Decis. Sci.最新文献_第8页

σ-Hole Bonds and the VSEPR Model—From the Tetrahedral Structure to the Trigonal Bipyramid σ-空穴键与VSEPR模型——从四面体结构到三角双棱锥结构

Decis. Sci. Pub Date : 2022-04-19 DOI: 10.3390/sci4020017

S. J. Grabowski

引用次数: 0

Mathematics and Poetry · Yang–Baxter Equations, Boolean Algebras, and BCK-Algebras 数学与诗歌·杨-巴克斯特方程，布尔代数和bck代数

Decis. Sci. Pub Date : 2022-04-11 DOI: 10.3390/sci4020016

Tuǧce Kalkan, F. Nichita, T. Oner, Ibrahim Senturk, Mehmet Terzier

引用次数: 3

Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics 细胞凋亡及其在癌症治疗中的靶向药物治疗

Decis. Sci. Pub Date : 2022-04-06 DOI: 10.3390/sci4020015

Vishakha Singh, Amit Khurana, Umashanker Navik, P. Allawadhi, K. Bharani, R. Weiskirchen

{"title":"Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics","authors":"Vishakha Singh, Amit Khurana, Umashanker Navik, P. Allawadhi, K. Bharani, R. Weiskirchen","doi":"10.3390/sci4020015","DOIUrl":"https://doi.org/10.3390/sci4020015","url":null,"abstract":"Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a homeostatic balance between cell formation and cell death. It is a vital process for normal eukaryotic development as it contributes to the renewal of cells and tissues. Further, it plays a crucial role in the elimination of unnecessary cells through phagocytosis and prevents undesirable immune responses. Apoptosis is regulated by a complex signaling mechanism, which is driven by interactions among several protein families such as caspases, inhibitors of apoptosis proteins, B-cell lymphoma 2 (BCL-2) family proteins, and several other proteases such as perforins and granzyme. The signaling pathway consists of both pro-apoptotic and pro-survival members, which stabilize the selection of cellular survival or death. However, any aberration in this pathway can lead to abnormal cell proliferation, ultimately leading to the development of cancer, autoimmune disorders, etc. This review aims to elaborate on apoptotic signaling pathways and mechanisms, interacting members involved in signaling, and how apoptosis is associated with carcinogenesis, along with insights into targeting apoptosis for disease resolution.","PeriodicalId":10987,"journal":{"name":"Decis. Sci.","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86827985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

HPLC–NMR-Based Chemical Profiling of Matricaria pubescens (Desf.) Schultz and Matricaria recutita and Their Protective Effects on UVA-Exposed Fibroblasts 基于高效液相色谱-核磁共振的毛蕊草化学谱分析舒尔兹和麻属植物及其对暴露于uva的成纤维细胞的保护作用

Decis. Sci. Pub Date : 2022-03-18 DOI: 10.3390/sci4010014

Maria-Elena Ignatiadou, M. Kostaki, Z. Kabouche, P. Chatzopoulou, M. Rallis, A. Karioti

{"title":"HPLC–NMR-Based Chemical Profiling of Matricaria pubescens (Desf.) Schultz and Matricaria recutita and Their Protective Effects on UVA-Exposed Fibroblasts","authors":"Maria-Elena Ignatiadou, M. Kostaki, Z. Kabouche, P. Chatzopoulou, M. Rallis, A. Karioti","doi":"10.3390/sci4010014","DOIUrl":"https://doi.org/10.3390/sci4010014","url":null,"abstract":"The present study aimed to investigate the chemical profile and the protective activity on fibroblasts of two Matricaria species: M. pubescens, which grows wild in Algeria, and M. recutita, which is cultivated in Greece. A comparative phytochemical investigation using High-Performance Liquid Chromatography, coupled with Photodiode Array Detection and Mass Spectrometry (HPLC–PDA–MS) combined with Nuclear Magnetic Resonance (NMR), was performed for the identification of the main constituents in the flowerheads of these medicinal plants. In M. pubescens more than 25 compounds were identified and/or isolated; among them are quercetagenin-3-O-glucopyranoside, reported for the first time in Matricaria sp., and two polyamines previously reported in other Asteraceae species. In M. recutita, which is the officially recognized species in Europe, 19 constituents were identified. To minimize time analysis, the structure elucidation was based on a multi-analytical approach directly on subfractions. Two representative polar extracts from each species were characterized chemically and further screened for their protective effects on 3T3 fibroblasts. The cells were exposed to a mild toxic dose of UVA light (6 J/cm2), in the presence of different concentrations of the extracts. Both M. recutita and M. pubescens extracts were effective. The methanolic extract was the best protective agent at lower concentrations (0.1 to 10 μg/mL), and hydromethanolic was best at higher ones (100–200 μg/mL). M. recutita exhibited the most enhanced cell viability in relation to those not exposed to UV control; it ranged from of 28 to 49% higher viability, depending on the dose, leading to the conclusion that the latter seems to exhibit potent cytoprotective activity and significant regeneration activity.","PeriodicalId":10987,"journal":{"name":"Decis. Sci.","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75399371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Kinetic Analysis of Nitrite Reduction Reactions by Nitrite Reductase Derived from Spinach in the Presence of One-Electron Reduced Riboflavin 单电子还原核黄素存在下菠菜亚硝酸盐还原酶还原亚硝酸盐的动力学分析

Decis. Sci. Pub Date : 2022-03-15 DOI: 10.3390/sci4010013

Shusaku Ikeyama, H. Tabe

引用次数: 0

Deleterious Effect of Ultraviolet Radiation on Glossogobius giuris: A Short Experimental Study 紫外线辐射对拇舌肌损伤的实验研究

Decis. Sci. Pub Date : 2022-03-15 DOI: 10.3390/sci4010012

Azhagu Raj Ramakrishnan, Krishna Kumar, Palavesam Arunachalam, M. Sankar, Prathap Selvaraj, S. Jheeta

{"title":"Deleterious Effect of Ultraviolet Radiation on Glossogobius giuris: A Short Experimental Study","authors":"Azhagu Raj Ramakrishnan, Krishna Kumar, Palavesam Arunachalam, M. Sankar, Prathap Selvaraj, S. Jheeta","doi":"10.3390/sci4010012","DOIUrl":"https://doi.org/10.3390/sci4010012","url":null,"abstract":"Ultraviolet (UV) radiation is a part of the spectrum of electromagnetic radiation emitted by the Sun. The present study was conducted to examine the deleterious effects of UV radiation on the stratum corneum of fish—namely, Glossogobius giuris. In this study, healthy living specimens of G. giuris species weighing (1.20 g) and length (4.06 cm) were collected from Thandavarayankulam lake, Srivaikuntam Taluk, Thoothukudi District, Tamil Nadu. They were transported to the laboratory in well-aerated containers. During the experiment, the fish G. giuris (n = 6) was introduced into the UV Chamber (UVA and UVB) for one hour. After that, experimental fishes were collected from the UV Chamber were dissected for histological and biochemical studies using standard methodology. The short-term exposure of UVA and UVB rays on freshwater G. giuris muscle tissue showed marked degeneration of the epithelium, the disappearance of striations, thickened septal wall, broken fibre, and the disappearance of striation, followed by branchial arterial rupture. It was also determined that carbohydrate, protein, and lipid contents of the muscle tissue were significantly reduced. This study confirmed the destructive effects of UV radiation on the stratum corneum of fish G. giuris. The ultrastructural and biochemical changes occur depending largely on the energy of the UV rays; in this case, the UVB radiation, with higher destructive energy (4.4 eV), had a greater detrimental effect on the muscles of G. giuris than UVA, with its energy level of 3.9 eV.","PeriodicalId":10987,"journal":{"name":"Decis. Sci.","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81938659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

How Could Nanomedicine Improve the Safety of Contrast Agents for MRI during Pregnancy? 纳米医学如何提高妊娠期MRI造影剂的安全性?

Decis. Sci. Pub Date : 2022-03-15 DOI: 10.3390/sci4010011

Marinella Difonzo, Louise Fliedel, N. Mignet, K. Andrieux, Khair Alhareth

{"title":"How Could Nanomedicine Improve the Safety of Contrast Agents for MRI during Pregnancy?","authors":"Marinella Difonzo, Louise Fliedel, N. Mignet, K. Andrieux, Khair Alhareth","doi":"10.3390/sci4010011","DOIUrl":"https://doi.org/10.3390/sci4010011","url":null,"abstract":"Pregnancy is a delicate state, during which timely investigation of possible physiological anomalies is essential to reduce the risk of maternal and fetal complications. Medical imaging encompasses different technologies to image the human body for the diagnosis, course of treatment management, and follow-up of diseases. Ultrasound (US) is currently the imaging system of choice for pregnant patients. However, sonographic evaluations can be non-effective or give ambiguous results. Therefore, magnetic resonance imaging (MRI), due to its excellent tissue penetration, the possibility of acquisition of three-dimensional anatomical information, and its high spatial resolution, is considered a valid diagnostical alternative. Nevertheless, currently employed contrast agents to improve the MRI image quality are harmful to the fetus. Because of their ability to cross the placenta, their use on pregnant patients is avoided. This review will firstly recapitulate the most common non-obstetrical, obstetrical, and fetal indications for magnetic resonance imaging on pregnant women. Fetal safety risks, due to the use of strong magnetic fields and exogenous contrast agents, will be presented. Then, possible advantages of nanostructured contrast agents compared to current molecular ones are explored. Nanosystems’ characteristics affecting contrast efficiency, and their potential for improving contrast-enhanced MRI’s safety in pregnant women, are discussed. Lastly, promising examples of nanoparticles as safer alternatives to current MRI contrast agents in pregnancy are discussed.","PeriodicalId":10987,"journal":{"name":"Decis. Sci.","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86468478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sci: An Inclusive, Multidisciplinary Scientific Journal 《科学》:综合性、多学科的科学期刊

Decis. Sci. Pub Date : 2022-03-07 DOI: 10.3390/sci4010010

Ahmad Yaman Abdin, Claus Jacob

引用次数: 0

Halogen-Bonded Driven Tetra-Substituted Benzene Dimers and Trimers: Potential Hosts for Metal Ions 卤素键驱动的四取代苯二聚体和三聚体:金属离子的潜在宿主

Decis. Sci. Pub Date : 2022-02-25 DOI: 10.3390/sci4010009

R. Parra

{"title":"Halogen-Bonded Driven Tetra-Substituted Benzene Dimers and Trimers: Potential Hosts for Metal Ions","authors":"R. Parra","doi":"10.3390/sci4010009","DOIUrl":"https://doi.org/10.3390/sci4010009","url":null,"abstract":"Cyclic dimers and trimers of tetra-substituted benzenes, ((HOOC)2-C6H2-(NHI)2), are selected as convenient model systems for investigating NI…O=C halogen bond strength and cooperativity. The four substituents in benzene are chosen so that two of them act as halogen bond acceptors (COOH) and two act as halogen bond donors (NHI), as shown in the graphical abstract below. The potential for metal ion binding by each of the halogen-bonded aggregates is also investigated using the monoatomic sodium ion, Na+. Density functional theory calculations performed using the wB97XD functional and the DGDZVP basis set confirmed the ability of halogen bonding to drive the formation of the cyclic dimers and trimers of the model system chosen for this study. Evidence of halogen bond cooperativity is seen, for example, in a 9% shortening of each NI…O=C halogen bond distance with a corresponding 53% increase in the respective critical point density value, ρNI…O=C. Cooperativity also results in a 36% increase in the magnitude of the complexation energy per halogen-bond of the trimer relative to that of the dimer. The results of this study confirm the potential for binding a single Na+ ion by either the dimer or the trimer through their respective halogen-bond networks. Binding of two metal ions was shown to be possible by the dimer. Likewise, the trimer was also found to bind three metal ions. Lastly, the overall structure of the halogen-bonded dimer or trimer endured after complexation of the Na+ ions.","PeriodicalId":10987,"journal":{"name":"Decis. Sci.","volume":"93 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91401160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Malonaldehyde-like Systems: BeF2 Clusters—A Subtle Balance between Hydrogen Bonds, Beryllium Bonds, and Resonance 类丙二醛系统:BeF2团簇——氢键、铍键和共振之间的微妙平衡

Decis. Sci. Pub Date : 2022-02-13 DOI: 10.3390/sci4010007

M. M. Montero‐Campillo, O. Mó, M. Yáñez

引用次数: 0