Current Hypertension Reports最新文献_第9页

Antihypertensives in Children and Adolescents. 儿童和青少年的抗高血压药物。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2022-11-01 DOI: 10.1007/s11906-022-01220-6

Craig Authement, Joshua Samuels, Joyce P Samuel

引用次数: 0

Machine Learning for Hypertension Prediction: a Systematic Review. 高血压预测的机器学习：系统综述。

IF 3.9 2区医学

Current Hypertension Reports Pub Date : 2022-11-01 Epub Date: 2022-06-22 DOI: 10.1007/s11906-022-01212-6

Gabriel F S Silva, Thales P Fagundes, Bruno C Teixeira, Alexandre D P Chiavegatto Filho

{"title":"Machine Learning for Hypertension Prediction: a Systematic Review.","authors":"Gabriel F S Silva, Thales P Fagundes, Bruno C Teixeira, Alexandre D P Chiavegatto Filho","doi":"10.1007/s11906-022-01212-6","DOIUrl":"10.1007/s11906-022-01212-6","url":null,"abstract":"Purpose of review: To provide an overview of the literature regarding the use of machine learning algorithms to predict hypertension. A systematic review was performed to select recent articles on the subject.Recent findings: The screening of the articles was conducted using a machine learning algorithm (ASReview). A total of 21 articles published between January 2018 and May 2021 were identified and compared according to variable selection, train-test split, data balancing, outcome definition, final algorithm, and performance metrics. Overall, the articles achieved an area under the ROC curve (AUROC) between 0.766 and 1.00. The algorithms most frequently identified as having the best performance were support vector machines (SVM), extreme gradient boosting (XGBoost), and random forest. Machine learning algorithms are a promising tool to improve preventive clinical decisions and targeted public health policies for hypertension. However, technical factors such as outcome definition, availability of the final code, predictive performance, explainability, and data leakage need to be consistently and critically evaluated.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":"24 11","pages":"523-533"},"PeriodicalIF":3.9,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10629233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WNT/β-catenin Pathway: a Possible Link Between Hypertension and Alzheimer's Disease. WNT/β-catenin通路:高血压与阿尔茨海默病之间的可能联系

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2022-10-01 Epub Date: 2022-07-05 DOI: 10.1007/s11906-022-01209-1

Alexandre Vallée, Jean-Noël Vallée, Yves Lecarpentier

{"title":"WNT/β-catenin Pathway: a Possible Link Between Hypertension and Alzheimer's Disease.","authors":"Alexandre Vallée, Jean-Noël Vallée, Yves Lecarpentier","doi":"10.1007/s11906-022-01209-1","DOIUrl":"https://doi.org/10.1007/s11906-022-01209-1","url":null,"abstract":"Purpose of review: Recent research has shown that older people with high blood pressure (BP), or hypertension, are more likely to have biomarkers of Alzheimer's disease (AD). Essential hypertension represents the most common cardiovascular disease worldwide and is thought to be responsible for about 13% of all deaths. People with essential hypertension who regularly take prescribed BP medications are half as likely to develop AD as those who do not take them. What then is the connection?Recent findings: We know that high BP can damage small blood vessels in the brain, affecting those parts that are responsible for memory and thinking. However, the link between AD and hypertension remains unclear. Recent advances in the field of molecular and cellular biology have revealed a downregulation of the canonical WNT/β-catenin pathway in both hypertension and AD. In AD, the glutamate transport function is decreased, a decrease that is associated with a loss of synapse and neuronal death. β-catenin signaling appears to act as a major regulator of glutamate transporters (EAAT and GS) expression and can be harnessed to remove excess glutamate in AD. This review focuses on the possible link between hypertension and AD through the decreased WNT/β-catenin which interacts with the glutamatergic pathway.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"465-475"},"PeriodicalIF":5.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40572225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Updated Blood Pressure Guidelines: Implications for Athletes. 最新血压指南:对运动员的影响。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2022-10-01 Epub Date: 2022-07-05 DOI: 10.1007/s11906-022-01210-8

Wesley Ghasem, Christiane Abouzeid, Brett G Toresdahl, Ankit B Shah

{"title":"Updated Blood Pressure Guidelines: Implications for Athletes.","authors":"Wesley Ghasem, Christiane Abouzeid, Brett G Toresdahl, Ankit B Shah","doi":"10.1007/s11906-022-01210-8","DOIUrl":"https://doi.org/10.1007/s11906-022-01210-8","url":null,"abstract":"Purpose of review: To review the prevalence, short- and long-term impact of exercise on blood pressure, and the evaluation and treatment of hypertension in competitive athletes.Recent findings: Due, in part, to inconsistencies in measurement and the definitions used, the true prevalence of hypertension is unknown as reports range from 0 to 83%. With recent changes in the blood pressure guidelines, the proportion of athletes that meet criteria for elevated blood pressure or stage 1 hypertension has increased dramatically with over one-third of collegiate and professional athletes meeting criteria for hypertension. Data consistently show that American-style football players, particularly linemen, display the highest rates of hypertension. These athletes typically have a larger body mass index, higher body fat percentage, and weight gain in serial follow-up. Many athletes with hypertension have traditional risk factors, and, to date, there is no evidence of a causal relationship between long-term sport participation and increased risk of developing hypertension. Many more athletes now meet criteria for hypertension, given the updated blood pressure guidelines. This should be taken as an opportunity for early intervention, as athletes are not immune to the development of cardiovascular risk factors and disease.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"477-484"},"PeriodicalIF":5.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40572226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Vitamin D Supplementation an Effective Treatment for Hypertension? 补充维生素D是治疗高血压的有效方法吗?

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2022-10-01 Epub Date: 2022-06-23 DOI: 10.1007/s11906-022-01204-6

Songcang Chen, Gio Gemelga, Yerem Yeghiazarians

{"title":"Is Vitamin D Supplementation an Effective Treatment for Hypertension?","authors":"Songcang Chen, Gio Gemelga, Yerem Yeghiazarians","doi":"10.1007/s11906-022-01204-6","DOIUrl":"https://doi.org/10.1007/s11906-022-01204-6","url":null,"abstract":"Purpose of the review: Results from epidemiological studies suggest that vitamin D (VD) deficiency (VDD) may be a cause of hypertension (HTN). However, the results of randomized clinical trials (RCTs) designed to address the impact of VD supplementation on reducing blood pressure (BP) remain equivocal. To determine whether VD might serve as a beneficial treatment option for a specific subset of hypertensive patients, we performed a stratified analysis of RCT data and addressed problems associated with some methodological issues.Recent findings: HTN is caused by multiple factors. VDD may be one of the factors contributing to the development of this disorder. There are more than 70 RCTs that examined the impact of VD supplementation on BP. These RCTs can be classified into four groups based on their respective study populations, including participants who are (1) VD-sufficient and normotensive, (2) VD-deficient and normotensive, (3) VD-sufficient and hypertensive, and (4) VD-deficient and hypertensive. Our evaluation of these studies demonstrates that VD supplementation is ineffective when used to reduce BP in VD-sufficient normotensive subjects. VD supplementation for five years or more may reduce the risk of developing HTN specifically among those with VDD. Interestingly, findings from 12 RCTs indicate that daily or weekly supplementation, as opposed to large bolus dosing, results in the reduction of BP in VD-deficient hypertensive patients. Our ongoing research focused on elucidating the mechanisms of VDD-induced HTN will ultimately provide evidence to support the development of etiology-specific prevention and treatment strategies focused on HTN in the VD-deficient population.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"445-453"},"PeriodicalIF":5.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40266830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Preeclampsia and COVID-19: the Role of Inflammasome Activation. 子痫前期与COVID-19:炎性体激活的作用。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2022-09-01 DOI: 10.1007/s11906-022-01195-4

Denise C Cornelius, Xi Wang, Ashley Griffin, Rachael Morris, Kedra Wallace

{"title":"Preeclampsia and COVID-19: the Role of Inflammasome Activation.","authors":"Denise C Cornelius, Xi Wang, Ashley Griffin, Rachael Morris, Kedra Wallace","doi":"10.1007/s11906-022-01195-4","DOIUrl":"https://doi.org/10.1007/s11906-022-01195-4","url":null,"abstract":"Purpose of review: It is well established that controlled immune activation and balance is critical for women's reproductive health and successful pregnancy outcomes. Research in recent decades in both clinical and animal studies has demonstrated that aberrant immune activation and inflammation play a role in the development and progression of women's reproductive health and pregnancy-related disorders. Inflammasomes are multi-protein cytoplasmic complexes that mediate immune activation. In this review, we summarize current knowledge on the role of inflammasome activation in pregnancy-related disorders.Recent findings: Increased activation of inflammasome is associated with multiple women's health reproductive disorders and pregnancy-associated disorders, including preeclampsia (PreE). Inflammasome activation is also associated with the novel coronavirus disease 2019 (COVID-19) disease caused by the SARS-Cov-2 virus. We and others have observed a positive association between increased PreE incidences with the onset of the COVID-19 pandemic. Here, we present our recent data indicating increased inflammasome activation, represented by caspase-1 activity, in women with COVID-19 and PreE compared to normotensive pregnant women COVID-19. The role of inflammation in pregnancy-related disorders is an area of intense research interest. With the onset of the COVID-19 pandemic and the associated increase in PreE observed clinically, there is a greater need to identify mechanisms of pathophysiology and targets to treat this maternal disorder. Inflammasome activation is associated with PreE and COVID-19 infection and may hold therapeutic potential to improve outcomes associated with PreE and curb the morbidity attributed to PreE.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":"24 9","pages":"341-348"},"PeriodicalIF":5.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9224104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Interpreting High-Sensitive Troponins in Patients with Hypertension. 解读高血压患者的高敏感肌钙蛋白。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2022-09-01 Epub Date: 2022-06-18 DOI: 10.1007/s11906-022-01197-2

Mary C McHugh, Deborah B Diercks

{"title":"Interpreting High-Sensitive Troponins in Patients with Hypertension.","authors":"Mary C McHugh, Deborah B Diercks","doi":"10.1007/s11906-022-01197-2","DOIUrl":"https://doi.org/10.1007/s11906-022-01197-2","url":null,"abstract":"Purpose of review: As the high-sensitivity cardiac troponin (hs-cTn) becomes more broadly used, physicians must understand the strengths and limitations of using the hs-cTn in the hypertensive population.Recent findings: The most common cause of hs-cTn elevation is cardiac myocyte injury and death; alternate mechanisms for hs-cTn elevation in the absence of cardiac myocyte death are not clearly understood. Hs-cTn elevation has been found in significant proportions of patients with asymptomatic hypertension, in patients with acute hypertensive crisis, and has even been used to predict patients who will go on to develop hypertension. While the mechanisms remain undefined, there is evidence that elevations in hs-cTn are associated with both short- and long-term morbidity and mortality. While ongoing research further defines the relationship between hypertension and hs-cTn, the emergency medicine physician must make clinical decisions today regarding the utility of this increasingly used biomarker. Given the current evidence, clinical context must be utilized including a complete clinical picture, EKGs findings, and importantly serial hs-cTn when needed to establish whether myocardial injury or myocardial infarction is occurring.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"349-352"},"PeriodicalIF":5.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39986540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlates of Blood Pressure Awareness, Treatment, and Control Among Adults 50 Years or Older by HIV Status in Northwestern Tanzania. 坦桑尼亚西北部50岁及以上成年人与HIV感染状况相关的血压意识、治疗和控制

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2022-08-01 DOI: 10.1007/s11906-022-01188-3

Charles Muiruri, Bahati Wajanga, Christine Kim, Brandon A Knettel, Carl J Mhina, John A Bartlett, Jamal J Msangi, Msabah A Msabah, Helene Vilme, Samuel Kalluvya

{"title":"Correlates of Blood Pressure Awareness, Treatment, and Control Among Adults 50 Years or Older by HIV Status in Northwestern Tanzania.","authors":"Charles Muiruri, Bahati Wajanga, Christine Kim, Brandon A Knettel, Carl J Mhina, John A Bartlett, Jamal J Msangi, Msabah A Msabah, Helene Vilme, Samuel Kalluvya","doi":"10.1007/s11906-022-01188-3","DOIUrl":"https://doi.org/10.1007/s11906-022-01188-3","url":null,"abstract":"Purpose of review: The objective of this study was to describe the increasing incidence and risk of cardiovascular disease among persons living with HIV (PLWH) in Sub-Saharan Africa. We also used data to compare hypertension (a common NCD among PLWH) outcomes between PLWH and HIV-uninfected individuals among older adults in Northwestern Tanzania.Recent findings: Hypertension is increasingly common in Sub-Saharan Africa and a leading cause of cardiovascular disease for PLWH. Among those with hypertension, PLWH have a 50% higher risk of incident myocardial infarction compared to the general population. In response to the rising incidence of these non-communicable diseases (NCDs) among PLWH, recently, the Joint United Nations Program on HIV/AIDS supported the integration of NCD care into routine clinical care for HIV. However, data are lacking on levels of awareness of hypertension status, diagnosis, and antihypertensive medication adherence. Given the higher likelihood of elevated blood pressure among PLWH, there is an urgent need to implement interventions to improve blood pressure control in this population. Researchers should evaluate treatment barriers at multiple levels including health system, healthcare providers, and patients' level and tailor evidence-based interventions to increase achievement of blood pressure control for PLWH.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":"24 8","pages":"259-266"},"PeriodicalIF":5.6,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357024/pdf/nihms-1798186.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10289004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Addressing Hypertension Outcomes Using Telehealth and Population Health Managers: Adaptations and Implementation Considerations. 利用远程医疗和人口健康管理人员解决高血压问题:适应和实施考虑

IF 3.9 2区医学

Current Hypertension Reports Pub Date : 2022-08-01 Epub Date: 2022-05-10 DOI: 10.1007/s11906-022-01193-6

Connor Drake, Allison A Lewinski, Abigail Rader, Julie Schexnayder, Hayden B Bosworth, Karen M Goldstein, Jennifer Gierisch, Courtney White-Clark, Felicia McCant, Leah L Zullig

{"title":"Addressing Hypertension Outcomes Using Telehealth and Population Health Managers: Adaptations and Implementation Considerations.","authors":"Connor Drake, Allison A Lewinski, Abigail Rader, Julie Schexnayder, Hayden B Bosworth, Karen M Goldstein, Jennifer Gierisch, Courtney White-Clark, Felicia McCant, Leah L Zullig","doi":"10.1007/s11906-022-01193-6","DOIUrl":"10.1007/s11906-022-01193-6","url":null,"abstract":"Purpose of review: There is a growing evidence base describing population health approaches to improve blood pressure control. We reviewed emerging trends in hypertension population health management and present implementation considerations from an intervention called Team-supported, Electronic health record-leveraged, Active Management (TEAM). By doing so, we highlight the role of population health managers, practitioners who use population level data and to proactively engage at-risk patients, in improving blood pressure control.Recent findings: Within a population health paradigm, we discuss telehealth-delivered approaches to equitably improve hypertension care delivery. Additionally, we explore implementation considerations and complementary features of team-based, telehealth-delivered, population health management. By leveraging the unique role and expertise of a population health manager as core member of team-based telehealth, health systems can implement a cost-effective and scalable intervention that addresses multi-level barriers to hypertension care delivery. We describe the literature of telehealth-based population health management for patients with hypertension. Using the TEAM intervention as a case study, we then present implementation considerations and intervention adaptations to integrate a population health manager within the health care team and effectively manage hypertension for a defined patient population. We emphasize practical considerations to inform implementation, scaling, and sustainability. We highlight future research directions to advance the field and support translational efforts in diverse clinical and community contexts.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":"24 1","pages":"267-284"},"PeriodicalIF":3.9,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48915821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Critical Role for the Paraventricular Nucleus of the Hypothalamus in the Regulation of the Volume Reflex in Normal and Various Cardiovascular Disease States. 下丘脑室旁核在调节正常和各种心血管疾病状态下的体积反射中的关键作用

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2022-07-01 DOI: 10.1007/s11906-022-01187-4

Hong Zheng, Kenichi Katsurada, Shyam Nandi, Yifan Li, Kaushik P Patel

{"title":"A Critical Role for the Paraventricular Nucleus of the Hypothalamus in the Regulation of the Volume Reflex in Normal and Various Cardiovascular Disease States.","authors":"Hong Zheng, Kenichi Katsurada, Shyam Nandi, Yifan Li, Kaushik P Patel","doi":"10.1007/s11906-022-01187-4","DOIUrl":"https://doi.org/10.1007/s11906-022-01187-4","url":null,"abstract":"Purpose of review: This review focuses on studies implicating forebrain neural pathways and neuromodulator systems, particularly, the nitric oxide system within the paraventricular nucleus of the hypothalamus in regulating neurohumoral drive, autonomic pathways, and fluid balance.Recent findings: Accumulating evidence from animals with experimental models of hypertension and heart failure as well as humans with hypertension suggests that alterations in central neural pathways, particularly, within the PVN neuromodulated by neuronal nitric oxide, are involved in regulating sympathetic outflow particularly to the kidney resulting in alterations in fluid balance commonly observed in hypertension and heart failure states. The characteristics of the hypertensive and heart failure states include alterations in neuronal nitric oxide within the PVN to cause an increase in renal sympathetic nerve activity to result in sodium and fluid retention in these diseases. A comprehensive understanding of these mechanisms will enhance our ability to treat hypertensive and heart failure conditions and their cardiovascular complications more efficiently.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":"24 7","pages":"235-246"},"PeriodicalIF":5.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308710/pdf/nihms-1809657.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10090147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4