Diabetes & Vascular Disease Research最新文献_第7页

Silencing of FOS-like antigen 1 represses restenosis via the ERK/AP-1 pathway in type 2 diabetic mice. fos样抗原1的沉默通过ERK/AP-1途径抑制2型糖尿病小鼠的再狭窄

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-11-01 DOI: 10.1177/14791641211058855

Chaoxi Zhou, Fujun Wang, Hongfang Ma, Na Xing, Lin Hou, Yaping Du, Haixia Ding

{"title":"Silencing of FOS-like antigen 1 represses restenosis via the ERK/AP-1 pathway in type 2 diabetic mice.","authors":"Chaoxi Zhou, Fujun Wang, Hongfang Ma, Na Xing, Lin Hou, Yaping Du, Haixia Ding","doi":"10.1177/14791641211058855","DOIUrl":"https://doi.org/10.1177/14791641211058855","url":null,"abstract":"Restenosis is a major limiting factor for a successful outcome in type 2 diabetes (T2D) patients undergoing percutaneous coronary intervention (PCI). The aim of this study is to explore the role and regulatory mechanism of FOS-like antigen 1 (FOSL1) in restenosis in T2D. A T2D with restenosis mouse model was established by the combination of high-fat diet and streptozotocin injection and by wire-injury. High glucose (HG)-treated vascular smooth muscle cells (VSMCs) were used to mimic T2D in vitro. The results of quantitative real time PCR and western blotting demonstrated that the expression of FOSL1 was increased not only in T2D mice or HG-induced VSMCs, but also in T2D mice that underwent wire-injury. HE staining revealed that FOSL1 knockdown significantly reduced the intimal/media ratio of T2D mice after wire-injury. Silencing of FOSL1 reversed the promoting effects of HG treatment on viability, migration and inflammation reactions, and the inhibiting effect on the apoptosis of VSMCs. Inhibition of ERK/AP-1 pathway obtained similar patterns in HG-induced VSMCs. The activation of ERK/AP-1 pathway reversed the influence of FOSL1 knockdown on HG-induced VSMCs. Our findings indicate that silencing of FOSL1 may suppress restenosis via regulation of the ERK/AP-1 pathway in T2D mice, pointing out a potential therapeutic target to prevent restenosis in T2D.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 6","pages":"14791641211058855"},"PeriodicalIF":2.4,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/60/10.1177_14791641211058855.PMC8669130.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39706087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Impaired subendocardial perfusion in patients with metabolic syndrome. 代谢综合征患者的心内膜下灌注受损。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-11-01 DOI: 10.1177/14791641211047135

Francesco Fantin, Anna Giani, Ludovico Gasparini, Andrea P Rossi, Elena Zoico, Gloria Mazzali, Mauro Zamboni

{"title":"Impaired subendocardial perfusion in patients with metabolic syndrome.","authors":"Francesco Fantin, Anna Giani, Ludovico Gasparini, Andrea P Rossi, Elena Zoico, Gloria Mazzali, Mauro Zamboni","doi":"10.1177/14791641211047135","DOIUrl":"https://doi.org/10.1177/14791641211047135","url":null,"abstract":"Background: Metabolic Syndrome (MS) is associated to vascular damage, increased arterial stiffness, and impaired myocardial perfusion. Subendocardial viability ratio (SEVR) is a noninvasive estimation of myocardial workload, oxygen supply, and perfusion. The aim of the study was to describe the relation between arterial stiffness, SEVR, and cardio-metabolic risk factors.Methods: A cohort of 55 patients, aged 59.9 ± 10.8 years, was studied; 28 subjects (50.9%) had metabolic syndrome. All patients underwent a clinical evaluation and blood venous sampling, to assess glico-lipid profile. Applanation tonometry was performed, to obtain pulse wave analysis and SEVR values.Results: In the overall study population, SEVR showed negative associations with mean (r = -0.301; p = 0.026) and systolic (borderline relation, r = -0.257; p = 0.058) arterial pressure. Metabolic syndrome patients presented lower level of SEVR (p = 0.012), even after adjusting for age, sex, and mean arterial pressure (p = 0.040). Subdividing the study population by the number of metabolic syndrome components, SEVR significantly decreased as the number of Metabolic Syndrome components increased (p for trend 0.005). In a logistic backward regression analysis, both metabolic syndrome and mean arterial pressure resulted significant predictors of SEVR, accounting for 18% of variance.Conclusion: The reduced SEVR in metabolic syndrome patients could be an important pathophysiological determinant of the increased cardiovascular risk.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 6","pages":"14791641211047135"},"PeriodicalIF":2.4,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/64/10.1177_14791641211047135.PMC8591647.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39708128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Peripheral oscillometric arterial performance does not depict coronary status in patients with type 2 diabetes mellitus. 外周动脉振荡表现不能反映2型糖尿病患者的冠状动脉状态。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-11-01 DOI: 10.1177/14791641211046522

Magdalene Jaeger, Bernd Stratmann, Diethelm Tschoepe

{"title":"Peripheral oscillometric arterial performance does not depict coronary status in patients with type 2 diabetes mellitus.","authors":"Magdalene Jaeger, Bernd Stratmann, Diethelm Tschoepe","doi":"10.1177/14791641211046522","DOIUrl":"https://doi.org/10.1177/14791641211046522","url":null,"abstract":"Background: Arterial stiffness is associated with cardiovascular events. Matrix metalloproteases (MMPs), their tissue inhibitors (TIMPs) and galectin-3 are involved in the pathogenesis of end organ damage. This study aimed to evaluate the contribution of arterial stiffness, MMPs, TIMPs and galectin-3 with the current vascular status in type 2 diabetes mellitus (T2DM).Methods: 74 patients with T2DM, 36 with coronary heart disease (CHD) (T2DM + CHD) and 38 without CHD (T2DM - CHD) were included. Aortic pulse wave velocity (PWVao), aortic and brachial augmentation indices (AIx aortic and AIx brachial) and central-aortic blood pressure values were determined by non-invasive arteriography. MMPs, TIMPs and galectin-3 plasma concentrations were analysed by ELISA.Results: Patients with T2DM and CHD presented with significantly increased arterial stiffness determined as AIx and significantly elevated values for TIMP-4 and galectin-3. Heterogeneous peripheral vascular status regardless of the CHD status was observed, and increasing severity of CHD was associated with an increased arterial stiffness. TIMP-4 correlated significantly with an elevated PWVao in the whole cohort independently from CHD status.Conclusion: Determination of arterial stiffness is an effective and, compared to laboratory markers, more reliable method for determining the peripheral vascular situation in patients with T2DM, but it does not clearly depict coronary situation.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 6","pages":"14791641211046522"},"PeriodicalIF":2.4,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a1/f1/10.1177_14791641211046522.PMC8743959.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39749714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspirin use in patients with diagnosed diabetes in the United States and China: Nationally representative analysis. 美国和中国诊断为糖尿病的患者阿司匹林的使用:全国代表性分析

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-10-01 DOI: 10.1177/14791641211067416

Xin Wang, Guang Hao, Zuo Chen, Linfeng Zhang, Yuting Kang, Ying Yang, Congyi Zheng, Haoqi Zhou, Lu Chen, Zengwu Wang, Runlin Gao

{"title":"Aspirin use in patients with diagnosed diabetes in the United States and China: Nationally representative analysis.","authors":"Xin Wang, Guang Hao, Zuo Chen, Linfeng Zhang, Yuting Kang, Ying Yang, Congyi Zheng, Haoqi Zhou, Lu Chen, Zengwu Wang, Runlin Gao","doi":"10.1177/14791641211067416","DOIUrl":"https://doi.org/10.1177/14791641211067416","url":null,"abstract":"Background: The epidemiological data on the use of aspirin in diabetic patients is very limited. The main purpose of this study is to examine the current status of aspirin use in the United States (US) and China in large representative populations.Methods: Data came from the National Health and Nutrition Examination Survey (NHANES) and China Hypertension Survey (CHS), two nationally representative cross-sectional studies.Results: The percentage of aspirin use was 73.8% in US diabetic patients with ASCVD, and the percentage of aspirin use in diabetic patients with high ASCVD risk was marginally higher in men (p = .052), 54.5% in men and 37.1% in women. The percentages of aspirin use in diabetic patients with intermediate and low ASCVD risk were 55.1% and 35.0%, respectively. In China, the percentage of aspirin use in diabetic patients with ASCVD was 53.5%, and were 14.3%, 9.7%, and 3.2% among diabetic patients with high, intermediate, and low ASCVD risk, respectively.Conclusions: In summary, the percentage of aspirin use in primary prevention in US diabetic patients in men was higher than in women, and this percentage for primary and secondary prevention in US patients was higher than that in Chinese patients.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 6","pages":"14791641211067416"},"PeriodicalIF":2.4,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b4/ff/10.1177_14791641211067416.PMC8867494.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39900642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Diabetes mellitus is associated with an increased incidence of aortic valve stenosis. 糖尿病与主动脉瓣狭窄发生率增高有关。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-09-01 DOI: 10.1177/14791641211033819

Christoph Roderburg, Sven H Loosen, Tom Luedde, Karel Kostev, Mark Luedde

{"title":"Diabetes mellitus is associated with an increased incidence of aortic valve stenosis.","authors":"Christoph Roderburg, Sven H Loosen, Tom Luedde, Karel Kostev, Mark Luedde","doi":"10.1177/14791641211033819","DOIUrl":"https://doi.org/10.1177/14791641211033819","url":null,"abstract":"Background: The prognosis of patients with diabetes mellitus (DM) is particularly determined by vascular comorbidities. A recent theory implies that DM could also promote aortic valve stenosis (AS). The present study investigates this association in a large collective of outpatients.Methods: This retrospective cohort study compared the incidence of AS in patients with an initial diagnosis of type 2 DM and a matched non-DM cohort in 809 general and diabetologist practices in Germany between January 2005 and December 2018. Cox regression models were performed to study the association between type 2 DM and AS incidence.Results: A total of 78,805 patients with type 2 DM and 78,805 patients without diabetes were analysed. Diabetes patients were more frequently diagnosed with obesity (52% vs 21%). Four percent of patients with and three percent of without diabetes were diagnosed with AS (p < 0.001). Diabetes was significantly associated with an increased incidence of AS (HR: 1.36, p < 0.001). This association was higher in men (HR: 1.41) versus women (HR: 1.30). The strongest association was observed in young patients (18-50 years, HR: 2.35, p < 0.001).Conclusion: In our study, diabetes patients had a higher incidence of aortic stenosis during their disease course.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 5","pages":"14791641211033819"},"PeriodicalIF":2.4,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/37/10.1177_14791641211033819.PMC8532229.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39531197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Polymorphism in the HaeIII single nucleotide polymorphism of the SLC2A1 gene and cardiovascular disease in the early type 2 diabetes mellitus. SLC2A1基因HaeIII单核苷酸多态性与早期2型糖尿病心血管疾病的关系

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-09-01 DOI: 10.1177/14791641211041225

Dong-Hwa Lee, Gun Woo Won, Yong Hee Lee, Jong Sung Shin, Eu Jeong Ku, Tae Keun Oh, Hyun Jeong Jeon

{"title":"Polymorphism in the HaeIII single nucleotide polymorphism of the SLC2A1 gene and cardiovascular disease in the early type 2 diabetes mellitus.","authors":"Dong-Hwa Lee, Gun Woo Won, Yong Hee Lee, Jong Sung Shin, Eu Jeong Ku, Tae Keun Oh, Hyun Jeong Jeon","doi":"10.1177/14791641211041225","DOIUrl":"https://doi.org/10.1177/14791641211041225","url":null,"abstract":"Introduction: SLC2A1 polymorphism may play a role in the smooth muscle cell proliferation and extracellular matrix synthesis in vessels. However, the role of SLC2A1 polymorphism on diabetic cardiovascular disease (CVD) have not yet been identified. In this study, we aimed to investigate the association between SLC2A1 HaeIII polymorphism and CVD in Korean patients with type 2 diabetes mellitus (T2DM) according to disease duration.Methods: A total of 846 patients with T2DM who visited the Chungbuk National University Hospital were investigated. The HaeIII polymorphism of SLC2A1 gene was determined by real time polymerase chain reaction method. Genotyping results were presented GG, AG, or AA. Subgroup analysis was performed according to duration of T2DM (⩽10, 11-20, >20 years).Results: The AA genotype was significantly associated with higher prevalence of CVD in patients with DM duration less than 10 years (26.3% vs 9.2%, p = 0.014). There was no significant association between SLC2A1 HaeIII polymorphism and other diabetic complications including, retinopathy, nephropathy, neuropathy, cerebrovascular disease, and peripheral artery disease.Conclusions: The SLC2A1 HaeIII polymorphism was associated with CVD in Korean patients with T2DM with short disease duration.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 5","pages":"14791641211041225"},"PeriodicalIF":2.4,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/79/c9/10.1177_14791641211041225.PMC8481723.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39392021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The impact of flash glucose monitoring on glycated hemoglobin in type 2 diabetes managed with basal insulin in Canada: A retrospective real-world chart review study. 加拿大基础胰岛素治疗的2型糖尿病患者瞬时血糖监测对糖化血红蛋白的影响:一项回顾性现实世界图表回顾研究。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-07-01 DOI: 10.1177/14791641211021374

Tom Elliott, Sorin Beca, Rajendra Beharry, Michael A Tsoukas, Alexandro Zarruk, Alexander Abitbol

{"title":"The impact of flash glucose monitoring on glycated hemoglobin in type 2 diabetes managed with basal insulin in Canada: A retrospective real-world chart review study.","authors":"Tom Elliott, Sorin Beca, Rajendra Beharry, Michael A Tsoukas, Alexandro Zarruk, Alexander Abitbol","doi":"10.1177/14791641211021374","DOIUrl":"https://doi.org/10.1177/14791641211021374","url":null,"abstract":"Background: The real-world effect of intermittently scanned continuous glucose monitoring on glucose control in type 2 diabetes treated with basal insulin is uncertain. This retrospective real-world study aimed to evaluate change in glycated hemoglobin (HbA1c) amongst adults with type 2 diabetes managed with basal insulin starting flash glucose monitoring.Methods: Medical records were reviewed for adults with type 2 diabetes treated with basal insulin for ⩾1 year and using FreeStyle LibreTM Flash Glucose Monitoring for ⩾3 months. Prior to device use an HbA1c 8.0%-12.0% was recorded and a further HbA1c result was recorded 3-6 months (90-194 days) after starting device use.Results: Medical records (n = 91) analyzed from six Canadian diabetes centers showed HbA1c significantly decreased by 0.8% ± 1.1 (mean ± SD, [p < 0.0001]) from mean baseline HbA1c 8.9% ± 0.9 to 8.1% ± 1.0 at 3-6 months after initiating flash glucose monitoring. HbA1c improvement was not independently associated with age, BMI, insulin use duration, or sex.Conclusion: This Canadian real-world retrospective study showed significantly reduced HbA1c following initiation of ﬂash glucose monitoring technology to further support management of type 2 diabetes treated with basal insulin.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 4","pages":"14791641211021374"},"PeriodicalIF":2.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/14791641211021374","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39195275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Deteriorated regional calf microcirculation measured by contrast-free MRI in patients with diabetes mellitus and relation with physical activity. 糖尿病患者局部小腿微循环恶化与身体活动的关系。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-07-01 DOI: 10.1177/14791641211029002

Jie Zheng, Christopher Sorensen, Ran Li, Hongyu An, Charles F Hildebolt, Mohamed A Zayed, Michael J Mueller, Mary K Hastings

{"title":"Deteriorated regional calf microcirculation measured by contrast-free MRI in patients with diabetes mellitus and relation with physical activity.","authors":"Jie Zheng, Christopher Sorensen, Ran Li, Hongyu An, Charles F Hildebolt, Mohamed A Zayed, Michael J Mueller, Mary K Hastings","doi":"10.1177/14791641211029002","DOIUrl":"https://doi.org/10.1177/14791641211029002","url":null,"abstract":"Objective: To evaluate regional calf muscle microcirculation in people with diabetes mellitus (DM) with and without foot ulcers, compared to healthy control people without DM, using contrast-free magnetic resonance imaging methods.Methods: Three groups of subjects were recruited: non-DM controls, DM, and DM with foot ulcers (DM + ulcer), all with ankle brachial index (ABI) > 0.9. Skeletal muscle blood flow (SMBF) and oxygen extraction fraction (SMOEF) in calf muscle were measured at rest and during a 5-min isometric ankle plantarflexion exercise. Subjects completed the Yale physical activity survey.Results: The exercise SMBF (ml/min/100 g) of the medial gastrocnemius muscle were progressively impaired: 63.7 ± 18.9 for controls, 42.9 ± 6.7 for DM, and 36.2 ± 6.2 for DM + ulcer, p < 0.001. Corresponding exercise SMOEF was the lowest in DM + ulcers (0.48 ± 0.09). Exercise SMBF in the soleus muscle was correlated moderately with the Yale physical activity survey (r = 0.39, p < 0.01).Conclusions: Contrast-free MR imaging identified progressively impaired regional microcirculation in medial gastrocnemius muscles of people with DM with and without foot ulcers. Exercise SMBF in the medial gastrocnemius muscle was the most sensitive index and was associated with HbA1c. Lower exercise SMBF in the soleus muscle was associated with lower Yale score.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 4","pages":"14791641211029002"},"PeriodicalIF":2.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/14791641211029002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39225316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The relationship of neutrophil elastase and proteinase 3 with risk factors, and chronic complications in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) sub-study. 中性粒细胞弹性酶和蛋白酶3与2型糖尿病危险因素和慢性并发症的关系:非诺贝特干预和糖尿病事件降低(FIELD)亚研究

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-07-01 DOI: 10.1177/14791641211032547

Kwok-Leung Ong, Liang Wu, Andrzej S Januszewski, Rachel O'Connell, Aimin Xu, Russell S Scott, David R Sullivan, Kerry-Anne Rye, Huating Li, Ronald Cw Ma, Liping Li, Val Gebski, Alicia J Jenkins, Weiping Jia, Anthony C Keech

{"title":"The relationship of neutrophil elastase and proteinase 3 with risk factors, and chronic complications in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) sub-study.","authors":"Kwok-Leung Ong, Liang Wu, Andrzej S Januszewski, Rachel O'Connell, Aimin Xu, Russell S Scott, David R Sullivan, Kerry-Anne Rye, Huating Li, Ronald Cw Ma, Liping Li, Val Gebski, Alicia J Jenkins, Weiping Jia, Anthony C Keech","doi":"10.1177/14791641211032547","DOIUrl":"https://doi.org/10.1177/14791641211032547","url":null,"abstract":"Introduction: Neutrophil elastase (NE) and proteinase 3 (PR3) are novel inflammation biomarkers. We investigated their associations with chronic complications, determinants of biomarker levels and effects of fenofibrate in patients with type 2 diabetes mellitus (T2DM) from Fenofibrate Intervention and Event Lowering in Diabetes study.Methods: Plasma NE and PR3 levels were quantified at baseline (n = 2000), and relationships with complications over 5-years assessed. Effects of fenofibrate on biomarker levels (n = 200) were determined at four follow-up visits.Results: Higher waist-to-hip ratio, homocysteine and C-reactive protein and lower apoA-II were determinants of higher NE and PR3 levels. Higher NE levels were associated with on-trial stroke and cardiovascular mortality, and higher PR3 levels with on-trial stroke, but associations were not significant after adjustment for confounding factors. Although higher NE and PR3 levels were associated with baseline total microvascular disease, only NE levels were associated with on-trial neuropathy or amputation. These associations were not significant after adjusting for multiple comparisons. NE and PR3 levels did not change with fenofibrate.Conclusions: In T2DM plasma NE and PR3 levels are associated with vascular risk factors, and total microvascular disease at baseline, but on rigorous analyses were not associated with on-trial complications. Levels were not changed by fenofibrate.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 4","pages":"14791641211032547"},"PeriodicalIF":2.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/14791641211032547","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39194554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Rationale and design of the randomised controlled cross-over trial: Cardiovascular effects of empaglifozin in diabetes mellitus. 随机对照交叉试验的基本原理和设计:恩格列净对糖尿病患者心血管的影响。

IF 2.4 4区医学

Diabetes & Vascular Disease Research Pub Date : 2021-05-01 DOI: 10.1177/14791641211021585

Sharmaine Thirunavukarasu, Louise Ae Brown, Amrit Chowdhary, Nicholas Jex, Peter Swoboda, John P Greenwood, Sven Plein, Eylem Levelt

{"title":"Rationale and design of the randomised controlled cross-over trial: Cardiovascular effects of empaglifozin in diabetes mellitus.","authors":"Sharmaine Thirunavukarasu, Louise Ae Brown, Amrit Chowdhary, Nicholas Jex, Peter Swoboda, John P Greenwood, Sven Plein, Eylem Levelt","doi":"10.1177/14791641211021585","DOIUrl":"10.1177/14791641211021585","url":null,"abstract":"Background: Type 2 diabetes (T2D) is associated with an increased risk of cardiovascular (CV) disease. In patients with T2D and established CV disease, selective inhibitors of sodium-glucose cotransporter 2 (SGLT2) have been shown to decrease CV and all-cause mortality, and heart failure (HF) admissions. Utilising CV magnetic resonance imaging (CMR) and continuous glucose monitoring (CGM) by FreeStyle Libre Pro Sensor, we aim to explore the mechanisms of action which give Empagliflozin, an SGLT2 inhibitor, its beneficial CV effects and compare these to the effects of dipeptidyl peptidase-4 inhibitor Sitagliptin.Methods: This is a single centre, open-label, cross-over trial conducted at the Leeds Teaching Hospitals NHS Trust. Participants are randomised for the order of treatment and receive 3 months therapy with Empagliflozin, and 3 months therapy with Sitagliptin sequentially. Twenty-eight eligible T2D patients with established ischaemic heart disease will be recruited. Patients undergo serial CMR scans on three visits.Discussion: The primary outcome measure is the myocardial perfusion reserve in remote myocardium. We hypothesise that Empaglifozin treatment is associated with improvements in myocardial blood flow and reductions in myocardial interstitial fibrosis, independent of CGM measured glycemic control in patients with T2D and established CV disease.Trial registration: This study has full research ethics committee approval (REC: 18/YH/0190) and data collection is anticipated to finish in December 2021. This study was retrospectively registered at https://doi.org/10.1186/ISRCTN82391603 and monitored by the University of Leeds. The study results will be submitted for publication within 6 months of completion.","PeriodicalId":11092,"journal":{"name":"Diabetes & Vascular Disease Research","volume":"18 3","pages":"14791641211021585"},"PeriodicalIF":2.4,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/14791641211021585","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39036212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0