Dermato-Endocrinology最新文献_第5页

Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance. 指关节黑棘皮病:一个早期的、可及的、直接的、敏感的临床工具来预测胰岛素抵抗。

Dermato-Endocrinology Pub Date : 2018-05-21 eCollection Date: 2018-01-01 DOI: 10.1080/19381980.2018.1471958

Gloria González-Saldivar, René Rodríguez-Gutiérrez, Andrés Marcelo Treviño-Alvarez, Minerva Gómez-Flores, Juan Montes-Villarreal, Neri Alejandro Álvarez-Villalobos, Anasofía Elizondo-Plazas, Alejandro Salcido-Montenegro, Jorge Ocampo-Candiani, José Gerardo González-González

{"title":"Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance.","authors":"Gloria González-Saldivar, René Rodríguez-Gutiérrez, Andrés Marcelo Treviño-Alvarez, Minerva Gómez-Flores, Juan Montes-Villarreal, Neri Alejandro Álvarez-Villalobos, Anasofía Elizondo-Plazas, Alejandro Salcido-Montenegro, Jorge Ocampo-Candiani, José Gerardo González-González","doi":"10.1080/19381980.2018.1471958","DOIUrl":"https://doi.org/10.1080/19381980.2018.1471958","url":null,"abstract":"Any clinical/biochemical marker revealing obesity or diabetes before their appearance is valuable. Insulin resistance (IR) is present in both disorders many years before occurrence. Accordingly, we determined whether acanthosis nigricans (AN) in the knuckles is associated to higher insulin and homeostasis model assessment for estimated insulin resistance (HOMA-IR) index values, and assessed the influence of body-mass index (BMI) and the diagnostic performance of AN in the knuckles to detect IR. In this cross-sectional controlled study, we included men or women, 18 to 23 years old, with or without AN in the knuckles. In 149 cases with AN in the knuckles and 145 controls, fasting insulin was higher in cases (13.45 µU/mL ± 7.8 vs. 8.59 µU/mL ± 3.63, P < .001, respectively). Mean HOMA-IR index was also higher (2.86 ± 1.68 vs. 1.78 ± 0.77, P < .001). A significant increase in fasting insulin and HOMA-IR values between and within BMI groups from normal through obese category was identified in controls and cases. By multivariate regression analysis, cases with normal BMI were significantly associated to a HOMA-IR ≥2.5 (OR = 3.09, CI95% = 1.75-5.48, P = .001). A model of AN in the knuckles, normal BMI, and increased waist circumference allowed identifying 2 out of 3 cases with HOMA-IR index ≥2.5. AN in the knuckles could be addressed with two aims: as an easy, accessible, and costless diagnostic tool suggesting hyperinsulinemia secondary to IR, and, an early marker of IR even in the absence of overweight or obesity.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"10 1","pages":"e1471958"},"PeriodicalIF":0.0,"publicationDate":"2018-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2018.1471958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36543339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The rs2167270 polymorphism of leptin gene is associated with atopic dermatitis. 瘦素基因rs2167270多态性与特应性皮炎相关。

Dermato-Endocrinology Pub Date : 2018-03-26 eCollection Date: 2018-01-01 DOI: 10.1080/19381980.2018.1454191

Saleem A Banihani, Rawan A Elmadhoun, Omar F Khabour, Karem H Alzoubi

{"title":"The rs2167270 polymorphism of leptin gene is associated with atopic dermatitis.","authors":"Saleem A Banihani, Rawan A Elmadhoun, Omar F Khabour, Karem H Alzoubi","doi":"10.1080/19381980.2018.1454191","DOIUrl":"https://doi.org/10.1080/19381980.2018.1454191","url":null,"abstract":"Atopic dermatitis is a chronic inflammatory skin disease that arises because of complex environmental, immunological, and genetic interactions. Adipokines are bioactive mediators secreted from adipocytes of white adipose tissue and are known to have a role in body metabolism and regulation of immune responses. Leptin is a proinflammatory adipokine that functions mainly to regulate food intake and energy expenditure. Few studies have implicated adipokines in the pathogenesis of atopic dermatitis. In this study, we investigated the association of three leptin gene polymorphisms: -2548G>A (rs7799039), -188 C/A (rs791620), and A19G (rs2167270), with the incidence of atopic dermatitis. One hundred and sixty-four patients and one hundred and sixty-seven age- and gender-matched controls were genotyped using the polymerase chain reaction-restriction fragment length polymorphism procedure. A significant association was found between rs2167270 and the incidence of atopic dermatitis (P < 0.05). The GG allele was more prevalent in the patients' group with genotype frequency of 38.7%, compared to 26.1% for the control group. No significant differences were found in the genotype distribution or allelic frequency of the other two examined polymorphisms, rs7799039 and rs791620, between atopic dermatitis patients and controls (P > 0.05). The results suggest that rs2167270 might play a role in the pathogenesis of atopic dermatitis.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"10 1","pages":"e1454191"},"PeriodicalIF":0.0,"publicationDate":"2018-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2018.1454191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36224869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

The pivotal role of inflammation in scar/keloid formation after acne. 炎症在痤疮后疤痕/瘢痕疙瘩形成中的关键作用。

Dermato-Endocrinology Pub Date : 2018-03-13 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2018.1448327

Chao Shi, Jianyu Zhu, Degang Yang

引用次数: 10

Hormonal and dietary factors in acne vulgaris versus controls. 激素和饮食因素对寻常痤疮的影响。

Dermato-Endocrinology Pub Date : 2018-02-22 eCollection Date: 2018-01-01 DOI: 10.1080/19381980.2018.1442160

Thomas Jonathan Stewart, Carl Bazergy

{"title":"Hormonal and dietary factors in acne vulgaris versus controls.","authors":"Thomas Jonathan Stewart, Carl Bazergy","doi":"10.1080/19381980.2018.1442160","DOIUrl":"https://doi.org/10.1080/19381980.2018.1442160","url":null,"abstract":"Background: Acne vulgaris is an inflammatory skin disorder with not as yet fully understood pathogenesis. In this controlled study, we assessed acne vulgaris patients for several possible pathogenic factors such as vitamin D deficiency, vegan diet, increased body mass index (BMI) and positive anti-transglutaminase antibody. Methods: We screened 10 years of records at a family medicine clinic for patients diagnosed with acne vulgaris. In eligible subjects, we collected data regarding 25-hydroxylvitamin D levels, BMI, dietary preference and serum IgA tissue transglutaminase levels. Controls were age- (+/- 12 months) and sex-matched patients seen during the study period without a diagnosis of acne vulgaris. Results: 453 patients were given a diagnosis of acne vulgaris during the study period. Compared with controls, we found significant associations between vitamin D deficiency (<50nmol/L), and/or positive transglutaminase antibody level (>4.0U/mL) and a diagnosis of acne vulgaris. Conclusions: Our study adds important information to the current body of literature in pursuit of elucidating the pathogenesis of this complex multifactorial disease.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"10 1","pages":"e1442160"},"PeriodicalIF":0.0,"publicationDate":"2018-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2018.1442160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36225498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Serum 25-hydroxyvitamin D levels in patients with skin diseases including psoriasis, infections, and atopic dermatitis. 银屑病、感染和特应性皮炎等皮肤病患者血清25-羟基维生素D水平

Dermato-Endocrinology Pub Date : 2018-02-22 eCollection Date: 2018-01-01 DOI: 10.1080/19381980.2018.1442159

Ulrich Amon, Laura Baier, Raul Yaguboglu, Madeleine Ennis, Michael F Holick, Julian Amon

{"title":"Serum 25-hydroxyvitamin D levels in patients with skin diseases including psoriasis, infections, and atopic dermatitis.","authors":"Ulrich Amon, Laura Baier, Raul Yaguboglu, Madeleine Ennis, Michael F Holick, Julian Amon","doi":"10.1080/19381980.2018.1442159","DOIUrl":"https://doi.org/10.1080/19381980.2018.1442159","url":null,"abstract":"The pathogenetic role of vitamin D as well as its clinical correlation in inflammatory skin diseases is still uncertain. This study aimed to compare serum levels of 25(OH) vitamin D (calcidiol) in outpatients suffering from different skin diseases using the same laboratory method in one study. In routine serum samples of 1,532 patients from the previous 12 months we identified retrospectively 180 (mean age 49.4 years, 80 female, 100 male) and 205 (mean age 36.3 years, 116 female, 89 male) patients with psoriasis (PSO) and atopic dermatitis (AD), respectively. Clinical disease activity and quality of life was evaluated using Physicians Global Assessment Scores (PGA), Dermatology Life Quality Index (DLQI), and a Visual Analog Scale for pruritus in AD, respectively. The median 25(OH)D serum level of all patients (22.97 ng/mL, range 2.61-96.0, n = 1,461) was significantly lower in comparison to healthy controls (41.6 ng/mL, range 16.9-77.57, p < 0.0001, n = 71). In PSO and AD we measured 21.05 ng/mL (44% < 20 ng/mL) and 22.7 ng/mL (39% < 20 ng/mL), respectively (p = 0.152). Among all subgroups, patients with severe acute or chronic infectious skin diseases had the lowest median 25(OH)D serum levels (17.11 ng/mL, n = 94, 66% <20 ng/mL, p < 0,001 vs. AD, p = 0,007 vs. PSO). For PSO and AD there was no significant correlation between 25(OH)D levels and PGA scores and DLQI values, respectively, or the extent of pruritus in AD. 25(OH)D serum levels in inflammatory skin diseases might correlate more with the type of disease and the degree of inflammation than with clinical activity itself.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"10 1","pages":"e1442159"},"PeriodicalIF":0.0,"publicationDate":"2018-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2018.1442159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36225497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Recent advances in the endocrinology of the sebaceous gland. 皮脂腺内分泌学研究进展。

Dermato-Endocrinology Pub Date : 2018-01-23 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1361576

Attila G Szöllősi, Attila Oláh, Tamás Bíró, Balázs István Tóth

引用次数: 28

Local cortisol activation is involved in EGF-induced immunosuppression. 局部皮质醇激活参与了egf诱导的免疫抑制。

Dermato-Endocrinology Pub Date : 2017-12-26 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1412018

Sayaka Matsumura, Mika Terao, Satoshi Itami, Ichiro Katayama

{"title":"Local cortisol activation is involved in EGF-induced immunosuppression.","authors":"Sayaka Matsumura, Mika Terao, Satoshi Itami, Ichiro Katayama","doi":"10.1080/19381980.2017.1412018","DOIUrl":"https://doi.org/10.1080/19381980.2017.1412018","url":null,"abstract":"The major effects of the epidermal growth factor receptor (EGFR) signalling pathway on keratinocytes are cell proliferation, cell differentiation, and wound healing. In addition to these effects, an immunosuppressive effect of EGFR signalling has been reported. However, the precise mechanism of immunosuppression by EGFR signalling is not well understood. In this study, we clarified the involvement of increased local cortisol activation in EGFR signalling-induced immunosuppression in keratinocytes. EGF treatment up-regulated the expression of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and supernatant cortisol levels in a dose-dependent manner in keratinocytes. 11β-HSD1 is an enzyme that catalyses the conversion of cellular hormonally inactive cortisone into active cortisol. qRT-PCR and ELISA assays indicated that EGF significantly decreased tumour necrosis factor α (TNF- α)-induced interleukin-6 (IL-6) expression in keratinocytes. Similarly, 11β-HSD1 overexpression significantly decreased TNF-α-induced IL-6 expression. We evaluated the role of 11β-HSD1 in immunosuppression through EGFR signalling. Blockade of 11β-HSD1 via 11β-HSD1 inhibitor reversed both the expression and production of TNF-α-induced IL-6, which was decreased by EGF in keratinocytes. Therefore, increased local cortisol activation by 11β-HSD1 is involved in EGFR signalling-induced immunosuppression in keratinocytes. Finally, we evaluated whether EGFR inhibition by cetuximab affects the expression of 11β-HSD1. We found that 0.1 µg cetuximab decreased 11β-HSD1 transcript levels in keratinocytes. The changes in 11β-HSD1 were more apparent in TNF-α-treated cells. As 11β-HSD1 expression in keratinocytes is associated with inflammation and cell proliferation, this mechanism may be associated with adverse skin reactions observed in patients treated with EGFR inhibitors.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"9 1","pages":"e1412018"},"PeriodicalIF":0.0,"publicationDate":"2017-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2017.1412018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35865754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Thyroid autoimmunity in female post-adolescent acne: A case-control study. 女性青春期后痤疮的甲状腺自身免疫:一项病例对照研究

Dermato-Endocrinology Pub Date : 2017-12-12 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1405198

Thomas Jonathan Stewart, Carl Bazergy

{"title":"Thyroid autoimmunity in female post-adolescent acne: A case-control study.","authors":"Thomas Jonathan Stewart, Carl Bazergy","doi":"10.1080/19381980.2017.1405198","DOIUrl":"https://doi.org/10.1080/19381980.2017.1405198","url":null,"abstract":"Acne vulgaris is an incompletely understood disorder of poliosebaceous follicles. A scourge of adolescence, it is increasingly persisting into the mid-forties, especially in females. 45% of women aged 21–30 years, 26% aged 31–40 years, and 12% aged 41–50 years, suffer from clinically-visible acne.1 The reasons for this rising prevalence have been unclear. Polycystic ovarian syndrome (PCOS) has been suggested as a possible contributor, however most acne sufferers have normal serum androgen levels.2,3 \u0000 \u0000There has been increasing suspicion of a key autoinflammatory role in pathogenesis of chronic acne vulgaris. Autoinflammatory syndromes associated with acne have been described as possibly sharing common pathogeneses, involving dysregulated immunity with abnormal interleukin-1 signaling, leading to clinically significant inflammation.4,5 Thyroid autoimmunity has been detected in a number of chronic inflammatory skin conditions including acne vulgaris and chronic idiopathic urticaria.6,7 \u0000 \u0000In 2012, Vergou and colleagues were the first to show female post-adolescent acne sufferers had significantly higher rates of thyroid autoimmunity compared with healthy controls.7 The relationship has not been examined since, despite a sound theoretical grounding. We aimed to confirm this association between thyroid autoimmunity and post-adolescent acne in adult women, as well as qualify its practical value with subsequent endocrinologist referral and intervention.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"9 1","pages":"e1405198"},"PeriodicalIF":0.0,"publicationDate":"2017-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2017.1405198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35865753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cutaneous manifestations of diabetic peripheral neuropathy. 糖尿病周围神经病变的皮肤表现。

Dermato-Endocrinology Pub Date : 2017-12-06 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1395537

S N Dogiparthi, K Muralidhar, K G Seshadri, S Rangarajan

{"title":"Cutaneous manifestations of diabetic peripheral neuropathy.","authors":"S N Dogiparthi, K Muralidhar, K G Seshadri, S Rangarajan","doi":"10.1080/19381980.2017.1395537","DOIUrl":"https://doi.org/10.1080/19381980.2017.1395537","url":null,"abstract":"There is a rise in number of people diagnosed with Diabetes Mellitus. The incidence is rising in modern Indian society because of Industrial development and drastically changing lifestyles. Diabetic neuropathies are microvascular disorders that are usually associated with the duration of Diabetes. Among the various forms, the most common is Diabetic Peripheral Neuropathy. The disease if neglected leads to chronic ulcer formation leading to amputations frequently. Hence the aim of this study is to document the early cutaneous changes and create an early awareness in the importance of controlling Diabetes. The study consisted of 205 patients with Type 2 DM. Participant's neuropathy status was determined based on Neuropathy Disability Score and Diabetic Neuropathy Symptom Score. Among the Skin changes documented, the common changes seen were: Peripheral hair loss in 185 (90.2%), Xerosis in 168 (82%), Anhydrosis in 162 (79%), Plantar Fissures in 136 (66.3%), Plantar Ulcer in 80 (39%), common nail changes documented were Onychomycosis in 165 (80.5%) and Onychauxis in 53 (25.8%) patients in relation to the occupation and duration of Diabetes mellitus. In conclusion, it is important to control glycemic levels in the all stages of Diabetes and institute foot care measures to prevent the complications of neuropathy.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"9 1","pages":"e1395537"},"PeriodicalIF":0.0,"publicationDate":"2017-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2017.1395537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35865752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Differential biological effects of dehydroepiandrosterone (DHEA) between mouse (B16F10) and human melanoma (BLM) cell lines. 小鼠(B16F10)和人黑色素瘤(BLM)细胞系间脱氢表雄酮(DHEA)的差异生物学效应

Dermato-Endocrinology Pub Date : 2017-11-20 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1389360

Kumud Joshi, Sherif S Hassan, Pandurangan Ramaraj

引用次数: 6