Dermato-Endocrinology最新文献_第6页

Untangling the most probable role for vitamin D₃ in autism. 解开维生素 D3 在自闭症中最可能扮演的角色。

Dermato-Endocrinology Pub Date : 2017-10-23 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1387702

Dianne E Godar, Stephen J Merrill

引用次数: 0

Cutaneous fungal microbiome: Malassezia yeasts in seborrheic dermatitis scalp in a randomized, comparative and therapeutic trial. 皮肤真菌微生物组:马拉色菌在头皮脂溢性皮炎中的随机、比较和治疗试验。

Dermato-Endocrinology Pub Date : 2017-10-23 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1361573

C S L Kamamoto, A S Nishikaku, O F Gompertz, A S Melo, K M Hassun, E Bagatin

{"title":"Cutaneous fungal microbiome: Malassezia yeasts in seborrheic dermatitis scalp in a randomized, comparative and therapeutic trial.","authors":"C S L Kamamoto, A S Nishikaku, O F Gompertz, A S Melo, K M Hassun, E Bagatin","doi":"10.1080/19381980.2017.1361573","DOIUrl":"https://doi.org/10.1080/19381980.2017.1361573","url":null,"abstract":"Malassezia spp in skin microbiome scalp has been implicated in seborrheic dermatitis pathogenesis. Thus, treatment based in antifungal combined to topical keratolitic agents have been indicated as well as oral isotretinoin as it reduces the sebum production, glandular's size and possesses anti-inflammatory properties. This randomized, comparative and therapeutic trial aimed toper form the genotypic identification of Malassezia species before and after low-dose oral isotretinoin or topical antifungal treatments for moderate to severe seborrhea and/or seborrheic dermatitis on scalp. Scales and sebum of the scalp were seeded in the middle of modified Dixon and incubated at 32°C. For genotypic identification polymerase chain reaction primers for the ITS and D1/D2 ribossomal DNA were used and followed by samples sequencing. The procedure was conducted before and after therapeutic and randomized intervention for moderate to severe seborrhea/seborrheic dermatitis on the scalp, including oral isotretinoin, 10 mg, every other day and anti-seborrheic shampoo (piroctone olamine), over six months. The M. globosa and M. restricta were the most frequent species isolated on the scalp before and after both treatments. Other non-Malassezia species were also identified. The Malassezia spp. were maintained in the scalp after both treatments that were equally effective for the control of seborrhea/seborrheic dermatitis clinical signs.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"9 1","pages":"e1361573"},"PeriodicalIF":0.0,"publicationDate":"2017-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2017.1361573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35865836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Sunbeds with UVB radiation can produce physiological levels of serum 25-Hydroxyvitamin D in healthy volunteers. 有UVB辐射的日光浴床可以使健康志愿者的血清25-羟基维生素D达到生理水平。

Dermato-Endocrinology Pub Date : 2017-10-17 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1375635

Samantha M Kimball, Jasmine Lee, Reinhold Vieth

{"title":"Sunbeds with UVB radiation can produce physiological levels of serum 25-Hydroxyvitamin D in healthy volunteers.","authors":"Samantha M Kimball, Jasmine Lee, Reinhold Vieth","doi":"10.1080/19381980.2017.1375635","DOIUrl":"https://doi.org/10.1080/19381980.2017.1375635","url":null,"abstract":"Vitamin D3 is produced in the skin in response to UVB irradiation, from either sun exposure or UVB sunbeds. The objective of the current study was to characterize serum 25(OH)D response to regular sunbed use from several lamp outputs following their respective time exposure recommendations. There were three groups that tanned over 12 weeks during the winter months in dedicated sunbeds based on lamp outputs (100 W and 160 W low pressure fluorescent and 700 W high pressure filtered metal halide lamps) and a control group provided serum 25(OH)D samples at baseline and end-of-study. Tanning session lengths were calculated based on Health Canada guidelines to stay below the erythema levels. Mean 25(OH)D were increased by an average of 42 nmol/L in the sunbeds that used 100 W and 160 W fluorescents. Change in 25(OH)D was dependent on baseline 25(OH)D levels and sunbed (p = 0.003) and age (p = 0.03), but was not affected by gender, BMI, Fitzpatrick type or cumulative length of tanning sessions. There was no significant increase in 25(OH)D levels in participants using the 700 W filtered metal halide lamp sunbed or in the control participants. Skin pigmentation, [Formula: see text], was markedly increased in all tanners and skin lightness, L*, significantly decreased at 12 weeks. Both L* and [Formula: see text] were significantly correlated with 25(OH)D concentrations for the sunbeds with fluorescent lamps emitting UVB (100 W and 160W). Participants following standardized exposure schedules meeting Health Canada regulations in sunbeds irradiating adequate UVB showed continuous increases of 25(OH)D to physiological levels even after producing a tan in a controlled manner. ClinicalTrials.gov Registration: NCT02334592.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"9 1","pages":"e1375635"},"PeriodicalIF":0.0,"publicationDate":"2017-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2017.1375635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35865840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Sebaceous-immunobiology is orchestrated by sebum lipids. 皮脂免疫生物学是由皮脂组织的。

Dermato-Endocrinology Pub Date : 2017-10-17 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1375636

Marianna Lovászi, Andrea Szegedi, Christos C Zouboulis, Dániel Törőcsik

{"title":"Sebaceous-immunobiology is orchestrated by sebum lipids.","authors":"Marianna Lovászi, Andrea Szegedi, Christos C Zouboulis, Dániel Törőcsik","doi":"10.1080/19381980.2017.1375636","DOIUrl":"https://doi.org/10.1080/19381980.2017.1375636","url":null,"abstract":"The major role of sebaceous glands in mammals is to produce sebum, which coats the epidermis and the hair providing waterproofing, thermoregulation and photoprotection. However, as the need for these functions decreased along the evolutionary changes in humans, a relevant question has been raised: are sebaceous glands and sebum the remnants of our mammalian heritage or do they have overtaken a far more complex role in human skin biology? Trying to provide answers to this question, this review introduces the evolving field of sebaceous immunobiology and puts into the focus the pathways that sebum lipids use to influence the immune milieu of the skin. By introducing possible modifiers of sebaceous lipogenesis and discussing the - human-specific - alterations in composition and amount of sebum, the attribute of sebum as a sensitive tool, which is capable of translating multiple signalling pathways into the dermal micro environment is presented. Further their interaction with macrophages and keratinocytes involves sebum lipid fractions into disease pathogenesis, which could lead - on the other side - to the development of novel sebum-based therapeutic strategies.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"9 1","pages":"e1375636"},"PeriodicalIF":0.0,"publicationDate":"2017-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2017.1375636","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35865841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 84

The effect on acne quality of life of topical azelaic acid 15% gel versus a combined oral contraceptive in adult female acne: A randomized trial. 在成年女性痤疮患者中，外用 15%壬二酸凝胶与复方口服避孕药对痤疮患者生活质量的影响：随机试验。

Dermato-Endocrinology Pub Date : 2017-10-13 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1361572

Marco Rocha, Adriana Sanudo, Edileia Bagatin

{"title":"The effect on acne quality of life of topical azelaic acid 15% gel versus a combined oral contraceptive in adult female acne: A randomized trial.","authors":"Marco Rocha, Adriana Sanudo, Edileia Bagatin","doi":"10.1080/19381980.2017.1361572","DOIUrl":"10.1080/19381980.2017.1361572","url":null,"abstract":"Acne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. Recent studies have shown an increasing number of cases of acne in adult women. These cases are predominantly normoandrogenic and have show some clinical differences compared to adolescent acne. In addition to the physical aspects, acne has a strong psychosocial impact and can lead to the onset of signs and symptoms of depression, such as anger. Our objective was to evaluate the effect on acne-specific quality of life in adult women treated with topical azelaic acid versus a combined oral contraceptive. The study population consisted of 38 adult women with acne and without any features of hyperandrogenism recruited from the clinic of Dermatology Hospital Division of São Paulo, Federal University of São Paulo from January 2012 to September 2014. Patients were randomized into two different groups: one receiving containing 20 ug of ethinylestradiol and 3 mg drospirenone in a regimen of 24 days of medication, a combined oral contraceptive (COC), and the other group topical 15% azelaic acid (AA) gel, twice daily, both for six months. The quality of life was evaluated at baseline and end of treatment with an acne specific measure (Acne-QoL). Before treatment, our data revealed a significant impact of the presence of acne on quality of life. Both treatments resulted in improvement with significant statistical values in quality of life scores. Comparing the four domains of Acne-QoL, patients treated with an oral contraceptive showed greater improvement in two domains (self-perception and acne symptoms) than those treated with azelaic acid.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"9 1","pages":"e1361572"},"PeriodicalIF":0.0,"publicationDate":"2017-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/49/kder-09-01-1361572.PMC5821159.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35865835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical 5-aminolevulinic photodynamic therapy with red light vs intense pulsed light for the treatment of acne vulgaris: A spilit face, randomized, prospective study. 局部5-氨基乙酰丙酸光动力疗法与红光与强脉冲光治疗寻常性痤疮:一项溢出脸，随机，前瞻性研究。

Dermato-Endocrinology Pub Date : 2017-10-13 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1375634

Linglin Zhang, Yun Wu, Yunfeng Zhang, Xiaojing Liu, Bo Wang, Peiru Wang, Guolong Zhang, Xiuli Wang

{"title":"Topical 5-aminolevulinic photodynamic therapy with red light vs intense pulsed light for the treatment of acne vulgaris: A spilit face, randomized, prospective study.","authors":"Linglin Zhang, Yun Wu, Yunfeng Zhang, Xiaojing Liu, Bo Wang, Peiru Wang, Guolong Zhang, Xiuli Wang","doi":"10.1080/19381980.2017.1375634","DOIUrl":"https://doi.org/10.1080/19381980.2017.1375634","url":null,"abstract":"5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has been an effective method for treating acne vulgaris. Red light is the most widely used light source while Intense pulsed lights (IPL) is reported effective and well-tolerated. The purpose of this study was to evaluate the efficacy and adverse reactions of ALA-PDT with red light on acne compared with ALA-PDT with IPL.12 patients were recruited in the randomized, prospective and split-face study. 5% ALA cream were applied on the whole face with 2 hours' incubation before narrow band LED(633 ± 10 nm, 36 ∼ 108J/cm2) on one side of face and IPL(590∼1200 nm, 15∼17J/cm2) on the other side. Three treatment sessions were administered with 2-week interval each time and 8 weeks' follow up. The number of the total acne lesions and inflammatory lesions of the side treated by red light-PDT showed a relatively higher reduction rate that that by IPL-PDT (P < 0.05). Significant PpIX fluorescence decrease was observed only for the group of red light (P < 0.05). Lower pain intensity numeric rating scale values and Investigator's Global Severity Assessment (IGA) grading for erythema of the IPL side were observed (P<0.05).The results suggested that both red light and IPL are effective for ALA-PDT on acne vulgaris. ALA-PDT with red light may achieve better efficacy by more effective photobleaching of protoporphyrin IX (PpIX), whereas IPL may accomplish less adverse reactions and better tolerance.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"9 1","pages":"e1375634"},"PeriodicalIF":0.0,"publicationDate":"2017-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2017.1375634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35802869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

ADT-G as a promising biomarker for peripheral hyperandrogenism in adult female acne. ADT-G作为成年女性痤疮外周雄激素过多的有希望的生物标志物。

Dermato-Endocrinology Pub Date : 2017-10-13 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1361571

Marco Rocha, Karina H M Cardozo, Valdemir M Carvalho, Edieia Bagatin

{"title":"ADT-G as a promising biomarker for peripheral hyperandrogenism in adult female acne.","authors":"Marco Rocha, Karina H M Cardozo, Valdemir M Carvalho, Edieia Bagatin","doi":"10.1080/19381980.2017.1361571","DOIUrl":"https://doi.org/10.1080/19381980.2017.1361571","url":null,"abstract":"Acne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. Recent studies have shown an increasing number of cases of acne in adult women. These cases are predominantly normoandrogenic and present some clinical differences compared to adolescent acne. Local glandular metabolism turns some weak hormonal precursors into more active substances that increase the production of sebum, leaving these areas more prone to an increasing the colonization by Propionibacterium acnes (P. acnes). Our objective was to evaluate the usefulness of an androgenic metabolite as an adult female acne biomarker. The study population consisted of 38 adult women with acne without any features of hyperandrogenism and a control group. They were recruited from the clinic of Dermatology Hospital Division of São Paulo, Federal University of São Paulo from January 2012 to September 2014. After the first hormonal dosages, patients with acne were randomized into two different groups: one receiving a combined oral contraceptive (COC) containing 0,02 mg of ethinylestradiol and 3 mg drospirenone in a regimen of 24 days of medication, and the other group was treated with a topical gel containing 15% azelaic acid (AA), twice daily, both for six months. With the end of treatment new dosages were performed. Regarding the hormones, total and free testosterone and dehydroepiandrosterone sultate were quantified. In addition, the detection and quantification of androsterone glucuronate (ADT-G), an androgenic metabolite, has been developed. Only ADT-G was sensitive in detecting differences between the control and acne groups, and presented reduction of their values with systemic treatment. Therefore, only ADT-G was able to analyze the peripheral hyperandrogenism in cases of adult female acne.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"9 1","pages":"e1361571"},"PeriodicalIF":0.0,"publicationDate":"2017-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2017.1361571","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35877515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Editorial - The 3rd International Conference on Sebaceous Gland, Acne, Rosacea and Related Disorders. 社论-第三届皮脂腺、痤疮、酒渣鼻及相关疾病国际会议。

Dermato-Endocrinology Pub Date : 2017-10-13 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1386419

Christos C Zouboulis, Qiang Ju, Lei-Hong Flora Xiang

引用次数: 0

Insulin and Insulin-like growth factor-1 can activate the phosphoinositide-3-kinase /Akt/FoxO1 pathway in T cells in vitro. 胰岛素和胰岛素样生长因子-1可以激活体外T细胞中磷酸肌醇-3-激酶/Akt/FoxO1通路。

Dermato-Endocrinology Pub Date : 2017-10-04 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1356518

Yasaman Mirdamadi, Ursula Bommhardt, Alexander Goihl, Karina Guttek, Christos C Zouboulis, Sven Quist, Harald Gollnick

{"title":"Insulin and Insulin-like growth factor-1 can activate the phosphoinositide-3-kinase /Akt/FoxO1 pathway in T cells in vitro.","authors":"Yasaman Mirdamadi, Ursula Bommhardt, Alexander Goihl, Karina Guttek, Christos C Zouboulis, Sven Quist, Harald Gollnick","doi":"10.1080/19381980.2017.1356518","DOIUrl":"https://doi.org/10.1080/19381980.2017.1356518","url":null,"abstract":"Hyper-glycemic food increases insulin-like growth factor 1 (IGF-1) and insulin signaling and regulates endocrine responses and thereby may modulate the course of acne. Inflammation and adaptive immune responses have a pivotal role in all stages of acne. Recent hypothesis suggests that hyperglycemic food reduces nuclear forkhead box-O1 (FoxO1) transcription factor and may eventually induces acne. The aim of our study was to investigate the role of IGF-1 and insulin on the phosphoinositide-3-kinase (PI3K)/Akt/FoxO1 pathway in human primary T cells and on the molecular functions of T cells in vitro. T cells were stimulated with 0.001 μM IGF-1 or 1 μM insulin +/- 20 μM PI3K inhibitor LY294002. T cells were also exposed to SZ95 sebocyte supernatants which were pre-stimulated with IGF-1 or insulin. We found that 0.001 µM IGF-1 and 1 µM insulin activate the PI3K pathway in T cells leading to up-regulation of p-Akt and p-FoxO1 at 15 and 30 minutes. Nuclear FoxO1 was decreased and FoxO transcriptional activity was reduced. 0.001 µM IGF-1 and 1 µM insulin increased T cell proliferation but have no significant effect on Toll-like receptor2/4 (TLR) expression. Interestingly, supernatants from IGF-1- or insulin-stimulated sebocytes activated the PI3K pathway in T cells but reduced T cell proliferation. Taken together, this study helps to support that high glycemic load diet may contribute to induce activation of the PI3K pathway and increase of proliferation in human primary T cells. Factors secreted by IGF-1- and insulin-stimulated sebocytes induce the PI3K pathway in T cells and reduce T cell proliferation, which probably can reflect a protective mechanism of the sebaceous gland basal cells.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"9 1","pages":"e1356518"},"PeriodicalIF":0.0,"publicationDate":"2017-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2017.1356518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35865367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Seeking new acne treatment from natural products, devices and synthetic drug discovery. 寻求新的痤疮治疗从天然产品，设备和合成药物的发现。

Dermato-Endocrinology Pub Date : 2017-10-04 eCollection Date: 2017-01-01 DOI: 10.1080/19381980.2017.1356520

Ji Hoon Yang, Ji Young Yoon, Hyuck Hoon Kwon, Seonguk Min, Jungyoon Moon, Dae Hun Suh

{"title":"Seeking new acne treatment from natural products, devices and synthetic drug discovery.","authors":"Ji Hoon Yang, Ji Young Yoon, Hyuck Hoon Kwon, Seonguk Min, Jungyoon Moon, Dae Hun Suh","doi":"10.1080/19381980.2017.1356520","DOIUrl":"https://doi.org/10.1080/19381980.2017.1356520","url":null,"abstract":"Despite lots of research on the pathogenesis of acne, the development of new therapeutic agents is still stagnant. Conventional agents which target multiple pathological processes have some serious side effects and this makes seeking new treatment options important for treating acne. As new therapeutic options, researchers are focusing on natural products, synthetic drugs and devices. From natural products, epigallocatechin-3 gallate, lupeol, cannabidiol and Lactobacillus fermented Chamaecyperis obtusa were reported to be possible candidates for novel drugs, targeting multiple pathogenic factors. Synthetic anti-P.acnes agent, nitric oxide nanoparticles and α-mangostin nanoparticles are shown to be effective in acne treatment. Device or procedural methods such as fractional microneedling radiofrequency, cryolysis, photothermolysis and daylight photodynamic therapy have potential as new treatment options for acne. Further large clinical trials comparing these new treatments with existing agents will be necessary in the future.","PeriodicalId":11115,"journal":{"name":"Dermato-Endocrinology","volume":"9 1","pages":"e1356520"},"PeriodicalIF":0.0,"publicationDate":"2017-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381980.2017.1356520","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35865368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12