Francesco Ripa, Amelia Pietropaolo, Robert Geraghty, Stephen Griffin, Paul Cook, Bhaskar Somani
{"title":"Outcomes of Paediatric Cystine Stone Management: Results of a Systematic Review.","authors":"Francesco Ripa, Amelia Pietropaolo, Robert Geraghty, Stephen Griffin, Paul Cook, Bhaskar Somani","doi":"10.1007/s11934-023-01162-9","DOIUrl":"https://doi.org/10.1007/s11934-023-01162-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>We wanted to analyse the outcomes of surgical (SWL, URS, PCNL) and medical management of cystine stones in the paediatric population in terms of stone-free status and complication rates, based on all the available literature evidence.</p><p><strong>Recent findings: </strong>A systematic review of literature was performed for all studies with paediatric cystine stone management. Twelve studies met the eligibility criteria, of which 4 analysed outcomes of SWL, 2 of URS and 3 of PCNL and 3 focused on the effect of either alkalising agents (potassium citrate, citric acid) or cysteine-binding thiol (CBT) agents (tiopronin, penicillamine). The reported SFR in studies ranged from 50 to 83%, 59 to 100% and 63 to 80.6%, with a complication rate of 2.8-51%, 14-27% and 12.9-15.4% with SWL, URS and PCNL, respectively. Paediatric cystine stones treatment should aim at complete stone clearance, preservation of renal function and prevention of further recurrences. SWL achieves inferior results in case of cystine stones. URS and PCNL are safe and effective procedures in the paediatric population, with a low rate of major complications. Adherence to medical prevention therapies may prolong recurrence-free periods.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 8","pages":"371-380"},"PeriodicalIF":2.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9943567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabel Sanz-Gómez, Oriol Angerri, Michael Baboudjian, Andrés Kanashiro, Sílvia Gracia, Félix Millán, Francisco Sánchez-Martín, Bhaskar Somani, Juan Antonio Galan-Llopis, Yazeed Barghouthy, Esteban Emiliani
{"title":"Correction: Role, Cost, and Availably of Urinary pH Monitoring for Kidney Stone Disease-A Systematic Review of the Literature.","authors":"Isabel Sanz-Gómez, Oriol Angerri, Michael Baboudjian, Andrés Kanashiro, Sílvia Gracia, Félix Millán, Francisco Sánchez-Martín, Bhaskar Somani, Juan Antonio Galan-Llopis, Yazeed Barghouthy, Esteban Emiliani","doi":"10.1007/s11934-023-01176-3","DOIUrl":"https://doi.org/10.1007/s11934-023-01176-3","url":null,"abstract":"","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 8","pages":"389"},"PeriodicalIF":2.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10288387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Ong, George Brown, Theodoros Tokas, B M Zeeshan Hameed, Joe Philip, Bhaskar K Somani
{"title":"Selection and Outcomes for Dissolution Therapy in Uric Acid Stones: A Systematic Review of Literature.","authors":"Andrea Ong, George Brown, Theodoros Tokas, B M Zeeshan Hameed, Joe Philip, Bhaskar K Somani","doi":"10.1007/s11934-023-01164-7","DOIUrl":"https://doi.org/10.1007/s11934-023-01164-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>The prevalence of uric acid (UA) urolithiasis contributes significantly to global disease burden, due to high rates of recurrence and diagnostic challenges. Dissolution therapy plays a valuable role in the conservative management of UA calculi, reducing the requirement for surgical intervention. This review summarises the existing evidence for the efficacy of medical dissolution of uric acid urolithiasis.</p><p><strong>Recent findings: </strong>A systematic search was conducted of worldwide literature according to PRISMA methodology and Cochrane standards for systematic review. Studies were included if they reported outcome data for the administration of medical therapy for the dissolution of UA calculi. A total of 1075 patients were included in the systematic review. Complete or partial dissolution of UA calculi was observed in 80.5% of patients (865/1075 patients), with 61.7% (647/1048 patients) achieving complete dissolution and 19.8% (207/1048 patients) achieving partial dissolution. A discontinuation rate of 10.2% (110/1075 patients) was noted, and 15.7% (169/1075 patients) required surgical intervention. Dissolution therapy is a safe and effective method of conservatively managing uric acid stones in the short term. Despite the significant disease burden of UA calculi, current guidelines are limited by deficiencies in the existing body of research. Further research should be undertaken to develop evidence-based clinical guidelines for diagnosis, treatment, and prevention of UA urolithiasis.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 8","pages":"355-363"},"PeriodicalIF":2.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9943569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endourological Options for Small (< 2 cm) Lower Pole Stones - Does the Lower Pole Angle Matter?","authors":"Angus Luk, Robert Geraghty, Bhaskar Somani","doi":"10.1007/s11934-023-01161-w","DOIUrl":"https://doi.org/10.1007/s11934-023-01161-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>Small renal stones in the lower pole are often difficult to treat. The angle of the lower pole to the renal pelvis (lower pole angle) is a limiting factor to rendering the patient stone free. This review explores the definitions of the lower pole angle, the various treatment options available, and how outcomes are influenced by the angle.</p><p><strong>Recent findings: </strong>It is clear the lower pole angle definition varies widely depending on described technique and imaging modality. However, it is clear that outcomes are worse with a steeper angle, especially for shock wave lithotripsy and retrograde intrarenal surgery (RIRS). Percutaneous nephrolithotomy has similar reported outcomes to RIRS, and there is limited evidence it may be superior for steeper angles over RIRS. Lower pole stones can be technically challenging and adequate assessment prior to choosing operative approach is key.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 8","pages":"365-370"},"PeriodicalIF":2.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10299763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charles Mazeaud, Natalia Hernandez, Ricardo R Gonzalez
{"title":"Role of Bladder Functional Testing Prior to Surgeries for Benign Prostatic Obstruction.","authors":"Charles Mazeaud, Natalia Hernandez, Ricardo R Gonzalez","doi":"10.1007/s11934-023-01165-6","DOIUrl":"https://doi.org/10.1007/s11934-023-01165-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>There is no consensus on preoperative functional testing prior to surgeries for benign prostatic obstruction causing lower urinary tract symptoms (LUTS).</p><p><strong>Recent findings: </strong>Surgical management offers definite benefits, but the results are not always satisfactory. The urodynamic study (UDS) is the gold standard for assessing bladder outlet obstruction (BOO) which is the best predictor of surgical success. Yet, it is not recommended by our urologic societies as standard testing prior to surgery. In this narrative review of the literature, we report recent findings and controversies regarding the benefits and downside of UDS, and the use of other less-invasive approaches to achieve this goal. The lack of strong evidence for or against performing UDS was surprising. Prospective UDS data may not predict surgical outcomes if there is no consensus on criteria that directs surgical intervention. However, confirming the presence of BOO and characterizing the bladder function to identify detrusor over- and underactivity may help counselling and setting patient's post-operative expectations. Urocuff, a non-invasive testing offers promising results to address this problem with a less-invasive assessment of BOO. We emphasize better pre-operative characterization of patients to confirm BOO and better define subgroups to improve surgical decision-making.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 8","pages":"401-407"},"PeriodicalIF":2.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9944514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabel Sanz-Gómez, Oriol Angerri, Michael Baboudjian, Andrés Kanashiro, Sílvia Gracia, Félix Millán, Francisco Sánchez-Martín, Bhaskar Somani, Juan Antonio Galan-Llopis, Yazeed Barghouthy, Esteban Emiliani
{"title":"Role, Cost, and Availably of Urinary pH Monitoring for Kidney Stone Disease-A Systematic Review of the Literature.","authors":"Isabel Sanz-Gómez, Oriol Angerri, Michael Baboudjian, Andrés Kanashiro, Sílvia Gracia, Félix Millán, Francisco Sánchez-Martín, Bhaskar Somani, Juan Antonio Galan-Llopis, Yazeed Barghouthy, Esteban Emiliani","doi":"10.1007/s11934-023-01166-5","DOIUrl":"https://doi.org/10.1007/s11934-023-01166-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>Urinary pH is an important factor related to renal stone disease, and it plays an essential role in stone prevention. Monitoring of urinary pH by patients at home provides information that can help to assess the treatment needed by each patient. We conducted a systematic review is to assess the available evidence concerning urinary pH monitoring methods along with their accuracy, cost, and usefulness by patients with urolithiasis.</p><p><strong>Recent findings: </strong>A total of 9 articles were included (1886 urinary pH measurements). They reported information about urinary dipsticks, portable electronic pH meters and electronic strip readers, amongst other methods. Accuracy was compared with a laboratory pH meter (gold standard). Urinary dipsticks were found to be not accurate enough to guide clinical decision making and portable electronic pH meters showed promising results. Urinary dipsticks are neither precise nor accurate enough. Portable electronic pH meters seem to be more accurate, easy to use, and cost-effective. They are a reliable source for patients to use at home in order to prevent future episodes of nephrolithiasis.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 8","pages":"381-388"},"PeriodicalIF":2.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10317951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mriganka Mani Sinha, Vineet Gauhar, Lazaros Tzelves, Tzevat Tefik, Rifat Burak Ergul, Patrick Juliebø-Jones, Bhaskar K Somani
{"title":"Technical Aspects and Clinical Outcomes of Robotic Ureteroscopy: Is It Ready for Primetime?","authors":"Mriganka Mani Sinha, Vineet Gauhar, Lazaros Tzelves, Tzevat Tefik, Rifat Burak Ergul, Patrick Juliebø-Jones, Bhaskar K Somani","doi":"10.1007/s11934-023-01167-4","DOIUrl":"https://doi.org/10.1007/s11934-023-01167-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>Robotic surgery in urology has already been widely employed in robotic-assisted laparoscopic surgery for minimally invasive procedures (MIS). We wanted to analyse rapidly developing robotic ureteroscopy (RoboURS) for the treatment of renal stone disease.</p><p><strong>Recent findings: </strong>A comprehensive literature review was performed for technical aspects and clinical outcomes of RoboURS. RoboURS has made significant breakthroughs with each model proving that this technology improves ergonomics and supports surgeon and instrument longevity while minimising musculoskeletal issues in retrograde intra-renal surgery (RIRS). Further randomised controlled trials are required to compare the efficacy of RoboURS vs manual flexible ureteroscopy (FURS). The cost-effectiveness will also need to be assessed prior to widespread acceptance into urological infrastructure and mainstream practice. RoboURS continues to evolve despite the limitations of infrastructure and cost-effectiveness. It holds the promise of a better future for surgeon longevity, reduced peri-operative morbidity and better workplace environment.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 8","pages":"391-400"},"PeriodicalIF":2.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9943793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasound-Guided PCNL - Why Are We Still Performing Exclusively Fluoroscopic Access?","authors":"David T Tzou, Thomas O Tailly, Karen L Stern","doi":"10.1007/s11934-023-01163-8","DOIUrl":"https://doi.org/10.1007/s11934-023-01163-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>While urologists are traditionally taught to perform percutaneous nephrolithotomy (PCNL) utilizing exclusively fluoroscopy, ultrasound has emerged as a safe alternative. This article showcases the major reasons why ultrasound-guided access should be considered the first-line approach for performing access for PCNL.</p><p><strong>Recent findings: </strong>There continues to be a need to further reduce radiation exposure in the management of kidney stone patients. This review showcases how performing ultrasound-guided PCNL has been associated with a shorter learning curve, increased patient safety, and the ability to perform x-ray free PCNL. Ultrasound-guided PCNL is not only an achievable skill for urologists to learn but provides multiple advantages over traditional fluoroscopic access. As every effort should be given to help reduce radiation exposure for kidney stone patients as well as performing surgeons and operating theater personnel, endourologists should strive to add this technique to their armamentarium.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 7","pages":"335-343"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9683583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John Fastenau, Kunj Jain, Aleksandar Popovic, Evan Kovac
{"title":"Review of Active Surveillance in Underrepresented and High-Risk Populations: Feasibility and Safety.","authors":"John Fastenau, Kunj Jain, Aleksandar Popovic, Evan Kovac","doi":"10.1007/s11934-023-01158-5","DOIUrl":"https://doi.org/10.1007/s11934-023-01158-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of this review is to investigate the current use and effectiveness of active surveillance (AS) for clinical low-risk prostate cancer (PCa) in men considered to be \"high-risk\" based on the factors of race, genetics, healthcare access, and socioeconomic status.</p><p><strong>Recent findings: </strong>Advances in molecular biomarkers and imaging have improved the detection, risk stratification, and treatment of PCa. Still, overdiagnosis and overtreatment of indolent disease remain a concern. AS is therefore the preferred option for clinical low-risk disease. Yet, because of the variability in PCa presentation based on the aforementioned environmental and genetic factors, the question remains: Is active surveillance a safe option for everyone? Provider hesitancy should not necessarily exclude high-risk men from participating in AS. Rather, clinicians should employ shared decision-making, sound clinical judgment, and stringent follow-up in order to effectively counsel AS candidates and optimize AS-related outcomes in \"high-risk\" individuals.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 7","pages":"307-315"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9633014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ellen M Cahill, John L Pfail, Melinda Z Fu, Biren Saraiya, Tina Mayer, Ryan D Stephenson, Ronald D Ennis, Lara Hathout, Matthew P Deek, Saum Ghodoussipour, Thomas L Jang
{"title":"Metastasis-Directed Therapy for Oligometastatic Castration-Sensitive Prostate Cancer: An Alternative to ADT?","authors":"Ellen M Cahill, John L Pfail, Melinda Z Fu, Biren Saraiya, Tina Mayer, Ryan D Stephenson, Ronald D Ennis, Lara Hathout, Matthew P Deek, Saum Ghodoussipour, Thomas L Jang","doi":"10.1007/s11934-023-01159-4","DOIUrl":"https://doi.org/10.1007/s11934-023-01159-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>The standard treatment of patients with metastatic prostate cancer is systemic treatment with androgen-deprivation therapy (ADT). The spectrum-based model of metastatic disease includes the presence of an oligometastatic state, an intermediary between localized and widespread metastatic disease, in which radical local treatment might improve systemic control. Our purpose is to review the literature on metastasis-directed therapy in the treatment of oligometastatic prostate cancer.</p><p><strong>Recent findings: </strong>Several prospective clinical trials have reported improvements in ADT-free survival and progression-free survival with metastasis-directed therapy of oligometastatic prostate cancer. Retrospective studies have found improvements in oncologic outcomes for patients with oligometastatic prostate cancer undergoing metastasis-directed therapy, and several recent prospective clinical trials have confirmed these results. Advancements in imaging as well as an understanding of the genomics of oligometastatic prostate cancer may allow for better patient selection for metastasis-directed therapy and the potential for cure in selected patients.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 7","pages":"299-306"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9621092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}