Dermato-Endocrinology最新文献_第4页

Investigating the Early Events after Skin-Barrier Disruption Using Microdialysis—A Human Ex Vivo Skin Model 利用微透析研究皮肤屏障破坏后的早期事件——人离体皮肤模型

Dermato-Endocrinology Pub Date : 2021-11-30 DOI: 10.3390/dermato1020008

K. Baumann, N. P. Knudsen, A. O. Gadsbøll, A. Woetmann, P. Skov

{"title":"Investigating the Early Events after Skin-Barrier Disruption Using Microdialysis—A Human Ex Vivo Skin Model","authors":"K. Baumann, N. P. Knudsen, A. O. Gadsbøll, A. Woetmann, P. Skov","doi":"10.3390/dermato1020008","DOIUrl":"https://doi.org/10.3390/dermato1020008","url":null,"abstract":"Skin-barrier restoration following abrasive trauma is facilitated by mediator release from skin-resident cells, a process that has been investigated primarily in mice or simplified human systems with previous studies focusing on a limited number of biomarkers. Here, we demonstrate how early events caused by skin-barrier disruption can be studied in a human ex vivo skin model. Ten relevant biomarkers were recovered from the interstitial fluid by skin microdialysis with subsequent sample analysis using a multiplex platform. As a control, the biomarker profiles obtained from microdialysis sampling were compared to profiles of skin biopsy homogenates. We found that nine (GM-CSF, CXCL1/GROα, CXCL8/IL-8 CXCL10/IP-10, IL-1α, IL-6, MIF, TNF-α, and VEGF) of the 10 biomarkers were significantly upregulated in response to abrasive trauma. Only dialysate levels of CCL27/CTACK were unaffected by skin abrasion. Biomarker levels in the homogenates corresponded to dialysate levels for CCL27/CTACK, CXCL1/GROα, CXCL8/IL-8, and IL-6. However, IL-1α showed an inverse trend in response to trauma, and biopsy levels of MIF were unchanged. GM-CSF, CXCL10/IP-10, TNF-α, and VEGF were not detected in the biopsy homogenates. Our results suggest that the human ex vivo skin model is a reliable approach to study early events after disruption of the skin barrier.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72598728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Atypical Klippel-Trenaunay Syndrome 非典型Klippel-Trenaunay综合征1例

Dermato-Endocrinology Pub Date : 2021-11-04 DOI: 10.3390/dermato1020007

Yujin Han, Se-Hoon Lee, M. Cho, S. Cho, Jeong-Deuk Lee, Yukari Woo, Hei Sung Kim

引用次数: 1

Dermal Melanocytic Disorders 皮肤黑色素细胞疾病

Dermato-Endocrinology Pub Date : 2021-10-01 DOI: 10.3390/dermato1020006

Yujin Han, Se-Hoon Lee, M. Cho, S. Cho, Jeong-Deuk Lee, Y. Woo, Hei Sung Kim

引用次数: 1

Friction-Induced Biphasic Cutaneous Amyloidosis 摩擦诱导的双期皮肤淀粉样变性

Dermato-Endocrinology Pub Date : 2021-08-19 DOI: 10.3390/dermato1010005

T. Gambichler, L. Susok, M. H. Segert

引用次数: 1

A Case of Unilateral Hyperpigmentation 单侧色素沉着症1例

Dermato-Endocrinology Pub Date : 2021-07-01 DOI: 10.3390/DERMATO1010004

Yujin Han, Se-Hoon Lee, M. Cho, S. Cho, Jeong-Deuk Lee, Yukari Woo, Hei Sung Kim

引用次数: 0

Rare TERT Promoter Mutations Present in Benign and Malignant Cutaneous Vascular Tumors 良恶性皮肤血管肿瘤中罕见的TERT启动子突变

Dermato-Endocrinology Pub Date : 2021-06-25 DOI: 10.3390/dermato1010003

P. Jansen, G. Lodde, A. Zaremba, C. M. Thielmann, Johanna Matull, H. Müller, Inga Möller, A. Sucker, S. Esser, J. Schaller, D. Schadendorf, T. Mentzel, E. Hadaschik, K. Griewank

{"title":"Rare TERT Promoter Mutations Present in Benign and Malignant Cutaneous Vascular Tumors","authors":"P. Jansen, G. Lodde, A. Zaremba, C. M. Thielmann, Johanna Matull, H. Müller, Inga Möller, A. Sucker, S. Esser, J. Schaller, D. Schadendorf, T. Mentzel, E. Hadaschik, K. Griewank","doi":"10.3390/dermato1010003","DOIUrl":"https://doi.org/10.3390/dermato1010003","url":null,"abstract":"Mutations in the promoter of the telomerase reverse transcriptase (TERT) gene have been described as the most common hot-spot mutations in different solid tumors. High frequencies of TERT promoter mutations have been reported to occur in tumors arising in tissues with low rates of self-renewal. For cutaneous vascular tumors, the prevalence of TERT promoter mutations has not yet been investigated in larger mixed cohorts. With targeted next-generation sequencing (NGS), we screened for different known recurrent TERT promoter mutations in various cutaneous vascular proliferations. In our cohort of 104 representative cutaneous vascular proliferations, we identified 7 TERT promoter mutations. We could show that 4 of 64 (6.3%) hemangiomas and vascular malformations harbored TERT promoter mutations (1 Chr.5:1295228 C > T mutations, 1 Chr.5:1295228_9 CC > TT mutation, and 2 Chr.5:1295250 C > T mutations), 1 of 19 (5.3%) angiosarcomas harbored a Chr.5:1295250 C > T TERT promoter mutation, and 2 of 21 (9.5%) Kaposi’s sarcomas harbored TERT promoter mutations (2 Chr.5:1295250 C > T mutations). To our knowledge, this is the first general description of the distribution of TERT promoter mutations in a mixed cohort of cutaneous vascular tumors, revealing that TERT promoter mutations seem to occur with low prevalence in both benign and malignant cutaneous vascular proliferations.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89433918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Titanium Dioxide Type Combined with Coffee Oil Obtained from Coffee Industry Waste on Sunscreen Product Performance 从咖啡工业废料中提取的二氧化钛型复合咖啡油对防晒产品性能的影响

Dermato-Endocrinology Pub Date : 2021-06-21 DOI: 10.3390/dermato1010002

B. G. Chiari-Andréo, J. Marto, A. Ascenso, C. Carneiro, L. Rodríguez, Antonio José Guillot, T. Garrigues, H. Ribeiro, A. Melero, V. Isaac

{"title":"The Impact of Titanium Dioxide Type Combined with Coffee Oil Obtained from Coffee Industry Waste on Sunscreen Product Performance","authors":"B. G. Chiari-Andréo, J. Marto, A. Ascenso, C. Carneiro, L. Rodríguez, Antonio José Guillot, T. Garrigues, H. Ribeiro, A. Melero, V. Isaac","doi":"10.3390/dermato1010002","DOIUrl":"https://doi.org/10.3390/dermato1010002","url":null,"abstract":"(1) Background: Titanium dioxide (TiO2) consists of three polymorphs, including anatase, rutile and brookite. This work aimed to elucidate the influence of rutile and anatase forms in the performance of sunscreens formulated with green coffee oil (GCO) from coffee beans discarded in the agri-food industry. (2) Methods: TiO2 particles were characterized in terms of size and wettability. The sunscreens formulated with GCO were characterized regarding the droplet size, rheology, texture profile analysis (TPA), in vitro Sun Protection Factor and Water Resistance Retention. Topical delivery and permeation studies were performed to confirm caffeine release and skin penetration. (3) Results: Particle size distributions of rutile and anatase TiO2 particles were similar, however, smaller droplets as well as decreased viscosity and increased thixotropy were obtained for anatase TiO2 and GCO formulation compared to rutile form formulations. Notwithstanding, all formulations exhibited linear viscoelastic behavior. Regarding the TPA, a wide range of mechanical properties improved mainly by GCO rather than TiO2 form has been demonstrated. The influence of TiO2 form on UV protection was better evidenced in absence of GCO. The sunscreen formulations containing GCO presented a favorable topical delivery as confirmed by caffeine release and permeation. (4) Conclusions: Both TiO2 forms combined with GCO provided suitable properties including an effective ultraviolet (UV)-light protection.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80296874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Editorial Retraction. 编辑收缩。

Dermato-Endocrinology Pub Date : 2018-11-02 eCollection Date: 2018-01-01 DOI: 10.1080/19381980.2018.1512251

引用次数: 0

Relation between cutaneous and extracutaneous complications in pediatric patients with type 1 diabetes. 1 型糖尿病儿童患者皮肤和皮肤外并发症之间的关系。

Dermato-Endocrinology Pub Date : 2018-08-17 eCollection Date: 2018-01-01 DOI: 10.1080/19381980.2018.1467717

M I Kamel, Y I Elhenawy, W M Saudi

{"title":"Relation between cutaneous and extracutaneous complications in pediatric patients with type 1 diabetes.","authors":"M I Kamel, Y I Elhenawy, W M Saudi","doi":"10.1080/19381980.2018.1467717","DOIUrl":"10.1080/19381980.2018.1467717","url":null,"abstract":"Background: The relationship between cutaneous and extracutaneous complications in pediatric patients with type 1 diabetes is unclear. Objective: The objective of the current study is to investigate the relationship between skin disorders and diabetic microangiopathic changes in pediatric and adolescent patients with type 1 diabetes. Patients and methods: Eighty patients with type 1 diabetes and 50 healthy controls were enrolled in the study. All recruited patients were followed up monthly for a total period of 12 month. Monthly visit included thorough clinical examination with system review, as well as whole-body cutaneous examination. HbA1c was assessed every 3 month. Twenty-four hours urine was collected for measurement of urinary albumin. Results: Fifty percent of the screened diabetic cohort had diabetic nephropathy (DN). The overall prevalence of cutaneous lesion among the studied diabetic cohort was high (72.5%), with cutaneous infections (40%) and xerosis (30%) being the most prevalent. The frequency of cutaneous infections, xerosis and rubeosis faciei was higher in patients with nephropathy than in those without nephropathy. Conclusion: cutaneous affection in patients with diabetes may be a clue to the presence of associated microangioapthic complications. The significant association between diabetic nephropathy and cutaneous lesions support the concept that cutaneous lesion in diabetes is a reflection of diabetic angiopathy, highlighting the importance of identifying patients at risk of other microvascular complications.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"10 1","pages":"e1467717"},"PeriodicalIF":0.0,"publicationDate":"2018-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5c/8e/kder-10-01-1467717.PMC6166603.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36543338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship of adiponectin level and ADIPOQ gene variants with BMI among young adult women. 年轻成年女性脂联素水平和ADIPOQ基因变异与BMI的关系。

Dermato-Endocrinology Pub Date : 2018-06-18 eCollection Date: 2018-01-01 DOI: 10.1080/19381980.2018.1477902

Omar F Khabour, Mahmoud A Alomari, Asmaa A Abu Obaid

引用次数: 15