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2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)最新文献

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A three-dimensional printing device to produce organs and tissues for transplant 一种三维打印装置，用于生产供移植的器官和组织
2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-06-04 DOI: 10.1109/NEBEC.2015.7117232
T. J. Korzinski, M. P. Primmer, B. Ulrey
{"title":"A three-dimensional printing device to produce organs and tissues for transplant","authors":"T. J. Korzinski, M. P. Primmer, B. Ulrey","doi":"10.1109/NEBEC.2015.7117232","DOIUrl":"https://doi.org/10.1109/NEBEC.2015.7117232","url":null,"abstract":"Organ failure is a condition where an organ system not able to function as intended, preventing the body from maintaining homeostasis. An organ transplant replaces the patient's organ with a donated organ, but the procedure includes several risks, such as rejection or infection. Organ printers aim to eliminate some risks involved with organ transplantation by producing an organ from the patient's own cells. This organ printer uses a system of motors with three degrees of freedom controlled by a custom written algorithm. The printer will lay down polyethylene glycol and cells onto a biocompatible scaffold where the cells will combine and create a new tissue or organ. Tests will be performed to ensure nozzle precision and flow, speed of printing, and cell survivability.","PeriodicalId":111398,"journal":{"name":"2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124244321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Characterizing the effects of metal oxide nanoparticle ingestion on intestinal function 表征金属氧化物纳米颗粒摄入对肠道功能的影响
2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-06-04 DOI: 10.1109/NEBEC.2015.7117177
Nicole J. Martucci, Rajesh Burela, Gretchen J. Mahler
{"title":"Characterizing the effects of metal oxide nanoparticle ingestion on intestinal function","authors":"Nicole J. Martucci, Rajesh Burela, Gretchen J. Mahler","doi":"10.1109/NEBEC.2015.7117177","DOIUrl":"https://doi.org/10.1109/NEBEC.2015.7117177","url":null,"abstract":"Silicon Dioxide (SiO2) and Titanium Dioxide (TiO2) are engineered nanoparticles often ingested from food and food packaging. SiO2 is a common additive, where it is used as a flow agent or to absorb extra water [1]. TiO2 is commonly used as a pigment for foods including candy and medications, and is often found in cosmetic skin care products [2]. The effects of ingesting these materials, however, is not yet fully understood. The purpose of this study is to characterize the size and surface chemistry of 30 nm SiO2 and TiO2 nanoparticles following digestion and to determine how nanoparticle ingestion affects small intestinal alkaline phosphatase activity.","PeriodicalId":111398,"journal":{"name":"2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124686081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enzyme loaded poly(lactic-co-glycolic acid) nanoparticles as anti-biofilm treatment strategy for chronic biofilm infections 载酶聚乳酸-羟基乙酸纳米颗粒作为抗生物膜治疗慢性生物膜感染的策略
2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-06-04 DOI: 10.1109/NEBEC.2015.7117094
Chendong Han, James S. Goodwine, Nicholas Romero, Julia Dookran, K. Sauer, Amber L. Doiron
{"title":"Enzyme loaded poly(lactic-co-glycolic acid) nanoparticles as anti-biofilm treatment strategy for chronic biofilm infections","authors":"Chendong Han, James S. Goodwine, Nicholas Romero, Julia Dookran, K. Sauer, Amber L. Doiron","doi":"10.1109/NEBEC.2015.7117094","DOIUrl":"https://doi.org/10.1109/NEBEC.2015.7117094","url":null,"abstract":"The enzyme responsible for depleting a key metabolite required by biofilms, was encapsulated into poly(lactic-co-glycolic acid) PLGA nanoparticles in order to develop an adjunctive anti-biofilm treatment therapy.","PeriodicalId":111398,"journal":{"name":"2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)","volume":"05 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130677112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of intercellular conductance and stimuli coupling interval on reentrant arrhythmia 细胞间传导和刺激耦合间隔对再入性心律失常的影响
2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-06-04 DOI: 10.1109/NEBEC.2015.7117189
P. Priya, M. Reddy
{"title":"Effect of intercellular conductance and stimuli coupling interval on reentrant arrhythmia","authors":"P. Priya, M. Reddy","doi":"10.1109/NEBEC.2015.7117189","DOIUrl":"https://doi.org/10.1109/NEBEC.2015.7117189","url":null,"abstract":"Arrhythmia generation post ischemia has been linked to loss of cell-to-cell electrical interaction. Arrhythmias like ventricular fibrillation and tachycardia manifest as reentrant circuits at the tissue level. In this paper, a discrete venticular myocyte network of 100×100 cells interconnected using gap junction conductances is simulated along with an ischemic inclusion to study the wave patterns that arise from the ischemic zone due to varied coupling intervals of the stimulus. It is observed from the simulations that premature excitation of the tissue in presence of an ischemic zone can act as a substrate to induce sustained reentrant arrhythmias. Also, these reentrant wave patterns are generated only within a limited window of reduced coupling intervals.","PeriodicalId":111398,"journal":{"name":"2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131636414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biocompatibility of human Whartons Jelly Mesenchymal Stem Cells on poly-caprolactone and collagen based nanofiber mats 人wharton果冻间充质干细胞在聚己内酯和胶原基纳米纤维垫上的生物相容性
2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-06-04 DOI: 10.1109/NEBEC.2015.7117106
E. Lafond, A. Lawson, R. Niemeier, C. Cady, K. Nair
{"title":"Biocompatibility of human Whartons Jelly Mesenchymal Stem Cells on poly-caprolactone and collagen based nanofiber mats","authors":"E. Lafond, A. Lawson, R. Niemeier, C. Cady, K. Nair","doi":"10.1109/NEBEC.2015.7117106","DOIUrl":"https://doi.org/10.1109/NEBEC.2015.7117106","url":null,"abstract":"Nanofiber scaffolds were fabricated to analyze the proliferation of human Whartons Jelly Mesenchymal Stem Cells (hWJMSCs) for skin tissue engineering applications. Poly-caprolactone (PCL) and PCL mixed with collagen scaffolds were fabricated using electrospinning. ImageJ analysis was carried out on SEM images to characterize the structural and morphological properties of the nanofiber scaffolds. Tensile testing was also performed to quantify the mechanical properties of the scaffolds. The scaffolds were then seeded with hWJMSCs to study cell proliferation over five days in order to determine the feasibility for tissue regeneration. The average fiber diameters for the PCL scaffold and for the PCL/collagen scaffold were 0.542 μm and 0.633 μm, respectively. The Young's Moduli of the PCL and PCL/collagen scaffolds were 0.00370 Pa and 0.00683 Pa. respectively. After analyzing the data, it can be concluded that the PCL/collagen scaffold is better suited for regeneration of damaged or diseased nervous tissue.","PeriodicalId":111398,"journal":{"name":"2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123170793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effect of stimulation shapes on the Steady-State Visual-Evoked response 刺激形状对稳态视觉诱发反应的影响
2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-06-04 DOI: 10.1109/NEBEC.2015.7117158
Sharat S. Embrandiri, S. Teja, Reddy M. Ramasubba, Nitin Chandrachoodan
{"title":"Effect of stimulation shapes on the Steady-State Visual-Evoked response","authors":"Sharat S. Embrandiri, S. Teja, Reddy M. Ramasubba, Nitin Chandrachoodan","doi":"10.1109/NEBEC.2015.7117158","DOIUrl":"https://doi.org/10.1109/NEBEC.2015.7117158","url":null,"abstract":"The strength of Steady-State Visual-Evoked Potentials (SSVEPs) have been observed to greatly depend on the stimulation source and paradigm. Orientation and size specific neurons have been discovered in the occipital cortex, which activate only when excited with specific patterns. Different shapes have different orientation and size aspects that eventually lead to activation of different neuronal groups. In this study, we investigate the potential for a novel shape switching based stimulation paradigm for SSVEP elicitation. Pattern reversal stimuli was found to elicit stronger SSVEP relative to single graphic stimuli. Results indicate that there might exist a subject-dependent connection between the elicited SSVEP and choice of shapes for the stimulation paradigm.","PeriodicalId":111398,"journal":{"name":"2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125010849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Exploiting shape memory to study the effect of change in fiber alignment on cancer cell motility 利用形状记忆研究纤维排列变化对癌细胞运动的影响
2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-06-04 DOI: 10.1109/NEBEC.2015.7117134
J. Wang, J. H. Henderson
{"title":"Exploiting shape memory to study the effect of change in fiber alignment on cancer cell motility","authors":"J. Wang, J. H. Henderson","doi":"10.1109/NEBEC.2015.7117134","DOIUrl":"https://doi.org/10.1109/NEBEC.2015.7117134","url":null,"abstract":"Extracellular matrix (ECM) architecture can play a critical role in cell motility during disease pathogenesis, including that of cancer. Aligned collagen fibers have previously been used to study the effect of ECM architecture on cancer cell motility. Due in part to the stasis of such in vitro model systems, the relationship between changes in ECM architecture and cell motility remains poorly understood. The goal of the present study was to establish a model system to study the effect of change in fiber alignment on cell motility. We present a model system that employs a programmable shape memory electrospun scaffold and automated cell tracking and show that changes in fiber alignment can direct cell motility.","PeriodicalId":111398,"journal":{"name":"2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126326176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An automatic ICA-based method for removing artifacts from EEG data acquired during fMRI in real time 一种基于ica的实时去除fMRI采集的脑电数据伪影的方法
2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-04-17 DOI: 10.1109/NEBEC.2015.7117056
Ahmad Mayeli, V. Zotev, H. Refai, J. Bodurka
{"title":"An automatic ICA-based method for removing artifacts from EEG data acquired during fMRI in real time","authors":"Ahmad Mayeli, V. Zotev, H. Refai, J. Bodurka","doi":"10.1109/NEBEC.2015.7117056","DOIUrl":"https://doi.org/10.1109/NEBEC.2015.7117056","url":null,"abstract":"Simultaneous EEG-fMRI recording provides complementary advantages with regard to the temporal and spatial resolution of neuronal activity measurements. However, raw EEG data collected during fMRI experiments are contaminated by imaging and ballistocardiographic (BCG) artifacts in addition to muscle, ocular, and other EEG artifacts. We describe a new method developed based on independent component analysis (ICA) to automatically detect and remove ocular, muscle and residual imaging and BCG artifacts from EEG data recorded simultaneously with fMRI. The method can be implemented in real time.","PeriodicalId":111398,"journal":{"name":"2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127337761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Multi-sensory system for monitoring dyskinesia in movement disorders 多感觉系统监测运动障碍中的运动障碍
2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-04-17 DOI: 10.1109/NEBEC.2015.7117226
Thomas Lennon, Trevor Bernier, Daniel Tamayo, Cody Goldberg, K. Mankodiya
{"title":"Multi-sensory system for monitoring dyskinesia in movement disorders","authors":"Thomas Lennon, Trevor Bernier, Daniel Tamayo, Cody Goldberg, K. Mankodiya","doi":"10.1109/NEBEC.2015.7117226","DOIUrl":"https://doi.org/10.1109/NEBEC.2015.7117226","url":null,"abstract":"Movement disorders such as Parkinson's disease, ADHD, essential tremor disorder and restless leg syndrome can be difficult to treat due to the complexity of monitoring medication efficacy. Using our multi-sensory system for monitoring dyskinesia disorders, physicians can get insight into the everyday symptoms of their patients. The system we have designed includes an intelligent wristband that has motion sensors to collect and send high quality data of dyskinesia to an application on an Android mobile phone where our signal processing algorithms process the data to be used by physicians for remote healthcare management.","PeriodicalId":111398,"journal":{"name":"2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124868502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Effects of hydrogel properties and extrusion parameters on 3D bioprinting 水凝胶性质和挤出参数对生物3D打印的影响
2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC) Pub Date : 2015-04-17 DOI: 10.1109/NEBEC.2015.7117090
Nathan Tessema Ersumo, K. Spiller
{"title":"Effects of hydrogel properties and extrusion parameters on 3D bioprinting","authors":"Nathan Tessema Ersumo, K. Spiller","doi":"10.1109/NEBEC.2015.7117090","DOIUrl":"https://doi.org/10.1109/NEBEC.2015.7117090","url":null,"abstract":"In recent years, advances in tissue engineering have brought about the development of 3D bioprinting. By encapsulating cells within a biomaterial for three-dimensional extrusion, this efficient and integrated biofabrication method overcomes the limitations of two-dimensional cell culture, allows for the study of complex cell interactions in a physiologically relevant microenvironment and is a promising stepping stone to the functional replacement of lost or damaged tissue. Despite efforts to improve the cytocompatibility of the extruded biomaterial and to induce specific tissue formation upon extrusion, the effects of hydrogel properties on the extruded construct have been poorly characterized. Here, we assess the impact of various parameters, including biomaterial composition, computer-designed structure and printing speed, on the structural integrity, stress distribution and resolution of the extruded construct.","PeriodicalId":111398,"journal":{"name":"2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126634306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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