Current Opinion in Nephrology and Hypertension最新文献_第10页

New therapeutic perspectives for vascular and valvular calcifications in chronic kidney disease. 慢性肾脏病血管和瓣膜钙化的新治疗视角。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-04-05 DOI: 10.1097/mnh.0000000000000985

Sharon Huish, Smeeta Sinha

引用次数: 0

Mitochondrial bioenergetics: coupling of transport to tubular mitochondrial metabolism. 线粒体生物能：运输与肾小管线粒体新陈代谢的耦合。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-04-05 DOI: 10.1097/mnh.0000000000000986

Yong-Yao W Cheng, Chih-Jen Cheng

引用次数: 0

Phosphate sensing in health and disease. 健康和疾病中的磷酸盐感应。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-04-03 DOI: 10.1097/mnh.0000000000000984

Christoph Zechner, Eugene P Rhee

引用次数: 0

The genetics of cystinuria - an update and critical reevaluation. 胱氨酸尿症的遗传学--最新进展和重要的重新评估。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-03-01 Epub Date: 2023-11-06 DOI: 10.1097/MNH.0000000000000949

Clàudia Abad Baucells, Ria Schönauer, Jan Halbritter

{"title":"The genetics of cystinuria - an update and critical reevaluation.","authors":"Clàudia Abad Baucells, Ria Schönauer, Jan Halbritter","doi":"10.1097/MNH.0000000000000949","DOIUrl":"10.1097/MNH.0000000000000949","url":null,"abstract":"Purpose of review: We aimed to critically evaluate how the establishment of genotype-based treatment for cystinuria has been hampered due to the large number of variants of unknown significance (VUS) within the disease causing genes as well as challenges in accessing a large enough sample size for systematic analysis of endpoint parameters that truly reflect disease severity. This review further discusses how to overcome these hurdles with the establishment of a cystinuria-specific refinement of the current American College of Medical Genetics and Genomics (ACMG)-criteria of variant interpretation.Recent findings: Novel tools such as AlphaMissense combined with the establishment of a refined ACMG criterion will play a significant role in classifying VUS within the responsible disease genes SLC3A1 (rBAT) and SLC7A9 (BAT1). This will also be essential in elucidating the role of promising candidate genes, such as SLC7A13 (AGT1), which have been derived from murine model systems and still need further research to determine if they are involved in human cystinuria.Summary: Cystinuria was one of the first disorders to receive a gene-based classification, nonetheless, the clinically actionable implications of genetic diagnostics is still minor. This is due to poorly characterized genotype-phenotype correlations which results in a lack of individualized (genotype-) based management and metaphylaxis.","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":"33 2","pages":"231-237"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive models in chronic kidney disease: essential tools in clinical practice. 慢性肾脏疾病的预测模型：临床实践中的重要工具。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-03-01 Epub Date: 2023-11-08 DOI: 10.1097/MNH.0000000000000950

Andrea Spasiano, Claudia Benedetti, Giovanni Gambaro, Pietro Manuel Ferraro

{"title":"Predictive models in chronic kidney disease: essential tools in clinical practice.","authors":"Andrea Spasiano, Claudia Benedetti, Giovanni Gambaro, Pietro Manuel Ferraro","doi":"10.1097/MNH.0000000000000950","DOIUrl":"10.1097/MNH.0000000000000950","url":null,"abstract":"Purpose of review: The integration of risk prediction in managing chronic kidney disease (CKD) is universally considered a key point of routine clinical practice to guide time-sensitive choices, such as dialysis access planning or counseling on kidney transplant options. Several prognostic models have been developed and validated to provide individualized evaluation of kidney failure risk in CKD patients. This review aims to analyze the current evidence on existing predictive models and evaluate the different advantages and disadvantages of these tools.Recent findings: Since Tangri et al. introduced the Kidney Failure Risk Equation in 2011, the nephrological scientific community focused its interest in enhancing available algorithms and finding new prognostic equations. Although current models can predict kidney failure with high discrimination, different questions remain unsolved. Thus, this field is open to new possibilities and discoveries.Summary: Accurately informing patients of their prognoses can result in tailored therapy with important clinical and psychological implications. Over the last 5 years, the number of disease-modifying therapeutic options has considerably increased, providing possibilities to not only prevent the kidney failure onset in patients with advanced CKD but also delay progression from early stages in at-risk individuals.","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":" ","pages":"238-246"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clearing the air: a review of the effects of air pollution on dialysis outcomes. 净化空气：回顾空气污染对透析结果的影响。

IF 2.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-03-01 Epub Date: 2024-01-11 DOI: 10.1097/MNH.0000000000000968

Annika Spencer, Linda-Marie Lavenburg, Alison P Sanders, Ankur D Shah

{"title":"Clearing the air: a review of the effects of air pollution on dialysis outcomes.","authors":"Annika Spencer, Linda-Marie Lavenburg, Alison P Sanders, Ankur D Shah","doi":"10.1097/MNH.0000000000000968","DOIUrl":"10.1097/MNH.0000000000000968","url":null,"abstract":"Purpose of review: An evolving body of literature indicates exposure to air pollutants is associated with adverse health outcomes in dialysis patients. As the prevalence of kidney disease increases, understanding the role of environmental agents on the health of dialysis patients is critical to reducing global morbidity and mortality.Recent findings: We identified 16 publications that investigated associations between pollutants including particulate matter (PM 2.5 and PM 10 ), carbon monoxide (CO), nitrogen dioxide (NO 2 ), sulfur dioxide (SO 2 ), and ozone (O 3 ) and health outcomes among dialysis patients. Eight studies examined the effects of particulate matter (PM) and four studies examined the effects CO exposure on dialysis patients. Exposure to PM was consistently associated with outcomes including all-cause mortality and a smaller body of literature suggested relationships with subclinical outcomes. Exposure to CO was associated with all-cause mortality, generalized inflammation, and uremic pruritus. An additional four studies examined multiple pollutant exposures including NO 2 , SO 2 , and O 3 and reported associations with all-cause mortality in dialysis patients.Summary: This review emphasized the nascent literature that demonstrates consistent relationships between air pollutant exposure and adverse outcomes among dialysis patients. Further research is needed to assess the impact of air pollutants, including how co-exposures will impact dialysis patient health.","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":" ","pages":"192-202"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10805370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139416627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eryptosis: a driver of anemia in chronic kidney disease. 贫血:慢性肾脏疾病贫血的驱动因素。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-03-01 Epub Date: 2023-11-17 DOI: 10.1097/MNH.0000000000000957

Rosi Bissinger, Syed M Qadri, Ferruh Artunc

{"title":"Eryptosis: a driver of anemia in chronic kidney disease.","authors":"Rosi Bissinger, Syed M Qadri, Ferruh Artunc","doi":"10.1097/MNH.0000000000000957","DOIUrl":"10.1097/MNH.0000000000000957","url":null,"abstract":"Purpose of review: Anemia, characterized by a reduction in red blood cell (RBC) count or hemoglobin concentration, commonly accompanies chronic kidney disease (CKD), significantly impacting patients' quality of life. This review delves into the multifaceted nature of anemia in CKD, with a focus on novel mechanisms, particularly the dysregulation of eryptosis or programmed cell death of RBCs, leading to shortened RBC lifespan.Recent findings: Recent studies in CKD patients and mouse models revealed that eryptosis, driven by factors such as uremic toxins, inflammation, and imbalances in calcium homeostasis, plays a pivotal role in the development of renal anemia. Dysregulated eryptosis results in premature RBC destruction, exacerbating the hypoproliferative character of anemia in CKD.Summary: Recognizing the intricate relationship between eryptosis and anemia in CKD opens promising prospects for improving patient outcomes and enhancing our understanding of this complex condition. Future research and therapeutic development in this area hold the potential to improve anemia treatment of CKD patients.","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":" ","pages":"220-225"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138175865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin-15 in kidney disease and therapeutics. 肾脏疾病和治疗中的白细胞介素-15。

IF 2.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-03-01 Epub Date: 2023-12-26 DOI: 10.1097/MNH.0000000000000964

Gentzon Hall

{"title":"Interleukin-15 in kidney disease and therapeutics.","authors":"Gentzon Hall","doi":"10.1097/MNH.0000000000000964","DOIUrl":"10.1097/MNH.0000000000000964","url":null,"abstract":"Purpose of review: Interleukin 15 (IL-15) is a member of the IL-2 family of common gamma chain receptor cytokines with well described anti-inflammatory, pro-survival and pro-proliferative signaling properties. The cytoprotective role of IL-15 in the kidney is now coming into focus with recent reports of its beneficial actions in various forms of kidney disease. This review will summarize what is currently known about IL-15 signaling in the kidney and highlight recent evidence of its beneficial effects on kidney physiology.Recent findings: IL-15 and its heterotrimeric receptor are expressed throughout the kidney. Like all IL-2 family cytokines, IL-15 can activate signaling through the Janus Kinase (JAK)/Signal transducer of activated T-cells (STAT), phosphoinositol-3 kinase (PI-3K)/AKT and mitogen activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathways and recent evidence suggests that STAT5B is an essential transcriptional mediator of prosurvival signaling in glomerular visceral epithelial cells (i.e. podocytes). IL-15 has also been shown to suppress pro-apoptotic signaling in models of acute kidney injury and pro-fibrotic signaling in models of chronic kidney disease.Summary: The cytoprotective properties of IL-15 suggest that it may have potential as a nonimmunosuppresive therapeutic for kidney disease. A novel class of IL-15 immunotherapies has emerged for the treatment cancer and some have demonstrated efficacy in clinical trials. These well tolerated IL-15 agonists could possibly be repurposed for the treatment of kidney disease and warrant further exploration.","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":" ","pages":"174-180"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10893218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139073616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thrombotic microangiopathy - the importance of a multidisciplinary approach. 血栓性微血管病-多学科方法的重要性。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-03-01 Epub Date: 2023-11-29 DOI: 10.1097/MNH.0000000000000954

Minh-Ha Tran, Samir Patel, Sheetal Desai, Stefan Ciurea, Benjamin J Lee, Ramy Hanna

{"title":"Thrombotic microangiopathy - the importance of a multidisciplinary approach.","authors":"Minh-Ha Tran, Samir Patel, Sheetal Desai, Stefan Ciurea, Benjamin J Lee, Ramy Hanna","doi":"10.1097/MNH.0000000000000954","DOIUrl":"10.1097/MNH.0000000000000954","url":null,"abstract":"Purpose of review: The purpose of this review is to highlight the importance of a multidisciplinary thrombotic microangiopathies (TMA) Team. This goal will be accomplished through review of the complement system, discuss various causes of thrombotic microangiopathies (TMA), and aspects of their diagnosis and management. In so doing, readers will gain an appreciation for the complexity of this family of disorders and realize the benefit of a dedicated multidisciplinary TMA Team.Recent findings: TMA causes derive from multiple specialty areas, are difficult to timely recognize, pose complex challenges, and require multidisciplinary management. Hematopoietic stem cell transplant-associated TMA (TA-TMA) and TA-TMA related multiorgan dysfunction syndrome (TA-TMA MODS) are areas of burgeoning research; use of complement testing and eculizumab precision-dosing has been found to better suppress complement activity in TA-TMA than standard eculizumab dosing. Newer tests are available to risk-stratify obstetric patients at risk for severe pre-eclampsia, whose features resemble those of TA-TMA MODS. Numerous disorders may produce TMA-like findings, and a systematic approach aids in their identification. TMA Teams elevate institutional awareness of increasingly recognized TMAs, will help expedite diagnostic and therapeutic interventions, and create pathways to future TMA-related research and facilitate access to clinical trials.Summary: Establishment of a TMA-Team is valuable in developing the necessary institutional expertise needed to promptly recognize and appropriately manage patients with TMA.","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":" ","pages":"247-256"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interferon gamma in the pathogenesis of hypertension - recent insights. 高血压发病机制中的γ干扰素--最新见解。

IF 3.2 3区医学

Current Opinion in Nephrology and Hypertension Pub Date : 2024-03-01 Epub Date: 2024-01-04 DOI: 10.1097/MNH.0000000000000966

Lance N Benson, Shengyu Mu

{"title":"Interferon gamma in the pathogenesis of hypertension - recent insights.","authors":"Lance N Benson, Shengyu Mu","doi":"10.1097/MNH.0000000000000966","DOIUrl":"10.1097/MNH.0000000000000966","url":null,"abstract":"Purpose of review: The mounting body of evidence underscores the pivotal role of interferon gamma (IFNγ) in the pathogenesis of hypertension, prompting exploration of the mechanisms by which this cytokine fosters a pro-inflammatory immune milieu, subsequently exacerbating hypertension. In this review, we delve into recent preclinical and clinical studies from the past two years to elucidate how IFNγ participates in the progression of hypertension.Recent findings: IFNγ promotes renal CD8 + T cell accumulation by upregulating tubular PDL1 and MHC-I, intensifying cell-to-cell interaction. Intriguingly, a nucleotide polymorphism in LNK, predisposing towards hypertension, correlates with augmented T cell IFNγ production. Additionally, anti-IFNγ treatment exhibits protective effects against T cell-mediated inflammation during angiotensin II infusion or transverse aortic constriction. Moreover, knockout of the mineralocorticoid receptor in T cells protects against cardiac dysfunction induced by myocardial infarction, correlating with reduced IFNγ and IL-6, decreased macrophage recruitment, and attenuated fibrosis. Interestingly, increased IFNγ production correlates with elevated blood pressure, impacting individuals with type 2 diabetes, nondiabetics, and obese hypertensive patients.Summary: These revelations spotlight IFNγ as the critical mediator bridging the initial phase of blood pressure elevation with the sustained and exacerbated pathology. Consequently, blocking IFNγ signaling emerges as a promising therapeutic target to improve the management of this 'silent killer.'","PeriodicalId":10960,"journal":{"name":"Current Opinion in Nephrology and Hypertension","volume":" ","pages":"154-160"},"PeriodicalIF":3.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10842676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139073615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0