Dermatologica最新文献

{"title":"Immunophenotyping of skin cells during healing of suction blister injury.","authors":"M K Reusch,&nbsp;J N Mansbridge,&nbsp;B J Nickoloff,&nbsp;V B Morhenn","doi":"10.1159/000247665","DOIUrl":"https://doi.org/10.1159/000247665","url":null,"abstract":"<p><p>The time course of appearance and the dynamic changes of immunocompetent cells were assessed in human skin following sterile suction blister would healing. During epidermal regeneration, a local increase in Langerhans cells (LC) and the appearance of a mononuclear cell infiltrate were observed. Initially, T cells were exclusively of the T helper/inducer subtype, whereas during the later stages of the healing process an increasing number of cytotoxic/suppressor T cells (up to 30%) was observed. Keratinocytes of neither the adjacent nor the newly formed epidermis expressed HLA-DR over the course of the wound-healing process. Our results suggest that immune-competent cells such as T cells and LC may play an important role in the regulation of the wound-healing process.</p>","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"183 3","pages":"179-83"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247665","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12849138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"73rd Annual Meeting of the Swiss Society for Dermatology and Venereology. Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"183 4","pages":"297-307"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12851823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of c-myc in cutaneous lymphomas and pseudolymphomas.","authors":"K Peris,&nbsp;L Cerroni,&nbsp;H Kerl,&nbsp;T Radaszkiewicz,&nbsp;S Chimenti,&nbsp;H Höfler","doi":"10.1159/000247622","DOIUrl":"https://doi.org/10.1159/000247622","url":null,"abstract":"<p><p>The expression of the proto-oncogene c-myc was studied in tumorous skin lesions of (cutaneous) lymphoproliferative diseases (3 cases of pseudolymphoma, 8 cases of non-Hodgkin lymphoma and 1 case of lymph node involvement in mycosis fungoides) in a total of 12 patients. c-myc mRNA levels were quantified by Northern blot analysis followed by densitometric evaluation of the specific bands. Higher levels of c-myc mRNA expression were observed in lymphomas as compared with pseudolymphomas (p greater than 0.05). No significant differences in c-myc mRNA values were detected between B and T cell pseudolymphomas. Our results suggest that c-myc mRNA overexpression is associated with malignant lymphomas of the skin. We conclude that the measurement of c-myc mRNA levels may contribute to further characterize cutaneous lymphoproliferative diseases.</p>","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"183 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247622","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12931518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous metastases from follicular thyroid carcinoma: histology, immunohistology, and electron microscopy. A report of two cases.","authors":"M Tronnier,&nbsp;M Winzer,&nbsp;H H Wolff","doi":"10.1159/000247702","DOIUrl":"https://doi.org/10.1159/000247702","url":null,"abstract":"<p><p>Cutaneous metastases from thyroid carcinoma are extremely rare. We report 2 cases of skin metastases from a follicular thyroid carcinoma. A 53-year-old female patient underwent subtotal thyroidectomy because of the clinical suspicion of malignancy. Histological examination of the resected tissue did not clearly prove malignant features. Eight years later a cutaneous metastasis erupted next to the operation site at the neck. A 66-year-old female patient noticed a growing solitary skin nodule in the occipitoparietal region of her scalp 2 years before a follicular thyroid carcinoma was detected.</p>","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"183 4","pages":"286-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12970568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical minoxidil in monilethrix.","authors":"U Saxena,&nbsp;V Ramesh,&nbsp;R S Misra","doi":"10.1159/000247808","DOIUrl":"https://doi.org/10.1159/000247808","url":null,"abstract":"","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"182 4","pages":"252-3"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247808","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13044283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced versus drug-triggered pemphigus.","authors":"R Wolf,&nbsp;A Tamir,&nbsp;S Brenner","doi":"10.1159/000247795","DOIUrl":"https://doi.org/10.1159/000247795","url":null,"abstract":"<p><p>112 cases of induced pemphigus were reviewed. The causative drugs were divided into three groups according to their chemical structure, and the clinical, prognostic and laboratory characteristics were analyzed and compared. Our literature screening indicates that the biological progress and clinical course of the disease depend upon the type of the inducing/triggering drug in the majority of patients. Patients with penicillamine-induced pemphigus or with pemphigus induced by SH drugs (drugs containing a sulfhydryl radical) showed spontaneous recovery in 39.4 and 52.6%, respectively, once the drug was discontinued. Patients whose pemphigus was induced by other drugs showed spontaneous recovery in only 15% of the cases. These results indicate that in patients with pemphigus induced by penicillamine (or SH drugs), the drug plays a major role in the pathogenesis of the disease, as compared to patients with pemphigus induced by other drugs. It seems that penicillamine (and SH drugs) actually induces pemphigus in most of the cases, whereas other drugs only trigger the disease in patients with a previous predisposition.</p>","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"182 4","pages":"207-10"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247795","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13046424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verrucous carcinoma of a leg amputation stump.","authors":"R A Schwartz,&nbsp;M P Bagley,&nbsp;C K Janniger,&nbsp;W C Lambert","doi":"10.1159/000247782","DOIUrl":"https://doi.org/10.1159/000247782","url":null,"abstract":"<p><p>Verrucous carcinoma of the skin is a rare cancer which tends to appear on the soles of the feet, although it can appear elsewhere on the cutaneous surface. It has not, to our knowledge, been previously reported on a leg amputation stump.</p>","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"182 3","pages":"193-5"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247782","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13040802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased isotretinoin efficacy during acute alcohol intake.","authors":"C Soria,&nbsp;F Allegue,&nbsp;J Galiana,&nbsp;A Ledo","doi":"10.1159/000247785","DOIUrl":"https://doi.org/10.1159/000247785","url":null,"abstract":"","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"182 3","pages":"203"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247785","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12992829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Darier's disease and corneal opacity.","authors":"K N Mohamed","doi":"10.1159/000247787","DOIUrl":"https://doi.org/10.1159/000247787","url":null,"abstract":".Tear film – Surface cells -Wing cells Epithelium-■Basement 7 Bowman’s layer The cornea and conjunctiva can be considered as modified skin ‚ and cutaneous disorders, especially that involving the epidermis, also affect the corneal epithelium. The epithelium, derived from the surface ectoderm is a 5to 6-cell layer forming 10% of the corneal thickness; the stroma which is of mesodermal origin forms about 90% [1]. The basal cells that are attached to the basement membrane by hemidesmosomes give rise to wing cells which become the surface cells and are shed into the tears (fig. 1); thus, the corneal epithelium is structurally and physiologically somewhat similar to the epidermis. A case of Darier’s disease with a peripheral corneal opacity is reported to stress the importance of examining the eyes in this genodermatosis. A 36-year-old Malay lady was referred to the Skin Clinic for a spreading papular, warty lesion on the body since childhood. She was treated in the Eye Ward for a small left corneal ulcer of undetermined cause. The patient was a gravida 8, para 7, in 34 weeks of gestation with no history of injury or foreign body in the eye. She presented with redness, pain, lacrimation and photophobia of the affected eye which on slit-lamp examination showed fluorescein staining of the cornea at the 6-o’clock position and few cells at the anterior chamber. She was treated with mydriatics and antibiotics, and after a week‚ the ulcer healed leaving an oval opacity. A skin biopsy confirmed Darier’s disease; her second son was also affected. We decided to start her on etretinate after a post-partum bilateral tubal ligation. There are several skin disorders, especially genodermatoses, which are associated with corneal changes. In a study involving 21 patients with Darier’s disease, various ocular abnormalities were observed [2]; unique peripheral corneal opacities, central corneal surface irregularities and keratotic plaques on eyelids were seen in 16 patients. The opacities were teardrop-sized to tiny, clustered oval-shaped lesions, and the irregularities were distributed in a radiating cobweb pattern. In two patients trephine biopsy of the opacities showed epithelial oedema especially of the basal cells and thickened basement membrane – features that are different from the skin pathology because the cornea is not a keratinizing epithelium. Darier’s disease in two brothers associated with retinitis pigmentosa has also been reported [3]. In view of the high prevalence of","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"182 3","pages":"205"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247787","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13039398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Borrelia burgdorferi and different types of morphea.","authors":"E. Aberer, H. Klade, G. Stanek, W. Gebhart","doi":"10.1159/000247767","DOIUrl":"https://doi.org/10.1159/000247767","url":null,"abstract":"Thirty patients with different clinical manifestations of morphea (circumscribed scleroderma) were investigated for serum antibodies against Borrelia burgdorferi determined by ELISA and Western blot analysis. Forty-six percent of the patients were seropositive. Western blots confirmed the ELISA results in 10 of 25 patients (40%), showing a reactivity pattern which can be seen in the course of Lyme borreliosis. In some cases the outcome after antibiotic treatment suggests a direct correlation between the further development of skin lesions and Borrelia infection. Because of these findings we suggest some morphea types to be possibly due to a B. burgdorferi infection.","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"33 1","pages":"145-54"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79445861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}