Diabetes & Vascular Disease Research最新文献_第8页

Roles of vascular endothelial and smooth muscle cells in the vasculoprotective effect of insulin in a mouse model of restenosis. 血管内皮细胞和平滑肌细胞在小鼠再狭窄模型中胰岛素的血管保护作用中的作用。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-05-01 DOI: 10.1177/14791641211027324

Yusaku Mori, Marel Gonzalez Medina, Zhiwei Liu, June Guo, Luke S Dingwell, Simon Chiang, Carl Ronald Kahn, Mansoor Husain, Adria Giacca

{"title":"Roles of vascular endothelial and smooth muscle cells in the vasculoprotective effect of insulin in a mouse model of restenosis.","authors":"Yusaku Mori, Marel Gonzalez Medina, Zhiwei Liu, June Guo, Luke S Dingwell, Simon Chiang, Carl Ronald Kahn, Mansoor Husain, Adria Giacca","doi":"10.1177/14791641211027324","DOIUrl":"10.1177/14791641211027324","url":null,"abstract":"Background: Insulin exerts vasculoprotective effects on endothelial cells (ECs) and growth-promoting effects on vascular smooth muscle cells (SMCs) in vitro, and suppresses neointimal growth in vivo. Here we determined the role of ECs and SMCs in the effect of insulin on neointimal growth.Methods: Mice with transgene CreERT2 under the control of EC-specific Tie2 (Tie2-Cre) or SMC-specific smooth muscle myosin heavy chain promoter/enhancer (SMMHC-Cre) or littermate controls were crossbred with mice carrying a loxP-flanked insulin receptor (IR) gene. After CreERT2-loxP-mediated recombination was induced by tamoxifen injection, mice received insulin pellet or sham (control) implantation, and underwent femoral artery wire injury. Femoral arteries were collected for morphological analysis 28 days after wire injury.Results: Tamoxifen-treated Tie2-Cre+ mice showed lower IR expression in ECs, but not in SMCs, than Tie2-Cre- mice. Insulin treatment reduced neointimal area after arterial injury in Tie2-Cre- mice, but had no effect in Tie2-Cre+ mice. Tamoxifen-treated SMMHC-Cre+ mice showed lower IR expression in SMCs, but not in ECs, than SMMHC-Cre- mice. Insulin treatment reduced neointimal area in SMMHC-Cre- mice, whereas unexpectedly, it failed to inhibit neointima formation in SMMHC-Cre+ mice.Conclusion: Insulin action in both ECs and SMCs is required for the \"anti-restenotic\" effect of insulin in vivo.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 3","pages":"14791641211027324"},"PeriodicalIF":2.4,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/49/10.1177_14791641211027324.PMC8482728.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39055150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accurate prediction of HbA1c by continuous glucose monitoring using a kinetic model with patient-specific parameters for red blood cell lifespan and glucose uptake. 使用具有患者特异性红细胞寿命和葡萄糖摄取参数的动力学模型，通过持续血糖监测准确预测HbA1c。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-05-01 DOI: 10.1177/14791641211013734

Yongjin Xu, Yushi Hirota, Ramzi A Ajjan, Akane Yamamoto, Atsuko Matsuoka, Wataru Ogawa, Timothy C Dunn

{"title":"Accurate prediction of HbA1c by continuous glucose monitoring using a kinetic model with patient-specific parameters for red blood cell lifespan and glucose uptake.","authors":"Yongjin Xu, Yushi Hirota, Ramzi A Ajjan, Akane Yamamoto, Atsuko Matsuoka, Wataru Ogawa, Timothy C Dunn","doi":"10.1177/14791641211013734","DOIUrl":"https://doi.org/10.1177/14791641211013734","url":null,"abstract":"Background: A recent kinetic model proposed a new individualized glycaemic marker, calculated HbA1c (cHbA1c), based on kinetic parameters and glucose levels that are specific to each person. The aims of the current work were to validate the accuracy of this glucose metric for clinical use and evaluate data requirements for the estimation of personal kinetic factors.Methods: We retrieved HbA1c and glucose data from a group of 51 Japanese T1D patients under sensor-augmented pump (SAP) therapy. Two patient-specific kinetic parameters were identified by data sections, defined as continuous glucose data between two laboratory HbA1c measurements. The cHbA1c was prospectively validated employing subsequent HbA1c data that were not originally used to determine personal kinetic parameters.Results: Compared to estimated HbA1c (eHbA1c) and glucose management indicator (GMI), cHbA1c showed clinically relevant accuracy improvement, with 20% or more within ±0.5% (±5.5 mmol/mol) of laboratory HbA1c. The mean absolute deviation of the cHbA1c calculation was 0.11% (1.2 mmol/mol), substantially less than for eHbA1c and GMI at 0.54% (5.9 mmol/mol) and 0.47% (5.1 mmol/mol), respectively.Conclusion: Our study shows superior performance of cHbA1c compared with eHbA1c and GMI at reflecting laboratory HbA1c, making it a credible glucose metric for routine clinical use.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 3","pages":"14791641211013734"},"PeriodicalIF":2.4,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/14791641211013734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38959135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The influence of cardiac rehabilitation on heart rate variability indices in men with type 2 diabetes and coronary artery disease. 心脏康复对男性2型糖尿病合并冠心病患者心率变异性指标的影响

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-05-01 DOI: 10.1177/14791641211020184

Katarzyna Szmigielska, Anna Jegier

{"title":"The influence of cardiac rehabilitation on heart rate variability indices in men with type 2 diabetes and coronary artery disease.","authors":"Katarzyna Szmigielska, Anna Jegier","doi":"10.1177/14791641211020184","DOIUrl":"https://doi.org/10.1177/14791641211020184","url":null,"abstract":"Method: The study population included 141 male CAD patients prospectively and consecutively admitted to an outpatient comprehensive CR program. Twenty-seven patients with type-2 diabetes were compared with 114 males without diabetes. The participants performed a 45-min cycle ergometer interval training alternating 4-min workload and a 2-min active restitution three times a week for 8 weeks. The training intensity was adjusted so that the patient's heart rate achieved the training heart rate calculated according to the Karvonen formula. At the baseline and after 8 weeks, all the patients underwent the HRV assessment.Results: HRV indices in the patients with diabetes were significantly lower as compared to the patients without diabetes in SDNN, TP, LF parameters, both at the baseline and after 8 weeks of CR. After 8 weeks of CR, a significant improvement of TP, SDNN, pNN50% and HF occurred in the patients without diabetes, whereas in the patients with diabetes only HF component improved significantly.Conclusions: As regards HRV indices, CR seems to be less effective in patients with CAD and type-2 diabetes.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 3","pages":"14791641211020184"},"PeriodicalIF":2.4,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/14791641211020184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39107354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Endothelial deletion of PKCδ prevents VEGF inhibition and restores blood flow reperfusion in diabetic ischemic limb. PKCδ的内皮缺失可防止VEGF的抑制并恢复糖尿病缺血性肢体的血流再灌注。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-03-01 DOI: 10.1177/1479164121999033

Laura Croteau, Clément Mercier, Étienne Fafard-Couture, Alexandre Nadeau, Stéphanie Robillard, Valérie Breton, Andréanne Guay, Farah Lizotte, Marc-Antoine Despatis, Pedro Geraldes

{"title":"Endothelial deletion of PKCδ prevents VEGF inhibition and restores blood flow reperfusion in diabetic ischemic limb.","authors":"Laura Croteau, Clément Mercier, Étienne Fafard-Couture, Alexandre Nadeau, Stéphanie Robillard, Valérie Breton, Andréanne Guay, Farah Lizotte, Marc-Antoine Despatis, Pedro Geraldes","doi":"10.1177/1479164121999033","DOIUrl":"10.1177/1479164121999033","url":null,"abstract":"Aims: Peripheral artery disease is a complication of diabetes leading to critical hindlimb ischemia. Diabetes-induced inhibition of VEGF actions is associated with the activation of protein kinase Cδ (PKCδ). We aim to specifically investigate the role of PKCδ in endothelial cell (EC) function and VEGF signaling.Methods: Nondiabetic and diabetic mice, with (ec-Prkcd-/-) or without (ec-Prkcdf/f) endothelial deletion of PKCδ, underwent femoral artery ligation. Blood flow reperfusion was assessed up to 4 weeks post-surgery. Capillary density, EC apoptosis and VEGF signaling were evaluated in the ischemic muscle. Src homology region 2 domain-containing phosphatase-1 (SHP-1) phosphatase activity was assessed in vitro using primary ECs.Results: Ischemic muscle of diabetic ec-Prkcdf/f mice exhibited reduced blood flow reperfusion and capillary density while apoptosis increased as compared to nondiabetic ec-Prkcdf/f mice. In contrast, blood flow reperfusion and capillary density were significantly improved in diabetic ec-Prkcd-/- mice. VEGF signaling pathway was restored in diabetic ec-Prkcd-/- mice. The deletion of PKCδ in ECs prevented diabetes-induced VEGF unresponsiveness through a reduction of SHP-1 phosphatase activity.Conclusions: Our data provide new highlights in mechanisms by which PKCδ activation in EC contributed to poor collateral vessel formation, thus, offering novel therapeutic targets to improve angiogenesis in the diabetic limb.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 2","pages":"1479164121999033"},"PeriodicalIF":2.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25480643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma levels of tissue inhibitor of metalloproteinase-1 in patients with type 1 diabetes mellitus associate with early diabetic neuropathy and nephropathy. 1型糖尿病患者血浆金属蛋白酶-1组织抑制剂水平与早期糖尿病神经病变和肾病相关

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-03-01 DOI: 10.1177/14791641211002470

Nektaria Papadopoulou-Marketou, Per A Whiss, Andreas C Eriksson, Lars Hyllienmark, Ioannis Papassotiriou, Jeanette Wahlberg

{"title":"Plasma levels of tissue inhibitor of metalloproteinase-1 in patients with type 1 diabetes mellitus associate with early diabetic neuropathy and nephropathy.","authors":"Nektaria Papadopoulou-Marketou, Per A Whiss, Andreas C Eriksson, Lars Hyllienmark, Ioannis Papassotiriou, Jeanette Wahlberg","doi":"10.1177/14791641211002470","DOIUrl":"https://doi.org/10.1177/14791641211002470","url":null,"abstract":"Background: Tissue inhibitor of metalloproteinase-1 (TIMP-1) has been suggested as a marker for abnormal regulation of tissue remodelling in type 1 diabetes. Metalloproteinase-9 (MMP-9) has been associated with matrix turnover, and Neutrophil gelatinase associated lipocalin (NGAL) is a marker of tubular injury in diabetic nephropathy. The aim was to analyse these biomarkers to unmask early diabetic complications.Methods: Thirty-three type 1 diabetes patients, aged 20-35 years, and disease duration 20 ± 5.3 years were included. Along with clinical examination, neurophysiological measurements, routine biochemistry, plasma concentrations of TIMP-1, MMP-9 and NGAL were determined with immunoenzymatic techniques.Results: TIMP-1 correlated with abnormal unilateral and bilateral vibratory sense foot perception (r = -0.49 and r = -0.51, respectively), foot neuropathy impairment assessment score (NIA; r = -0.55), neuropathy symptom assessment score (r = 0.42), microalbuminuria (r = 0.50) and eGFR (r = -0.45). MMP-9 correlated with impaired foot NIA (r = 0.51). Multiple regression analysis showed an association for TIMP-1 (p = 0.004) with impaired neurophysiological examinations and renal dysfunction along with NGAL (p = 0.016 and p = 0.015 respectively).Conclusions: This study suggests that plasma levels of TIMP-1, MMP-9 and NGAL may serve as useful biomarkers in unravelling subclinical neuropathy and nephropathy in type 1 diabetes.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 2","pages":"14791641211002470"},"PeriodicalIF":2.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/14791641211002470","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25524404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Glucose-dependent insulinotropic polypeptide inhibits cardiac hypertrophy and fibrosis in diabetic mice via suppression of TGF-β2. 葡萄糖依赖性胰岛素多肽通过抑制TGF-β2抑制糖尿病小鼠心肌肥大和纤维化。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-03-01 DOI: 10.1177/1479164121999034

Munenori Hiromura, Yusaku Mori, Michishige Terasaki, Hideki Kushima, Tomomi Saito, Naoya Osaka, Hironori Yashima, Makoto Ohara, Tomoyasu Fukui, Takanori Matsui, Sho-Ichi Yamagishi

{"title":"Glucose-dependent insulinotropic polypeptide inhibits cardiac hypertrophy and fibrosis in diabetic mice via suppression of TGF-β2.","authors":"Munenori Hiromura, Yusaku Mori, Michishige Terasaki, Hideki Kushima, Tomomi Saito, Naoya Osaka, Hironori Yashima, Makoto Ohara, Tomoyasu Fukui, Takanori Matsui, Sho-Ichi Yamagishi","doi":"10.1177/1479164121999034","DOIUrl":"https://doi.org/10.1177/1479164121999034","url":null,"abstract":"Diabetic cardiomyopathy is associated with an increased risk for heart failure and death in patients with diabetes. We investigated here whether and how GIP attenuated cardiac hypertrophy and fibrosis in diabetic mice with obesity. Diabetic db/db mice at 7 weeks old were infused with vehicle or GIP (50 nmol/kg/day) for 6 weeks, and hearts were collected for histological and RT-PCR analyzes. Cardiomyocytes isolated from neonatal mice were incubated with or without 300 nM [D-Ala2]-GIP, 30 mM glucose, or 100 μg/mL advanced glycation end products (AGEs) for RT-PCR and lucigenin assays. Compared with non-diabetic mice, diabetic mice exhibited larger left ventricle wall thickness and cardiomyocyte sizes and more fibrotic areas in association with up-regulation of myosin heavy chain β (β-Mhc) and transforming growth factor-beta2 (Tgf-β2) mRNA levels, all of which were inhibited by GIP infusion. High glucose increased NADPH oxidase-driven superoxide generation and up-regulated β-Mhc, Tgf-β2, and receptor for AGEs mRNA levels in cardiomyocytes, and augmented the AGE-induced β-Mhc gene expression. [D-Ala2]-GIP attenuated all of the deleterious effects of high glucose and/or AGEs on cardiomyocytes. Our present findings suggest that GIP could inhibit cardiac hypertrophy and fibrosis in diabetic mice via suppression of TGF-β2.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 2","pages":"1479164121999034"},"PeriodicalIF":2.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c7/5f/10.1177_1479164121999034.PMC8755933.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39921606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Mobilization of endothelial progenitor cells promotes angiogenesis after full thickness excision by AMD3100 combined with G-CSF in diabetic mice by SDF-1/CXCR4 axis. 通过SDF-1/CXCR4轴，AMD3100联合G-CSF对糖尿病小鼠进行全层切除后，调动内皮祖细胞促进血管生成。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-03-01 DOI: 10.1177/14791641211002473

Xiaoying Lin, Hong Wang, Xiaolan Li

{"title":"Mobilization of endothelial progenitor cells promotes angiogenesis after full thickness excision by AMD3100 combined with G-CSF in diabetic mice by SDF-1/CXCR4 axis.","authors":"Xiaoying Lin, Hong Wang, Xiaolan Li","doi":"10.1177/14791641211002473","DOIUrl":"10.1177/14791641211002473","url":null,"abstract":"Aim: The aim of the present study was to investigate the effect of the mobilization of EPCs by AMD3100 combined with G-CSF on wound healing in diabetic mice.Methods: The full-thickness excisional wounds model of diabetic mice (db/db) was examined by hematoxylin and eosin staining, immunohistochemical staining, and western blotting to compare the wound healing and neovascularization among the combination, AMD3100 alone, G-CSF alone, and control groups.Results: The wounds reached the complete closure in the combination, AMD3100 alone, G-CSF alone, and control groups on days 17, 20, 21, 21 after surgery, respectively. In addition, the combination group promoted the inflammatory cell recruitment and glandular formation. On day 10 from injury, the protein expression of CD31 in the combination group was significantly higher compared with the other three groups (p < 0.001). The level of SDF-1 protein remained high in the combined group until on day 10 after surgery (p < 0.001).Conclusion: The mobilization of endogenous EPCs by AMD3100 combine with G-CSF is able to enhance the complete healing of full-thickness wounds and neovascularization in db/db mice may by SDF-1/CXCR4 axis. These findings provided a novel method and indication of duration of mobilization on diabetic wound healing and tissue regeneration.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 2","pages":"14791641211002473"},"PeriodicalIF":2.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/04/8f/10.1177_14791641211002473.PMC8481732.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25529010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testosterone and sex hormone-binding globulin in dysglycemic women at high cardiovascular risk: A report from the Outcome Reduction with an Initial Glargine Intervention trial. 睾酮和性激素结合球蛋白在血糖异常女性心血管高危人群中的作用:一项来自初始甘精干预试验的结果降低报告

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-03-01 DOI: 10.1177/14791641211002475

Anne Wang, Hertzel C Gerstein, Shun Fu Lee, Sibylle Hess, Guillaume Paré, Lars Rydén, Linda G Mellbin

{"title":"Testosterone and sex hormone-binding globulin in dysglycemic women at high cardiovascular risk: A report from the Outcome Reduction with an Initial Glargine Intervention trial.","authors":"Anne Wang, Hertzel C Gerstein, Shun Fu Lee, Sibylle Hess, Guillaume Paré, Lars Rydén, Linda G Mellbin","doi":"10.1177/14791641211002475","DOIUrl":"https://doi.org/10.1177/14791641211002475","url":null,"abstract":"Aims: Total and free testosterone and sex hormone-binding globulin may affect cardiovascular prognosis in women. The objective was to study the association between sex hormones and prognosis in women with dysglycemia and high cardiovascular risk.Methods: This epidemiological report included dysglycemic women from the Outcome Reduction with an Initial Glargine Intervention trial (n = 2848) with baseline total testosterone and sex hormone-binding globulin. Free testosterone was calculated with the Vermeulen formula. Cox regression analyses adjusted for variables including age, previous diseases and pharmacological treatments were used to estimate the association between these levels and the composite cardiovascular outcome (death from cardiovascular causes, nonfatal myocardial infarction or nonfatal stroke) and all-cause mortality per one standard deviation.Results: Patients (73% post-menopausal) were followed for a median of 6.1 years during which 377 cardiovascular events and 389 deaths occurred. In Cox analyses, total and free testosterone were not associated with any outcomes, but sex hormone-binding globulin was related to all-cause mortality in age adjusted (HR 1.15; 95% CI 1.06-1.24; p < 0.01) and fully adjusted analyses (HR 1.14; 95% CI 1.05-1.24; p < 0.01).Conclusions: Increasing levels of baseline sex hormone-binding globulin were associated with an increased risk of all-cause mortality in dysglycemic women at high cardiovascular risk.Trial registration: ClinicalTrials.gov no. NCT00069784.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 2","pages":"14791641211002475"},"PeriodicalIF":2.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/14791641211002475","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25506864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Coronary revascularization in patients with stable coronary disease and diabetes mellitus. 稳定型冠状动脉疾病和糖尿病患者的冠状动脉血运重建。

IF 2.8 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-03-01 DOI: 10.1177/14791641211002469

Salman Bhat, Yan Yatsynovich, Umesh C Sharma

{"title":"Coronary revascularization in patients with stable coronary disease and diabetes mellitus.","authors":"Salman Bhat, Yan Yatsynovich, Umesh C Sharma","doi":"10.1177/14791641211002469","DOIUrl":"10.1177/14791641211002469","url":null,"abstract":"Purpose of study: Diabetes mellitus accelerates the development of atherosclerosis. Patients with diabetes mellitus have higher incidence and mortality rates from cardiovascular disease and undergo a disproportionately higher number of coronary interventions compared to the general population. Proper selection of treatment modalities is thus paramount. Treatment strategies include medical management and interventional approaches including coronary artery bypass graft (CABG) surgery and percutaneous coronary interventions (PCI). The purpose of this review is to assimilate emerging evidence comparing CABG to PCI in patients with diabetes and present an outlook on the latest advances in percutaneous interventions, in addition to the optimal medical therapies in patients with diabetes.Key methods: A systematic search of PubMed, Web of Science and EMBASE was performed to identify prospective, randomized trials comparing outcomes of CABG and PCI, and also PCI with different generations of stents used in patients with diabetes. Additional review of bibliography of selected studies was also performed.Main conclusions: Most of the trials discussed above demonstrate a survival advantage of CABG over PCI in patients with diabetes. However, recent advances in PCI technology are starting to challenge this narrative. Superior stent designs, use of specific drug-eluting stents, image-guided stent deployment, and the use of contemporary antiplatelet and lipid-lowering therapies are continuing to improve the PCI outcomes. Prospective data for such emerging interventional technologies in diabetes is however lacking currently and is the need of the hour.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 2","pages":"14791641211002469"},"PeriodicalIF":2.8,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/cc/10.1177_14791641211002469.PMC8482730.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38931943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin increases central aortic stiffness in response to hyperglycemia in healthy humans: A randomized four-arm study. 胰岛素会增加健康人主动脉中央僵硬度以应对高血糖：四臂随机研究

IF 2.8 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-03-01 DOI: 10.1177/14791641211011009

William B Horton, Linda A Jahn, Lee M Hartline, Kevin W Aylor, James T Patrie, Eugene J Barrett

{"title":"Insulin increases central aortic stiffness in response to hyperglycemia in healthy humans: A randomized four-arm study.","authors":"William B Horton, Linda A Jahn, Lee M Hartline, Kevin W Aylor, James T Patrie, Eugene J Barrett","doi":"10.1177/14791641211011009","DOIUrl":"10.1177/14791641211011009","url":null,"abstract":"Introduction: Increasing arterial stiffness is a feature of vascular aging that is accelerated by conditions that enhance cardiovascular risk, including diabetes mellitus. Multiple studies demonstrate divergence of carotid-femoral pulse wave velocity and augmentation index in persons with diabetes mellitus, though mechanisms responsible for this are unclear.Materials and methods: We tested the effect of acutely and independently increasing plasma glucose, plasma insulin, or both on hemodynamic function and markers of arterial stiffness (including carotid-femoral pulse wave velocity, augmentation index, forward and backward wave reflection amplitude, and wave reflection magnitude) in a four-arm, randomized study of healthy young adults.Results: Carotid-femoral pulse wave velocity increased only during hyperglycemic-hyperinsulinemia (+0.36 m/s; p = 0.032), while other markers of arterial stiffness did not change (all p > 0.05). Heart rate (+3.62 bpm; p = 0.009), mean arterial pressure (+4.14 mmHg; p = 0.033), central diastolic blood pressure (+4.16 mmHg; p = 0.038), and peripheral diastolic blood pressure (+4.09 mmHg; p = 0.044) also significantly increased during hyperglycemic-hyperinsulinemia.Conclusions: Hyperglycemic-hyperinsulinemia acutely increased cfPWV, heart rate, mean arterial pressure, and diastolic blood pressure in healthy humans, perhaps reflecting enhanced sympathetic tone. Whether repeated bouts of hyperglycemia with hyperinsulinemia contribute to chronically-enhanced arterial stiffness remains unknown.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 2","pages":"14791641211011009"},"PeriodicalIF":2.8,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2a/72/10.1177_14791641211011009.PMC8481749.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38915784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0