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Current Opinion in Pulmonary Medicine最新文献

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Clinical trials in pulmonary sarcoidosis; what is needed, what is happening and what is next? 肺肉样瘤病的临床试验；需要什么、正在发生什么以及下一步是什么？
IF 2.8 3区 医学
Current Opinion in Pulmonary Medicine Pub Date : 2024-09-01 Epub Date: 2024-07-04 DOI: 10.1097/MCP.0000000000001098
Marcel Veltkamp
{"title":"Clinical trials in pulmonary sarcoidosis; what is needed, what is happening and what is next?","authors":"Marcel Veltkamp","doi":"10.1097/MCP.0000000000001098","DOIUrl":"10.1097/MCP.0000000000001098","url":null,"abstract":"<p><strong>Purpose of review: </strong>There is a clinical unmet need to improve treatment for patients with pulmonary sarcoidosis. Both retrospective and prospective drug trials are hampered by the fact that patients with sarcoidosis are characterized by a heterogeneous presentation and disease course. In this review, an overview is given of different drug trials in pulmonary sarcoidosis with an emphasis on different primary endpoints and the problems related to them.</p><p><strong>Recent findings: </strong>In recent years, using significant input from patients with sarcoidosis, different task-forces/studies tried to develop a core set of most important outcomes to measure in future studies on treatment of sarcoidosis. Furthermore, at present, three major clinical trials are being conducted on new drugs for treatment of pulmonary sarcoidosis.</p><p><strong>Summary: </strong>Progress has been made to develop a core set of outcomes measures that can be used in making a combined primary endpoint in future drug trials in sarcoidosis.</p>","PeriodicalId":11090,"journal":{"name":"Current Opinion in Pulmonary Medicine","volume":" ","pages":"576-582"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimal long-term anticoagulation after acute pulmonary embolism: current state of the art and a look into the near future. 急性肺栓塞后的最佳长期抗凝治疗：当前技术水平与不远的将来。
IF 2.8 3区 医学
Current Opinion in Pulmonary Medicine Pub Date : 2024-09-01 Epub Date: 2024-07-10 DOI: 10.1097/MCP.0000000000001106
Andreas Rainer Kimmerle, Maria Noflatscher, Reinhard Bernd Raggam
{"title":"Optimal long-term anticoagulation after acute pulmonary embolism: current state of the art and a look into the near future.","authors":"Andreas Rainer Kimmerle, Maria Noflatscher, Reinhard Bernd Raggam","doi":"10.1097/MCP.0000000000001106","DOIUrl":"10.1097/MCP.0000000000001106","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to summarize the current state of the art and future directions in optimal long-term anticoagulation following acute pulmonary embolism (PE).</p><p><strong>Recent findings: </strong>Actual studies and guidelines underscore the preference for direct oral anticoagulants (DOAC) in standard therapeutic doses for maintenance therapy post-PE, while considering patient-specific factors and dose-reduction criteria. Risk stratification should always include the assessment of concomitant trigger- or risk factors regarding their strength and persistence. The use of tools like specific scores can facilitate the identification of optimal candidates for long-term therapy, emphasizing once more personalized approaches and strategies. Special patient groups, such as cancer associated thrombosis, chronic thromboembolic pulmonary hypertension or antiphospholipid syndrome require even more tailored therapy approaches.</p><p><strong>Summary: </strong>Optimal long-term anticoagulation post-PE should be guided by straightforward and individual risk assessment strategies. The array of indications for DOACs has gotten wider in last years, also within special patient groups. Still, chronic thromboembolic pulmonary hypertension and antiphospholipid syndrome remains domain of vitamin K agonists.</p>","PeriodicalId":11090,"journal":{"name":"Current Opinion in Pulmonary Medicine","volume":" ","pages":"421-428"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress for all: addressing disparities in sarcoidosis. 人人都有进步：解决肉样瘤病的差异问题。
IF 2.8 3区 医学
Current Opinion in Pulmonary Medicine Pub Date : 2024-09-01 Epub Date: 2024-07-10 DOI: 10.1097/MCP.0000000000001104
Ogugua Ndili Obi, Michelle Sharp, Logan Harper
{"title":"Progress for all: addressing disparities in sarcoidosis.","authors":"Ogugua Ndili Obi, Michelle Sharp, Logan Harper","doi":"10.1097/MCP.0000000000001104","DOIUrl":"10.1097/MCP.0000000000001104","url":null,"abstract":"<p><strong>Purpose of review: </strong>The impact of healthcare disparities in the treatment, care, and outcomes of patients with sarcoidosis has been described. There is paucity of literature on ways to address these disparities with a goal to improving health outcomes for patients with sarcoidosis.</p><p><strong>Recent findings: </strong>Recent findings in other respiratory and systemic diseases suggest that multifaceted interventions directed at improving care at various levels including individual, family, and larger societal levels have been successful in dismantling some of the social and structural barriers to care and consequently have resulted in a reduction in disparate disease outcomes. We explore what some of these interventions would look like in sarcoidosis.</p><p><strong>Summary: </strong>The impact of healthcare disparities in the treatment, care, and outcomes of patients with sarcoidosis has been described. We outline various steps and approaches aimed at addressing these health disparities with a goal to improving outcomes for those most impacted by disease.</p>","PeriodicalId":11090,"journal":{"name":"Current Opinion in Pulmonary Medicine","volume":" ","pages":"551-560"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lobar or sublobar resection of peripheral stage I non-small cell lung cancer. 外周 I 期非小细胞肺癌的叶状或叶下切除术。
IF 3.3 3区 医学
Current Opinion in Pulmonary Medicine Pub Date : 2024-07-01 Epub Date: 2024-02-26 DOI: 10.1097/MCP.0000000000001063
Pedro Guimarães Rocha Lima, Matthieu Glorion, Moishe Liberman
{"title":"Lobar or sublobar resection of peripheral stage I non-small cell lung cancer.","authors":"Pedro Guimarães Rocha Lima, Matthieu Glorion, Moishe Liberman","doi":"10.1097/MCP.0000000000001063","DOIUrl":"10.1097/MCP.0000000000001063","url":null,"abstract":"<p><strong>Purpose of review: </strong>We aim to highlight two recent clinical trials that have altered the approach of the management of stage I nonsmall cell lung cancer.</p><p><strong>Recent findings: </strong>The JCOG 0802 and CALGB 140503 trials demonstrated that sublobar resection is noninferior to lobectomy for overall and disease-free survival in patients with stage I nonsmall cell lung cancer.</p><p><strong>Summary: </strong>Since 1962, lobectomy has been deemed the gold standard treatment for operable lung cancer. However, two recent clinical trials have demonstrated that, for select patients, sublobar resection is oncologically noninferior; results, which are leading us into a new era for the surgical management of lung cancer. Notwithstanding the progress made by these studies and the opportunities that have been put forth, questions remain. This review aims at reviewing the results of both trials and to discuss future perspectives for the surgical treatment of lung cancer.</p>","PeriodicalId":11090,"journal":{"name":"Current Opinion in Pulmonary Medicine","volume":" ","pages":"352-358"},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How do we expand the lung donor pool? 如何扩大肺捐献者库？
IF 3.3 3区 医学
Current Opinion in Pulmonary Medicine Pub Date : 2024-07-01 Epub Date: 2024-03-28 DOI: 10.1097/MCP.0000000000001076
Bronwyn J Levvey, Gregory I Snell
{"title":"How do we expand the lung donor pool?","authors":"Bronwyn J Levvey, Gregory I Snell","doi":"10.1097/MCP.0000000000001076","DOIUrl":"10.1097/MCP.0000000000001076","url":null,"abstract":"<p><strong>Purpose of review: </strong>Lung transplantation activity continues to be limited by the availability of timely quality donor lungs. It is apparent though that progress has been made. The steady evolution of clinical practice, combined with painstaking scientific discovery and innovation are described.</p><p><strong>Recent findings: </strong>There have been successful studies reporting innovations in the wider use and broader consideration of donation after circulatory death donor lungs, including an increasing number of transplants from each of the controlled, uncontrolled and medically assisted dying donor descriptive categories. Donors beyond age 70 years are providing better than expected long-term outcomes. Hepatitis C PCR positive donor lungs can be safely used if treated postoperatively with appropriate antivirals. Donor lung perfusion at a constant 10 degrees appears capable of significantly improving donor logistics and ex-vivo lung perfusion offers the potential of an ever-increasing number of novel donor management roles. Bioartificial and xenografts remain distant possibilities only at present.</p><p><strong>Summary: </strong>Donor lungs have proved to be surprisingly robust and combined with clinical, scientific and engineering innovations, the realizable lung donor pool is proving to be larger than previously thought.</p>","PeriodicalId":11090,"journal":{"name":"Current Opinion in Pulmonary Medicine","volume":" ","pages":"398-404"},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An update of palliative care in lung transplantation with a focus on symptoms, quality of life and functional outcomes. 肺移植姑息治疗的最新进展，重点关注症状、生活质量和功能结果。
IF 3.3 3区 医学
Current Opinion in Pulmonary Medicine Pub Date : 2024-07-01 Epub Date: 2024-03-27 DOI: 10.1097/MCP.0000000000001075
Dmitry Rozenberg, Rogih Riad Andrawes, Kirsten Wentlandt
{"title":"An update of palliative care in lung transplantation with a focus on symptoms, quality of life and functional outcomes.","authors":"Dmitry Rozenberg, Rogih Riad Andrawes, Kirsten Wentlandt","doi":"10.1097/MCP.0000000000001075","DOIUrl":"10.1097/MCP.0000000000001075","url":null,"abstract":"<p><strong>Purpose of review: </strong>Palliative care (PC) in lung transplantation is increasingly acknowledged for its important role in addressing symptoms, enhancing functionality, and facilitating advance care planning for patients, families, and caregivers. The present review provides an update in PC management in lung transplantation.</p><p><strong>Recent findings: </strong>Research confirms the effectiveness of PC for patients with advanced lung disease who are undergoing transplantation, showing improvements in symptoms and reduced healthcare utilization. Assessment tools and patient-reported outcome measures for PC are commonly used in lung transplant candidates, revealing discrepancies between symptom severity and objective measures such as exercise capacity. The use of opioids to manage dyspnea and cough in the pretransplant period is deemed safe and does not heighten risks posttransplantation. However, the integration of PC support in managing symptoms and chronic allograft dysfunction in the posttransplant period has not been as well described.</p><p><strong>Summary: </strong>Palliative care support should be provided in the pretransplant and select peri-operative and posttransplant periods to help support patient quality of life, symptoms, communication and daily function.</p>","PeriodicalId":11090,"journal":{"name":"Current Opinion in Pulmonary Medicine","volume":" ","pages":"410-418"},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140293123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparities across the continuum of lung cancer care: a review of recent literature. 肺癌治疗过程中的差异：最新文献综述。
IF 3.3 3区 医学
Current Opinion in Pulmonary Medicine Pub Date : 2024-07-01 Epub Date: 2024-02-23 DOI: 10.1097/MCP.0000000000001064
Lauren Kearney, Tatyana Nguyen, Katrina Steiling
{"title":"Disparities across the continuum of lung cancer care: a review of recent literature.","authors":"Lauren Kearney, Tatyana Nguyen, Katrina Steiling","doi":"10.1097/MCP.0000000000001064","DOIUrl":"10.1097/MCP.0000000000001064","url":null,"abstract":"<p><strong>Purpose of review: </strong>Lung cancer remains the leading cause of cancer mortality worldwide. Health disparities have long been noted in lung cancer incidence and survival and persist across the continuum of care. Understanding the gaps in care that arise from disparities in lung cancer risk, screening, treatment, and survivorship are essential to guiding efforts to achieve equitable care.</p><p><strong>Recent findings: </strong>Recent literature continues to show that Black people, women, and people who experience socioeconomic disadvantage or live in rural areas experience disparities throughout the spectrum of lung cancer care. Contributing factors include structural racism, lower education level and health literacy, insurance type, healthcare facility accessibility, inhaled carcinogen exposure, and unmet social needs. Promising strategies to improve lung cancer care equity include policy to reduce exposure to tobacco smoke and harmful pollutants, more inclusive lung cancer screening eligibility criteria, improved access and patient navigation in lung cancer screening, diagnosis and treatment, more deliberate offering of appropriate surgical and medical treatments, and improved availability of survivorship and palliative care.</p><p><strong>Summary: </strong>Given ongoing disparities in lung cancer care, research to determine best practices for narrowing these gaps and to guide policy change are an essential focus of future lung cancer research.</p>","PeriodicalId":11090,"journal":{"name":"Current Opinion in Pulmonary Medicine","volume":" ","pages":"359-367"},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung transplantation: practical and important directions of care. 肺移植：实用而重要的护理方向。
IF 2.8 3区 医学
Current Opinion in Pulmonary Medicine Pub Date : 2024-07-01 Epub Date: 2024-05-30 DOI: 10.1097/MCP.0000000000001081
Allan R Glanville, Carli J Lehr
{"title":"Lung transplantation: practical and important directions of care.","authors":"Allan R Glanville, Carli J Lehr","doi":"10.1097/MCP.0000000000001081","DOIUrl":"10.1097/MCP.0000000000001081","url":null,"abstract":"","PeriodicalId":11090,"journal":{"name":"Current Opinion in Pulmonary Medicine","volume":"30 4","pages":"375-376"},"PeriodicalIF":2.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The changing landscape of infections in the lung transplant recipient. 肺移植受者感染情况的变化。
IF 3.3 3区 医学
Current Opinion in Pulmonary Medicine Pub Date : 2024-07-01 Epub Date: 2024-02-26 DOI: 10.1097/MCP.0000000000001060
Jessica Lum, Christine Koval
{"title":"The changing landscape of infections in the lung transplant recipient.","authors":"Jessica Lum, Christine Koval","doi":"10.1097/MCP.0000000000001060","DOIUrl":"10.1097/MCP.0000000000001060","url":null,"abstract":"<p><strong>Purpose of review: </strong>Infections in lung transplant recipients remain a major challenge and can affect lung allograft function and cause significant morbidity and mortality. New strategies for the prevention and treatment of infection in lung transplantation have emerged and are reviewed.</p><p><strong>Recent findings: </strong>For important vaccine preventable infections (VPIs), guidance has been updated for at risk solid organ transplant (SOT) recipients. However, data on the efficacy of newer vaccines in lung transplant, including the respiratory syncytial virus (RSV) vaccine, are limited. Studies demonstrate improved vaccination rate with Infectious Diseases consultation during pretransplant evaluation. Two new antiviral agents for the treatment and prevention of cytomegalovirus (CMV) in SOT, letermovir and maribavir, are being incorporated into clinical care. CMV-specific cell-mediated immune function assays are more widely available. Antibiotics for the management of multidrug resistant pathogens and Burkholderia cepacia complex have been described in case series and case reports in lung transplant.</p><p><strong>Summary: </strong>Although new vaccines and novel therapies for preventing and treating infections are available, larger studies evaluating efficacy in lung transplant recipients are needed.</p>","PeriodicalId":11090,"journal":{"name":"Current Opinion in Pulmonary Medicine","volume":" ","pages":"382-390"},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated management of stage III in nonsmall cell lung cancer: where do perioperative chemotherapy and immunotherapy fit? 非小细胞肺癌 III 期的综合治疗：围手术期化疗和免疫疗法该何去何从？
IF 3.3 3区 医学
Current Opinion in Pulmonary Medicine Pub Date : 2024-07-01 Epub Date: 2024-05-07 DOI: 10.1097/MCP.0000000000001079
Ana Collazo-Lorduy, Mariola Blanco, Virginia Calvo, Mariano Provencio
{"title":"Integrated management of stage III in nonsmall cell lung cancer: where do perioperative chemotherapy and immunotherapy fit?","authors":"Ana Collazo-Lorduy, Mariola Blanco, Virginia Calvo, Mariano Provencio","doi":"10.1097/MCP.0000000000001079","DOIUrl":"10.1097/MCP.0000000000001079","url":null,"abstract":"<p><strong>Purpose of review: </strong>Early-stage nonsmall cell lung cancer (NSCLC) accounts for 30% of the total NSCLC, being the stage III a heterogeneous disease that represents a challenge in the management of these patients. Multidisciplinary approach is essential for an adequate treatment strategy, with surgery being the only curative treatment. Neoadjuvant or adjuvant chemotherapy has been the standard of care for a long period, with modest results.</p><p><strong>Recent findings: </strong>Combination of chemotherapy and immunotherapy has revolutionized the neoadjuvant setting of resectable NSCLC, improving pathologic complete responses and survival outcomes in this scenario. Furthermore, perioperative treatment with immunotherapy has also recently shown promising results in several phase III trials.</p><p><strong>Summary: </strong>The landscape of early-stage resectable NSCLC has evolved in recent years, with an improvement in the survival of these patients since the incorporation of immunotherapy in this scenario.</p>","PeriodicalId":11090,"journal":{"name":"Current Opinion in Pulmonary Medicine","volume":" ","pages":"346-351"},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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