Der Hautarzt最新文献

[Human polyomavirus-associated skin diseases]. [人类多瘤病毒相关皮肤病]。

Der Hautarzt Pub Date : 2022-06-01 Epub Date: 2022-04-28 DOI: 10.1007/s00105-022-04993-8

Steffi Silling, Alexander Kreuter, Ulrike Wieland

{"title":"[Human polyomavirus-associated skin diseases].","authors":"Steffi Silling, Alexander Kreuter, Ulrike Wieland","doi":"10.1007/s00105-022-04993-8","DOIUrl":"10.1007/s00105-022-04993-8","url":null,"abstract":"Of the 15 currently known human polyomaviruses (HPyV), eight have been found on healthy skin. Merkel cell polyomavirus (MCPyV), HPyV6, HPyV7, and to a lesser extent Saint Louis polyomavirus (STLPyV) are considered part of the human cutaneous virome. The most important cutaneous polyomavirus, MCPyV, causes the majority of Merkel cell carcinomas (MCC). MCC is a rare but very aggressive malignant skin tumor that affects both immunocompetent and immunosuppressed patients. A steady increase in incidence rates of this skin tumor has been observed in recent decades. MCC occurs primarily on sunlight-exposed skin of fair-skinned individuals. Risk factors for MCC development include immunosuppression and advanced age. In immunocompromised individuals, primary infection with trichodysplasia spinulosa-associated polyomavirus (TSPyV) can cause the very rare skin disease trichodysplasia spinulosa (TS). Keratin spines (spicules), mainly in the center of the face, clinically characterize this disease. Skin lesions associated with further HPyV have been described exclusively in immunocompromised individuals. For HPyV6 and HPyV7, cases of epithelial proliferation and pruritic dyskeratotic dermatitis have been published. HPyV9 and New Jersey polyomavirus (NJPyV-13) were each found in different skin lesions of individual patients. The role of these polyomaviruses in the development of the skin lesions is still unclear.","PeriodicalId":11114,"journal":{"name":"Der Hautarzt","volume":"101 1","pages":"426-433"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79351357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Role of human papillomavirus (HPV) in the development of skin cancer]. [人乳头瘤病毒（HPV）在皮肤癌发展中的作用]。

Der Hautarzt Pub Date : 2022-06-01 Epub Date: 2022-04-27 DOI: 10.1007/s00105-022-04990-x

Daniel Hasche, Baki Akgül

{"title":"[Role of human papillomavirus (HPV) in the development of skin cancer].","authors":"Daniel Hasche, Baki Akgül","doi":"10.1007/s00105-022-04990-x","DOIUrl":"10.1007/s00105-022-04990-x","url":null,"abstract":"The incidence of nonmelanoma skin cancer, the most common cancer in humans, continues to rise. The development of precancerous actinic keratoses and cutaneous squamous cell carcinoma (cSCC) is associated with infection with human papillomavirus (HPV) of genus beta (betaHPV). Persistent betaHPV infections in immunocompetent individuals are generally very well controlled by the immune system and largely asymptomatic. However, immunosuppression results in high levels of betaHPV in the skin and consequently increased viral oncoprotein activity, which in turn leads to a significantly increased risk for skin cancer. However, even in immunocompetent individuals, the risk of cSCC increases with age as a result of accumulated UV-induced DNA damage in the skin. In these patients, the mechanism of betaHPV-dependent carcinogenesis seems to be different from that observed in immunocompromised patients. The underlying mechanism of oncogenesis in immunocompetent patients is currently less well understood. This review summarizes the current research data, which provide compelling evidence that cutaneous papillomaviruses, particularly in interaction with UV light, promote skin carcinogenesis via a \"hit-and-run\" mechanism by enhancing the genotoxic effects of UV light in the initial phases of this multistep process. Furthermore, an overview of novel vaccination strategies against papillomaviruses that are currently tested in clinical trials is provided, which could significantly improve the treatment options for high-risk patients in the future.","PeriodicalId":11114,"journal":{"name":"Der Hautarzt","volume":"127 1","pages":"417-425"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78783994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Robotics in nursing-opportunties and limits]. [护理中的机器人技术——机遇与限制]。

Der Hautarzt Pub Date : 2022-05-01 Epub Date: 2022-03-03 DOI: 10.1007/s00105-022-04965-y

Jan Zöllick, Adelheid Kuhlmey, Johanna Nordheim, Stefan Blüher

引用次数: 0

[Digital health applications and data protection]. [数字卫生应用和数据保护]。

Der Hautarzt Pub Date : 2022-05-01 Epub Date: 2022-04-26 DOI: 10.1007/s00105-022-04980-z

N Kirsten, M Augustin, K Strömer

引用次数: 0

[Frontal fibrosing alopecia-update]. [额部纤维化脱发-更新]。

Der Hautarzt Pub Date : 2022-05-01 Epub Date: 2022-04-08 DOI: 10.1007/s00105-022-04983-w

Ulrike Blume-Peytavi, Kathrin Hillmann, Andria Constantinou, Annika Vogt

{"title":"[Frontal fibrosing alopecia-update].","authors":"Ulrike Blume-Peytavi, Kathrin Hillmann, Andria Constantinou, Annika Vogt","doi":"10.1007/s00105-022-04983-w","DOIUrl":"10.1007/s00105-022-04983-w","url":null,"abstract":"The number of patients presenting with frontal fibrosing alopecia (FAA) is increasing not only in hair clinics. The recognition of the peculiar clinical pattern and associated symptoms is an important prerequisite to ensure adequate counseling and therapeutic management of the patients. Experimental studies and a range of case series give first insights into the pathogenesis, possible trigger factors, clinical course of disease and treatment options. The clinical spectrum of FFA extends beyond the typical recession of the frontal hair line initially observed in postmenopausal women. Younger women, men and rarely adolescents may also be affected. Band-like extension to the occiput, diffuse bitemporal hair thinning, eyebrow and body hair involvement as well as facial papules are part of the clinical spectrum. Similar to lichen planopilaris, inflammation and fibrosis with involvement of the stem cell region result in permanent loss of hair follicles. Which additional factors contribute to the characteristic pattern remains to be elucidated. Currently, therapeutic management largely relies on anti-inflammatory treatment with combined topical, intralesional and systemic administration depending on disease activity. The chronic progressive course, sometimes even in the absence of pronounced inflammation remains a challenge for both the affected individuals and the treating physicians. Controlled studies are required to develop evidence-based recommendations and to explore novel treatment strategies.","PeriodicalId":11114,"journal":{"name":"Der Hautarzt","volume":"45 1","pages":"344-352"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74129120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Preservative allergy : An enduring issue].

Der Hautarzt Pub Date : 2020-03-01 DOI: 10.1007/s00105-019-04517-x

B Kreft, J Geier

{"title":"[Preservative allergy : An enduring issue].","authors":"B Kreft, J Geier","doi":"10.1007/s00105-019-04517-x","DOIUrl":"10.1007/s00105-019-04517-x","url":null,"abstract":"Background: Preservatives in cosmetics are often suspected as contact sensitizers and hence frequently patch tested in dermatitis patients. Exposure in this field has changed over the course of years.Objective: To describe the frequency of contact sensitization to various preservatives.Materials and methods: Retrospective data analysis from the Information Network of Departments of Dermatology (IVDK) for the years 2009-2018.Results: Frequency of sensitization to methylisothiazolinone (MI) has increased from 2.0% in 2009 to 7.2% in 2013. Since 2014, the rate has been falling again. Increasing the patch test concentration of methyldibromo glutaronitrile (MDBGN) in 2016 has caused a sudden rise in positive patch test reactions from 2.0% to more than 4.5%. Allergic reactions to other preservatives occurred in less than 1% of the patients tested.Discussion: Since 2014, the worldwide \"epidemic\" of sensitization to MI has been subsiding in Central Europe, thanks to corresponding restrictions on use. Since 2008, there is no longer any widespread exposure to MDBGN; the new, higher test concentration elicits many false-positive test reactions and explains the sudden rise in positive patch test reactions since 2016. Despite widespread use, phenoxyethanol, benzoates, benzyl alcohol, parabens and sorbates rarely cause allergic reactions. Therefore, they can be recommended for cosmetics from the epidemiological-allergological point of view.","PeriodicalId":11114,"journal":{"name":"Der Hautarzt","volume":"9 1","pages":"190-196"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79593044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prevalence of contact sensitization in the general population and in patch tested patients]. [接触致敏在普通人群和贴片试验患者中的流行程度]。

Der Hautarzt Pub Date : 2020-03-01 DOI: 10.1007/s00105-019-04506-0

Wolfgang Uter

{"title":"[Prevalence of contact sensitization in the general population and in patch tested patients].","authors":"Wolfgang Uter","doi":"10.1007/s00105-019-04506-0","DOIUrl":"10.1007/s00105-019-04506-0","url":null,"abstract":"Background: Contact sensitization is a common condition. The spectrum of the most important allergens may change over the course of time owing to changes in exposure. Using the so-called baseline series, a collection of the most important and frequent allergens, both population-related and clinical epidemiological studies have been performed.Objectives: Basic epidemiological concepts and special aspects regarding the epidemiology of contact allergies are presented.Materials and methods: A concise adaptation of textbook knowledge and a selective literature search were performed.Results: On the population level, about 25% of people are sensitized to at least one substance included in the baseline series, by far most often to nickel. In view of a prevalence of around 4%, fragrances are important contact allergens, too, along with preservatives. Among patients patch tested for suspected allergic contact dermatitis, the ranking of the most important allergen groups is similar, but the prevalences are (much) higher.Conclusions: Short-term changes in exposure and subsequently in the spectrum of major contact allergens can best be illustrated by clinical surveillance based on routinely collected data and, if needed, preventive measures can be initiated. In addition to time trend analyses, subgroup analyses may offer important clues regarding the identification of sensitizing and eliciting exposures, respectively.","PeriodicalId":11114,"journal":{"name":"Der Hautarzt","volume":"49 1","pages":"166-173"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82247286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Sebaceous carcinoma in situ in extraocular skin : Case report and discussion of the new entity]. [眼外皮肤皮脂腺原位癌：病例报告和新实体的讨论]。

Der Hautarzt Pub Date : 2020-01-01 DOI: 10.1007/s00105-019-4464-y

Jan Hrudka, Alžběta Bezvodová, Monika Arenbergerová, Eva Sticová, Dave Bandke

引用次数: 0

Medikamentös induzierte interstitielle Lungenerkrankung (DILD) unter Ustekinumab u盘驱动器下

Der Hautarzt Pub Date : 2019-12-02 DOI: 10.1007/s00105-019-04519-9

Constantin Sorger, J. Simon, R. Treudler

引用次数: 5

[Treatment of psoriasis via lifestyle changes]. [通过改变生活方式治疗牛皮癣]。

Der Hautarzt Pub Date : 2019-12-01 DOI: 10.1007/s00105-019-04495-0

Evgenia Makrantonaki

引用次数: 0