Current Urology Reports最新文献_第10页

Role of the Renin-Angiotensin System Components in Renal Cell Carcinoma: A Literature Review. 肾素-血管紧张素系统成分在肾细胞癌中的作用:文献综述。

IF 2.6 2区医学

Current Urology Reports Pub Date : 2023-07-01 DOI: 10.1007/s11934-023-01160-x

Thiago Camelo Mourão, Stephania Martins Bezerra, Victor Espinheira Santos, Eder Silveira Brazão, Walter Henriques da Costa, Stênio de Cássio Zequi

{"title":"Role of the Renin-Angiotensin System Components in Renal Cell Carcinoma: A Literature Review.","authors":"Thiago Camelo Mourão, Stephania Martins Bezerra, Victor Espinheira Santos, Eder Silveira Brazão, Walter Henriques da Costa, Stênio de Cássio Zequi","doi":"10.1007/s11934-023-01160-x","DOIUrl":"https://doi.org/10.1007/s11934-023-01160-x","url":null,"abstract":"Purpose of review: The physiological aspects of renin-angiotensin system (RAS) components are described in this review. Additionally, we present the main results of studies that could indicate an association between alterations in these components and cancer, particularly renal cell carcinoma (RCC).Recent findings: The RAS undergoes a series of homeostatic and modulatory processes that extend to hypertrophy, hyperplasia, fibrosis, and remodeling, as well as angiogenesis, pro-inflammatory responses, cell differentiation, stem cell programming, and hematopoiesis. The link between cancer-related inflammation and RAS signaling converge in the response to tumor hypoxia and oxidative stress mechanisms, particularly with the angiotensin type 1 receptor leading to activation of transcription factors such as nuclear factor κB (NF-κB), as well as members of the signal transducer and activation of transcription (STAT) family and HIF1⍺. Dysregulation of the physiological actions of RAS in the microenvironment of inflammation and angiogenesis promotes tumor cell growth.","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 7","pages":"345-353"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9621578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging Techniques to Determine Degree of Sarcopenia and Systemic Inflammation in Advanced Renal Cell Carcinoma. 影像学技术测定晚期肾细胞癌中肌肉减少和全身性炎症程度。

IF 2.6 2区医学

Current Urology Reports Pub Date : 2023-07-01 DOI: 10.1007/s11934-023-01157-6

Benjamin N Schmeusser, Adil A Ali, Florian J Fintelmann, Jose M Garcia, Grant R Williams, Viraj A Master, Sarah P Psutka

{"title":"Imaging Techniques to Determine Degree of Sarcopenia and Systemic Inflammation in Advanced Renal Cell Carcinoma.","authors":"Benjamin N Schmeusser, Adil A Ali, Florian J Fintelmann, Jose M Garcia, Grant R Williams, Viraj A Master, Sarah P Psutka","doi":"10.1007/s11934-023-01157-6","DOIUrl":"https://doi.org/10.1007/s11934-023-01157-6","url":null,"abstract":"Purpose of review: The purpose of this review is to provide an up-to-date understanding regarding the literature on sarcopenia and inflammation as prognostic factors in the context of renal cell carcinoma (RCC).Recent findings: Sarcopenia is increasingly recognized as a prognostic factor in RCC. Emerging literature suggests monitoring quantity of muscle on successive imaging and examining muscle density may be additionally informative. Inflammation has prognostic ability in RCC and is also considered a key contributor to development and progression of both RCC and sarcopenia. Recent studies suggest these two prognostic factors together may provide additional prognostic ability when used in combination. Ongoing developments include quality control regarding sarcopenia research and imaging, improving understanding of muscle loss mechanisms, and enhancing clinical incorporation of sarcopenia via improving imaging analysis practicality (i.e., artificial intelligence) and feasible biomarkers. Sarcopenia and systemic inflammation are complementary prognostic factors for adverse outcomes in patients with RCC. Further study on high-quality sarcopenia assessment standardization and expedited sarcopenia assessment is desired for eventual routine clinical incorporation of these prognostic factors.","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 7","pages":"317-334"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330545/pdf/nihms-1900776.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9822268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Residency Surgical BPH Training Paradigms from MIST to HOLEP. 从MIST到HOLEP的住院医师外科BPH培训范式。

IF 2.6 2区医学

Current Urology Reports Pub Date : 2023-06-01 DOI: 10.1007/s11934-023-01153-w

Thaiphi Luu, Ricardo R Gonzalez

{"title":"Residency Surgical BPH Training Paradigms from MIST to HOLEP.","authors":"Thaiphi Luu, Ricardo R Gonzalez","doi":"10.1007/s11934-023-01153-w","DOIUrl":"https://doi.org/10.1007/s11934-023-01153-w","url":null,"abstract":"Purpose of review: Benign prostatic hyperplasia (BPH) is a common medical condition of older men that often requires medical or surgical therapy. Surgical options for BPH have grown exponentially over the last two decades. The numerous options and/or lack of access to them can make it challenging for new trainees to gain proficiency. We examine the literature for available BPH surgical simulators, learning curves, and training pathways.Recent findings: Each BPH surgical therapy has a learning curve which must be overcome. There is an abundance of TURP simulators which have shown face, content, and construct validity in the literature. Similarly, laser therapies have validated simulators. Newer technologies do have available simulators, but they have not been validated. There are strategies to improve learning and outcomes, such as having a structured training program. Simulators are available for BPH surgical procedures and some have been implemented in urology residencies. It is likely that such simulation may make urologists more facile on their learning curves for newer technologies. Further studies are needed. Future directions may include integration of simulator technology into training pathways that include surgical observation and proctorship.","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 6","pages":"261-269"},"PeriodicalIF":2.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9457728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Advancing Urology Resident Surgical Autonomy. 推进泌尿外科住院医师的手术自主权。

IF 2.5 2区医学

Current Urology Reports Pub Date : 2023-06-01 Epub Date: 2023-03-14 DOI: 10.1007/s11934-023-01152-x

Anh T Nguyen, Devashish J Anjaria, Hossein Sadeghi-Nejad

引用次数: 0

An Update of In Vivo Application of Artificial Intelligence and Robotics for Percutaneous Nephrolithotripsy: Results from a Systematic Review. 人工智能和机器人技术在经皮肾镜碎石术中的体内应用进展:一项系统综述的结果。

IF 2.6 2区医学

Current Urology Reports Pub Date : 2023-06-01 DOI: 10.1007/s11934-023-01155-8

Vineet Gauhar, Carlo Giulioni, Nariman Gadzhiev, Virgilio De Stefano, Jeremy Yuen-Chun Teoh, Ho Yee Tiong, Kazumi Taguchi, Giulio Milanese, Andrea Benedetto Galosi, Bhaskar Kumar Somani, Daniele Castellani

{"title":"An Update of In Vivo Application of Artificial Intelligence and Robotics for Percutaneous Nephrolithotripsy: Results from a Systematic Review.","authors":"Vineet Gauhar, Carlo Giulioni, Nariman Gadzhiev, Virgilio De Stefano, Jeremy Yuen-Chun Teoh, Ho Yee Tiong, Kazumi Taguchi, Giulio Milanese, Andrea Benedetto Galosi, Bhaskar Kumar Somani, Daniele Castellani","doi":"10.1007/s11934-023-01155-8","DOIUrl":"https://doi.org/10.1007/s11934-023-01155-8","url":null,"abstract":"Purpose of review: Kidney puncture is a key step in percutaneous nephrolithotomy (PCNL). Ultrasound/fluoroscopic-guided access to the collecting systems is commonly used in PCNL. Performing a puncture is often challenging in kidneys with congenital malformations or complex staghorn stones. We aim to perform a systematic review to examine data on in vivo applications, outcomes, and limitations of using artificial intelligence and robotics for access in PCNL.Recent findings: The literature search was performed on November 2, 2022, using Embase, PubMed, and Google Scholar. Twelve studies were included. 3D in PCNL is useful for image reconstruction but also in 3D printing with definite benefits seen in improving anatomical spatial understanding for preoperative and intraoperative planning. 3D model printing and virtual and mixed reality allow for an enhanced training experience and easier access which seems to translate into a shorter learning curve and better stone-free rate compared to standard puncture. Robotic access improves the accuracy of the puncture for ultrasound- and fluoroscopic-guided access in both supine and prone positions. The potential advantage robotics are using artificial intelligence to do remote access, reduced number of needle punctures, and less radiation exposure during renal access. Artificial intelligence, virtual and mixed reality, and robotics may play a key role in improving PCNL surgery by enhancing all aspects of a successful intervention from entry to exit. There is a gradual adoption of this newer technology into clinical practice but is yet limited to centers with access and the ability to afford this.","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 6","pages":"271-280"},"PeriodicalIF":2.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9954476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Single-Use Ureteroscopy and Environmental Footprint: Review of Current Evidence. 一次性输尿管镜检查与环境足迹:当前证据综述。

IF 2.6 2区医学

Current Urology Reports Pub Date : 2023-06-01 DOI: 10.1007/s11934-023-01154-9

George Brown, Andrea Ong, Patrick Juliebø-Jones, Niall F Davis, Andreas Skolarikos, Bhaskar Somani

{"title":"Single-Use Ureteroscopy and Environmental Footprint: Review of Current Evidence.","authors":"George Brown, Andrea Ong, Patrick Juliebø-Jones, Niall F Davis, Andreas Skolarikos, Bhaskar Somani","doi":"10.1007/s11934-023-01154-9","DOIUrl":"https://doi.org/10.1007/s11934-023-01154-9","url":null,"abstract":"Purpose of review: Ureteroscopy is a well-established treatment modality for kidney and ureteric calculi in addition to playing a key role in upper tract cancer diagnostics. Traditional reusable flexible ureteroscopes are technologically advanced and expensive pieces of equipment that require repeat sterilisation and periodical repair. These issues have led to the development of single-use flexible ureteroscopes that are disposed of after each case. Whilst this may be advantageous in many respects, the environmental impact of such technology is yet to be fully determined. The aim of this review is to therefore identify and summarise the available literature concerning the environmental footprint of single-use ureteroscopy.Recent findings: To identify the latest research on this topic, a systematic search of world literature was conducted using the Medline, Embase, and PsycINFO databases. PRISMA guidelines were followed and articles were assessed by all authors and relevant study results were included in a narrative format. Only one relevant article was identified and included. This study found that a single-use flexible ureteroscope (LithoVueTM by Boston Scientific) generated an equivalent amount of carbon dioxide per case to a contemporary reusable flexible ureteroscope. Literature concerning the environmental footprint of single-use ureteroscopy is worryingly lacking. No conclusions can be definitively drawn from a single study and further research is imperative given the global climate crisis and the significant contribution that healthcare services have to the environmental problem.","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 6","pages":"281-285"},"PeriodicalIF":2.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9455993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Kidney Xenotransplantation: Are We Ready for Prime Time? 异种肾脏移植:我们准备好进入黄金时代了吗?

IF 2.6 2区医学

Current Urology Reports Pub Date : 2023-06-01 DOI: 10.1007/s11934-023-01156-7

Rafael Miyashiro Nunes Dos Santos

{"title":"Kidney Xenotransplantation: Are We Ready for Prime Time?","authors":"Rafael Miyashiro Nunes Dos Santos","doi":"10.1007/s11934-023-01156-7","DOIUrl":"https://doi.org/10.1007/s11934-023-01156-7","url":null,"abstract":"Purpose of review: With the exponential increase in interest and great strides toward clinical application, many experts believe we are ready for kidney xenotransplant human trials. In this review, we will examine the obstacles overcome and those yet to be conquered, discussing the human trials performed and the questions they raised. Additionally, we will revisit overlooked aspects that may be crucial for improvements and suggest future approaches for xenotransplant research.Recent findings: Improving survival in pig-to-non-human-primate models with the identification of an ideal immunosuppression regimen led to 3 cases of kidney xenotransplant in brain-dead humans with limited follow-up and a single clinical case of pig-to-human heart xenotransplant with 2-month survival. With limited human results and unlimited potential, xenotransplantation shines a beacon of hope for a brighter future. However, we must navigate through the complexities of balancing scientific progress and patient welfare, avoiding being blinded by xenotransplantation's unquestionable potential.","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 6","pages":"287-297"},"PeriodicalIF":2.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9468299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding Options for the Unmatched Urology Applicant. 了解不匹配泌尿外科申请人的选择。

IF 2.6 2区医学

Current Urology Reports Pub Date : 2023-05-01 DOI: 10.1007/s11934-023-01151-y

Shreya R Lamba, Casey A Seideman, Nishant D Patel, Ryan W Dobbs

引用次数: 0

Comparison of Contemporary Surgical Outcomes Between Holmium Laser Enucleation of the Prostate and Robotic-Assisted Simple Prostatectomy. 钬激光前列腺摘除与机器人辅助单纯前列腺切除术当代手术效果的比较。

IF 2.6 2区医学

Current Urology Reports Pub Date : 2023-05-01 DOI: 10.1007/s11934-023-01146-9

T Max Shelton, Connor Drake, Ruben Vasquez, Marcelino Rivera

{"title":"Comparison of Contemporary Surgical Outcomes Between Holmium Laser Enucleation of the Prostate and Robotic-Assisted Simple Prostatectomy.","authors":"T Max Shelton, Connor Drake, Ruben Vasquez, Marcelino Rivera","doi":"10.1007/s11934-023-01146-9","DOIUrl":"https://doi.org/10.1007/s11934-023-01146-9","url":null,"abstract":"Purpose of review: This study reviews contemporary literature on RASP and HoLEP to evaluate perioperative outcomes, common complications, cost analytics, and future directions of both procedures.Recent findings: RASP is indicated for prostates > 80 mL, while HoLEP is size-independent. No notable differences were found in operative time, PSA nadir (surrogate for enucleation volume), re-catheterization rates, or long-term durability. Prolonged incontinence and bladder neck contracture rates are low for both surgeries. Patients experience similar satisfaction outcomes and improvements in uroflowmetry and post-void residual volumes. HoLEP demonstrates shorter hospitalizations, lower transfusion rates, lower costs, and higher rates of same-day discharge. RASP offers a shorter learning curve and lower rates of early postoperative urinary incontinence. HoLEP is a size-independent surgery that offers advantages for patients seeking a minimally invasive procedure with the potential for catheter-free same-day discharge. Future directions with single-port simple prostatectomy may offer parity in same-day discharge, but further research is needed to determine broader feasibility.","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 5","pages":"221-229"},"PeriodicalIF":2.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9281383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Prostatitis: A Review. 前列腺炎:综述。

IF 2.6 2区医学

Current Urology Reports Pub Date : 2023-05-01 DOI: 10.1007/s11934-023-01150-z

A Yebes, C Toribio-Vazquez, S Martinez-Perez, J M Quesada-Olarte, A Rodriguez-Serrano, M Álvarez-Maestro, L Martinez-Piñeiro

{"title":"Prostatitis: A Review.","authors":"A Yebes, C Toribio-Vazquez, S Martinez-Perez, J M Quesada-Olarte, A Rodriguez-Serrano, M Álvarez-Maestro, L Martinez-Piñeiro","doi":"10.1007/s11934-023-01150-z","DOIUrl":"https://doi.org/10.1007/s11934-023-01150-z","url":null,"abstract":"Purpose of review: Pathologies of the prostate in men are one of the most prevalent clinical conditions today [1]. Specifically, pelvic inflammatory disease such as prostatitis can cause symptoms and syndromes different from urological ones, such as bowel or nervous system manifestations. This has a largely negative impact on the quality of life of patients. Therefore, it is convenient to know and update the information about the therapeutic approach to prostatitis, which is a challenge that involves different medical specialties. The aim of this article is to provide summarized and focused evidence to help in the therapeutic approach of patients with prostatitis. A computer-based search of the PubMed and Cochrane Library databases was used to perform a comprehensive literature review on prostatitis, with special interest in recent findings and latest therapeutic guideline recommendations.Recent findings: Recent discoveries about the epidemiology and clinical classifications of prostatitis seem to incur in an increasingly individualized and directed management, with the aim of covering all the confluent factors in prostatic inflammatory pathology. In addition, the role of new drugs and combination with phytotherapy open up a range of new treatment possibilities, although future randomized studies will be necessary to better understand how to use all treatment modalities. Despite all the knowledge acquired about the pathophysiology of prostate diseases, and due to their interrelation with other pelvic systems and organs, there are still gaps that make it difficult for us to provide an optimal and standardized treatment in many of our patients. Being aware of the influence of all the factors potentially involved in prostate symptoms is crucial for a correct diagnosis and establishing an effective treatment plan.","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"24 5","pages":"241-251"},"PeriodicalIF":2.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9288570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1