavan, W. Hunter

{"title":"Cooperative thin filament activation of a kinetic model of cardiac sarcomere dynamics","authors":"J. Raghavan, W. Hunter","doi":"10.1109/NEBEC.2015.7117191","DOIUrl":"https://doi.org/10.1109/NEBEC.2015.7117191","url":null,"abstract":"Actin-myosin crossbridges form in a sarcomere under the control of calcium ions binding to the thin filament. Crossbridges first form weak attachments before they transform into strong bonds that generate force. An appropriately simplified model of this action is critical for developing higherlevel models of cardiac function. Models can be simplified by separating slower from faster processes, where the fast processes have achieved equilibrium. Processes in equilibrium can also be analyzed using the Ising model of statistical mechanics, which allows us to study a row of cooperatively interacting units - as occurs along the thin filament. Using these concepts, the sarcomere model was simplified to 3 states: (1) strong crossbridges attached to a regulatory unit (RU) on the thin filament that had calcium bound to it; (2) strong crossbridges attached to an RU without calcium; (3) an equilibrium mixture of detached and weakly attached crossbridges with and without calcium bound. This simplified model predicted steady-state relationships between force and calcium that reproduced the experimentally seen trend toward less cooperativity as force rises to more than half maximum. It also predicted a trend for clustering of strong crossbridges along the thin filament due to cooperative interactions.","PeriodicalId":111398,"journal":{"name":"2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123015984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering a microfluidic organ model using 3-dimensional micropatterned cellular constructs 利用三维微图案细胞结构构建微流控器官模型

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-04-17 DOI: 10.1109/NEBEC.2015.7117104

E. Clément, S. Knowlton, T. Mandelkern, S. Tasoglu

{"title":"Engineering a microfluidic organ model using 3-dimensional micropatterned cellular constructs","authors":"E. Clément, S. Knowlton, T. Mandelkern, S. Tasoglu","doi":"10.1109/NEBEC.2015.7117104","DOIUrl":"https://doi.org/10.1109/NEBEC.2015.7117104","url":null,"abstract":"This novel design represents a broadly applicable three-dimensional technique for fabricating an “organ-on-a-chip” that serves as a viable platform for tissue studies. Current methods of biological research rely on animal testing and two-dimensional tissue cultures, but fail to provide physiologically accurate models of human tissue. This demonstrates a pressing need for convenient, physiologically relevant tissue models to advance biomedical research. Advances in microfluidics and cell encapsulation within hydrogels have made significant strides in trying to meet these needs, but the potential to use these technologies for engineering physiologically relevant tissue models has yet to be fully realized. Here, we present a microfluidic device which will integrate three-dimensional micro-patterned cellular constructs that may be subjected to flow through microfluidic channels. This microphysiological platform takes advantage of microfluidics, cell encapsulation within 3-dimensional constructs, and microscale patterning of different cell types. This creates a spatially patterned co-culture environment which accurately mimics the physiological conditions within many human organs. Here, we aim to model bone tissue, but the developed technology is generally applicable to any tissue or organ in either the healthy or diseased state. This work represents a significant improvement to biomedical research tools and tissue models currently available.","PeriodicalId":111398,"journal":{"name":"2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129960326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor-penetrating aerosol nanocomposite microparticles for the treatment of lung cancer 穿透肿瘤的气溶胶纳米复合微粒治疗肺癌

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-04-17 DOI: 10.1109/NEBEC.2015.7117203

Elisa A. Torrico-Guzman, Samantha A. Meenach

{"title":"Tumor-penetrating aerosol nanocomposite microparticles for the treatment of lung cancer","authors":"Elisa A. Torrico-Guzman, Samantha A. Meenach","doi":"10.1109/NEBEC.2015.7117203","DOIUrl":"https://doi.org/10.1109/NEBEC.2015.7117203","url":null,"abstract":"One of the major public health problems in the Unites States is cancer, where over 1 in 4 deaths is due to this disease each year. As of 2010, lung and bronchus cancers are the leading types of cancer-related deaths in all ages for males and females in the US [1]. The chemotherapeutic treatment most often applied for lung cancer is intravenous paclitaxel (PTX) in the form of Taxol. Methods used to treat respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) involve the use of aerosols devices. The first use of aerosolized chemotherapy was reported in 1968 [2]. The advantage of using aerosols treatment is the targeting directly to the lungs and the reduction of systemic side effects provoked by high doses of drug in the body. In this project we have developed a dry powder nanocomposite microparticle (nCmP) aerosol containing PTX-loaded nanoparticles comprised of acetalated dextran (Ac-Dex). Ac-Dex is easily biodegradable and results in fast release of therapeutic agents under acidic conditions as seen in tumor tissues [3]. In addition to the drug, a tumor-penetrating peptide (iRDG) was conjugated to Ac-Dex to help the targeting and penetration into the inner layers of solid tumors. Finally, we formulated nCmPs in mannitol via spray drying. The effectiveness of the complex drug produced was tested in lung cancer cells (A459 lung adenocarcinoma) in two-dimensional (2-D) and three-dimensional (3-D) cell culture studies.","PeriodicalId":111398,"journal":{"name":"2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116358419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Design of porous silica gels for bioremediation of aromatic hydrocarbons 芳烃生物修复用多孔硅胶的设计

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-04-17 DOI: 10.1109/NEBEC.2015.7117037

Jonathan K. Sakkos, Daniel P. Kieffer, L. Wackett, A. Aksan

引用次数: 1

Lymphangiectasia detection in Wireless Capsule Endoscopy images using Fisher Transform Method 应用Fisher变换方法检测无线胶囊内窥镜图像中的淋巴管扩张

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-04-17 DOI: 10.1109/NEBEC.2015.7117145

M. Alizadeh, H. Eskandari, K. Sharzehi

引用次数: 3

Re-tessellated mesh-based Monte Carlo for wide-field illumination sources 用于宽视场照明光源的重新细分网格蒙特卡罗

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-04-17 DOI: 10.1109/NEBEC.2015.7117208

Ruoyang Yao, X. Intes, Q. Fang

引用次数: 1

A smartphone based activity analyzer for monitoring and encouraging exercise 基于智能手机的活动分析器，用于监测和鼓励锻炼

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-04-17 DOI: 10.1109/NEBEC.2015.7117225

Nouaying R. Kue, Kelsey Matthews, Nicholas Paiva, E. Chabot, P. Burbank, Ying Sun

引用次数: 3

TCNJ Athlete Tracker TCNJ运动员追踪器

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-04-17 DOI: 10.1109/NEBEC.2015.7117126

R. Cortinas, J. M. Gonzaga, A. R. Green, A. Saulenas, B. BuSha

引用次数: 1

On the detection of independent finger movements through two forearm myoelectrodes 通过两个前臂肌电极检测独立的手指运动

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-04-17 DOI: 10.1109/NEBEC.2015.7117220

P. Steele, J. Brooks, N. Gomes, Y. Sun, E. Chabot

引用次数: 0

The effect of mineralization on the time-dependent flexural deformation of cortical bone 矿化对皮质骨时间依赖性弯曲变形的影响

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-04-17 DOI: 10.1109/NEBEC.2015.7117160

G. Feuer, M. Espitalie, K. Velez, H. Multani, R. Pivec, S. Saha

引用次数: 1