Current Urology ReportsPub Date : 2024-09-01Epub Date: 2024-06-26DOI: 10.1007/s11934-024-01213-9
Amelia Pantazis, Israel Franco, Jordan Gitlin
{"title":"Erectile Dysfunction in Adolescents and Young Adults.","authors":"Amelia Pantazis, Israel Franco, Jordan Gitlin","doi":"10.1007/s11934-024-01213-9","DOIUrl":"10.1007/s11934-024-01213-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>The goal of this paper is to provide a summary of the recent research, evaluation, work-up, and treatment recommendations regarding erectile dysfunction in adolescents and young adults to better equip pediatric urologists to manage patients with this condition.</p><p><strong>Recent findings: </strong>The latest research regarding erectile dysfunction in this population includes organic and psychogenic etiologies, correlations between the COVID-19 pandemic, and online pornography consumption. In our large pediatric urology practice, we found an 31x increase of adolescent males presenting with erectile dysfunction since 2014. The majority of cases are attributed to a psychogenic etiology such as anxiety or depression. It is likely that with stress from anxiety and depression, cortisol levels rise, increasing vascular resistance and leading erectile dysfunction in this population. Most patients want to be reassured of normal testosterone levels, offered cognitive behavioral therapy, and be rehabilitated with tadalafil starting at 5 mg p.o. daily until tapered.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":" ","pages":"225-232"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Current Urology ReportsPub Date : 2024-09-01Epub Date: 2024-06-21DOI: 10.1007/s11934-024-01216-6
Vinayak Madhusoodanan, Joshua Bitran, Maxwell Towe, Chad Ritch
{"title":"Financial and Business Literacy Among Urology Residents: Is this a Problem and How Can We Better Prepare Residents for their Careers?","authors":"Vinayak Madhusoodanan, Joshua Bitran, Maxwell Towe, Chad Ritch","doi":"10.1007/s11934-024-01216-6","DOIUrl":"10.1007/s11934-024-01216-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>Although financial wellness is a predictor of physician burnout, we are yet to optimize financial education or wellness of Urology trainees. We assessed existing studies, compared them to those of other specialties, and discussed resources and methods to address this deficiency.</p><p><strong>Recent findings: </strong>Urology residents tend to be less fiscally savvy (carry significant debt, and lack retirement savings or disability insurance), and 90% of trainees and young Urologists do not feel comfortable with the business of practice, including skills like coding and billing, contract negotiation, and self-value assessment. Financial and business literacy are deficiencies of Urology training, as in other specialties. Eventually, the goal should be universal adoption of a formal curriculum that is graded in nature. In the interim, we need to propose and endorse adoption of a formal curriculum, and we should support trainees by promoting a space for easily accessible and transparent information regarding best practices in personal finance and the business of healthcare.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":" ","pages":"207-214"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Current Urology ReportsPub Date : 2024-09-01Epub Date: 2024-07-02DOI: 10.1007/s11934-024-01214-8
Timothy C Boswell
{"title":"Advancements in Surgical Management of Megaureters.","authors":"Timothy C Boswell","doi":"10.1007/s11934-024-01214-8","DOIUrl":"10.1007/s11934-024-01214-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>To review and describe the recent evolution of surgery for the various types of pediatric megaureter.</p><p><strong>Recent findings: </strong>Megaureter management first relies on determining the underlying cause, whether by obstruction, reflux, or a combination, and then setting appropriate surgical indications because many cases do not require surgery as shown by observation studies. Endoscopic balloon dilation has been on the rise as a major treatment option for obstructive megaureter, while refluxing megaureters can also be treated by laparoscopic and robotic techniques, whether extravesically or transvesicoscopically. During ureteral reimplantation, tapering is sometimes necessary to address the enlarged ureter, but there are also considerations for not tapering or for tapering alternatives. Endoscopic and minimally invasive surgeries for megaureter have been the predominant focus of recent megaureter literature. These techniques still need collaborative prospective studies to better define which surgeries are best for patients needing megaureter interventions.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":" ","pages":"215-223"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11306539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robert Geraghty, Catherine Lovegrove, Sarah Howles, John A. Sayer
{"title":"Role of Genetic Testing in Kidney Stone Disease: A Narrative Review","authors":"Robert Geraghty, Catherine Lovegrove, Sarah Howles, John A. Sayer","doi":"10.1007/s11934-024-01225-5","DOIUrl":"https://doi.org/10.1007/s11934-024-01225-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3><p>Kidney stone disease (KSD) is a common and potentially life-threatening condition, and half of patients experience a repeat kidney stone episode within 5–10 years. Despite the ~50% estimate heritability of KSD, international guidelines have not kept up with the pace of discovery of genetic causes of KSD. The European Association of Urology guidelines lists 7 genetic causes of KSD as ‘high risk’.</p><h3 data-test=\"abstract-sub-heading\">Recent Findings</h3><p>There are currently 46 known monogenic (single gene) causes of kidney stone disease, with evidence of association in a further 23 genes. There is also evidence for polygenic risk of developing KSD. Evidence is lacking for recurrent disease, and only one genome wide association study has investigated this phenomenon, identifying two associated genes (<i>SLC34A1</i> and <i>TRPV5</i>). However, in the absence of other evidence, patients with genetic predisposition to KSD should be treated as ‘high risk’. Further studies are needed to characterize both monogenic and polygenic associations with recurrent disease, to allow for appropriate risk stratification. Durability of test result must be balanced against cost. This would enable retrospective analysis if no genetic cause was found initially.</p><h3 data-test=\"abstract-sub-heading\">Summary</h3><p>We recommend genetic testing using a gene panel for all children, adults < 25 years, and older patients who have factors associated with high risk disease within the context of a wider metabolic evaluation. Those with a genetic predisposition should be managed via a multi-disciplinary team approach including urologists, radiologists, nephrologists, clinical geneticists and chemical pathologists. This will enable appropriate follow-up, counselling and potentially prophylaxis.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"15 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141881735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Current Urology ReportsPub Date : 2024-08-01Epub Date: 2024-05-21DOI: 10.1007/s11934-024-01209-5
Xianming Yao, Gang Zhang, Qianwei Xiong, Shaoguang Feng, Xian Liu
{"title":"Plastic Clamp Versus Conventional Surgical Dissection Technique in Pediatric Circumcision: A Systematic Review and Meta-Analysis.","authors":"Xianming Yao, Gang Zhang, Qianwei Xiong, Shaoguang Feng, Xian Liu","doi":"10.1007/s11934-024-01209-5","DOIUrl":"10.1007/s11934-024-01209-5","url":null,"abstract":"<p><strong>Purpose: </strong>Phimosis is a common condition of the urinary system in children and often requires surgical treatment. However, the optimal method of circumcision for children has not been determined. We conducted a systematic review and meta-analysis to compare the safety and effectiveness of plastic clamp with conventional surgical circumcision in pediatric circumcision.</p><p><strong>Methods: </strong>A literature search was carried out to compare the plastic clamp and conventional dissection technique in the pediatric population. The following search terms were used: \"circumcision\", \"plastic clamp\", \"conventional\", \"plastibell\", \"children\" and etc. Meta-analysis was used to pool and evaluate variables such as operative time, blood loss, wound infection, bleeding, edema, and total postoperative complications.</p><p><strong>Results: </strong>The plastic clamp technique (PCT) was used in 10,412 of the 17,325 participants in the nine studies, while the conventional surgical dissection technique (CST) was used on 6913 patients. When compared to the CST approach, the PCT approach resulted in shorter operative times (mean difference (MD) -17.48, 95% CI -22 to -12.96; P < 0.001), less blood loss (MD -4.25, 95% CI -7.75 to -0.77; P = 0.02), and a higher incidence of postoperative edema (OR 2.33, 95% CI 1.34 to 4.08; P = 0.003). However, no significant difference was found in the incidence of postoperative complications, including wound infection and bleeding between PCT and CST.</p><p><strong>Conclusions: </strong>PCT is a safe and time-saving option in the pediatric population. However, this method appeared to have a significant greater rate of postoperative edema.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":" ","pages":"173-180"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Current Urology ReportsPub Date : 2024-08-01Epub Date: 2024-06-11DOI: 10.1007/s11934-024-01217-5
Malcolm D Mattes
{"title":"Overview of Radiation Therapy in the Management of Localized and Metastatic Prostate Cancer.","authors":"Malcolm D Mattes","doi":"10.1007/s11934-024-01217-5","DOIUrl":"10.1007/s11934-024-01217-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>The goal is to describe the evolution of radiation therapy (RT) utilization in the management of localized and metastatic prostate cancer.</p><p><strong>Recent findings: </strong>Long term data for a variety of hypofractionated definitive RT dose-fractionation schemes has matured, allowing patients and providers many standard-of-care options to choose from. Post-prostatectomy, adjuvant RT has largely been replaced by an early salvage approach. Multiparametric MRI and PSMA PET have enabled increasingly targeted RT delivery to the prostate and oligometastatic tumors. Areas of active investigation include determining the value of proton beam therapy and perirectal spacers, and optimally incorporate genomic tumor profiling and next generation hormonal therapies with RT in the curative setting. The use of radiation therapy to treat prostate cancer is rapidly evolving. In the coming years, there will be continued improvements in a variety of areas to enhance the value of RT in multidisciplinary prostate cancer management.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":" ","pages":"181-192"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Current Urology ReportsPub Date : 2024-08-01Epub Date: 2024-06-13DOI: 10.1007/s11934-024-01218-4
Lane Shish, Joseph Zabell
{"title":"Digital Rectal Exam in Prostate Cancer Screening and Elevated PSA Work-up-Is there a role anymore?","authors":"Lane Shish, Joseph Zabell","doi":"10.1007/s11934-024-01218-4","DOIUrl":"10.1007/s11934-024-01218-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>Prostate cancer (PCa) screening tools, particularly digital rectal examination (DRE), are under scrutiny. This review assesses the utility of DRE in PCa screening.</p><p><strong>Recent findings: </strong>Recent studies reaffirm the DRE's sensitivity and specificity, a higher PCa detection rate with PSA in conjunction with DRE, and a slightly elevated risk of clinically significant PCa (CSPC) in those with elevated PSA and suspicious DRE. Studies confirm high accuracy of MRI in identifying CSPC, with ongoing research exploring its screening potential. DRE alone lacks accuracy for PCa screening, often resulting in missed diagnoses and unnecessary biopsies. Its supplementary use with PSA marginally increases detection rates of identifying a small percentage of CSPC, but the benefit remains questionable. Emerging evidence suggests MRI has the potential as a superior screening tool compared to DRE, although direct comparative studies are lacking. Overall, the DRE has a limited role in current PCa screening.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":" ","pages":"193-199"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Current Urology ReportsPub Date : 2024-08-01Epub Date: 2024-05-26DOI: 10.1007/s11934-024-01207-7
Lan Anh S Galloway, Amy N Luckenbaugh
{"title":"Preparing Trainees to Rebound from Surgical Complications.","authors":"Lan Anh S Galloway, Amy N Luckenbaugh","doi":"10.1007/s11934-024-01207-7","DOIUrl":"10.1007/s11934-024-01207-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>In this review, we aim to summarize the impact of surgical complications and adverse events on surgeons, including psychiatric illnesses. We evaluate current programs to develop trainee well-being and investigate research within the field of urology.</p><p><strong>Recent findings: </strong>Surgical complications and adverse events affect all surgeons, including surgical trainees. Research estimates that 80% of healthcare professionals have been involved in an event that affected them emotionally. These events can affect physicians in many ways, ranging from negatively impacting their quality of life to leading to psychiatric disorders such as acute stress reactions and post-traumatic stress disorder. Unfortunately, there is no standardized preparation to equip trainees to manage and rebound from the profound emotional impact of surgical complications. Data in this realm is insufficient, especially in urology, and we need more research in order to better evaluate emotional implications of complications on trainees and how we can prepare trainees to handle them.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":" ","pages":"169-172"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Current Urology ReportsPub Date : 2024-07-01Epub Date: 2024-05-10DOI: 10.1007/s11934-024-01204-w
Campbell Vogt, Neha R Malhotra
{"title":"Fertility Preservation in Children and Adolescents: Where We Are and Where We Are Going.","authors":"Campbell Vogt, Neha R Malhotra","doi":"10.1007/s11934-024-01204-w","DOIUrl":"10.1007/s11934-024-01204-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review will describe current pediatric and adolescent fertility preservation methodologies and the ethical concerns surrounding these procedures, as well as highlight recent research that may pave the way for the development of new fertility preservation options.</p><p><strong>Recent findings: </strong>Research is ongoing to allow prepubertal patients, particularly those with testes, to be able to have biologic children in the future. Studies on sperm in vitro maturation highlight the importance of supporting the spermatogonial stem cell niche for the development of mature sperm. The live birth of a rhesus macaque from in vitro fertilization using prepubertal testicular tissue and in vivo matured sperm gives hope to future human births. For patients with ovaries, prior work has led to successful fertility but further research is underway to refine these techniques and optimize outcomes. Organoid scaffolds have shown promise when being used for in vitro oocyte maturation. For children and adolescents undergoing gonadotoxic treatment, such as chemotherapy, or hormonal treatment, such as gender-affirming hormone therapy, future fertility potential may be negatively impacted. It is recommended that fertility preservation (FP) be offered to these patients and families prior to undergoing treatment. Fertility preservation for postpubertal patients mimics that in adults. For prepubertal children, however, the options are limited and in some cases still experimental. It is essential that this work continues so that we may offer children and adolescents the right to an open future and preserve their fertility potential.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":" ","pages":"133-140"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Current Urology ReportsPub Date : 2024-07-01Epub Date: 2024-05-10DOI: 10.1007/s11934-024-01205-9
Seyed Sajjad Tabei, Wesley Baas, Ayman Mahdy
{"title":"Pharmacotherapy in Stress Urinary Incontinence; A Literature Review.","authors":"Seyed Sajjad Tabei, Wesley Baas, Ayman Mahdy","doi":"10.1007/s11934-024-01205-9","DOIUrl":"10.1007/s11934-024-01205-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>Stress urinary incontinence (SUI) is a commonly observed condition in females, as well as in males who have undergone prostatectomy. Despite the significant progress made in surgical techniques, pharmacotherapy has not yielded substantial outcomes within the clinical domain. This review aims to present a comprehensive overview of the existing pharmacotherapy options for stress urinary incontinence (SUI) and the emerging therapeutic targets in this field.</p><p><strong>Recent findings: </strong>One meta-analysis demonstrated that α-adrenergic medications are more efficacious in improving rather than curing SUI symptoms. One trial showed reduced pad weight gain with PSD-503, a locally administered α-adrenergic receptor agonist. New data show that duloxetine's risk outweighs its benefits. One small-scale trial was found to support the use of locally administered estriol in improving subjective outcomes. Emerging targets include serotonin 5HT<sub>2C</sub> agonists, selective inhibitors of norepinephrine uptake, and myostatin inhibitors. Only one of the evaluated drugs, duloxetine, has been approved by some countries. Currently, trials are evaluating novel targets. Systemic adverse effects such as gastrointestinal upset with duloxetine and orthostatic hypotension with α-adrenoceptor agonists have hampered the efficacy of drugs used to treat SUI in women and men.</p>","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":" ","pages":"141-148"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}