Diabetes & Vascular Disease Research最新文献_第8页

High myopia is protective against diabetic retinopathy via thinning retinal vein: A report from Fushun Diabetic Retinopathy Cohort Study (FS-DIRECT). 抚顺糖尿病视网膜病变队列研究(FS-DIRECT)报告:高度近视通过视网膜静脉变薄对糖尿病视网膜病变具有保护作用。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2020-07-01 DOI: 10.1177/1479164120940988

Zhong Lin, Dong Li, Gang Zhai, Yu Wang, Liang Wen, Xiao Xia Ding, Feng Hua Wang, Yu Dou, Cong Xie, Yuan Bo Liang

{"title":"High myopia is protective against diabetic retinopathy via thinning retinal vein: A report from Fushun Diabetic Retinopathy Cohort Study (FS-DIRECT).","authors":"Zhong Lin, Dong Li, Gang Zhai, Yu Wang, Liang Wen, Xiao Xia Ding, Feng Hua Wang, Yu Dou, Cong Xie, Yuan Bo Liang","doi":"10.1177/1479164120940988","DOIUrl":"https://doi.org/10.1177/1479164120940988","url":null,"abstract":"Purpose: To investigate the association between high myopia and diabetic retinopathy, and its possible mechanism, in a northeastern Chinese population with type 2 diabetic mellitus.Methods: Patients were included from Fushun Diabetic Retinopathy Cohort Study. High myopia was defined as spherical equivalent of autorefraction less than -5D.Results: A total of 1817 patients [688 (37.9%) diabetic retinopathy, 102 (5.6%) high myopia] were included. Compared to eyes without high myopia, the frequency of diabetic retinopathy and non-proliferative diabetic retinopathy was significantly less in eyes with high myopia (23.5% vs 38.7%, p = 0.002; 22.5% vs 35.3%, p = 0.005). Eyes with high myopia were less likely to have diabetic retinopathy (multivariate odds ratio, 95% confidence interval: 0.39, 0.22-0.68) or non-proliferative diabetic retinopathy (odds ratio, 95% confidence interval: 0.40, 0.23-0.70). High myopia was negatively associated with central retinal venular equivalent (multivariate β, 95% confidence interval: -37.1, -42.3 to -31.8, p < 0.001). Furthermore, central retinal venular equivalent (per 10 μm increase) had a significant association with diabetic retinopathy (odds ratio, 95% confidence interval: 1.24, 1.17-1.31) as well as non-proliferative diabetic retinopathy (odds ratio, 95% confidence interval: 1.24, 1.18-1.31).Conclusions: High myopia was negatively associated with both diabetic retinopathy and non-proliferative diabetic retinopathy in this northeastern Chinese population. This protective effect may have been partially achieved via thinning retinal veins.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"17 4","pages":"1479164120940988"},"PeriodicalIF":2.4,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1479164120940988","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38170408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Role of platelet-derived growth factor in type II diabetes mellitus and its complications. 血小板衍生生长因子在 II 型糖尿病及其并发症中的作用。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2020-07-01 DOI: 10.1177/1479164120942119

Sihong Shen, Fuyan Wang, Alejandra Fernandez, Weining Hu

引用次数: 0

Rationale and design of the LIBERATES trial: Protocol for a randomised controlled trial of flash glucose monitoring for optimisation of glycaemia in individuals with type 2 diabetes and recent myocardial infarction. LIBERATES试验的基本原理和设计：一项随机对照试验的方案，用于优化2型糖尿病和近期心肌梗死患者的血糖。

IF 2.8 4区医学

Diabetes & Vascular Disease Research Pub Date : 2020-05-01 DOI: 10.1177/1479164120957934

Colin C Everett, Catherine Reynolds, Catherine Fernandez, Deborah D Stocken, Linda D Sharples, Thozhukat Sathyapalan, Simon Heller, Robert F Storey, Ramzi A Ajjan

{"title":"Rationale and design of the LIBERATES trial: Protocol for a randomised controlled trial of flash glucose monitoring for optimisation of glycaemia in individuals with type 2 diabetes and recent myocardial infarction.","authors":"Colin C Everett, Catherine Reynolds, Catherine Fernandez, Deborah D Stocken, Linda D Sharples, Thozhukat Sathyapalan, Simon Heller, Robert F Storey, Ramzi A Ajjan","doi":"10.1177/1479164120957934","DOIUrl":"10.1177/1479164120957934","url":null,"abstract":"Hyperglycaemia in individuals with type 2 diabetes (T2D) and myocardial infarction (MI) is associated with guarded clinical prognosis. Studies improving glucose levels in T2D following MI relied on HbA1c as the main glycaemic marker, failing to address potential adverse effects of hypoglycaemia and glucose variability. We describe the design of the LIBERATES trial that investigates the role of flash glucose monitoring in optimising glycaemic markers in high vascular risk individuals with T2D. This multicentre trial is designed to recruit up to 150 insulin and/or sulphonylurea-treated T2D patients, within 5 days of a proven MI. Individuals will be randomised 1:1 into intervention and control groups using flash glucose monitoring sensors and traditional self-monitoring of blood glucose, respectively. The control group will also wear a blinded continuous glucose monitoring sensor. The primary outcome is the difference in time spent in euglycaemia (defined as glucose levels between 3.9-10.0 mmol/l), comparing study groups 3 months following recruitment, assessed daily for 14 days and as an average. Secondary and exploratory end points include time spent in hypoglycaemia and hyperglycaemia, HbA1c, quality of life measures, major adverse cardiac events and cost-effectiveness of the intervention. This study will establish the role of flash glucose monitoring in glycaemic management of individuals with T2D sustaining a cardiac event.(Trial Registration: ISRCTN14974233, registered 12th June 2017).","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"17 5","pages":"1479164120957934"},"PeriodicalIF":2.8,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38511105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimated glucose disposal rate demographics and clinical characteristics of young adults with type 1 diabetes mellitus: A cross-sectional pilot study. 估计1型糖尿病年轻人的葡萄糖处理率、人口统计学和临床特征:一项横断面试点研究。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2020-05-01 DOI: 10.1177/1479164120952321

Revathi Nishtala, Noppadol Kietsiriroje, Mohammad Karam, Ramzi A Ajjan, Sam Pearson

{"title":"Estimated glucose disposal rate demographics and clinical characteristics of young adults with type 1 diabetes mellitus: A cross-sectional pilot study.","authors":"Revathi Nishtala, Noppadol Kietsiriroje, Mohammad Karam, Ramzi A Ajjan, Sam Pearson","doi":"10.1177/1479164120952321","DOIUrl":"https://doi.org/10.1177/1479164120952321","url":null,"abstract":"Background: Estimated glucose disposal rate (eGDR) is a practical measure of Insulin Resistance (IR) which can be easily incorporated into clinical practice. We profiled eGDR in younger adults with type 1 diabetes mellitus (T1DM) by their demographic and clinical characteristics.Methods: In this single centre study, medical records of TIDM were assessed and eGDR tertiles correlated with demographic and clinical variables.Results: Of 175 T1DM individuals, 108 (61.7%) were males. Mean age (±SD) was 22.0 ± 1.6 years and median time from diagnosis 11.0 years (range 1-23). Individuals were predominantly Caucasian (81.7%), with 27.4% being overweight (BMI: 25-30 kg/m2) and 13.7% obese (BMI > 30 kg/m2). Mean total cholesterol (TC) levels were significantly lower in high and middle eGDR tertiles (4.4 ± 1 and 4.3 ± 0.8 mmol/l, respectively) compared with low eGDR tertile (4.8 ± 1, p < 0.05 for both). Triglyceride (TG) levels showed a similar trend at 1.1 ± 0.5 and 1.1 ± 0.5 mmol/l for high and middle eGDR tertile compared to low eGDR tertile (1.5 ± 1 mmol/l, p < 0.05 for both). Renal function was similar across eGDR tertiles and no difference in retinopathy was detected.Conclusion: TC and TG are altered in individuals with T1DM and low eGDR, suggesting that this subgroup requires optimal lipid management to ameliorate their vascular risk.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"17 5","pages":"1479164120952321"},"PeriodicalIF":2.4,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1479164120952321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38342605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Evaluation of the relationship between cardiac autonomic function and glucose variability and HOMA-IR in prediabetes. 糖尿病前期心脏自主神经功能与血糖变异性和HOMA-IR关系的评估。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2020-05-01 DOI: 10.1177/1479164120958619

Rumyana Dimova, Nevena Chakarova, Greta Grozeva, Tsvetalina Tankova

{"title":"Evaluation of the relationship between cardiac autonomic function and glucose variability and HOMA-IR in prediabetes.","authors":"Rumyana Dimova, Nevena Chakarova, Greta Grozeva, Tsvetalina Tankova","doi":"10.1177/1479164120958619","DOIUrl":"https://doi.org/10.1177/1479164120958619","url":null,"abstract":"Aims: The present study aims to investigate the relationship between cardiac autonomic function (CAF) and glucose variability (GV) and HOMA-IR in subjects with prediabetes and normal glucose tolerance (NGT).Material and methods: Ninety-two subjects (59 with prediabetes and 33 with NGT), of mean age 50.3 ± 11.5 years, mean BMI 30.4 ± 6.0 kg/m2, were included in this cross-sectional study. Glucose tolerance was assessed by OGTT according to WHO 2006 criteria. Glucose, HbA1c, insulin, oxLDL, and 3-Nitrotyrosine were measured. CGM was performed with a blinded sensor (FreeStyle Libre Pro). CAF was assessed by ANX-3.0 technology.Results: GV indices were increased in prediabetes. CAF was suppressed in subjects with any stage of dysglycemia. The prevalence of cardiac autonomic dysfunction was higher in prediabetes -20.3% as compared to NGT -3.0%, p = 0.028. HOMA-IR [OR 1.5 (95% CI: 1.1-2.1), p = 0.010] and time in target range [OR 0.8 (95% CI: 0.67-0.97), p = 0.021] were found to be predictive variables for impaired CAF. Sympathetic and parasympathetic activity negatively correlated with mean glycemia and GV indices and were independently related to JINDEX in prediabetes (F[1, 47] = 5.76, p = 0.021 and F[1, 47] = 5.94, p = 0.019, respectively); and to time above target range in NGT (F[1, 18] = 4.48, p = 0.049 and F[1, 18] = 4.65, p = 0.046, respectively).Conclusion: CAF is declined in prediabetes and seems to be related to GV and HOMA-IR at early stages of dysglycemia.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"17 5","pages":"1479164120958619"},"PeriodicalIF":2.4,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1479164120958619","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38430654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Decrease of peripheral resistance after intraoperative administration of iloprost in patients with and without type 2 diabetes mellitus and with peripheral arterial occlusive disease. 有无2型糖尿病及外周动脉闭塞性疾病患者术中给予伊洛前列素后外周抵抗的降低

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2020-05-01 DOI: 10.1177/1479164120930589

Kornelia Hirsch, Marcus Säemann, Corinna Walter, Fadi Taher, Skrinjar Edda, Irene Mlekusch, Heidrun Jäger, Afshin Assadian, Jürgen Falkensammer

{"title":"Decrease of peripheral resistance after intraoperative administration of iloprost in patients with and without type 2 diabetes mellitus and with peripheral arterial occlusive disease.","authors":"Kornelia Hirsch, Marcus Säemann, Corinna Walter, Fadi Taher, Skrinjar Edda, Irene Mlekusch, Heidrun Jäger, Afshin Assadian, Jürgen Falkensammer","doi":"10.1177/1479164120930589","DOIUrl":"https://doi.org/10.1177/1479164120930589","url":null,"abstract":"Background: In many cases, Ilomedin® infusions are applied as part of a perioperative measure in patients with peripheral arterial occlusive disease because it makes a relevant vasodilatatory effect in patients with type 2 diabetes mellitus and with/without peripheral neuropathy.Aims: A prospective case-control study was performed to investigate the effect of prostanoids on peripheral resistance in patients with type 2 diabetes mellitus and patients without type 2 diabetes mellitus, as well as the role of peripheral neuropathy in patients undergoing arterial reconstruction.Methods: Sixty patients undergoing arterial reconstruction were enrolled. Sufficient data were collected on 38 patients. Prior to surgery, peripheral nerve conduction velocity was measured. Blood flow volume at the common femoral artery was assessed intraoperatively using a Doppler flowmeter at four time points: at baseline before arterial reconstruction (T0), after reconstruction (T1), after 5 (T2) and 10 min (T3) after intra-arterial application of 3000 ng of Ilomedin. Peripheral resistance units were calculated as a function of mean arterial pressure and flow volume using the following formula: peripheral resistance unit = mean arterial pressure (mm Hg) / flow volume (mL/min).Results: Ilomedin produced an immediate and significant drop of peripheral resistance in patients without type 2 diabetes mellitus as well as in patients with type 2 diabetes mellitus. Patients with peripheral neuropathy showed a less pronounced effect to Ilomedin compared to individuals with normal nerve conduction velocity.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"17 5","pages":"1479164120930589"},"PeriodicalIF":2.4,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1479164120930589","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38089761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An optical coherence tomography comparison of coronary arterial plaque calcification in patients with end-stage renal disease and diabetes mellitus. 终末期肾病和糖尿病患者冠状动脉斑块钙化的光学相干断层扫描比较。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2020-05-01 DOI: 10.1177/1479164120958425

Joseph R Weber, Brendan Martin, Nicholas Kassis, Kunal Shah, Tomas Kovarnik, Holly Mattix-Kramer, John J Lopez

{"title":"An optical coherence tomography comparison of coronary arterial plaque calcification in patients with end-stage renal disease and diabetes mellitus.","authors":"Joseph R Weber, Brendan Martin, Nicholas Kassis, Kunal Shah, Tomas Kovarnik, Holly Mattix-Kramer, John J Lopez","doi":"10.1177/1479164120958425","DOIUrl":"10.1177/1479164120958425","url":null,"abstract":"Background: Coronary arterial plaques in patients with end-stage renal disease (ESRD) are assumed to have increased calcification due to underlying renal disease or initiation of dialysis. This relationship may be confounded by comorbid type 2 diabetes mellitus (DM).Methods: From a single-center OCT registry, 60 patients were analyzed. Twenty patients with ESRD and diabetes (ESRD-DM) were compared to 2 groups of non-ESRD patients: 20 with and 20 without diabetes. In each patient, one 20 mm segment within the culprit vessel was analyzed.Results: ESRD-DM patients exhibited similar calcium burden, arc, and area compared to patients with diabetes alone. When compared to patients without diabetes, patients with diabetes exhibited a greater summed area of calcium (DM: Median 9.0, IQR [5.3-28] mm2 vs Non-DM: 3.5 [0.1-14] mm2, p = 0.04) and larger calcium deposits by arc (DM: Mean 45 ± SE 6.2° vs Non-DM: 21 ± 6.2°, p = 0.01) and area (DM: 0.58 ± 0.10 mm2 vs Non-DM: 0.26 ± 0.10 mm2, p = 0.03). Calcification deposits in ESRD-DM patients (0.14 ± 0.02 mm) and patients with diabetes (0.14 ± 0.02 mm) were more superficially located relative to patients without diabetes (0.21 ± 0.02 mm), p = 0.01 for both.Conclusions: Coronary calcification in DM and ESRD-DM groups exhibited similar burden, deposit size, and depth within the arterial wall. The increase in coronary calcification and cardiovascular disease events seen in ESRD-DM patients may not be secondary to ESRD and dialysis, but instead due to a combination of declining renal function and diabetes.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"17 5","pages":"1479164120958425"},"PeriodicalIF":2.4,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1479164120958425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38427027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Impact of low fasting plasma glucose on mortality in the general population. 低空腹血糖对一般人群死亡率的影响。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2020-05-01 DOI: 10.1177/1479164120930599

Parag A Chevli, Muhammad Imtiaz Ahmad, Krupal Hari, Muhammad Ali Anees, Elsayed Z Soliman

{"title":"Impact of low fasting plasma glucose on mortality in the general population.","authors":"Parag A Chevli, Muhammad Imtiaz Ahmad, Krupal Hari, Muhammad Ali Anees, Elsayed Z Soliman","doi":"10.1177/1479164120930599","DOIUrl":"https://doi.org/10.1177/1479164120930599","url":null,"abstract":"Background: While the association between hypoglycaemia and poor outcomes in diabetes is well established, it is unclear whether such an association is generalizable to those without diabetes.Methods: A total of 8497 participants free of cardiovascular disease and diabetes from the Third National Health and Nutrition Examination Survey were included. We examined the relationship between baseline low (<80 mg/dL) and high (⩾126 mg/dL) fasting plasma glucose compared to normal levels (80-99 mg/dL).Results: Over a median follow-up of 14 years, 2101 deaths occurred, of which 570 were due to cardiovascular disease. In a model adjusted for sociodemographic and cardiovascular disease risk factors, individuals with low fasting plasma glucose were at increased risk of cardiovascular disease and all-cause mortality [hazard ratio = 1.79 (95% confidence interval = 1.04-3.08) and hazard ratio = 1.35 (95% confidence interval = 1.02-1.78), respectively], compared to those with normal fasting plasma glucose. These associations were stronger among men than women for both cardiovascular disease mortality and all-cause mortality.Conclusion: Low fasting plasma glucose in individuals without diabetes is a risk factor for cardiovascular disease and all-cause mortality, especially in men.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"17 3","pages":"1479164120930599"},"PeriodicalIF":2.4,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1479164120930599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38201925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory and atheroprotective properties of glucagon. 胰高血糖素的抗炎和动脉粥样硬化保护特性。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2020-05-01 DOI: 10.1177/1479164120965183

Naoya Osaka, Hideki Kushima, Yusaku Mori, Tomomi Saito, Munenori Hiromura, Michishige Terasaki, Hironori Yashima, Makoto Ohara, Tomoyasu Fukui, Takanori Matsui, Tsutomu Hirano, Sho-Ichi Yamagishi

{"title":"Anti-inflammatory and atheroprotective properties of glucagon.","authors":"Naoya Osaka, Hideki Kushima, Yusaku Mori, Tomomi Saito, Munenori Hiromura, Michishige Terasaki, Hironori Yashima, Makoto Ohara, Tomoyasu Fukui, Takanori Matsui, Tsutomu Hirano, Sho-Ichi Yamagishi","doi":"10.1177/1479164120965183","DOIUrl":"https://doi.org/10.1177/1479164120965183","url":null,"abstract":"Although glucagon has been shown to exert pleiotropic actions in various types of cells and organs through the interaction with its receptor, its pathophysiological role in atherosclerotic cardiovascular disease remains unclear. Here, we examined whether and how glucagon could attenuate the progression of atherosclerotic plaques in apolipoprotein E-deficient mice (ApoE-/-), an animal model of atherosclerosis. Glucagon (138 or 413 nmol/kg/day) or vehicle was infused to mice at 16 weeks of age. After 4-week treatment, vascular samples were collected for histological and RT-PCR analyses. Human monocytic THP-1 cells were pre-incubated with or without a glucagon receptor antagonist L-168049, and then treated with or without glucagon for 7 h. Gene and protein expressions were determined by RT-PCR and western blot analyses, respectively. High-dose glucagon infusion significantly decreased aortic plaque area and volume in ApoE-/- mice, both of which were inversely correlated with plasma glucagon levels. Glucagon infusion also reduced the ratio of pro-inflammatory interleukin-1β to anti-inflammatory interleukin-10 gene expression in aortae. Glucagon receptor was expressed in THP-1 cells, and 1 nM glucagon decreased the ratio of interleukin-1β to interleukin-10 gene expression, which was significantly prevented by L-168049. Our present findings suggest that glucagon could exert atheroprotection partly via its anti-inflammatory property.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"17 5","pages":"1479164120965183"},"PeriodicalIF":2.4,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1479164120965183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38601621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Inhibition of myeloperoxidase increases revascularization and improves blood flow in a diabetic mouse model of hindlimb ischaemia. 抑制髓过氧化物酶可增加后肢缺血糖尿病小鼠模型的血运重建并改善血流。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2020-03-01 DOI: 10.1177/1479164120907971

Dorothee Weihrauch, Dustin P Martin, Deron Jones, John Krolikowski, Janine Struve, Stephen Naylor, Kirkwood A Pritchard

{"title":"Inhibition of myeloperoxidase increases revascularization and improves blood flow in a diabetic mouse model of hindlimb ischaemia.","authors":"Dorothee Weihrauch, Dustin P Martin, Deron Jones, John Krolikowski, Janine Struve, Stephen Naylor, Kirkwood A Pritchard","doi":"10.1177/1479164120907971","DOIUrl":"https://doi.org/10.1177/1479164120907971","url":null,"abstract":"Objective: Diabetes mellitus is a significant risk factor for peripheral artery disease. Diabetes mellitus induces chronic states of oxidative stress and vascular inflammation that increase neutrophil activation and release of myeloperoxidase. The goal of this study is to determine whether inhibiting myeloperoxidase reduces oxidative stress and neutrophil infiltration, increases vascularization, and improves blood flow in a diabetic murine model of hindlimb ischaemia.Methods: Leptin receptor-deficient (db/db) mice were subjected to hindlimb ischaemia. Ischaemic mice were treated with N-acetyl-lysyltyrosylcysteine-amide (KYC) to inhibit myeloperoxidase. After ligating the femoral artery, effects of treatments were determined with respect to hindlimb blood flow, neutrophil infiltration, oxidative damage, and the capability of hindlimb extracellular matrix to support human endothelial cell proliferation and migration.Results: KYC treatment improved hindlimb blood flow at 7 and 14 days in db/db mice; decreased the formation of advanced glycation end products, 4-hydroxynonenal, and 3-chlorotyrosine; reduced neutrophil infiltration into the hindlimbs; and improved the ability of hindlimb extracellular matrix from db/db mice to support endothelial cell proliferation and migration.Conclusion: These results demonstrate that inhibiting myeloperoxidase reduces oxidative stress in ischaemic hindlimbs of db/db mice, which improves blood flow and reduces neutrophil infiltration such that hindlimb extracellular matrix from db/db mice supports endothelial cell proliferation and migration.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"17 3","pages":"1479164120907971"},"PeriodicalIF":2.4,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1479164120907971","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37780197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4