Dermatologica最新文献

{"title":"Clinically relevant differences between amelanotic malignant melanoma and granuloma pyogenicum.","authors":"I D Bassukas,&nbsp;A Kuhnert,&nbsp;T L Diepgen,&nbsp;O P Hornstein","doi":"10.1159/000247750","DOIUrl":"https://doi.org/10.1159/000247750","url":null,"abstract":"<p><p>Macroscopic discrimination between amelanotic malignant melanoma (aMM) and the so-called granuloma pyogenicum (GP) is often uncertain since reliable criteria for a clear differentiation of either growth are lacking. In a search of such criteria we analysed the data of 57 consecutive in-patients with cutaneous aMM and of 83 with GP presenting at our Department during the years 1970-1988. The following items were compared with each other: duration from growth onset to definite diagnosis, site of growth, age and sex of the patients. Significant differences (p less than 0.01) between either growth were found for all items evaluated. Our results substantiate the hitherto gained impression of a remarkably shorter median history of GP as compared to aMM (5 vs. 26 weeks). Furthermore, aMM prevailed in elder (age greater than 50 years) particularly female (70%) patients, whereas GP developed about equally in both sexes and at all ages. Site distribution was also found to differ for either growth (GP predominantly in the head and neck region, rarely on lower limbs; aMM in all areas, rarely on the trunk). These data yield additional measures for clinical distinction between aMM and GP.</p>","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"182 2","pages":"81-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247750","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13206486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudohomozygous type II hyperlipoproteinemia.","authors":"M Fujita,&nbsp;S Okamoto,&nbsp;K Shirai,&nbsp;Y Saito,&nbsp;S Yoshida","doi":"10.1159/000247753","DOIUrl":"https://doi.org/10.1159/000247753","url":null,"abstract":"<p><p>Nodular xanthomas on both elbows and a streak-like xanthoma on the intergluteal area developed in a 4-year-old girl with type IIa hyperlipoproteinemia. She had no disease associated with secondary hypercholesterolemia and no family history of hypercholesterolemia. Her xanthomas regressed under fat restriction diet and cholestyramine therapy. She was diagnosed as having pseudohomozygous type II hyperlipoproteinemia. The low-density lipoprotein (LDL) receptor activities of her cultured fibroblasts in terms of binding, internalization and degradation rate of LDL were normal. These results are consistent with a new syndrome of pseudohomozygous type II hyperlipoproteinemia and suggest that the mechanism of hypercholesterolemia, which induced xanthoma, differs from familial hypercholesterolemia.</p>","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"182 2","pages":"94-7"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247753","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13206488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of inflammatory linear verrucous epidermal nevus.","authors":"H F Rulo,&nbsp;P C van de Kerkhof","doi":"10.1159/000247756","DOIUrl":"https://doi.org/10.1159/000247756","url":null,"abstract":"<p><p>Inflammatory linear verrucous epidermal nevus (ILVEN) is a rare and chronic skin disorder, which may trouble the patient considerably. The condition is generally believed to be resistant to therapy, although some authors have reported success with several treatments. including dithranol and etretinate. The present case, a classical presentation of ILVEN, again illustrates the refractoriness to various treatments, including an experimental treatment with topical 13-cis-retinoic acid. A review of the literature on therapeutic possibilities of ILVEN is presented. Based on our own observations and literature data, it is attractive to hypothesize that a positive result with treatments such as dithranol and retinoids should be interpreted as an antipsoriatic effect in ILVEN with superimposed psoriasis.</p>","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"182 2","pages":"112-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247756","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13206621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kaposi's sarcoma + HIV infection = AIDS?","authors":"M Harms,&nbsp;S Kinloch,&nbsp;J H Saurat","doi":"10.1159/000247743","DOIUrl":"https://doi.org/10.1159/000247743","url":null,"abstract":"","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"182 1","pages":"66"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247743","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13170876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatomyositis and pregnancy. Case report and review of the literature.","authors":"N Ishii,&nbsp;H Ono,&nbsp;T Kawaguchi,&nbsp;H Nakajima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dermatomyositis is a rare disease complicating pregnancy. We treated a patient in whom two pregnancies were complicated by dermatomyositis. In the first of the two gestations, a mild form of the disease arose in the last trimester. In the second gestation, the disease was inactive following treatment with 0.3 mg/kg/day prednisolone. Both the mother and two children have since been doing well.</p>","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"183 2","pages":"146-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12906419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent corticosteroid maintenance treatment of psoriasis: a double-blind multicenter trial of augmented betamethasone dipropionate ointment in a pulse dose treatment regimen.","authors":"H I Katz,&nbsp;S E Prawer,&nbsp;R S Medansky,&nbsp;G G Krueger,&nbsp;J J Mooney,&nbsp;M L Jones,&nbsp;C R Samson","doi":"10.1159/000247698","DOIUrl":"https://doi.org/10.1159/000247698","url":null,"abstract":"<p><p>Ninety psoriasis patients, who were either completely cleared of or manifested only a minimal presence of disease signs following 3-4 weeks of twice daily treatment with augmented betamethasone dipropionate (ABD) ointment 0.05%, were enrolled in this multicenter, double-blind, placebo-controlled study. The study was designed to determine if an intermittent pulse dose regimen of ABD ointment could safely and effectively maintain a remission disease status when treatment was applied in three consecutive applications 12 h apart, once a week for a maximum treatment period of 6 months. The disease of 60% of the patients in the active treatment group was successfully controlled for 6 months, while 80% of the placebo-treated patients experienced exacerbation of disease signs. No serious local or systemic treatment-related adverse experiences were reported. ABD ointment 0.05%, when applied using the intermittent treatment regimen described here, was shown to be a clinically beneficial and well-tolerated method of long-term (up to 6 months) maintenance therapy for psoriasis patients.</p>","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"183 4","pages":"269-74"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247698","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12970565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous metastases from follicular thyroid carcinoma: histology, immunohistology, and electron microscopy. A report of two cases.","authors":"M Tronnier,&nbsp;M Winzer,&nbsp;H H Wolff","doi":"10.1159/000247702","DOIUrl":"https://doi.org/10.1159/000247702","url":null,"abstract":"<p><p>Cutaneous metastases from thyroid carcinoma are extremely rare. We report 2 cases of skin metastases from a follicular thyroid carcinoma. A 53-year-old female patient underwent subtotal thyroidectomy because of the clinical suspicion of malignancy. Histological examination of the resected tissue did not clearly prove malignant features. Eight years later a cutaneous metastasis erupted next to the operation site at the neck. A 66-year-old female patient noticed a growing solitary skin nodule in the occipitoparietal region of her scalp 2 years before a follicular thyroid carcinoma was detected.</p>","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"183 4","pages":"286-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12970568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased isotretinoin efficacy during acute alcohol intake.","authors":"C Soria,&nbsp;F Allegue,&nbsp;J Galiana,&nbsp;A Ledo","doi":"10.1159/000247785","DOIUrl":"https://doi.org/10.1159/000247785","url":null,"abstract":"","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"182 3","pages":"203"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247785","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12992829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Darier's disease and corneal opacity.","authors":"K N Mohamed","doi":"10.1159/000247787","DOIUrl":"https://doi.org/10.1159/000247787","url":null,"abstract":".Tear film – Surface cells -Wing cells Epithelium-■Basement 7 Bowman’s layer The cornea and conjunctiva can be considered as modified skin ‚ and cutaneous disorders, especially that involving the epidermis, also affect the corneal epithelium. The epithelium, derived from the surface ectoderm is a 5to 6-cell layer forming 10% of the corneal thickness; the stroma which is of mesodermal origin forms about 90% [1]. The basal cells that are attached to the basement membrane by hemidesmosomes give rise to wing cells which become the surface cells and are shed into the tears (fig. 1); thus, the corneal epithelium is structurally and physiologically somewhat similar to the epidermis. A case of Darier’s disease with a peripheral corneal opacity is reported to stress the importance of examining the eyes in this genodermatosis. A 36-year-old Malay lady was referred to the Skin Clinic for a spreading papular, warty lesion on the body since childhood. She was treated in the Eye Ward for a small left corneal ulcer of undetermined cause. The patient was a gravida 8, para 7, in 34 weeks of gestation with no history of injury or foreign body in the eye. She presented with redness, pain, lacrimation and photophobia of the affected eye which on slit-lamp examination showed fluorescein staining of the cornea at the 6-o’clock position and few cells at the anterior chamber. She was treated with mydriatics and antibiotics, and after a week‚ the ulcer healed leaving an oval opacity. A skin biopsy confirmed Darier’s disease; her second son was also affected. We decided to start her on etretinate after a post-partum bilateral tubal ligation. There are several skin disorders, especially genodermatoses, which are associated with corneal changes. In a study involving 21 patients with Darier’s disease, various ocular abnormalities were observed [2]; unique peripheral corneal opacities, central corneal surface irregularities and keratotic plaques on eyelids were seen in 16 patients. The opacities were teardrop-sized to tiny, clustered oval-shaped lesions, and the irregularities were distributed in a radiating cobweb pattern. In two patients trephine biopsy of the opacities showed epithelial oedema especially of the basal cells and thickened basement membrane – features that are different from the skin pathology because the cornea is not a keratinizing epithelium. Darier’s disease in two brothers associated with retinitis pigmentosa has also been reported [3]. In view of the high prevalence of","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"182 3","pages":"205"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247787","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13039398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verrucous carcinoma of a leg amputation stump.","authors":"R A Schwartz,&nbsp;M P Bagley,&nbsp;C K Janniger,&nbsp;W C Lambert","doi":"10.1159/000247782","DOIUrl":"https://doi.org/10.1159/000247782","url":null,"abstract":"<p><p>Verrucous carcinoma of the skin is a rare cancer which tends to appear on the soles of the feet, although it can appear elsewhere on the cutaneous surface. It has not, to our knowledge, been previously reported on a leg amputation stump.</p>","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":"182 3","pages":"193-5"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247782","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13040802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}