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Treatment of disseminated granuloma annulare with pulse therapy upadacitinib. 用脉冲疗法达帕替尼治疗播散性环状肉芽肿。
Dermatology online journal Pub Date : 2024-10-15 DOI: 10.5070/D330564430
Alanna Trees, Cassi Smithem, Mallorie Bialick, Filamer Kabigting
{"title":"Treatment of disseminated granuloma annulare with pulse therapy upadacitinib.","authors":"Alanna Trees, Cassi Smithem, Mallorie Bialick, Filamer Kabigting","doi":"10.5070/D330564430","DOIUrl":"https://doi.org/10.5070/D330564430","url":null,"abstract":"<p><p>Granuloma annulare (GA) is an idiopathic inflammatory skin condition with a chronic and unpredictable course. Although localized GA is usually cleared with topical or systemic corticosteroids, generalized GA is often difficult to treat owing to the lack of treatment options and recurrence with treatment. Recent evidence has helped to elucidate the etiology behind GA, with growing confirmation for the use of JAK inhibitors as a possible treatment for GA. We present a 61-year-old woman with recalcitrant GA who responded successfully to pulse therapy upadacitinib, a JAK1 inhibitor. Our findings demonstrate the utility of this alternative and practical treatment strategy that may reduce the cumulative toxicity of upadacitinib and optimize its risk/benefit ratio.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What your patients need to know about skin supplements. 你的病人需要知道的关于皮肤补充剂的知识。
Dermatology online journal Pub Date : 2024-10-15 DOI: 10.5070/D330564441
Rajani Katta, Jenny She, Ariadna Perez-Sanchez
{"title":"What your patients need to know about skin supplements.","authors":"Rajani Katta, Jenny She, Ariadna Perez-Sanchez","doi":"10.5070/D330564441","DOIUrl":"https://doi.org/10.5070/D330564441","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of the atopic dermatitis yardstick via the electronic medical record: a pilot study to improve clinical documentation and patient education. 通过电子病历实施特应性皮炎标准：一项旨在改善临床文件和患者教育的试点研究。
Dermatology online journal Pub Date : 2024-10-15 DOI: 10.5070/D330564437
Jonathan D Greenzaid, Jessica N Pixley, Katherine A Kelly, Steven R Feldman, Lindsay C Strowd
{"title":"Implementation of the atopic dermatitis yardstick via the electronic medical record: a pilot study to improve clinical documentation and patient education.","authors":"Jonathan D Greenzaid, Jessica N Pixley, Katherine A Kelly, Steven R Feldman, Lindsay C Strowd","doi":"10.5070/D330564437","DOIUrl":"https://doi.org/10.5070/D330564437","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pseudoxanthoma elasticum-like papillary dermal elastolysis; A report of two cases and a literature review. 假黄色瘤弹性样乳头状真皮弹性松解；两例报告及文献回顾。
Dermatology online journal Pub Date : 2024-10-15 DOI: 10.5070/D330564429
Rand Murshidi, Salsabiela Bani Hamad, Awad Al-Tarawneh
{"title":"Pseudoxanthoma elasticum-like papillary dermal elastolysis; A report of two cases and a literature review.","authors":"Rand Murshidi, Salsabiela Bani Hamad, Awad Al-Tarawneh","doi":"10.5070/D330564429","DOIUrl":"10.5070/D330564429","url":null,"abstract":"<p><p>Pseudoxanthoma elasticum-like papillary dermal elastolysis is a rare, benign, acquired, gradually-developing chronic elastic tissue disorder that almost exclusively affects post-menopausal women. It is essential to recognize this disease as it mimics the inherited pseudoxanthoma clinically. The pathophysiology behind this disease is multifactorial; it includes intrinsic skin aging, ultraviolet radiation exposure, and genetic components. We report two patients with pseudoxanthoma elasticum-papillary dermal elastolysis diagnosis based on clinicopathologic correlation in two post-menopausal women who presented with multiple asymptomatic papules over the neck that developed gradually without systemic involvement, and were managed conservatively. We also discuss this disease's clinical, dermoscopic, and histopathologic features.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis of perianal pyramidal protrusion in infants. 诊断婴儿肛周锥体突出。
Dermatology online journal Pub Date : 2024-10-15 DOI: 10.5070/D330564433
Shae Margulies, Macartney Welborn, Vladimir Vincek
{"title":"Diagnosis of perianal pyramidal protrusion in infants.","authors":"Shae Margulies, Macartney Welborn, Vladimir Vincek","doi":"10.5070/D330564433","DOIUrl":"10.5070/D330564433","url":null,"abstract":"<p><p>Infantile perianal pyramidal protrusion is characterized by a light pink to skin-colored soft tissue protrusion that is often midline and anterior [A1]to the anus. It most commonly occurs in young females and is relatively asymptomatic. Although biopsies are not routinely done, histopathology is relatively nonspecific and can appear similar to an acrochordon. The differential diagnosis is broad and clinical misdiagnosis as condyloma can lead to unnecessary accusations of child abuse. We report a case of perianal pyramidal protrusion that was originally biopsied owing to concern of condyloma acuminatum or molluscum. This case raises awareness of this diagnosis to help avoid unnecessary procedures and prevent emotional distress that could come for families with an inaccurate diagnosis of condyloma in young children.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Light-based therapies in the treatment of alopecia. 治疗脱发的光疗法。
Dermatology online journal Pub Date : 2024-10-15 DOI: 10.5070/D330564423
Christina S Oh, Maria Karim, Elizabeth J Klein, Lu Yin, Daniel Gutierrez, Jerry Shapiro, Kristen Lo Sicco
{"title":"Light-based therapies in the treatment of alopecia.","authors":"Christina S Oh, Maria Karim, Elizabeth J Klein, Lu Yin, Daniel Gutierrez, Jerry Shapiro, Kristen Lo Sicco","doi":"10.5070/D330564423","DOIUrl":"https://doi.org/10.5070/D330564423","url":null,"abstract":"<p><p>All types of alopecia, including androgenetic alopecia, alopecia areata, and lichen planopilaris/frontal fibrosing alopecia, affect over half of men and women. Though a common dermatological experience, many patients with visible hair loss report significant psychological and social distress and, consequently seek treatment. Current existing therapeutic regimens have proven to be efficacious, though may result in various adverse effects and require lifelong use. Laser and light-based therapies have been emerging in the current literature as a safe and alternative treatment, but their utilization for treating alopecia is poorly understood. This review evaluates the existing evidence regarding the use of lasers in the treatment of various forms of alopecia. Overall, there has been promising evidence for potential alopecia treatment efficacy: low-level light therapy for androgenetic alopecia, fractional laser for androgenetic alopecia, and excimer laser for alopecia areata.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent aseptic abscesses resulting in superficial pyoderma gangrenosum-like ulcers in a patient with granulomatosis with polyangiitis. 一例肉芽肿病合并多血管炎的患者复发性无菌性脓肿导致浅表脓皮坏疽样溃疡。
Dermatology online journal Pub Date : 2024-10-15 DOI: 10.5070/D330564432
Toshiyuki Yamamoto
{"title":"Recurrent aseptic abscesses resulting in superficial pyoderma gangrenosum-like ulcers in a patient with granulomatosis with polyangiitis.","authors":"Toshiyuki Yamamoto","doi":"10.5070/D330564432","DOIUrl":"https://doi.org/10.5070/D330564432","url":null,"abstract":"<p><p>Patients with granulomatosis with polyangiitis occasionally present with cutaneous manifestations, which are important clues for the early diagnosis. Although pyoderma gangrenosum-like ulcers are rarely observed, a unique case with unusual clinical features is presented herein. A 75-year-old woman with positive proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA) repeatedly developed aseptic abscesses on the abdomen, buttock, lower legs, and forearms. Histopathological features of biopsy taken from ulcers showed necrotizing granulomatous inflammation with multinucleated giant cells without leukocytoclastic vasculitis. The present case was initially diagnosed as limited granulomatosis with polyangiitis without renal and lung involvement. However, two years later, she died of cerebral hemorrhage.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactation anaphylaxis: report of a rare case with recurrent postpartum anaphylaxis. 哺乳期过敏性休克：报告一例罕见的产后过敏性休克复发病例。
Dermatology online journal Pub Date : 2024-10-15 DOI: 10.5070/D330564435
Yasutoshi Hida, Shunsuke Takahagi, Ayaka Iwawaki, Kaori Ishii, Kayo Myogo
{"title":"Lactation anaphylaxis: report of a rare case with recurrent postpartum anaphylaxis.","authors":"Yasutoshi Hida, Shunsuke Takahagi, Ayaka Iwawaki, Kaori Ishii, Kayo Myogo","doi":"10.5070/D330564435","DOIUrl":"10.5070/D330564435","url":null,"abstract":"<p><p>Lactation anaphylaxis is extremely rare and has been scarcely reported in the literature. Breast feeding and/or milk expression immediately induces life-threatening anaphylactic reactions, including generalized urticaria, angioedema, respiratory symptoms, and hypotension. Six English-language case reports have described the clinical course in detail. The present report describes a case involving a 24-year-old woman with no history of allergic reactions or anaphylaxis who experienced anaphylactic reactions three times immediately after milk expression. Lactation anaphylaxis was suspected when a detailed medical history revealed lactation-related recurrent anaphylactic symptoms. The authors prescribed bromocriptine to stop lactation and switched her to formula feeding, which resulted in no further anaphylactic episodes. Based on a review of the relevant literature, this report describes the characteristics of lactation anaphylaxis and possible management strategies. The pathogenesis of lactation anaphylaxis has been inferred from various experimental results.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous ulcers in sarcoidosis. 结节病的皮肤溃疡。
Dermatology online journal Pub Date : 2024-08-15 DOI: 10.5070/D330464113
Hanadi Alsatti, Atheel Balkhy, Bashaer H Almahdi, Amal H Abualola
{"title":"Cutaneous ulcers in sarcoidosis.","authors":"Hanadi Alsatti, Atheel Balkhy, Bashaer H Almahdi, Amal H Abualola","doi":"10.5070/D330464113","DOIUrl":"10.5070/D330464113","url":null,"abstract":"<p><p>Sarcoidosis is a disease characterized by immunological granuloma formation in various organs. Cutaneous manifestations occur in about 25% of patients with rare cases showing ulcerative sarcoidosis, that can be debilitating if not treated promptly. This article presents a patient with isolated ulcerative sarcoidosis and reviews existing literature. A 44-year-old woman presented with a non-healing ulcer on her right gluteal area. A skin biopsy confirmed sarcoidosis with non-necrotizing granulomas. Systemic involvement of sarcoidosis was ruled out. Treatment involved topical corticosteroids and intralesional corticosteroid injections, resulting in complete healing. This case emphasizes the importance of considering ulcerative sarcoidosis in non-healing wounds and the efficacy of corticosteroid treatment.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diffuse face and ear hypertrichosis caused by 5% topical minoxidil in an adult woman with spontaneous resolution. 5%外用米诺地尔引起的弥漫性面部和耳朵多毛症，1例成年女性，自发性消退。
Dermatology online journal Pub Date : 2024-08-15 DOI: 10.5070/D330464117
Fares A Alkhayal, Ali A Alkinani
{"title":"Diffuse face and ear hypertrichosis caused by 5% topical minoxidil in an adult woman with spontaneous resolution.","authors":"Fares A Alkhayal, Ali A Alkinani","doi":"10.5070/D330464117","DOIUrl":"10.5070/D330464117","url":null,"abstract":"<p><p>Minoxidil is a vasodilator medication known for its ability to promote hair growth. Although it was first introduced as an oral drug to treat hypertension, minoxidil was observed to have the important side-effect of increasing hair growth. This led to the development of a topical formulation as a 2% concentration solution for the treatment of female androgenic alopecia (AGA) and 5% for treating male AGA, which is considered as a first line U.S. Food and Drug Administration (FDA)-approved treatment for AGA in addition to oral 5-alpha-reductase inhibitor (finasteride). The mechanism by which minoxidil promotes hair growth is not fully understood but can be related to increasing blood flow owing to its vasodilator effects. Androgenic alopecia is characterized by the gradual conversion of terminal hairs into vellus hairs. Alterations in the hair cycle include reduced duration of the anagen phase and increased duration of the telogen phase, resulting in shorter hairs and eventual balding. Side effects of topical minoxidil include irritant and allergic contact dermatitis, pruritus, and facial hypertrichosis, which are more often seen with the use of 5% solutions rather than 2%. Herein, we report a 24-year-old woman who developed severe ear and face hypertrichosis after using a topical 5% minoxidil solution. She later had spontaneous resolution of her hypertrichosis three months after stopping it.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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