Christoph Roderburg, Sven H Loosen, Tom Luedde, Karel Kostev, Mark Luedde
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引用次数: 4
摘要
背景:糖尿病(DM)患者的预后特别受血管合并症的影响。最近的一项理论表明，糖尿病也可能促进主动脉瓣狭窄(AS)。本研究在大量门诊病人中调查了这种关联。方法:本回顾性队列研究比较了2005年1月至2018年12月期间，德国809名普通医生和糖尿病医生的临床实践中，初始诊断为2型糖尿病的患者和匹配的非糖尿病患者的AS发病率。采用Cox回归模型研究2型糖尿病与AS发病率之间的关系。结果:共分析了78,805例2型糖尿病患者和78,805例非糖尿病患者。糖尿病患者更常被诊断为肥胖(52% vs 21%)。4%的糖尿病患者和3%的非糖尿病患者被诊断为AS (p < 0.001)。糖尿病与AS发病率增加显著相关(HR: 1.36, p < 0.001)。这一关联在男性(HR: 1.41)比女性(HR: 1.30)更高。相关性最强的是年轻患者(18-50岁，HR: 2.35, p < 0.001)。结论:在我们的研究中，糖尿病患者在其病程中有较高的主动脉狭窄发生率。
Diabetes mellitus is associated with an increased incidence of aortic valve stenosis.
Background: The prognosis of patients with diabetes mellitus (DM) is particularly determined by vascular comorbidities. A recent theory implies that DM could also promote aortic valve stenosis (AS). The present study investigates this association in a large collective of outpatients.
Methods: This retrospective cohort study compared the incidence of AS in patients with an initial diagnosis of type 2 DM and a matched non-DM cohort in 809 general and diabetologist practices in Germany between January 2005 and December 2018. Cox regression models were performed to study the association between type 2 DM and AS incidence.
Results: A total of 78,805 patients with type 2 DM and 78,805 patients without diabetes were analysed. Diabetes patients were more frequently diagnosed with obesity (52% vs 21%). Four percent of patients with and three percent of without diabetes were diagnosed with AS (p < 0.001). Diabetes was significantly associated with an increased incidence of AS (HR: 1.36, p < 0.001). This association was higher in men (HR: 1.41) versus women (HR: 1.30). The strongest association was observed in young patients (18-50 years, HR: 2.35, p < 0.001).
Conclusion: In our study, diabetes patients had a higher incidence of aortic stenosis during their disease course.
期刊介绍：
Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)
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