Current Opinion in Nephrology and Hypertension最新文献_第8页

The climate impact of dialysis. 透析对气候的影响。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-01-01 Epub Date: 2023-10-27 DOI: 10.1097/MNH.0000000000000940

Elaine Phua, Yvonne Shen

{"title":"The climate impact of dialysis.","authors":"Elaine Phua, Yvonne Shen","doi":"10.1097/MNH.0000000000000940","DOIUrl":"10.1097/MNH.0000000000000940","url":null,"abstract":"Purpose of review: A reciprocal relationship currently exists between climate change and healthcare, mutually influencing each other. There have been significant planetary shifts in recent decades, marked by escalating temperatures, frequent natural calamities, a disturbing surge in climate-linked fatalities, and a heightened incidence of kidney disease diagnoses.Recent findings: Dialysis, a life-preserving treatment for kidney failure, extends to 2-3 million patients globally, mainly through in-centre haemodialysis. This treatment exerts an environmental toll, contributing to the healthcare sector's carbon footprint through water usage, energy consumption, waste generation, and current procurement practices. Diligent scrutiny and data collection of these facets have spurred sustainability initiatives, beginning at the local level with water, energy, and waste management. Still, this represents just the tip of the iceberg, with a pressing need for more comprehensive and habitual sustainable dialysis practices.Summary: This review examines the carbon footprint from dialysis, probes its ecological ramifications, and underscores potential solutions to lessen its climate impact.","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54228040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kidney disease hotspots and water balance in a warming world. 肾脏疾病热点与全球变暖中的水平衡。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-01-01 Epub Date: 2023-10-25 DOI: 10.1097/MNH.0000000000000938

Marimar Contreras Nieves, Angelina Powers, Shuchi Anand, Penny Vlahos

{"title":"Kidney disease hotspots and water balance in a warming world.","authors":"Marimar Contreras Nieves, Angelina Powers, Shuchi Anand, Penny Vlahos","doi":"10.1097/MNH.0000000000000938","DOIUrl":"10.1097/MNH.0000000000000938","url":null,"abstract":"Purpose of review: Geographically localized areas with a high prevalence of kidney disease exist currently in several regions of the world. Although the exact cause is unclear, environmental exposures accelerated by climate change, particularly heat exposure and ground water contamination, are hypothesized as putative risk factors. Aiming to inform investigations of water-related exposures as risk factors for kidney disease, we excavate the history of major water sources in three regions that are described as hotspots of kidney disease: the low-lying coastal regions in El Salvador and Nicaragua, the dry central region in Sri Lanka, and the Central Valley of California.Recent findings: Historic data indicate that these regions have experienced water scarcity to which several human-engineered solutions were applied; these solutions could be hypothesized to increase residents' exposure to putative kidney toxins including arsenic, fluoride, pesticides, and cyanobacteria. Combined with heat stress experienced in context of climate change, there is potential for multistressor effects on kidney function. Climate change will also amplify water scarcity, and even if regional water sources are not a direct risk factor for development of kidney disease, their scarcity will complicate the treatment of the relatively larger numbers of persons with kidney disease living in these hotspots.Summary: Nephrologists and kidney disease researchers need to engage in systematic considerations of environmental exposures as potential risk factors for kidney disease, including water sources, their increasing scarcity, and threats to their quality due to changing climate.","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11027962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54228038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel pharmacological interventions for diabetic kidney disease. 糖尿病肾病的新型药物干预。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-01-01 Epub Date: 2023-10-25 DOI: 10.1097/MNH.0000000000000935

Seng Kiong Tan, Jairo A Pinzon-Cortes, Mark E Cooper

{"title":"Novel pharmacological interventions for diabetic kidney disease.","authors":"Seng Kiong Tan, Jairo A Pinzon-Cortes, Mark E Cooper","doi":"10.1097/MNH.0000000000000935","DOIUrl":"10.1097/MNH.0000000000000935","url":null,"abstract":"Purpose of review: The purpose of this review is to summarize the latest evidence on the prevention and progression of diabetic kidney disease (DKD), as well as novel pharmacological interventions from preclinical and early clinical studies with promising findings in the reduction of this condition's burden.Recent findings: We will cover the latest evidence on the reduction of proteinuria and kidney function decline in DKD achieved through established renin-angiotensin-aldosterone system (RAAS) system blockade and the more recent addition of SGLT2i, nonsteroidal mineralocorticoid receptor antagonists (MRAs) and GLP1-RA, that combined will most likely integrate the mainstay for current DKD treatment. We also highlight evidence from new mechanisms of action in DKD, including other haemodynamic anti-inflammatory and antifibrotic interventions, oxidative stress modulators and cell identity and epigenetic targets.Summary: Renal specific outcome trials have become more popular and are increasing the available armamentarium to diminish the progression of renal decline in patients at greater risk of end-stage kidney disease (ESKD) such as diabetic individuals. A combined pharmaceutical approach based on available rigorous studies should include RAAS blockade, SGLT2 inhibitors, nonsteroidal MRA and expectedly GLP1-RA on a personalized based-intervention. New specific trials designed to address renal outcomes will be needed for innovative therapies to conclude on their potential benefits in DKD.","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54228039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate change and its influence in nephron mass. 气候变化及其对肾单位质量的影响。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-01-01 Epub Date: 2023-10-06 DOI: 10.1097/MNH.0000000000000932

Ana Catalina Alvarez-Elias, Barry M Brenner, Valerie A Luyckx

{"title":"Climate change and its influence in nephron mass.","authors":"Ana Catalina Alvarez-Elias, Barry M Brenner, Valerie A Luyckx","doi":"10.1097/MNH.0000000000000932","DOIUrl":"10.1097/MNH.0000000000000932","url":null,"abstract":"Purpose of review: The consequences of climate change, including heat and extreme weather events impact kidney function in adults and children. The impacts of climate change on kidney development during gestation and thereby on kidney function later in life have been poorly described. Clinical evidence is summarized to highlight possible associations between climate change and nephron mass.Recent findings: Pregnant women are vulnerable to the effects of climate change, being less able to thermoregulate, more sensitive to the effects of dehydration, and more susceptible to infections. Exposure to heat, wildfire smoke, drought, floods and climate-related infections are associated with low birth weight, preterm birth and preeclampsia. These factors are associated with reduced nephron numbers, kidney dysfunction and higher blood pressures in offspring in later life. Exposure to air pollution is associated with higher blood pressures in children and has variable effects on estimated glomerular filtration rate.Summary: Climate change has important impacts on pregnant women and their unborn children. Being born too small or too soon is associated with life-time risk of kidney disease. Climate change may therefore have a dual effect of impacting fetal kidney development and contributing to cumulative postnatal kidney injury. The impact on population kidney health of future generations may be significant.","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41113196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate change and kidney stones. 气候变化和肾结石。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-01-01 Epub Date: 2023-09-18 DOI: 10.1097/MNH.0000000000000931

Grace E Maline, David S Goldfarb

{"title":"Climate change and kidney stones.","authors":"Grace E Maline, David S Goldfarb","doi":"10.1097/MNH.0000000000000931","DOIUrl":"10.1097/MNH.0000000000000931","url":null,"abstract":"Purpose of review: Kidney stones affect an increasing proportion of the population. We suggest that these trends are in part influenced by exposure to higher temperatures as a result of climate change and urbanization. The changing epidemiology of kidney stones is a topic worthy of discussion due to the economic and healthcare burden the condition poses as well as the quality-of-life disruption faced by individuals with kidney stones.Recent findings: The relationship between heat and kidney stones is well supported. Exposure to high temperatures has been shown to increase risk for stone development within a short time frame. Effects are modified by factors such as sex, comorbid conditions, and population vulnerability and adaptability. Urban heat islands (UHIs) likely exaggerate the effect of increasing global surface temperature. The concentration of UHIs often coincides with historic redlining practices in the United States, potentially contributing to observed disparities in kidney health among minoritized populations. As global surface temperature increases and urbanization trends continue, a greater proportion of the world's population is exposed to significant temperature extremes each year, leading to the expectation that kidney stone prevalence will continue to increase.Summary: This work describes the effect of increasing global surface temperature as a result of climate change on kidney stone disease and kidney health. These effects may result in further perpetuation of significant kidney stone related social disparities. We suggest strategies to mitigate the effects of heat exposure on stone formation.","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A paradigm shift from office to home-based blood pressure measurement approaches in kidney transplant recipients. 肾移植受者从办公室到家庭血压测量方法的范式转变。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-01-01 Epub Date: 2023-11-08 DOI: 10.1097/MNH.0000000000000951

Ekamol Tantisattamo, Antoney J Ferrey, Uttam G Reddy, Fatima T Malik, Man Kit Michael Siu, Fawaz Al Ammary, Wei Ling Lau

{"title":"A paradigm shift from office to home-based blood pressure measurement approaches in kidney transplant recipients.","authors":"Ekamol Tantisattamo, Antoney J Ferrey, Uttam G Reddy, Fatima T Malik, Man Kit Michael Siu, Fawaz Al Ammary, Wei Ling Lau","doi":"10.1097/MNH.0000000000000951","DOIUrl":"10.1097/MNH.0000000000000951","url":null,"abstract":"Purpose of review: The unattended blood pressure (BP) readings from home blood pressure (HBP) monitoring should provide more accurate BP readings than attended BP obtained from office blood pressure (OBP). Here, we review evidence supporting the clinical utility of HBP and automatic remote monitoring of blood pressure (ARM-BP) in kidney transplant recipients (KTR).Recent findings: BP from 24-h ambulatory blood pressure monitoring (24-h ABPM) is higher than but better associated with kidney and cardiovascular outcomes compared to OBP and HBP. While there is discordance of BP readings across different BP measurement methods causing BP misclassification, HBP provides BP readings closer to the readings from the 24-h ABPM than those from OBP. Systolic and diastolic BP is better controlled within 30 days after utilizing ARM-BP.Summary: Compared to OBP, HBP minimizes the attended effect of OBP, and its readings are closer to the gold standard 24-h ABPM. ARM-BP improves BP control in the short term and trials of longer follow-up duration are required to evaluate sustained clinical benefits in KTR. The paradigm of BP monitoring may shift toward HBP, while OBP may be utilized primarily for KTR who cannot perform HBP for hypertension diagnosis and management.","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tackling the intersectoral challenges in kidney diseases and transplantation: shared decision and realistic care for advanced diagnostic and therapeutic modalities for kidney diseases and transplantation. 应对肾脏疾病和移植领域的跨部门挑战:对肾脏疾病和移植的先进诊断和治疗方式的共同决策和现实护理。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-01-01 Epub Date: 2023-11-30 DOI: 10.1097/MNH.0000000000000941

Ekamol Tantisattamo, Ramy M Hanna, Kamyar Kalantar-Zadeh

引用次数: 0

Implications of climate change on acute kidney injury. 气候变化对急性肾损伤的影响。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-01-01 Epub Date: 2023-09-05 DOI: 10.1097/MNH.0000000000000926

Natalie Freidin, Eily Hayes, Sarah A Struthers

{"title":"Implications of climate change on acute kidney injury.","authors":"Natalie Freidin, Eily Hayes, Sarah A Struthers","doi":"10.1097/MNH.0000000000000926","DOIUrl":"10.1097/MNH.0000000000000926","url":null,"abstract":"Purpose of review: Climate change is an active and growing threat to human health. This review examines the evidence linking climate change to kidney diseases, with a focus on acute kidney injury (AKI).Recent findings: A growing body of evidence documents the adverse impact of various environmental and occupational exposures on kidney health. Extreme heat exposure increases the risk for AKI in vulnerable populations, particularly outdoor workers. These effects are being seen in both developed and developing nations, impacting equatorial as well as more northern climates. Climate change is also increasing the risk of water-borne and vector-borne infections, which are important causes of AKI in tropical regions. Due to overlapping environmental and social risk factors, populations in low-income and middle-income countries are likely to be disproportionately affected by climate-related health impacts, including heightened risk for kidney diseases.Summary: Climate change will adversely impact global kidney health over the course of the century through effects on temperature and risk of endemic infections. Alongside efforts to aggressively reduce carbon emissions, additional research is needed to guide public and environmental health policies aimed at mitigating the impact of climate change on human health.","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10552780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heating up: climate change and the threat to human health. 升温：气候变化和对人类健康的威胁。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-01-01 Epub Date: 2023-10-16 DOI: 10.1097/MNH.0000000000000933

Blaire Byg, Ankur D Shah

引用次数: 0

Climate change and kidney health: an urgent call to action. 气候变化与肾脏健康:紧急行动呼吁。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-01-01 Epub Date: 2023-11-30 DOI: 10.1097/MNH.0000000000000937

Ankur D Shah

引用次数: 0