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A case of mixed mycosis fungoides and superficial morphea: a clinicohistopathologic challenge. 蕈样霉菌病和浅表性morphea混合病例：临床组织病理学挑战。
Dermatology online journal Pub Date : 2025-02-15 DOI: 10.5070/D331164985
Oluwaseyi O Adeuyan, Celine M Schreidah, Lauren M Fahmy, Emily R Gordon, Brigit A Lapolla, Larisa J Geskin
{"title":"A case of mixed mycosis fungoides and superficial morphea: a clinicohistopathologic challenge.","authors":"Oluwaseyi O Adeuyan, Celine M Schreidah, Lauren M Fahmy, Emily R Gordon, Brigit A Lapolla, Larisa J Geskin","doi":"10.5070/D331164985","DOIUrl":"https://doi.org/10.5070/D331164985","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A unique presentation of diffuse multiple eruptive milia. 弥漫性多发发疹的独特表现。
Dermatology online journal Pub Date : 2025-02-15 DOI: 10.5070/D331164967
Mckenzie DiLeo, Reece Moore, Emelie E Nelson, Rashid M Rashid
{"title":"A unique presentation of diffuse multiple eruptive milia.","authors":"Mckenzie DiLeo, Reece Moore, Emelie E Nelson, Rashid M Rashid","doi":"10.5070/D331164967","DOIUrl":"10.5070/D331164967","url":null,"abstract":"<p><p>Milia are small, benign firm white papules that commonly manifest on the face and torso. Several subtypes exist, including multiple eruptive milia-a condition characterized by the eruption of numerous milia that arise over the course of weeks to months. Although limited literature exists on this rare presentation, there seems to be no uniform patient demographic, etiology, or consistent anatomical localization of the milia. We describe a case of multiple eruptive milia presenting diffusely across the cheeks, forehead, superior neck, and preauricular and postauricular skin of an adult female. Additionally, this case is particularly unique as biopsies of representative lesions demonstrate a distinct lymphohistiocytic infiltrate. This atypical presentation underscores a gap in literature regarding multiple eruptive milia and calls into question whether a subtype of milia may exist with an inflammatory component.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical pearls addressing hair growth and loss in transgender patients on hormone replacement therapy. 在激素替代治疗中处理变性患者头发生长和脱落的临床珍珠。
Dermatology online journal Pub Date : 2025-02-15 DOI: 10.5070/D331164961
Chinenye Onejeme, Mary Fitzgibbon, Antonio Jimenez, Lindy Ross
{"title":"Clinical pearls addressing hair growth and loss in transgender patients on hormone replacement therapy.","authors":"Chinenye Onejeme, Mary Fitzgibbon, Antonio Jimenez, Lindy Ross","doi":"10.5070/D331164961","DOIUrl":"https://doi.org/10.5070/D331164961","url":null,"abstract":"<p><p>Hair is a defining feature of human appearance and plays an essential role in personality and identity development. Currently, about 1.6% of US adults identify as transgender. Within the transgender community, hair serves not only as a means of self-expression but also as a crucial element in affirming gender identity, helping individuals to align their outward appearance with their inner sense of self. However, there are significant disparities in the care provided to transgender patients, particularly those seeking a more masculine or feminine appearance through hormone replacement therapy. Studies on transgender patient satisfaction with current therapies are limited but indicate overall dissatisfaction with the standard of care. Dermatologists play a pivotal role in advocating and caring for transgender patients regarding their hair and skin needs. A deeper understanding of hormone replacement therapy and hair growth/loss therapy is crucial to prescribing medications aligned with patients' treatment goals. This commentary aims to provide clinical guidance to dermatologists, aiding them in educating transgender patients undergoing hormone replacement therapy about accessible options for hair growth and loss. Treatment algorithms have been proposed based on efficacy, pharmacodynamic interactions with hormone replacement therapy, cost-effectiveness, adverse reactions, and care accessibility tailored specifically for transfeminine and transmasculine patients.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rituximab treatment of refractory skin involvement in anti-TIF1 gamma dermatomyositis. 利妥昔单抗治疗难治性皮肤受累的抗tif1 γ皮肌炎。
Dermatology online journal Pub Date : 2025-02-15 DOI: 10.5070/D331164969
Fatma Said, Maysam Jridi, Ines Naceur, Tayssir Ben Achour, Monia Smiti
{"title":"Rituximab treatment of refractory skin involvement in anti-TIF1 gamma dermatomyositis.","authors":"Fatma Said, Maysam Jridi, Ines Naceur, Tayssir Ben Achour, Monia Smiti","doi":"10.5070/D331164969","DOIUrl":"https://doi.org/10.5070/D331164969","url":null,"abstract":"<p><p>Dermatomyositis is one type among a heterogeneous group of idiopathic inflammatory myopathies. Among these anti-TIF1 gamma dermatomyositis is characterized by specific skin lesions, often severe and refractory to conventional treatments. We report a 58-year-old woman who had fatigue associated with myalgia with proximal and bilateral muscle weakness along with a generalized lilac erythematous rash on the face with Gottron papules on the metacarpophalangeal joints and periungual erythema on both hands. She also exhibited a widespread dark-violaceous-red skin eruption on the whole trunk. She was diagnosed with anti-TIF1 gamma dermatomyositis and received a treatment regimen of topical corticosteroids, hydroxychloroquine, oral corticosteroids, and conventional immunosuppressive drugs (methotrexate, azathioprine, mycophenolate mofetil, cyclophosphamide, and immunoglobulins) with no improvement of the skin rash. Therefore, she received rituximab, and three months later, the skin lesions improved magnificently. Rituximab is an efficient and safe option for patients with dermatomyositis-related skin disease refractory to conventional treatments.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recalcitrant Nicolau syndrome following repeated intramuscular diclofenac injections. 反复肌注双氯芬酸后的顽固性尼可劳综合征。
Dermatology online journal Pub Date : 2025-02-15 DOI: 10.5070/D331164973
Ismail H Unal, Gulsen Akoglu, Gulcin Simsek
{"title":"Recalcitrant Nicolau syndrome following repeated intramuscular diclofenac injections.","authors":"Ismail H Unal, Gulsen Akoglu, Gulcin Simsek","doi":"10.5070/D331164973","DOIUrl":"https://doi.org/10.5070/D331164973","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early malignant syphilis in an immunocompetent young man. 免疫能力强的青年早期恶性梅毒。
Dermatology online journal Pub Date : 2025-02-15 DOI: 10.5070/D331164981
Jesus Enrique Duenaz-Diaz, Dinorah Elizabeth Paz-Luna, Isaias Giovanni Duenaz-Diaz, Astrid Salcedo-Gomez, Gema Yasmin Aguilar-Roman, Vanesa Paredes-Solis, Sara Elena Chavez-Guzman, Elsa Daniela Zavala-Alvarez
{"title":"Early malignant syphilis in an immunocompetent young man.","authors":"Jesus Enrique Duenaz-Diaz, Dinorah Elizabeth Paz-Luna, Isaias Giovanni Duenaz-Diaz, Astrid Salcedo-Gomez, Gema Yasmin Aguilar-Roman, Vanesa Paredes-Solis, Sara Elena Chavez-Guzman, Elsa Daniela Zavala-Alvarez","doi":"10.5070/D331164981","DOIUrl":"https://doi.org/10.5070/D331164981","url":null,"abstract":"<p><p>Malignant syphilis, also known as lues maligna, is an atypical and aggressive form of secondary syphilis characterized by nodules and ulcers associated with a spectrum of nonspecific systemic manifestations. The underlying states of immunosuppression represent the primary risk factor. We present a 30-year-old immunocompetent man exhibiting dermatological lesions at various stages clinically and histologically consistent with the established criteria for malignant syphilis. He received antibiotic therapy with complete clearing. Furthermore, we emphasize the importance of proper interpretation of serological tests, both for diagnosis and systematic monitoring.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymptomatic hepatotoxicity following exposure to oral terbinafine for onychomycosis treatment. 暴露于口服特比萘芬治疗甲癣后无症状肝毒性。
Dermatology online journal Pub Date : 2025-02-15 DOI: 10.5070/D331164965
Rachel C Hill, Shari R Lipner
{"title":"Asymptomatic hepatotoxicity following exposure to oral terbinafine for onychomycosis treatment.","authors":"Rachel C Hill, Shari R Lipner","doi":"10.5070/D331164965","DOIUrl":"https://doi.org/10.5070/D331164965","url":null,"abstract":"<p><p>Hepatotoxicity is a known but very rare side effect of oral terbinafine therapy. To our knowledge, there are no reported cases of patients with cleared hepatitis B infection prescribed oral terbinafine. We report an 82-year-old woman with previous hepatitis B exposure who experienced asymptomatic elevation of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase levels following 28 days of therapy with 250mg of oral terbinafine daily for onychomycosis treatment. After drug discontinuation, her liver function tests returned to baseline about three months later, without permanent liver damage. Oral terbinafine therapy, although typically efficacious and well-tolerated for onychomycosis treatment, rarely causes hepatoxicity. Physician knowledge of this rare but important side effect is necessary to prevent morbidity and mortality resulting from continued therapy. Oral terbinafine therapy might not reactivate hepatitis B in patients with past infection.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous nodules secondary to Mycobacterium avium complex in a patient with human immunodeficiency virus. 人类免疫缺陷病毒患者继发于鸟分枝杆菌复合体的皮肤结节。
Dermatology online journal Pub Date : 2024-12-16 DOI: 10.5070/D330664688
Jay Patel, Shannon Sayyadioskoie, Hanna Siatecka, Theodore Rosen
{"title":"Cutaneous nodules secondary to Mycobacterium avium complex in a patient with human immunodeficiency virus.","authors":"Jay Patel, Shannon Sayyadioskoie, Hanna Siatecka, Theodore Rosen","doi":"10.5070/D330664688","DOIUrl":"10.5070/D330664688","url":null,"abstract":"<p><p>We present a patient with human immunodeficiency virus who developed multiple painful lesions that previously in the past had speciated as Cryptococcus neoformans cutaneously, and in the lung. Despite induction therapy for presumed re-infection, the patient did not improve so a biopsy was performed and this was speciated as Mycobacterium avium complex, with final diagnosis being disseminated Mycobacterium avium complex. This case highlights the importance of considering a broad differential diagnosis for any new lesions regardless of prior culture data.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lichen planus pigmentosus inversus presenting with clinical features mimicking acanthosis nigricans. 相反，色素性扁平苔藓表现出类似黑棘皮病的临床特征。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664690
Joohyung Youh, Hiroaki Iwata, Shinya Kitamura, Hideyuki Ujiie
{"title":"Lichen planus pigmentosus inversus presenting with clinical features mimicking acanthosis nigricans.","authors":"Joohyung Youh, Hiroaki Iwata, Shinya Kitamura, Hideyuki Ujiie","doi":"10.5070/D330664690","DOIUrl":"10.5070/D330664690","url":null,"abstract":"<p><p>Lichen planus pigmentosus (LPP) is recognized as a rare variant of lichen planus, characterized by dermal hyperpigmentation. Specifically, a particular intertriginous variant of LPP is known as lichen planus pigmentosus inversus (LPPI). In our case, the patient presented with symmetric, hyperpigmented dark brown patches mainly in axillary areas, closely resembling the features of acanthosis nigricans (AN). The differential diagnosis considered included LPPI, AN, post-inflammatory hyperpigmentation related to contact dermatitis, symmetrical drug-related intertriginous and flexural exanthema, fixed drug eruption, and erythema dyschromicum perstans (EDP). Histopathological examination revealed the absence of hyperkeratosis and papillomatosis, typically associated with AN. Dermoscopy revealed diffuse brownish hue along with dots and globules of inconsistent size, which suggests dermal pigmentary incontinence and the likelihood of LPPI. This case illustrates the challenge in differentiating LPPI from similar flexural hyperpigmentation disorders based on the comprehensive approach including thorough history taking, clinical manifestations, histopathological analysis, and dermoscopic examination.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personal protective equipment modification by health care workers owing to skin concerns during the COVID-19 pandemic: a multicenter cross-sectional study. COVID-19大流行期间卫生保健工作者因皮肤问题修改个人防护装备：一项多中心横断面研究
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664701
Nicole Trepanowski, Haya S Raef, Sarina B Elmariah, Ari M Goldminz, Allison R Larson, Rachel Meltzer
{"title":"Personal protective equipment modification by health care workers owing to skin concerns during the COVID-19 pandemic: a multicenter cross-sectional study.","authors":"Nicole Trepanowski, Haya S Raef, Sarina B Elmariah, Ari M Goldminz, Allison R Larson, Rachel Meltzer","doi":"10.5070/D330664701","DOIUrl":"https://doi.org/10.5070/D330664701","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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